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  1. Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patie...

    Authors: Louise A Knight, Christian M Kurbacher, Sharon Glaysher, Augusta Fernando, Ralf Reichelt, Susanne Dexel, Uwe Reinhold and Ian A Cree
    Citation: BMC Cancer 2009 9:38
    Content type: Research article Published on:

  2. The purpose of this study has been to establish the level of RCAS1 – a membrane protein expressed in various cancer cells and able to induce apoptosis of CTLs and NK cells in pharyngeal and laryngeal cancer an...

    Authors: Magdalena Dutsch-Wicherek, Romana Tomaszewska, Agata Lazar, Lukasz Wicherek and Jacek Skladzien
    Citation: BMC Cancer 2009 9:35
    Content type: Research article Published on:

  4. A consensus on the most reliable staging system for hepatocellular carcinoma (HCC) is still lacking but the most used is a revised Barcelona Clinic Liver Cancer (BCLC) system, adopted by the American Associati...

    Authors: Fabio Farinati, Adriana Sergio, Anna Baldan, Anna Giacomin, Maria Anna Di Nolfo, Paolo Del Poggio, Luisa Benvegnu, Gianludovico Rapaccini, Marco Zoli, Franco Borzio, Edoardo G Giannini, Eugenio Caturelli and Franco Trevisani
    Citation: BMC Cancer 2009 9:33
    Content type: Research article Published on:

  5. Clinical characterization of bladder carcinomas is still inadequate using the standard clinico-pathological prognostic markers. We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the cli...

    Authors: Hussein M Khaled, Abeer A Bahnassy, Amira A Raafat, Abdel-Rahman N Zekri, Maha S Madboul and Nadia M Mokhtar
    Citation: BMC Cancer 2009 9:32
    Content type: Research article Published on:

  6. Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands...

    Authors: Huining Tan, Yili Zhong and Zhongzong Pan
    Citation: BMC Cancer 2009 9:31
    Content type: Research article Published on:

  7. Prostate cancer is the second most frequently diagnosed cancer in men. Animal models that closely mimic clinical disease in humans are invaluable tools in the fight against prostate cancer. Recently, a Simian ...

    Authors: Curt E Harper, Brijesh B Patel, Leah M Cook, Jun Wang, Tomoyuki Shirai, Isam A Eltoum and Coral A Lamartiniere
    Citation: BMC Cancer 2009 9:30
    Content type: Research article Published on:

  8. The development of new therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models that generate both reproducible metastasis and the dis...

    Authors: Andreas Thalheimer, Christoph Otto, Marco Bueter, Bertram Illert, Stefan Gattenlohner, Martin Gasser, Detlef Meyer, Martin Fein, Christoph T Germer and Ana M Waaga-Gasser
    Citation: BMC Cancer 2009 9:29
    Content type: Research article Published on:

  9. Mesothelioma is a highly fatal cancer that is caused by exposure to asbestos fibres. In many populations, the occurrence of mesothelioma is monitored with the use of mortality data from death certification. We...

    Authors: Catherine Okello, Tom Treasure, Andrew G Nicholson, Julian Peto and Henrik Møller
    Citation: BMC Cancer 2009 9:28
    Content type: Research article Published on:

  11. Breast cancer is one of the main health problems in developed countries, occupying first place in mortality in women. It is well-known that there are risk factors associated with breast cancer development. Non...

    Authors: David Cantu de León, Delia Pérez Montiel, Jana Nemcova, Iva Mykyskova, Elmer Turcios, Verónica Villavicencio, Lucely Cetina, Alberto Coronel and Ondraj Hes
    Citation: BMC Cancer 2009 9:26
    Content type: Research article Published on:

  12. Microsatellite instability (MSI) refers to mutations in short motifs of tandemly repeated nucleotides resulting from replication errors and deficient mismatch repair (MMR). Colorectal cancer with MSI has chara...

    Authors: Søren A Jensen, Ben Vainer, Mogens Kruhøffer and Jens B Sørensen
    Citation: BMC Cancer 2009 9:25
    Content type: Research article Published on:

  13. Squamous cell carcinoma of esophagus (SCCE) occurs at a high incidence rate in certain parts of the world. This feature necessitates that different aspects of the disease and in particular genetic characterist...

    Authors: Maryam Zare, Ferdous Rastgar Jazii, Mohammad Reza Alivand, Negin Karimi Nasseri, Reza Malekzadeh and Mansour Yazdanbod
    Citation: BMC Cancer 2009 9:24
    Content type: Research article Published on:

  14. Traditionally standard treatment for patients with early stage endometrial cancer (EC) is total abdominal hysterectomy and bilateral salpingo oophorectomy (TAH+BSO) with or without lymph node dissection throug...

    Authors: Claudia BM Bijen, Justine M Briët, Geertruida H de Bock, Henriëtte JG Arts, Johanna A Bergsma-Kadijk and Marian JE Mourits
    Citation: BMC Cancer 2009 9:23
    Content type: Study protocol Published on:

  15. Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults. In an attempt to gain insight into the pathobiology of this eni...

    Authors: Luke H Stockwin, David T Vistica, Susan Kenney, David S Schrump, Donna O Butcher, Mark Raffeld and Robert H Shoemaker
    Citation: BMC Cancer 2009 9:22
    Content type: Research article Published on:

  16. Lumbar punctures (LPs) are common in children with cancer. Although pain management during the lumbar puncture has been well standardized, dealing with stress and anxiety is not well addressed yet. Our objecti...

    Authors: Perrine Marec-Bérard, Alvine Bissery, Kamila Kebaïli, Matthias Schell, Françoise Aubert, Ségolène Gaillard, Muriel Rabilloud, Behrouz Kassaï and Catherine Cornu
    Citation: BMC Cancer 2009 9:21
    Content type: Research article Published on:

  17. The metastatic disease rather than the primary tumor itself is responsible for death in most solid tumors, including breast cancer. The role of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMP...

    Authors: Rita CS Figueira, Luciana R Gomes, João S Neto, Fabricio C Silva, Ismael DCG Silva and Mari C Sogayar
    Citation: BMC Cancer 2009 9:20
    Content type: Research article Published on:

  18. Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation indu...

    Authors: Michelle S Cotroneo, Jill D Haag, Nicholas R Stapel, Jordy L Waller, Stephan Woditschka and Michael N Gould
    Citation: BMC Cancer 2009 9:19
    Content type: Research article Published on:

  19. To define a threshold value of apparent diffusion coefficient (ADC) with which malignant breast lesions can be distinguished from benign lesions, and to evaluate the ADC change of peri-tumor tissue in breast c...

    Authors: Zhang Yili, Huang Xiaoyan, Du Hongwen, Zhang Yun, Chen Xin, Wang Peng and Guo Youmin
    Citation: BMC Cancer 2009 9:18
    Content type: Research article Published on:

  20. Ewing sarcoma family of tumors (ESFT), characterized by t(11;22)(q24;q12), is one of the most common tumors of bone in children and young adults. In addition to EWS/FLI1 gene fusion, copy number changes are known...

    Authors: Suvi Savola, Arto Klami, Abhishek Tripathi, Tarja Niini, Massimo Serra, Piero Picci, Samuel Kaski, Diana Zambelli, Katia Scotlandi and Sakari Knuutila
    Citation: BMC Cancer 2009 9:17
    Content type: Research article Published on:

  21. Antibody-based immuneotherapy has achieved some success for cancer. But the main problem is that only a few tumor-associated antigens or therapeutic targets have been known to us so far. It is essential to ide...

    Authors: Ze-jun Lu, Qi-fang Song, Sa-sa Jiang, Qi Song, Wei Wang, Gao-hua Zhang, Bin Kan, Lan-tu Gou, Li-juan Chen, Feng Luo, Zhi Yong Qian, Jin-liang Yang and Yu Quan Wei
    Citation: BMC Cancer 2009 9:16
    Content type: Research article Published on:

  22. Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N-nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked meat and fish, the major dietary r...

    Authors: Chen-yu Liu, Yi-Hsiang Hsu, Ming-Tsang Wu, Pi-Chen Pan, Chi-Kung Ho, Li Su, Xin Xu, Yi Li and David C Christiani
    Citation: BMC Cancer 2009 9:15
    Content type: Research article Published on:

  23. We explored the heterogeneity of philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL) in a study of the effect of early features on prognosis in children. Here we report the long-term result...

    Authors: Virginie Gandemer, Marie-Francoise Auclerc, Yves Perel, Jean-Pierre Vannier, Edouard Le Gall, Francois Demeocq, Claudine Schmitt, Christophe Piguet, Jean-Louis Stephan, Odile Lejars, Marianne Debre, Philippe Jonveaux, Jean-Michel Cayuela, Sylvie Chevret, Guy Leverger and Andre Baruchel
    Citation: BMC Cancer 2009 9:14
    Content type: Study protocol Published on:

  24. It has been suggested that the single nucleotide polymorphism 309 (SNP309, T -> G) in the promoter region of the MDM2 gene is important for tumor development; however, with regards to breast cancer, inconsiste...

    Authors: Ying-Fang Sun, Jyh-Der Leu, Su-Mei Chen, I-Feng Lin and Yi-Jang Lee
    Citation: BMC Cancer 2009 9:13
    Content type: Research article Published on:

  25. Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, pr...

    Authors: Sanjay Sachdev, Yahao Bu and Irwin H Gelman
    Citation: BMC Cancer 2009 9:12
    Content type: Research article Published on:

  26. The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling.

    Authors: Cherry L Estilo, Pornchai O-charoenrat, Simon Talbot, Nicholas D Socci, Diane L Carlson, Ronald Ghossein, Tijaana Williams, Yoshihiro Yonekawa, Yegnanarayana Ramanathan, Jay O Boyle, Dennis H Kraus, Snehal Patel, Ashok R Shaha, Richard J Wong, Joseph M Huryn, Jatin P Shah…
    Citation: BMC Cancer 2009 9:11
    Content type: Research article Published on:

  27. With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulati...

    Authors: André O von Bueren, Tarek Shalaby, Christoph Oehler-Jänne, Lucia Arnold, Duncan Stearns, Charles G Eberhart, Alexandre Arcaro, Martin Pruschy and Michael A Grotzer
    Citation: BMC Cancer 2009 9:10
    Content type: Research article Published on:

  28. p75NTR has been used to isolate esophageal and corneal epithelial stem cells. In the present study, we investigated the expression of p75NTR in esophageal squamous cell carcinoma (ESCC) and explored the biologica...

    Authors: Sheng-Dong Huang, Yang Yuan, Xiao-Hong Liu, De-Jun Gong, Chen-Guang Bai, Feng Wang, Jun-Hui Luo and Zhi-Yun Xu
    Citation: BMC Cancer 2009 9:9
    Content type: Research article Published on:

  29. YKL-40 (chitinase-3-like-1) is a member of "mammalian chitinase-like proteins". The protein is expressed in many types of cancer cells and the highest plasma YKL-40 levels have been found in patients with meta...

    Authors: Estrid VS Høgdall, Merete Ringsholt, Claus K Høgdall, Ib Jarle Christensen, Julia S Johansen, Susanne K Kjaer, Jan Blaakaer, Lene Ostenfeld-Møller, Paul A Price and Lise H Christensen
    Citation: BMC Cancer 2009 9:8
    Content type: Research article Published on:

  31. Esophageal squamous cell carcinoma (ESCC) is the sixth most frequent neoplasia in Brazil. It is usually associated with a poor prognosis because it is often at an advanced stage when diagnosed and there is a h...

    Authors: Yukie Sato-Kuwabara, José I Neves, José HTG Fregnani, Rubens A Sallum and Fernando A Soares
    Citation: BMC Cancer 2009 9:6
    Content type: Research article Published on:

  32. We had earlier used the comparison of RAPD (Random Amplification of Polymorphic DNA) DNA fingerprinting profiles of tumor and corresponding normal DNA to identify genetic alterations in primary human glial tum...

    Authors: Kunzang Chosdol, Anjan Misra, Sachin Puri, Tapasya Srivastava, Parthaprasad Chattopadhyay, Chitra Sarkar, Ashok K Mahapatra and Subrata Sinha
    Citation: BMC Cancer 2009 9:5
    Content type: Research article Published on:

  33. Accurate assessment of HER-2/neu status is crucial for proper prognostic information and to offer direct appropriate treatment for breast cancer patients. Next to immunohistochemistry (IHC) to evaluate HER2 prote...

    Authors: Cathy B Moelans, Roel A de Weger, Chantal Ezendam and Paul J van Diest
    Citation: BMC Cancer 2009 9:4
    Content type: Research article Published on:

  35. Epithelial ovarian cancer survivors (EOCSs) frequently report multiple complaints after their treatment. The objective was to study somatic and mental morbidity in EOCSs associated with their Self- Rated Healt...

    Authors: Astrid Helene Liavaag, Anne Dørum, Sophie D Fosså, Claes Tropé and Alv A Dahl
    Citation: BMC Cancer 2009 9:2
    Content type: Research article Published on:

  36. The development of novel chemotherapeutic agents in colorectal cancer has improved survival. Following initial response to chemotherapeutic strategies many patients develop refractory disease. This poses a sig...

    Authors: Dara O Kavanagh, Gillian Chambers, Liam O' Grady, Kevin M Barry, Ronan P Waldron, Fadel Bennani, Paul W Eustace and Iqdam Tobbia
    Citation: BMC Cancer 2009 9:1
    Content type: Research article Published on:

  37. Accuracy in the diagnosis of breast cancer and classification of cancer subtypes has improved over the years with the development of well-established immunohistopathological criteria. More recently, diagnostic...

    Authors: Bala Gur-Dedeoglu, Ozlen Konu, Serkan Kir, Ahmet Rasit Ozturk, Betul Bozkurt, Gulusan Ergul and Isik G Yulug
    Citation: BMC Cancer 2008 8:396
    Content type: Research article Published on:

  38. The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dyspl...

    Authors: Jian-na Li, Chong-jin Feng, Yong-jun Lu, Hui-jun Li, Zheng Tu, Gui-qing Liao and Chun Liang
    Citation: BMC Cancer 2008 8:395
    Content type: Research article Published on:

  40. The treatment strategy usually depends on the disease state in the individual patient. However, it is difficult to estimate the disease state before treatment in many patients. The purpose of this study was to...

    Authors: Tomoko Furuya, Tetsuji Uchiyama, Atsushi Adachi, Takae Okada, Motonao Nakao, Atsunori Oga, Song-Ju Yang, Shigeto Kawauchi and Kohsuke Sasaki
    Citation: BMC Cancer 2008 8:393
    Content type: Research article Published on:

  41. SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet...

    Authors: Mehmet Ender Avci, Ozlen Konu and Tamer Yagci
    Citation: BMC Cancer 2008 8:392
    Content type: Research article Published on:

  42. Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical...

    Authors: Ilija Androic, Andrea Krämer, Ruilan Yan, Franz Rödel, Regine Gätje, Manfred Kaufmann, Klaus Strebhardt and Juping Yuan
    Citation: BMC Cancer 2008 8:391
    Content type: Research article Published on:

  43. Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are...

    Authors: Zohar A Dotan, Aviva Dotan, Jacob Ramon and Lydia Avivi
    Citation: BMC Cancer 2008 8:390
    Content type: Research article Published on:

  44. Better breast cancer prognostication may improve selection of patients for adjuvant therapy. We conducted a retrospective follow-up study in which we investigated sera of high-risk primary breast cancer patien...

    Authors: Marie-Christine W Gast, Harm van Tinteren, Marijke Bontenbal, René QGCM van Hoesel, Marianne A Nooij, Sjoerd Rodenhuis, Paul N Span, Vivianne CG Tjan-Heijnen, Elisabeth GE de Vries, Nathan Harris, Jos WR Twisk, Jan HM Schellens and Jos H Beijnen
    Citation: BMC Cancer 2008 8:389
    Content type: Research article Published on:

  45. Histone H1x is a ubiquitously expressed member of the H1 histone family. H1 histones, also called linker histones, stabilize compact, higher order structures of chromatin. In addition to their role as structur...

    Authors: Julia Warneboldt, Florian Haller, Olaf Horstmann, Bernhard C Danner, László Füzesi, Detlef Doenecke and Nicole Happel
    Citation: BMC Cancer 2008 8:388
    Content type: Research article Published on:

  46. Kidney and renal pelvis cancers account for 4% of all new cancer cases in the United States, among which 85% are renal cell carcinomas (RCC). While cigarette smoking is an established risk factor for RCC, litt...

    Authors: Ryan P Theis, Suzanne M Dolwick Grieb, Deborah Burr, Tariq Siddiqui and Nabih R Asal
    Citation: BMC Cancer 2008 8:387
    Content type: Research article Published on:

  47. Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression of ERCC1 correlates with insens...

    Authors: Kazumi Uchida, Peter V Danenberg, Kathleen D Danenberg and Jean L Grem
    Citation: BMC Cancer 2008 8:386
    Content type: Research article Published on:

  48. Vitamin D serum levels have been found to be related to sun exposure and diet, together with cell differentiation, growth control and consequently, cancer risk. Vitamin D receptor (VDR) genotypes may influence ca...

    Authors: Eva Barroso, Lara P Fernandez, Roger L Milne, Guillermo Pita, Elena Sendagorta, Uxua Floristan, Marta Feito, Jose A Aviles, Manuel Martin-Gonzalez, Jose I Arias, Pilar Zamora, Monserrat Blanco, Pablo Lazaro, Javier Benitez and Gloria Ribas
    Citation: BMC Cancer 2008 8:385
    Content type: Research article Published on:

  49. Higher standardized uptake value (SUV) detected by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) correlates with proliferation of primary breast cancer. The purpose of th...

    Authors: Shigeto Ueda, Nobuo Kondoh, Hitoshi Tsuda, Souhei Yamamoto, Hideki Asakawa, Kazuhiko Fukatsu, Takayuki Kobayashi, Junji Yamamoto, Katsumi Tamura, Jiro Ishida, Yoshiyuki Abe, Mikio Yamamoto and Hidetaka Mochizuki
    Citation: BMC Cancer 2008 8:384
    Content type: Research article Published on:

  50. Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies.

    Authors: Jie Yang, Lu Wang, Zhaoli Chen, Zhi-Qiang Shen, Min Jin, Xin-Wei Wang, Yufei Zheng, Zhi-Gang Qiu, Jing-feng Wang and Jun-Wen Li
    Citation: BMC Cancer 2008 8:383
    Content type: Research article Published on:

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