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  1. The p38 MAPK is constitutively activated in B-NHL cell lines and regulates chemoresistance. Accordingly, we hypothesized that activated p38 MAPK may be associated with the in vivo unresponsiveness to chemotherapy...

    Authors: Gabriel G. Vega, Alejandro Avilés-Salas, J. Ramón Chalapud, Melisa Martinez-Paniagua, Rosana Pelayo, Héctor Mayani, Rogelio Hernandez-Pando, Otoniel Martinez-Maza, Sara Huerta-Yepez, Benjamin Bonavida and Mario I. Vega
    Citation: BMC Cancer 2015 15:722
    Content type: Research article Published on:

  2. Clinical trials have indicated that preclinical results obtained with human tumor xenografts in mouse models may overstate the potential of adenovirus (Ad)-mediated oncolytic therapies. We have previously demo...

    Authors: Pei-Hsin Cheng, Xiao-Mei Rao, Stephen L. Wechman, Xiao-Feng Li, Kelly M. McMasters and Heshan Sam Zhou
    Citation: BMC Cancer 2015 15:716
    Content type: Research article Published on:

  3. To determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.

    Authors: Wei Liao, Gwen Jordaan, Phillipp Nham, Ryan T. Phan, Matteo Pelegrini and Sanjai Sharma
    Citation: BMC Cancer 2015 15:714
    Content type: Research article Published on:

  4. Neuroblastoma is the most common extracranial solid tumor of childhood. The heterogeneous microenvironment of solid tumors contains hypoxic regions associated with poor prognosis and chemoresistance. Hypoxia i...

    Authors: Joshua J. Glass, Phoebe A. Phillips, Peter W. Gunning and Justine R. Stehn
    Citation: BMC Cancer 2015 15:712
    Content type: Research article Published on:

  5. Prior studies have described a reduced risk of developing ovarian cancer with the use of oral contraceptives. In this context, we decided to examine if oral contraceptive use prior to a diagnosis of ovarian ca...

    Authors: Aminah Jatoi, Nathan R. Foster, Kimberly R. Kalli, Robert A. Vierkant, Zhiying Zhang, Melissa C. Larson, Brooke Fridley and Ellen L. Goode
    Citation: BMC Cancer 2015 15:711
    Content type: Research article Published on:

  6. Physical activity and consuming a healthy diet have clear benefits to the physical and psychosocial health of cancer survivors, with guidelines recognising the importance of these behaviors for cancer survivor...

    Authors: E. L. James, F. G. Stacey, K. Chapman, A. W. Boyes, T. Burrows, A. Girgis, G. Asprey, A. Bisquera and D. R. Lubans
    Citation: BMC Cancer 2015 15:710
    Content type: Research article Published on:

  7. To assess the feasibility of elective neck irradiation to level Ib in nasopharyngeal carcinoma (NPC) using intensity-modulated radiation therapy (IMRT).

    Authors: Fan Zhang, Yi-Kan Cheng, Wen-Fei Li, Rui Guo, Lei Chen, Ying Sun, Yan-Ping Mao, Guan-Qun Zhou, Xu Liu, Li-Zhi Liu, Ai-Hua Lin, Ling-Long Tang and Jun Ma
    Citation: BMC Cancer 2015 15:709
    Content type: Research article Published on:

  8. The treatment of intratumoral dentritic cells (DCs) commonly fails because it cannot evoke immunity in a poor tumor microenvironment (TME). Modulated electro-hyperthermia (mEHT, trade-name: oncothermia) repres...

    Authors: Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-Shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li and Kwan-Hwa Chi
    Citation: BMC Cancer 2015 15:708
    Content type: Research article Published on:

  9. The aim of this study was to determine the clinical benefit of transhepatic arterial chemoembolization (TACE) with or without recombinant human adenovirus type 5 (H101) administration for the treatment of pati...

    Authors: Xiao-jun Lin, Qi-jiong Li, Xiang-ming Lao, Han Yang and Sheng-ping Li
    Citation: BMC Cancer 2015 15:707
    Content type: Research article Published on:

  10. Increasing evidence indicates that Epithelial–mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). MiR-449a is a liver abundant miRNA. However, the role of miR-449a in the metastasis of hepatoc...

    Authors: Shu-peng Chen, Bao-xin Liu, Jie Xu, Xiao-feng Pei, Yi-ji Liao, Feng Yuan and Fang Zheng
    Citation: BMC Cancer 2015 15:706
    Content type: Research article Published on:

  11. The aim of this study was to evaluate the cost-effectiveness of CRC screening strategies from the healthcare service provider perspective based on Chinese population.

    Authors: Carlos KH Wong, Cindy LK Lam, YF Wan and Daniel YT Fong
    Citation: BMC Cancer 2015 15:705
    Content type: Research article Published on:

  13. CD26 is an ectoenzyme with dipeptidyl peptidase 4 (DPP4) activity expressed on a variety of cell types. Considering that serum CD26 levels have been previously associated with different cancers, we examined th...

    Authors: Virginia Boccardi, Luigi Marano, Rosaria Rita Amalia Rossetti, Maria Rosaria Rizzo, Natale di Martino and Giuseppe Paolisso
    Citation: BMC Cancer 2015 15:703
    Content type: Research article Published on:

  15. A capillary network is needed in cancer growth and metastasis. Induction of angiogenesis represents one of the major hallmarks of cancer. CDK11p58, a Ser/Thr kinase that belongs to the Cell Division Cycle 2-like ...

    Authors: Yayun Chi, Sheng Huang, Haojie Peng, Mengying Liu, Jun Zhao, Zhiming Shao and Jiong Wu
    Citation: BMC Cancer 2015 15:701
    Content type: Research article Published on:

  16. Advanced malignant solitary fibrous tumors (SFTs) are rare soft-tissue sarcomas with a poor prognosis. Several treatment options have been reported, but with uncertain rates of efficacy. Our aim is to describe...

    Authors: J. Khalifa, M. Ouali, L. Chaltiel, S. Le Guellec, A. Le Cesne, J-Y Blay, P. Cousin, L. Chaigneau, E. Bompas, S. Piperno-Neumann, B. Bui-Nguyen, M. Rios, J-P Delord, N. Penel and C. Chevreau
    Citation: BMC Cancer 2015 15:700
    Content type: Research article Published on:

  17. Triple-negative breast cancer (TNBC) is associated with an aggressive clinical course due to the lack of therapeutic targets. Therefore, identifying reliable prognostic biomarkers and novel therapeutic targets...

    Authors: Yanzhi Zhang, Jiali Dai, Keely M. McNamara, Bing Bai, Mumu Shi, Monica S. M. Chan, Ming Liu, Hironobu Sasano, Xiuli Wang, Xiaolei Li, Lijuan Liu, Ying Ma, Shuwen Cao, Yanchun Xing, Baoshan Zhao, Yinli Song…
    Citation: BMC Cancer 2015 15:699
    Content type: Research article Published on:

  18. Bcl-2 plays an anti-apoptotic role, resulting in poor clinical outcome or resistance to therapy in most tumor types expressing Bcl-2. In breast cancer, however, Bcl-2 expression has been reported to be a favor...

    Authors: Naoko Honma, Rie Horii, Yoshinori Ito, Shigehira Saji, Mamoun Younes, Takuji Iwase and Futoshi Akiyama
    Citation: BMC Cancer 2015 15:698
    Content type: Research article Published on:

  19. Anthracycline-based adjuvant chemotherapy improves survival in patients with high-risk node-negative breast cancer (BC). In this setting, prognostic factors predicting for treatment failure might help selectin...

    Authors: S. Rahal, J M Boher, J M Extra, C. Tarpin, E. Charafe-Jauffret, E. Lambaudie, R. Sabatier, J. Thomassin-Piana, A. Tallet, M. Resbeut, G. Houvenaeghel, L. Laborde, F. Bertucci, P. Viens and A. Gonçalves
    Citation: BMC Cancer 2015 15:697
    Content type: Research article Published on:

  20. The incidence of multiple primary malignancies (MPM) has increased sharply in recent decades. However, the clinical characteristics and prognosis of MPM patients involving lung cancer were not fully elucidated...

    Authors: Feng Li, Wen-Zhao Zhong, Fei-Yu Niu, Ning Zhao, Jin-Ji Yang, Hong-Hong Yan and Yi-Long Wu
    Citation: BMC Cancer 2015 15:696
    Content type: Research article Published on:

  21. The clinical benefit of cetuximab combined with oxaliplatin-based chemotherapy remains under debate. The aim of the present multicenter open-label Phase II study was to explore the efficacy and safety of biwee...

    Authors: Hitoshi Soda, Hiromichi Maeda, Junichi Hasegawa, Takao Takahashi, Shoichi Hazama, Mutsumi Fukunaga, Emiko Kono, Masahito Kotaka, Junichi Sakamoto, Naoki Nagata, Koji Oba and Hideyuki Mishima
    Citation: BMC Cancer 2015 15:695
    Content type: Research article Published on:

  22. Collagen XI is a key structural component of the extracellular matrix and consists of three alpha chains. One of these chains, the α1 (XI), is encoded by the COL11A1 gene and is transcribed to four different vari...

    Authors: Makrina Karaglani, Ioannis Toumpoulis, Nikolaos Goutas, Nikoleta Poumpouridou, Dimitrios Vlachodimitropoulos, Spyridon Vasilaros, Ioannis Rizos and Christos Kroupis
    Citation: BMC Cancer 2015 15:694
    Content type: Research article Published on:

  23. The aim of this study was to assess the efficacy and safety of a combination regimen of capecitabine plus cisplatin (CC) or capecitabine plus paclitaxel (CP) as a first-line treatment in patients with metastat...

    Authors: Su Jin Lee, Sungmin Kim, Moonjin Kim, Jeeyun Lee, Yeon Hee Park, Young-Hyuck Im and Se Hoon Park
    Citation: BMC Cancer 2015 15:693
    Content type: Research article Published on:

  24. Breast cancer (BC) cells secrete soluble factors that accelerate osteoclast (OC) differentiation, leading to the formation of osteolytic bone metastases. In the BOLERO-2 trial, BC patients with bone involvemen...

    Authors: Valeria Simone, Sabino Ciavarella, Oronzo Brunetti, Annalisa Savonarola, Mauro Cives, Marco Tucci, Giuseppina Opinto, Eugenio Maiorano and Franco Silvestris
    Citation: BMC Cancer 2015 15:692
    Content type: Research article Published on:

  25. Statistics regarding HPV prevalence and cervical cancer rates in rural China are high, however, low levels of HPV awareness and HPV-related knowledge pose a great challenge for cervical cancer control.

    Authors: Jing Li, Le-Ni Kang, Bayi Li, Yi Pang, Rong Huang and You-Lin Qiao
    Citation: BMC Cancer 2015 15:691
    Content type: Research article Published on:

  26. Asian population has different body mass index (BMI) profile compared to Caucasian population. However, the effect of obesity and body weight gain in Asian colorectal cancer patients treated with adjuvant chem...

    Authors: Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park and Tae-You Kim
    Citation: BMC Cancer 2015 15:690
    Content type: Research article Published on:

  27. Postoperative recurrence remains the major cause of death after curative resection for hepatocellular carcinoma (HCC). This study was conducted to evaluate the impact of postoperative complications on HCC recu...

    Authors: Yan-Ming Zhou, Xiao-Feng Zhang, Bin Li, Cheng-Jun Sui and Jia-Mei Yang
    Citation: BMC Cancer 2015 15:689
    Content type: Research article Published on:

  28. Integrated health care delivery systems, with their comprehensive and integrated electronic medical records (EMR), are well-poised to conduct research that leverages the detailed clinical data within the EMRs....

    Authors: Scarlett Lin Gomez, Salma Shariff-Marco, Julie Von Behren, Marilyn L. Kwan, Candyce H. Kroenke, Theresa H. M. Keegan, Peggy Reynolds and Lawrence H. Kushi
    Citation: BMC Cancer 2015 15:688
    Content type: Research article Published on:

  29. PH domain Leucine-rich-repeats protein phosphatase (PHLPP) is a novel family of Ser/Thr protein dephosphatases that play a critical role in maintaining the balance in cell signaling. PHLPP negatively regulates...

    Authors: Dongqing Lv, Haihua Yang, Wei Wang, Youyou Xie, Wei Hu, Minhua Ye and Xiaofeng Chen
    Citation: BMC Cancer 2015 15:687
    Content type: Research article Published on:

  30. MDT (multidisciplinary team) meetings are considered an essential component of care for patients with cancer. However there is remarkably little direct evidence that such meetings improve outcomes. We assessed...

    Authors: Alastair Munro, Mhari Brown, Paddy Niblock, Robert Steele and Frank Carey
    Citation: BMC Cancer 2015 15:686
    Content type: Research article Published on:

  31. Brain metastases are an increasing problem in women with invasive breast cancer. Strategies designed to treat brain metastases of breast cancer, particularly chemotherapeutics such as irinotecan, demonstrate l...

    Authors: Chris E. Adkins, Mohamed I. Nounou, Tanvirul Hye, Afroz S. Mohammad, Tori Terrell-Hall, Neel K. Mohan, Michael A. Eldon, Ute Hoch and Paul R. Lockman
    Citation: BMC Cancer 2015 15:685
    Content type: Research article Published on:

  32. The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1MET as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells.

    Authors: Thomas Grellety, Audrey Laroche-Clary, Vanessa Chaire, Pauline Lagarde, Frédéric Chibon, Agnes Neuville and Antoine Italiano
    Citation: BMC Cancer 2015 15:684
    Content type: Research article Published on:

  33. ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes. For better characte...

    Authors: Rita Demidenko, Deividas Razanauskas, Kristina Daniunaite, Juozas Rimantas Lazutka, Feliksas Jankevicius and Sonata Jarmalaite
    Citation: BMC Cancer 2015 15:683
    Content type: Research article Published on:

  34. Hesperidin (30, 5, 9-dihydroxy-40-methoxy-7-orutinosyl flavanone) is a flavanone that is found mainly in citrus fruits and has been shown to have some anti-neoplastic effects. The aim of the present study was ...

    Authors: Yaoxian Wang, Hui Yu, Jin Zhang, Jing Gao, Xin Ge and Ge Lou
    Citation: BMC Cancer 2015 15:682
    Content type: Research article Published on:

  35. Cancer-testis antigens are among the new promising biomarkers, especially for targeted therapy. Aberrant and specific expression of these proteins has been reported in some tumor tissues. Also understanding th...

    Authors: Rezvan Esmaeili, Keivan Majidzadeh-A, Leila Farahmand, Maryam Ghasemi, Malihe Salehi and Ali Reza Khoshdel
    Citation: BMC Cancer 2015 15:681
    Content type: Research article Published on:

  36. Cervical cancer is one of the most important cancers worldwide with a high incident and mortality rate and is caused by the human papilloma virus (HPV). Among sexually active women who get infected with human ...

    Authors: Koushik Chattopadhyay, Anna-Lise Williamson, Annapurna Hazra and Collet Dandara
    Citation: BMC Cancer 2015 15:680
    Content type: Research article Published on:

  38. Organ site-specific metastasis is an ominous feature for most poor-prognostic hepatocellular carcinoma (HCC) patients. Cancer cell lines and animal models are indispensable for investigating the molecular mech...

    Authors: Jinliang Wan, Duo Wen, Lili Dong, Jun Tang, Dongli Liu, Yang Liu, Zhonghua Tao, Dongmei Gao, Huichuan Sun, Ya Cao, Jia Fan and Weizhong Wu
    Citation: BMC Cancer 2015 15:678
    Content type: Research article Published on:

  39. In the era of personalized medicine, head and neck squamous cell carcinoma (HNSCC) represents a critical oncologic topic. Conventional chemotherapy regimens consist of drugs administration in cycles near or at...

    Authors: Francesca De Felice, Daniela Musio and Vincenzo Tombolini
    Citation: BMC Cancer 2015 15:677
    Content type: Review Published on:

  40. Increased mesenchymal–epithelial transition factor gene (c-MET) expression in several human malignancies is related to increased tumour progression. The aim of the present study is to explore the relationship ...

    Authors: Jaudah Al-Maghrabi, Eman Emam, Wafaey Gomaa, Moaath Saggaf, Abdelbaset Buhmeida, Mohammad Al-Qahtani and Mahmoud Al-Ahwal
    Citation: BMC Cancer 2015 15:676
    Content type: Research article Published on:

  41. SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the develop...

    Authors: Jun Liu, Manqi Sha, Qianfeng Wang, Yong Ma, Xiaoping Geng, Yufeng Gao, Lijie Feng, Yujun Shen and Yuxian Shen
    Citation: BMC Cancer 2015 15:675
    Content type: Research article Published on:

  42. Proven cost-effectiveness contrasted by low uptake of cancer screening (CS) calls for new methodologies promoting the service. Contemporary interventions in this regard relies primarily on strategies targeting...

    Authors: Rui Feng, Xingrong Shen, Jing Chai, Penglai Chen, Jing Cheng, Han Liang, Ting Zhao, Rui Sha, Kaichun Li and Debin Wang
    Citation: BMC Cancer 2015 15:674
    Content type: Study protocol Published on:

  43. It is known that cetuximab (an epidermal growth factor receptor [EGFr] inhibitor) is a radiosensitizer. Also, cetuximab is known to only partially inhibit the signal transducer and activator of transcription –...

    Authors: James A. Bonner, Hoa Q. Trummell, Andrew B. Bonner, Christopher D. Willey, Markus Bredel and Eddy S. Yang
    Citation: BMC Cancer 2015 15:673
    Content type: Research article Published on:

  44. Nutrition is believed to be a primary contributor in regulating gene expression by affecting epigenetic pathways such as DNA methylation and histone modification. Resveratrol and pterostilbene are phytoalexins...

    Authors: Rishabh Kala, Harsh N. Shah, Samantha L. Martin and Trygve O. Tollefsbol
    Citation: BMC Cancer 2015 15:672
    Content type: Research article Published on:

  45. Since the breast cancer screening programme in the Basque Country (BCSPBC) was started in 1996, more than 400,000 women aged 50 to 69 years have been invited to participate. Based on epidemiological observatio...

    Authors: Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Nerea Larrañaga, Garbiñe Sarriugarte and Javier Mar
    Citation: BMC Cancer 2015 15:671
    Content type: Research article Published on:

  46. There remains uncertainty in whether vitamin D status affects cancer survival. We investigated whether vitamin D (± calcium) supplementation affects cancer survival in women.

    Authors: Mona Jeffreys, Maria Theresa Redaniel and Richard M. Martin
    Citation: BMC Cancer 2015 15:670
    Content type: Research article Published on:

  47. Patients with breast cancer have an increased risk of developing subsequent breast cancers. It is important to distinguish whether these tumours are de novo or recurrences of the primary tumour in order to guide ...

    Authors: Katie T. Huang, Thomas Mikeska, Jason Li, Elena A. Takano, Ewan K A Millar, Peter H. Graham, Samantha E. Boyle, Ian G. Campbell, Terence P. Speed, Alexander Dobrovic and Stephen B. Fox
    Citation: BMC Cancer 2015 15:669
    Content type: Research article Published on:

  48. The oncogenic transcription factor MYC is pathologically activated in many human malignancies. A paradigm for MYC dysregulation is offered by Burkitt lymphoma, where chromosomal translocations leading to Immunogl...

    Authors: Giulia De Falco, Maria Raffaella Ambrosio, Fabio Fuligni, Anna Onnis, Cristiana Bellan, Bruno Jim Rocca, Mohsen Navari, Maryam Etebari, Lucia Mundo, Sara Gazaneo, Fabio Facchetti, Stefano A. Pileri, Lorenzo Leoncini and Pier Paolo Piccaluga
    Citation: BMC Cancer 2015 15:668
    Content type: Research article Published on:

  49. To improve antitumor effects against metastatic renal cell carcinoma (mRCC), use of molecular target-based drugs in sequential or combination therapy has been advocated. In combination therapy, interferon (IFN...

    Authors: Masatoshi Eto, Yoshiaki Kawano, Yoshihiko Hirao, Koji Mita, Yoichi Arai, Taiji Tsukamoto, Katsuyoshi Hashine, Akio Matsubara, Tomoaki Fujioka, Go Kimura, Nobuo Shinohara, Katsunori Tatsugami, Shiro Hinotsu and Seiji Naito
    Citation: BMC Cancer 2015 15:667
    Content type: Research article Published on:

  50. In the past decades, mortality of female gender related cancers declined in Switzerland and other developed countries. Differences in the decrease and in spatial patterns within Switzerland have been reported ...

    Authors: Christian Herrmann, Silvia Ess, Beat Thürlimann, Nicole Probst-Hensch and Penelope Vounatsou
    Citation: BMC Cancer 2015 15:666
    Content type: Research article Published on:

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