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  1. Neoadjuvant chemotherapy with dual-targeted therapy is the standard treatment for human epidermal growth factor 2 (HER2)-positive breast cancer. Although the dual-targeted therapy has significantly improved th...

    Authors: Zheng-Jun Yang, Fei Xin, Zu-Jin Chen, Yue Yu, Xin Wang and Xu-Chen Cao
    Citation: BMC Cancer 2024 24:134
    Content type: Research Published on:

  2. There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.

    Authors: Yinghao Lu, Limin Liao, Kunpeng Du, Jianhua Mo, Xia Zou, Junxian Liang, Jiahui Chen, Wenwen Tang, Liwei Su, Jieping Wu, Junde Zhang and Yujing Tan
    Citation: BMC Cancer 2024 24:133
    Content type: Research Published on:

  3. Studies have revealed that acute myeloid leukemia (AML) patients are prone to combined cardiac injury. We aimed to identify hematological risk factors associated with cardiac injury in newly diagnosed AML pati...

    Authors: Linlu Ma, Qian Wang, Xinqi Li, Yufeng Shang, Nan Zhang, Jinxian Wu, Yuxing Liang, Guopeng Chen, Yuxin Tan, Xiaoyan Liu, Guolin Yuan and Fuling Zhou
    Citation: BMC Cancer 2024 24:132
    Content type: Research Published on:

  4. Current guidelines advocate for colorectal cancer (CRC) screening in adults who are at risk by using direct visualization methods such as colonoscopy. However, in Egypt, there is a paucity of data regarding th...

    Authors: Abdallah R. Allam, Mostafa A. Elsayed, Ibrahim Tawfiq Daghash, Ali M. Abdelaziz, Omnia M. Mostafa, Hamdy Khaled Sabra, Ahmed Monib Eldaboush, Noor Maged Badrawy Ahmed, Rawan Tarek Elweza, Enas Sherif Adwy, Abdelrahman Elbendary Hammad, Ibrahim Ali Kabbash, Ahmed Hafez Allam, Ammar Ayman Bahbah, Marwa Ibrahim Ewis, Mohamed Mohamed Shawqi…
    Citation: BMC Cancer 2024 24:131
    Content type: Research Published on:

  5. Treatment summaries and a personalized survivorship care plans based on internationally approved, organ-specific follow-up care recommendations are essential in preserving the health and quality of life for ca...

    Authors: Charlotte Demoor-Goldschmidt, Pascal Veillon, Maxime Esvan, Mathilde Leonard, Sophie Chauvet, Amandine Bertrand, Liana Carausu, Fanny Delehaye, Julien Lejeune, Jérémie Rouger, Pascale Schneider, Caroline Thomas, Frédéric Millot, Line Claude, Julie Leseur, Fernand Missohou…
    Citation: BMC Cancer 2024 24:130
    Content type: Research Published on:

  6. Esophageal cancer (EC) is a deadly disease with limited therapeutic options. Although circulating tumor DNA (ctDNA) could be a promising tool in this regard, the availiable evidence is limited. We performed a ...

    Authors: Yaozhong Zhang, Huazhen Du, Na Wang, Lei Wang and Yajie Huang
    Citation: BMC Cancer 2024 24:129
    Content type: Research Published on:

  7. Sarcopenia has been identified as a potential negative prognostic factor in cancer patients. In this study, our objective was to investigate the relationship between the assessment method for sarcopenia using ...

    Authors: Katsuya Sakamoto, Shin-ichiro Hiraoka, Kohei Kawamura, Peiying Ruan, Shuji Uchida, Ryo Akiyama, Chonho Lee, Kazuki Ide and Susumu Tanaka
    Citation: BMC Cancer 2024 24:128
    Content type: Research Published on:

  8. To present the widely unknown perioperative outcomes and continence status of bladder cancer patients following robotic-assisted radical cystectomy (RARC) with Mainz pouch II urinary diversion (UD).

    Authors: Suoshi Jing, Enguang Yang, Zuoxi Luo, Yunxin Zhang, Hui Ding, Li Yang, Zhilong Dong, Panfeng Shang, Zhongjin Yue, Gongjin Wu, Junsheng Bao, Junqiang Tian, Jiaji Wang, Nan Xiao and Zhiping Wang
    Citation: BMC Cancer 2024 24:127
    Content type: Research Published on:

  9. Adolescents and young adults (AYAs) with cancer, defined as individuals aged 15–39 years at initial cancer diagnosis, form a unique population; they face age-specific issues as they transition to adulthood. Th...

    Authors: Olga Husson, Silvie H. M. Janssen, Bryce B. Reeve, Samantha C. Sodergren, Christabel K. Cheung, Martin G. McCabe, John M. Salsman, Winette T. A. van der Graaf and Anne-Sophie Darlington
    Citation: BMC Cancer 2024 24:126
    Content type: Study Protocol Published on:

  10. T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid l...

    Authors: Hooriyeh Shapourian, Mustafa Ghanadian, Nahid Eskandari, Abolfazl Shokouhi, Gülderen Yanikkaya Demirel, Alexandr V. Bazhin and Mazdak Ganjalikhani-Hakemi
    Citation: BMC Cancer 2024 24:125
    Content type: Research Published on:

  11. HLX01 (HanliKang®) is a rituximab biosimilar that showed bioequivalence to reference rituximab in untreated CD20-positive diffuse large B-cell lymphoma (DLBCL) in the phase 3 HLX01-NHL03 study. Here, we report th...

    Authors: Yan Qin, Yongping Song, Dong Wang, Ou Bai, Jifeng Feng, Xiuhua Sun, Lihua Qiu, Jianmin Yang, Yu Yang, Zhao Wang, Jianda Hu, Huaqing Wang, Hang Su, Zhengming Jin, Wenbin Qian, Chuan Jin…
    Citation: BMC Cancer 2024 24:124
    Content type: Research Published on:

  12. Brain metastasis is a common outcome in non-small cell lung cancer, and despite aggressive treatment, its clinical outcome is still frustrating. In recent years, immunotherapy has been developing rapidly, howe...

    Authors: Jin-Sheng Liu, Yu-Xiang Cai, Yong-Ze He, Jian Xu, Su-Fang Tian and Zhi-Qiang Li
    Citation: BMC Cancer 2024 24:123
    Content type: Research Published on:

  13. Ovarian cancer is one of the most common gynecological malignancies due to the lack of early symptoms, early diagnosis and limited screening. Therefore, it is necessary to understand the molecular mechanism un...

    Authors: Gendi Song, Zhengwei Sun, Man Chu, Zihan Zhang, Jiajia Chen, Zhiwei Wang and Xueqiong Zhu
    Citation: BMC Cancer 2024 24:122
    Content type: Research Published on:

  14. Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-tr...

    Authors: Yi-Hsuan Lee, Chung-Yen Huang, Yu-Han Hsieh, Chia-Hung Yang, Yu-Ling Hung, Yung-An Chen, Yu-Chieh Lin, Ching-Hung Lin, Jih-Hsiang Lee, Ming-Yang Wang, Wen-Hung Kuo, Yen-Yin Lin and Yen-Shen Lu
    Citation: BMC Cancer 2024 24:121
    Content type: Research Published on:

  17. Observational studies have explored the association of psychiatric disorders and the risk of brain cancers. However, the causal effect of specific mental illness on glioma remains elusive due to the lack of so...

    Authors: Wenzhuo Yang, Yu Han, Changjia He, Sheng Zhong, Fei Ren, Zhongping Chen, Yonggao Mou and Ke Sai
    Citation: BMC Cancer 2024 24:118
    Content type: Research Published on:

  18. For brain metastases (BMs) from EGFR/ALK-positive non-small cell lung cancer (NSCLC), the best time to administer tyrosine kinase inhibitors (TKIs) and brain radiotherapy (RT) has not been identified. This analys...

    Authors: Jing Qian, Zelai He, Ying Wu, Hongwei Li, Qun Zhang and Xianming Li
    Citation: BMC Cancer 2024 24:117
    Content type: Research Published on:

  19. Pancreatic adenocarcinoma (PDAC) ranks as the fourth leading cause for cancer-related deaths worldwide. N6-methyladenosine (m6A) and long non-coding RNAs (lncRNAs) are closely related with poor prognosis and i...

    Authors: Xia-Qing Li, Shi-Qi Yin, Lin Chen, Aziguli Tulamaiti, Shu-Yu Xiao, Xue-Li Zhang, Lei Shi, Xiao-Cao Miao, Yan Yang and Xin Xing
    Citation: BMC Cancer 2024 24:116
    Content type: Research Published on:

  20. Selective lateral pelvic lymph node (LPN) dissection (LPND) following neoadjuvant chemoradiotherapy (nCRT) for rectal cancer is widely recognized. This study aimed to determine the effects of nCRT before LPND ...

    Authors: Zhongshi Xie, Qichen Chen, Bo Feng, Yujuan Jiang, Xin Wang, Wei Xing and Qian Liu
    Citation: BMC Cancer 2024 24:115
    Content type: Research Published on:

  21. Authors: Elif Şenocak Taşçı, Başak Oyan, Özlem Sönmez, Arda Ulaş Mutlu, Muhammed Mustafa Atcı, Abdullah Sakin, İrem Öner, Havva Yeşil Çınkır, Melek Karakurt Eryılmaz, Dilek Çağlayan, Onur Yazdan Balçık, Nail Paksoy, Senem Karabulut, Derya Kıvrak Salim, Cemil Bilir, Miraç Özen…
    Citation: BMC Cancer 2024 24:114
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2024 24:16

  22. Extracellular vesicles (EVs) have been revealed to facilitate the development of oral squamous cavity cell carcinoma (OCSCC), while its supporting role in lymph node metastases is under continuous investigatio...

    Authors: Tianzhu Lv, Hongjing Liu, Ling Mao, Yanrong Song, Lili Liao, Kun Zhong, Binbin Shuai, Yingkun Luo, Tingting Guo, Wentao Huang and Shenyingjie Zhang
    Citation: BMC Cancer 2024 24:113
    Content type: Research Published on:

  23. Since the Z0011 trial, the assessment of axillary lymph node status has been redirected from the previous assessment of the occurrence of lymph node metastasis alone to the assessment of the degree of lymph no...

    Authors: Hua Shao, Yixin Sun, Ziyue Na, Hui Jing, Bo Li, Qiucheng Wang, Cui Zhang and Wen Cheng
    Citation: BMC Cancer 2024 24:112
    Content type: Research Published on:

  24. Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of ...

    Authors: Chunlai Yin, Yanqi Li, Cheng Zhang, Shizhu Zang, Zilong Wang, Xue Yan, Tonghui Ma, Xia Li and Weiping Li
    Citation: BMC Cancer 2024 24:111
    Content type: Research Published on:

  25. Lymphoplasmacyte-rich meningioma(LPM) is a rare subtype of meningioma with a low degree of malignancy and an overall preferable prognosis. The purpose of this article is to increase the understanding of the di...

    Authors: Xiaoxi Zhu, Yanhua Liu, Weiwei Guo, Qi Liang, Chengliang Pan, Bin Tan and Ying Yu
    Citation: BMC Cancer 2024 24:110
    Content type: Research Published on:

  26. There is an aberrant expression of NBAT-1 in various human cancers, which was proven to limit the proliferation, invasion, and metastasis of tumour cells via multiple approaches. Most existing research focuses...

    Authors: Yang Yu, Kedi Fan, Tingting Ni, Xun Lei Zhang, Xiaoqin Su and Lei Yang
    Citation: BMC Cancer 2024 24:109
    Content type: Research Published on:

  27. In neuro-oncology, the inclusion of tumor patients in the molecular tumor board has only become increasingly widespread in recent years, but so far there are no standards for indication, procedure, evaluation,...

    Authors: Lisa S. Hönikl, Sebastian Lange, Vicki M. Butenschoen, Claire Delbridge, Bernhard Meyer, Stephanie E. Combs, Anna Lena Illert and Friederike Schmidt-Graf
    Citation: BMC Cancer 2024 24:108
    Content type: Research Published on:

  28. Paclitaxel liposome (Lipusu) is known to be effective in non-small cell lung cancer (NSCLC) as first-line treatment. This study aimed to evaluate the effectiveness and safety of paclitaxel liposome based chemo...

    Authors: Ran Li, Hongge Liang, Jun Li, Zhenyu Shao, Donghong Yang, Jing Bao, Keqiang Wang, Wen Xi, Zhancheng Gao, Renhua Guo and Xinlin Mu
    Citation: BMC Cancer 2024 24:107
    Content type: Research Published on:

  30. Colibactin, a genotoxin produced by polyketide synthase harboring (pks+) bacteria, induces double-strand breaks and chromosome aberrations. Consequently, enrichment of pks+Escherichia coli in colorectal cancer an...

    Authors: Diantha Terlouw, Arnoud Boot, Quinten R. Ducarmon, Sam Nooij, Manon Suerink, Monique E. van Leerdam, Demi van Egmond, Carli M. Tops, Romy D. Zwittink, Dina Ruano, Alexandra M. J. Langers, Maartje Nielsen, Tom van Wezel and Hans Morreau
    Citation: BMC Cancer 2024 24:104
    Content type: Research Published on:

  31. Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a specific protein is a foundation of precision medicine and treatment. High expression of the pr...

    Authors: Karunakar Saamarthy, Kristofer Ahlqvist, Renée Daams, Navisraj Balagunaseelan, Agnes Rinaldo-Matthis, Julhash U. Kazi, Wondossen Sime and Ramin Massoumi
    Citation: BMC Cancer 2024 24:103
    Content type: Research Published on:

  32. Recent studies have demonstrated that accelerated enhanced recovery after colorectal surgery is feasible for specific patient populations. The accelerated enhanced recovery protocols (ERP) tend to vary, and th...

    Authors: Misha A. T. Sier, Anke H. C. Gielen, Thaís T. T. Tweed, Noémi C. van Nie, Tim Lubbers and Jan H. M. B. Stoot
    Citation: BMC Cancer 2024 24:102
    Content type: Research Published on:

  33. Vulvar and vaginal melanoma (VuM & VaM) is a rare gynecologic malignancy with high mortality but low effectiveness to checkpoint immunotherapy compared to cutaneous melanoma. This article aims to elucidate the...

    Authors: Xinqi Wang, Jiahui Li, Yifei Li, Mingyi Lv, Xue Dong, Zhenxin Fan and Tao Guo
    Citation: BMC Cancer 2024 24:101
    Content type: Research Published on:

  34. Immunotherapy targeting PD-1/PD-L1 has revolutionized the treatment of extensive-stage small cell lung cancer (ES-SCLC). However, clinical trials suggest differential efficacy of anti-PD-1 agents and anti-PD-L...

    Authors: Boyu Qin, Lingli Xin, Chen Liang, Lingling Li, Qi Song, Yaping Long, Xiaoling Zhang, Dan Wang, Weiwei Shi, Jing Zhang, Yi Hu, Bo Yang and Qi Xiong
    Citation: BMC Cancer 2024 24:100
    Content type: Research Published on:

  35. Pure uterine serous carcinoma (p-USC) and mixed tumors with serous component (m-USC) are aggressive subtypes of endometrial cancer associated with high mortality rates. This retrospective study aimed to compar...

    Authors: Xuewu You, Yangyang Dong, Jiaqi Wang, Yuan Cheng, Yuanyuan Jia, Xiaobo Zhang and Jianliu Wang
    Citation: BMC Cancer 2024 24:99
    Content type: Research Published on:

  37. The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here...

    Authors: Chie Takasu, Yuji Morine, Kozo Yoshikawa, Toshihiro Nakao, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto and Mitsuo Shimada
    Citation: BMC Cancer 2024 24:97
    Content type: Research Published on:

  38. Breast cancer rates and the number of breast cancer survivors have been increasing among women in Iran. Effective responses from healthcare depend on appropriately identifying survivors’ needs. This study inve...

    Authors: Rahimeh Khajoei, Payam Azadeh, Sima ZohariAnboohi, Mahnaz Ilkhani and Fatemah Heshmati Nabavi
    Citation: BMC Cancer 2024 24:96
    Content type: Research Published on:

  39. Sarcopenia has received increasing attention in non-small cell lung cancer (NSCLC). Red blood cell distribution width (RDW) is a significant component of the complete blood count and indicates the heterogeneit...

    Authors: Qing-chun Jia, Ling Qin, Ye Niu, Le Liu, Ping-ping Liu, Shi-di Miao, Ming-ming Cui and Rui-tao Wang
    Citation: BMC Cancer 2024 24:95
    Content type: Research Published on:

  40. Mitochondria, which serve as the fundamental organelle for cellular energy and metabolism, are closely linked to the growth and survival of cancer cells. This study aims to identify and assess Sideroflexin1 (S...

    Authors: Wenting Liu, Qingwu Du, Ting Mei, Jingya Wang, Dingzhi Huang and Tingting Qin
    Citation: BMC Cancer 2024 24:94
    Content type: Research Published on:

  41. Several publications suggest that UTP11 may be a promising gene engaged for involvement of hepatocellular carcinoma (HCC) pathology. However, there are extremely limited biological, mechanistic and clinical st...

    Authors: Yan Chen, Xiaowei Zhang, Mingcheng Zhang, Wenting Fan, Yueyue Lin and Guodong Li
    Citation: BMC Cancer 2024 24:93
    Content type: Research Published on:

  42. The efficacy and safety of subxiphoid thoracoscopic thymectomy (SVATS) for early thymoma are unknown. The purposes of this meta-analysis were to evaluate the effectiveness and safety of SVATS for early thymoma...

    Authors: Jincheng Wang, Ti Tong, Kun Zhang, Haiping Guo, Yang Liu, Jindong Li, Haiyang Zhang, Quanqing Li, Zhenxiao Zhang and Yinghao Zhao
    Citation: BMC Cancer 2024 24:92
    Content type: Research Published on:

  43. The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2 +) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted ther...

    Authors: Gavin P. Dowling, Sinead Toomey, Philip Bredin, Imelda Parker, Eibhlin Mulroe, Jacinta Marron, Olivia McLoughlin, Ausra Teiserskiene, Colm Power, Anne Marie O’Shea, Megan Greally, Patrick G. Morris, Deirdre Duke, Arnold D. K. Hill and Bryan T. Hennessy
    Citation: BMC Cancer 2024 24:91
    Content type: Study Protocol Published on:

  44. CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study see...

    Authors: Mathieu Pecqueux, Frederik Brückner, Florian Oehme, Sebastian Hempel, Franziska Baenke, Carina Riediger, Marius Distler, Jürgen Weitz and Christoph Kahlert
    Citation: BMC Cancer 2024 24:90
    Content type: Research Published on:

  45. Glioblastoma (GBM) is the most aggressive malignant central nervous system tumor with a poor prognosis.The malignant transformation of glioma cells via epithelial-mesenchymal transition (EMT) has been observed...

    Authors: Li Li, Siyu Xia, Zitong Zhao, Lili Deng, Hanbing Wang, Dongbo Yang, Yizhou Hu, Jingjing Ji, Dayong Huang and Tao Xin
    Citation: BMC Cancer 2024 24:89
    Content type: Research Published on:

  46. Recently, with the advancement of medical technology, the postoperative morbidity of pelvic exenteration (PE) has gradually decreased, and it has become a curative treatment option for some patients with recur...

    Authors: Jie-Hai Yu, Chong-Jie Tong, Qi-Dan Huang, Yun-Lin Ye, Gong Chen, Hao Li, Yong-Shan Wen, Fan Yang, Nan-Bin Luo, Guang-Yu Xu and Ying Xiong
    Citation: BMC Cancer 2024 24:88
    Content type: Research Published on:

  47. Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and its molecular mechanisms are unclear. Nucleolar and spindle-associated protein 1 (NUSAP1), an indispensable mitotic regulator, has been reporte...

    Authors: Yuan Liu, Rong Tang, Qing-Cai Meng, Si Shi, Jin Xu, Xian-Jun Yu, Bo Zhang and Wei Wang
    Citation: BMC Cancer 2024 24:87
    Content type: Research Published on:

  48. Surgical sentinel lymph node biopsy (SLNB) is routinely used to reliably stage axillary lymph nodes in early breast cancer (BC). However, SLNB may be associated with postoperative arm morbidities. For most pat...

    Authors: Ida Skarping, Julia Ellbrant, Looket Dihge, Mattias Ohlsson, Linnea Huss, Pär-Ola Bendahl and Lisa Rydén
    Citation: BMC Cancer 2024 24:86
    Content type: Research Published on:

  49. The aim of this study was to investigate genetic alterations within breast cancer in the setting of recurrent or de novo stage IV disease.

    Authors: Mirai Ido, Kimihito Fujii, Hideyuki Mishima, Akihito Kubo, Masayuki Saito, Hirona Banno, Yukie Ito, Manami Goto, Takahito Ando, Yukako Mouri, Junko Kousaka, Tsuneo Imai and Shogo Nakano
    Citation: BMC Cancer 2024 24:85
    Content type: Research Published on:

  50. Glioblastoma is the most common and most aggressive malignant primary brain tumor in adults. Glioblastoma cells synthesize and secrete large quantities of the excitatory neurotransmitter glutamate, driving epi...

    Authors: Maximilian Mastall, Patrick Roth, Andrea Bink, Angela Fischer Maranta, Heinz Läubli, Andreas Felix Hottinger, Thomas Hundsberger, Denis Migliorini, Adrian Ochsenbein, Katharina Seystahl, Lukas Imbach, Tibor Hortobagyi, Leonhard Held, Michael Weller and Hans-Georg Wirsching
    Citation: BMC Cancer 2024 24:82
    Content type: Study Protocol Published on:

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