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  1. Prognostic scores might be useful tools both in clinical practice and clinical trials, where they can be used as stratification parameter. The available scores for patients with brain metastases have never bee...

    Authors: Carsten Nieder, Kirsten Marienhagen, Sabrina T Astner and Michael Molls
    Citation: BMC Cancer 2009 9:105
  2. Breast cancer belongs to the most frequent and severe cancer types in human. Since excretion of modified nucleosides from increased RNA metabolism has been proposed as a potential target in pathogenesis of bre...

    Authors: Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell and Bernd Kammerer
    Citation: BMC Cancer 2009 9:104
  3. Insulin-like growth factor binding protein 5 (IGFBP5) has been shown to be associated with breast cancer metastasis in clinical marker studies. However, a major difficulty in understanding how IGFBP5 functions...

    Authors: Mustafa Akkiprik, Limei Hu, Aysegul Sahin, Xishan Hao and Wei Zhang
    Citation: BMC Cancer 2009 9:103
  4. Bone metastases are frequent complications of breast cancer. Recent literature implicates multiple chemokines in the formation of bone metastases in breast cancer. However, the molecular mechanism of metastati...

    Authors: Dongqing Cai, Jie Cao, Zhen Li, Xin Zheng, Yao Yao, Wanglin Li and Ziqiang Yuan
    Citation: BMC Cancer 2009 9:102
  5. In recurrent malignant gliomas (MGs), a high rate of haematological toxicity is observed with the use of fotemustine at the conventional schedule (100 mg/m2 weekly for 3 consecutive weeks followed by triweekly ad...

    Authors: Alessandra Fabi, Giulio Metro, Michelangelo Russillo, Antonello Vidiri, Carmine Maria Carapella, Marta Maschio, Francesco Cognetti, Bruno Jandolo, Maria Alessandra Mirri, Isabella Sperduti, Stefano Telera, Mariantonia Carosi and Andrea Pace
    Citation: BMC Cancer 2009 9:101
  6. During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis. Heat shock protein 27(HSP27) is confirmed as...

    Authors: Kun Guo, Nan Xiao Kang, Yan Li, Lu Sun, Lin Gan, Feng Jie Cui, Mei Dong Gao and Kun Yin Liu
    Citation: BMC Cancer 2009 9:100
  7. Colorectal carcinoma is one of the major causes of morbidity and mortality in the Western World. Novel therapeutic approaches are needed for colorectal carcinoma. Curcumin, the active component and yellow pigm...

    Authors: Ling Cen, Brian Hutzen, Sarah Ball, Stephanie DeAngelis, Chun-Liang Chen, James R Fuchs, Chenglong Li, Pui-Kai Li and Jiayuh Lin
    Citation: BMC Cancer 2009 9:99
  8. During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening ...

    Authors: Ester Vilaprinyo, Montserrat Rué, Rafael Marcos-Gragera and Montserrat Martínez-Alonso
    Citation: BMC Cancer 2009 9:98
  9. Resistance of high-risk metastatic neuroblastoma (HR-NB) to high dose chemotherapy (HD-CT) raises a major therapeutic challenge in pediatric oncology. Patients are treated by maintenance CT. For some patients,...

    Authors: Gilda Raguénez, Annick Mühlethaler-Mottet, Roland Meier, Caroline Duros, Jean Bénard and Nicole Gross
    Citation: BMC Cancer 2009 9:97
  10. The extent of angiogenesis is an important prognostic factor for colorectal carcinoma, however, there are few studies concerning changes in angiogenesis with radiotherapy (RTX). Our aim was to investigate chan...

    Authors: Saulius Svagzdys, Vaiva Lesauskaite, Dainius Pavalkis, Irena Nedzelskienė, Darius Pranys and Algimantas Tamelis
    Citation: BMC Cancer 2009 9:95
  11. Interactions between cancer cells and stroma are critical for growth and invasiveness of epithelial tumors. The biochemical mechanisms behind tumor-stromal interactions leading to increased invasiveness and me...

    Authors: Remedios Castelló-Cros, David R Khan, Jeffrey Simons, Matthildi Valianou and Edna Cukierman
    Citation: BMC Cancer 2009 9:94
  12. The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons. One major aspect is the lack of typical cytological crite...

    Authors: Nora Hinsch, Matthias Frank, Claudia Döring, Christian Vorländer and Martin-Leo Hansmann
    Citation: BMC Cancer 2009 9:93
  13. Prostate Cancer (PCa) is the second most frequent neoplasia in men worldwide. Previous reports suggest that the prevalence of PCa in Hispanic males is lower than in Africans (including communities with African...

    Authors: Lauro S Gomez-Guerra, Margarita L Martinez-Fierro, Valeria Alcantara-Aragon, Rocio Ortiz-Lopez, Rebeca T Martinez-Villarreal, Idelma B Morales-Rodriguez, Raquel Garza-Guajardo, Marco A Ponce-Camacho and Augusto Rojas-Martinez
    Citation: BMC Cancer 2009 9:91
  14. HER-2 gene testing has become an integral part of breast cancer patient diagnosis. The most commonly used assay in the clinical setting for evaluating HER-2 status is immunohistochemistry (IHC) and fluorescence

    Authors: Fabíola E Rosa, Sara M Silveira, Cássia GT Silveira, Nádia A Bérgamo, Francisco A Moraes Neto, Maria AC Domingues, Fernando A Soares, José RF Caldeira and Silvia R Rogatto
    Citation: BMC Cancer 2009 9:90
  15. There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrup...

    Authors: Stuart G Baker, Ana M Soto, Carlos Sonnenschein, Antonio Cappuccio, John D Potter and Barnett S Kramer
    Citation: BMC Cancer 2009 9:89
  16. UbcH10 participates in proper metaphase to anaphase transition, and abrogation of UbcH10 results in the premature separation of sister chromatids. To assess the potential role of UbcH10 in colon cancer progres...

    Authors: Takeo Fujita, Hirokuni Ikeda, Naruto Taira, Shinji Hatoh, Minoru Naito and Hiroyoshi Doihara
    Citation: BMC Cancer 2009 9:87
  17. Molecular screening for BRCA1 and BRCA2 mutations is now an established component of risk evaluation and management of familial breast cancer. Features of hereditary breast cancer include an early age-of-onset...

    Authors: SR Young, Robert T Pilarski, Talia Donenberg, Charles Shapiro, Lyn S Hammond, Judith Miller, Karen A Brooks, Stephanie Cohen, Beverly Tenenholz, Damini DeSai, Inuk Zandvakili, Robert Royer, Song Li and Steven A Narod
    Citation: BMC Cancer 2009 9:86
  18. Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In th...

    Authors: Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung, Sung-Ho Kim and Sung-Tae Yee
    Citation: BMC Cancer 2009 9:85
  19. Multidisciplinary attempts to understand the etiology of breast cancer are expanding to increasingly include new potential markers of disease risk. Those efforts may have maximal scientific and practical influ...

    Authors: James V Lacey Jr, Aimee R Kreimer, Saundra S Buys, Pamela M Marcus, Shih-Chen Chang, Michael F Leitzmann, Robert N Hoover, Philip C Prorok, Christine D Berg and Patricia Hartge
    Citation: BMC Cancer 2009 9:84
  20. BAFF and APRIL share two receptors – TACI and BCMA – and BAFF binds to a third receptor, BAFF-R. Increased expression of BAFF and APRIL is noted in hematological malignancies. BAFF and APRIL are essential for ...

    Authors: Jérôme Moreaux, Jean-Luc Veyrune, John De Vos and Bernard Klein
    Citation: BMC Cancer 2009 9:83
  21. Sunitinib is a protein tyrosine kinase-inhibitor targeting VEGFR, c-kit and PDGFR. It has been approved for the treatment of metastatic renal-cell carcinoma and gastrointestinal stromal tumors. Although it has...

    Authors: Loukas F Kontovinis, Konstantinos T Papazisis, Panagiota Touplikioti, Charalambos Andreadis, Despoina Mouratidou and Alexandros H Kortsaris
    Citation: BMC Cancer 2009 9:82
  22. Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more ma...

    Authors: Stacey L Fossey, Albert T Liao, Jennifer K McCleese, Misty D Bear, Jiayuh Lin, Pui-Kai Li, William C Kisseberth and Cheryl A London
    Citation: BMC Cancer 2009 9:81
  23. ADAM33 protein is a member of the family of transmembrane glycoproteins composed of multidomains. ADAM family members have different activities, such as proteolysis and adhesion, making them good candidates to...

    Authors: Gerusa G Seniski, Anamaria A Camargo, Daniela F Ierardi, Edneia AS Ramos, Mariana Grochoski, Enilze SF Ribeiro, Iglenir J Cavalli, Fabio O Pedrosa, Emanuel M de Souza, Silvio M Zanata, Fabrício F Costa and Giseli Klassen
    Citation: BMC Cancer 2009 9:80
  24. The metastasis of cancer cells and leukocyte extravasation into inflamed tissues share common features. Specialized carbohydrates modified with sialyl Lewis x (sLex) antigens on leukocyte membranes are ligands fo...

    Authors: Catherine A St Hill, Mariya Farooqui, Gregory Mitcheltree, H Evin Gulbahce, Jose Jessurun, Qing Cao and Bruce Walcheck
    Citation: BMC Cancer 2009 9:79
  25. The proinflammatory cytokine interleukin-1 (IL-1) is known to play an important role in the carcinogenesis of breast cancer. Although IL-1 gene polymorphisms were reported to be associated with increased risk ...

    Authors: Christoph Grimm, Eva Kantelhardt, Georg Heinze, Stephan Polterauer, Robert Zeillinger, Heinz Kölbl, Alexander Reinthaller and Lukas Hefler
    Citation: BMC Cancer 2009 9:78
  26. The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect clini...

    Authors: Anne Margrete Øyan, Nina Ånensen, Trond Hellem Bø, Laila Stordrange, Inge Jonassen, Øystein Bruserud, Karl-Henning Kalland and Bjørn Tore Gjertsen
    Citation: BMC Cancer 2009 9:77
  27. Breast cancer is the leading female malignancy in Nigeria. Screening for early detection has led to reduction in mortality from the disease. It is known that attitudes of physicians and motivation by community...

    Authors: Nasiru A Ibrahim and Olumuyiwa O Odusanya
    Citation: BMC Cancer 2009 9:76
  28. Inhibitor of differentiation 2 (Id2) is a critical factor for cell proliferation and differentiation in normal vertebrate development. Most of the biological function of Id2 has been ascribed to its helix-loop-he...

    Authors: Yuanguang Meng, Chenglei Gu, Zhiqiang Wu, Yali Zhao, Yiling Si, Xiaobing Fu and Weidong Han
    Citation: BMC Cancer 2009 9:75
  29. Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is s...

    Authors: David Sarrió, José Palacios, Marta Hergueta-Redondo, Gonzalo Gómez-López, Amparo Cano and Gema Moreno-Bueno
    Citation: BMC Cancer 2009 9:74
  30. In the course of surveillance of gastric cancer recurrence after curative resection, contrast CT scan is used in general. However, new findings from CT scan are not always confirmatory for the recurrence. In t...

    Authors: Sung Hoon Sim, Yu Jung Kim, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Won Jun Kang, Seock-Ah Im, Tae-You Kim, Woo Ho Kim, Dae Seog Heo and Yung-Jue Bang
    Citation: BMC Cancer 2009 9:73
  31. Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis. Topoisomerase IIα (topoIIα), located at chromosome 17q21-22, is consi...

    Authors: Shin-ichiro Maruya, Takashi Shirasaki, Takahiko Nagaki, Seiji Kakehata, Hidekachi Kurotaki, Hiroki Mizukami and Hideichi Shinkawa
    Citation: BMC Cancer 2009 9:72
  32. Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies. Besides sharing common growth features with other types ...

    Authors: Jean-Louis Boulay, Urs Stiefel, Elisabeth Taylor, Béatrice Dolder, Adrian Merlo and Frank Hirth
    Citation: BMC Cancer 2009 9:71
  33. A positive family history of chronic diseases including cancer can be used as an index of genetic and shared environmental influences. The tumours studied have several putative risk factors in common including...

    Authors: Helen H McDuffie, Punam Pahwa, Chandima P Karunanayake, John J Spinelli and James A Dosman
    Citation: BMC Cancer 2009 9:70
  34. Carboxypeptidase 4 (CPA4) is a zinc-dependent metallocarboxypeptidase on chromosome 7q32 in a region linked to prostate cancer aggressiveness. CPA4 is involved in the histone hyperacetylation pathway and may modu...

    Authors: Phillip L Ross, Iona Cheng, Xin Liu, Mine S Cicek, Peter R Carroll, Graham Casey and John S Witte
    Citation: BMC Cancer 2009 9:69
  35. Limited information is available regarding the effect of age on choice of surgical and oncological treatment for rectal cancer. The objective of this study was to assess the influence of age on treatment and o...

    Authors: Bärbel Jung, Lars Påhlman, Robert Johansson and Erik Nilsson
    Citation: BMC Cancer 2009 9:68
  36. The prerequisite for the potential use of the bacterial toxin verotoxin-1 in the treatment of breast cancer was investigated by first determining the expression of its receptor Gb3 (CD77) in clinical breast ca...

    Authors: David Johansson, Eldina Kosovac, Jasmin Moharer, Ingrid Ljuslinder, Thomas Brännström, Anders Johansson and Parviz Behnam-Motlagh
    Citation: BMC Cancer 2009 9:67
  37. Advanced pancreatic cancer has a poor prognosis, and the current standard of care (gemcitabine based chemotherapy) provides a small survival advantage. However the drawback is the accompanying systemic toxicit...

    Authors: Asma Sultana, Susannah Shore, Michael GT Raraty, Sobhan Vinjamuri, Jonathan E Evans, Catrin Tudur Smith, Steven Lane, Seema Chauhan, Lorraine Bosonnet, Conall Garvey, Robert Sutton, John P Neoptolemos and Paula Ghaneh
    Citation: BMC Cancer 2009 9:66
  38. Caveolin-1 is the main component of caveolae membrane structures and has different roles during tumorigenesis in different cancer types with varying expression profiles, indicating that the role of caveolin-1 ...

    Authors: Murat Cokakli, Esra Erdal, Deniz Nart, Funda Yilmaz, Ozgul Sagol, Murat Kilic, Sedat Karademir and Nese Atabey
    Citation: BMC Cancer 2009 9:65
  39. Cervical cancer is the most common malignant gynecological cancer, and lymphatic metastasis can occur in the early stage of tumor growth. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a marker f...

    Authors: Shi-qian Zhang, Hao Yu and Lin-lin Zhang
    Citation: BMC Cancer 2009 9:64
  40. The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism...

    Authors: Luke H Stockwin, Sherry X Yu, Howard Stotler, Melinda G Hollingshead and Dianne L Newton
    Citation: BMC Cancer 2009 9:63
  41. Germline mutations in BRCA1 or BRCA2 genes have been demonstrated to increase the risk of developing breast cancer. Conversely, the impact of BRCA mutations on prognosis and survival of breast cancer patients is ...

    Authors: Mario Budroni, Rosaria Cesaraccio, Vincenzo Coviello, Ornelia Sechi, Daniela Pirino, Antonio Cossu, Francesco Tanda, Marina Pisano, Grazia Palomba and Giuseppe Palmieri
    Citation: BMC Cancer 2009 9:62
  42. The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in ...

    Authors: Zi-Ke Qin, Jian-An Yang, Yun-lin Ye, Xing Zhang, Li-Hua Xu, Fang-Jian Zhou, Hui Han, Zuo-Wei Liu, Li-Bing Song and Mu-Sheng Zeng
    Citation: BMC Cancer 2009 9:61
  43. A germ line single nucleotide polymorphism (SNP) in the first intron of the gene encoding MDM2 at position 309, an important modulator of p53, has been described. BRCA1/2 mutation have been associated with inc...

    Authors: Hovav Nechushtan, Tamar Hamburger, Susan Mendelson, Luna Kadouri, Nir Sharon, Eli Pikarsky and Tamar Peretz
    Citation: BMC Cancer 2009 9:60
  44. The COOH terminal peptide of Pro-collagen type I (PICP, also called C3) is chemotactic for endothelial melanoma and breast cancer cells. PICP induces the expression of Metalloproteinases-2 and -9, of Vascular ...

    Authors: Davide Visigalli, Daniela Palmieri, Antonella Strangio, Simonetta Astigiano, Ottavia Barbieri, Gianluigi Casartelli, Antonio Zicca and Paola Manduca
    Citation: BMC Cancer 2009 9:59
  45. Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Ther...

    Authors: Shigeru Iida, Reiko Kuni-Kamochi, Katsuhiro Mori, Hirofumi Misaka, Miho Inoue, Akira Okazaki, Kenya Shitara and Mitsuo Satoh
    Citation: BMC Cancer 2009 9:58
  46. The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activi...

    Authors: Miikka Korja, Anne Jokilammi, Toivo T Salmi, Hannu Kalimo, Tarja-Terttu Pelliniemi, Jorma Isola, Immo Rantala, Hannu Haapasalo and Jukka Finne
    Citation: BMC Cancer 2009 9:57
  47. We previously found that r-hu-IFNγ exerts a potent anti-tumor effect on human nasopharyngeal carcinoma xenografts in vivo. Considering the fact that the clinical use of recombinant IFNγ is limited by its short ha...

    Authors: Jiangxue Wu, Xia Xiao, Hongyun Jia, Jiemin Chen, Yinghui Zhu, Peng Zhao, Huanxin Lin and Wenlin Huang
    Citation: BMC Cancer 2009 9:55

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