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  1. Heat shock protein 90 (Hsp90) overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications. The purpose of this study is to evaluate the immunohistochemica...

    Authors: Flora Zagouri, Afrodite Nonni, Theodoros N Sergentanis, Christos A Papadimitriou, Nikolaos V Michalopoulos, Andreas C Lazaris, Efstratios Patsouris and George C Zografos
    Citation: BMC Cancer 2008 8:312
  2. The ageing of the population is expected to bring an enormous growth in demand for oncological health care. In order to anticipate and respond to future trends, cancer care needs to be critically evaluated. Th...

    Authors: Ron Pritzkuleit, Annika Waldmann, Heiner Raspe and Alexander Katalinic
    Citation: BMC Cancer 2008 8:311
  3. Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim o...

    Authors: Do Kyung Lee, Seok Jang, Mi Jin Kim, Jung Hyun Kim, Myung Jun Chung, Kyung Jae Kim and Nam Joo Ha
    Citation: BMC Cancer 2008 8:310
  4. Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins.

    Authors: Tatsuya Toyama, Hiroko Yamashita, Naoto Kondo, Katsuhiro Okuda, Satoru Takahashi, Hidefumi Sasaki, Hiroshi Sugiura, Hirotaka Iwase and Yoshitaka Fujii
    Citation: BMC Cancer 2008 8:309
  5. 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant ...

    Authors: Zhihui Wang, Claes G Tropè, Zhenhe Suo, Gunhild Trøen, Guanrui Yang, Jahn M Nesland and Ruth Holm
    Citation: BMC Cancer 2008 8:308
  6. Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a sub...

    Authors: Jiyoung Rhee, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Wonshik Han, In Ae Park, Dong-Young Noh, Yung-Jue Bang and Tae-You Kim
    Citation: BMC Cancer 2008 8:307
  7. Bone marrow-derived stromal cells (BMSCs) are important for development, tissue cell replenishment, and wound healing in physiological and pathological conditions. BMSCs were found to preferably reach sites un...

    Authors: M Hu, J-L Yang, H Teng, Y-Q Jia, R Wang, X-W Zhang, Y Wu, Y Luo, X-C Chen, R Zhang, L Tian, X Zhao and Y-Q Wei
    Citation: BMC Cancer 2008 8:306
  8. Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. Some of these effects might be me...

    Authors: Elena Fiorio, Anna Mercanti, Marianna Terrasi, Rocco Micciolo, Andrea Remo, Alessandra Auriemma, Annamaria Molino, Veronica Parolin, Bruno Di Stefano, Franco Bonetti, Antonio Giordano, Gian Luigi Cetto and Eva Surmacz
    Citation: BMC Cancer 2008 8:305
  9. Despite the advances made during decades of research, the mechanisms by which glioma is initiated and established remain elusive. The discovery of glioma stem cells (GSCs) may help to elucidate the processes o...

    Authors: Qiang Huang, Quan-Bin Zhang, Jun Dong, Yin-Yan Wu, Yun-Tian Shen, Yao-Dong Zhao, Yu-De Zhu, Yi Diao, Ai-Dong Wang and Qing Lan
    Citation: BMC Cancer 2008 8:304
  10. NDRG2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that NDRG2 expressed differentially in normal and cancer tissues. Specifically, NDRG2 mRNA was down-r...

    Authors: Huadong Zhao, Jian Zhang, Jianguo Lu, Xianli He, Changsheng Chen, Xiaojun Li, Li Gong, Guoqiang Bao, Qiang Fu, Suning Chen, Wei Lin, Hai Shi, Jianjun Ma, Xinping Liu, Qingjiu Ma and Libo Yao
    Citation: BMC Cancer 2008 8:303
  11. Many cancers, including breast cancer, have been identified with increased levels of phosphorylated or the active form of Signal Transducers and Activators of Transcription 3 (STAT3) protein. However, whether ...

    Authors: Jacqueline C Lieblein, Sarah Ball, Brian Hutzen, A Kate Sasser, Huey-Jen Lin, Tim HM Huang, Brett M Hall and Jiayuh Lin
    Citation: BMC Cancer 2008 8:302
  12. Protease activated receptor-2 (PAR-2) has been implicated in cellular proliferation, invasion and metastasis in various tumors. Lymph node metastasis is an important patient prognostic factor for uterine cervi...

    Authors: Israt Jahan, Jiro Fujimoto, Syed Mahfuzul Alam, Eriko Sato and Teruhiko Tamaya
    Citation: BMC Cancer 2008 8:301
  13. Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development. This protein is replaced in the adult ...

    Authors: Renata Veselska, Marketa Hermanova, Tomas Loja, Petr Chlapek, Iva Zambo, Karel Vesely, Karel Zitterbart and Jaroslav Sterba
    Citation: BMC Cancer 2008 8:300
  14. Chronic myelomonocytic leukemia (CMML) is a hematological disease close to, but separate from both myeloproliferative disorders (MPD) and myelodysplastic syndromes and may show either myeloproliferative (MP-CM...

    Authors: Véronique Gelsi-Boyer, Virginie Trouplin, José Adélaïde, Nicola Aceto, Virginie Remy, Stephane Pinson, Claude Houdayer, Christine Arnoulet, Danielle Sainty, Mohamed Bentires-Alj, Sylviane Olschwang, Norbert Vey, Marie-Joëlle Mozziconacci, Daniel Birnbaum and Max Chaffanet
    Citation: BMC Cancer 2008 8:299
  15. While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor gro...

    Authors: Wenyi Qin, Weizhu Zhu, John E Hewett, George Rottinghaus, Yin-Chieh Chen, John T Flynn, Beth Kliethermes, Ferdinando Mannello and Edward R Sauter
    Citation: BMC Cancer 2008 8:298
  16. Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with si...

    Authors: Rachel E Ellsworth, Darrell L Ellsworth, Heather L Patney, Brenda Deyarmin, Brad Love, Jeffrey A Hooke and Craig D Shriver
    Citation: BMC Cancer 2008 8:297
  17. Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly de...

    Authors: Tae Yong Kim, Suck Joon Hong, Jung Min Kim, Won Gu Kim, Gyungyub Gong, Jin Sook Ryu, Won Bae Kim, Sung-Cheol Yun and Young Kee Shong
    Citation: BMC Cancer 2008 8:296
  18. The prediction of response to treatment would be valuable for managing cervical carcinoma with neoadjuvant chemotherapy.

    Authors: Chel Hun Choi, Sang Yong Song, Jung-Joo Choi, Young Ae Park, Heeseok Kang, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Je-Ho Lee and Duk-Soo Bae
    Citation: BMC Cancer 2008 8:295
  19. Since the second half of the 1990s, kidney cancer mortality has tended to stabilize and decline in many European countries, due to the decrease in the prevalence of smokers. Nevertheless, incidence of kidney c...

    Authors: Gonzalo López-Abente, Nuria Aragonés, Beatriz Pérez-Gómez, Rebeca Ramis, Enrique Vidal, Javier García-Pérez, Pablo Fernández-Navarro and Marina Pollán
    Citation: BMC Cancer 2008 8:293
  20. In recent years, numerous studies have investigated somatic mutations in mitochondrial DNA in various tumours. The observed high mutation rates might reflect mitochondrial deregulation; consequently, mutation ...

    Authors: Piotr Bragoszewski, Jolanta Kupryjanczyk, Ewa Bartnik, Andrea Rachinger and Jerzy Ostrowski
    Citation: BMC Cancer 2008 8:292
  21. In order to elucidate tumoral progression and drug resistance, cultured cell lines are valuable tools applied on tumor related assays provided they are well established and characterized. Our laboratory settle...

    Authors: Camila ML Machado, Rafael Y Ikemori, Tatiana Q Zorzeto, Ana CMA Nogueira, Suse DS Barbosa, Wilson Savino, André A Schenka, José Vassallo, Juliana K Heinrich, Fátima Boetcher-Luiz and Liana Verinaud
    Citation: BMC Cancer 2008 8:291
  22. Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription ...

    Authors: M Wenghoefer, A Pantelis, H Dommisch, W Götz, R Reich, S Bergé, M Martini, JP Allam, S Jepsen, S Merkelbach-Bruse, HP Fischer, N Novak and J Winter
    Citation: BMC Cancer 2008 8:290
  23. The oncoproteins of human papillomavirus (HPVs) directly effect cell-cycle control. We hypothesize that regulatory and cell cycle protein expression might be additionally modified in the cervix of HIV/HPV co-i...

    Authors: Alcina F Nicol, Andréa Rodrigues Cordovil Pires, Simone R de Souza, Gerard J Nuovo, Beatriz Grinsztejn, Aparecida Tristão, Fabio B Russomano, Luciane Velasque, José R Lapa e Silva and Claude Pirmez
    Citation: BMC Cancer 2008 8:289
  24. Rearrangement of the short arm of chromosome 8 (8p) is very common in epithelial cancers such as breast cancer. Usually there is an unbalanced translocation breakpoint in 8p12 (29.7 Mb – 38.5 Mb) with loss of ...

    Authors: Susanna L Cooke, Jessica CM Pole, Suet-Feung Chin, Ian O Ellis, Carlos Caldas and Paul AW Edwards
    Citation: BMC Cancer 2008 8:288
  25. Widespread use of mammography in breast cancer screening has led to the identification of increasing numbers of patients with ductal carcinoma in situ (DCIS). DCIS of the breast with an area of focal invasion 1 m...

    Authors: Yasuhiro Okumura, Yutaka Yamamoto, Zhenhuan Zhang, Tatsuya Toyama, Teru Kawasoe, Mutsuko Ibusuki, Yumi Honda, Ken-ichi Iyama, Hiroko Yamashita and Hirotaka Iwase
    Citation: BMC Cancer 2008 8:287
  26. Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer.

    Authors: Se Hun Kang, Keon Wook Kang, Kyung-Hee Kim, Bumi Kwon, Seok-Ki Kim, Ho-Young Lee, Sun-Young Kong, Eun Sook Lee, Sang-Geun Jang and Byong Chul Yoo
    Citation: BMC Cancer 2008 8:286
  27. Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy). The detection of m...

    Authors: John P Jakupciak, Samantha Maragh, Maura E Markowitz, Alissa K Greenberg, Mohammad O Hoque, Anirban Maitra, Peter E Barker, Paul D Wagner, William N Rom, Sudhir Srivastava, David Sidransky and Catherine D O'Connell
    Citation: BMC Cancer 2008 8:285
  28. Hypermethylation of the TGFBI promoter has been shown to correlate with decreased expression of this gene in human tumor cell lines. In this study, we optimized a methylation-specific polymerase chain reaction (M...

    Authors: Jinesh N Shah, Genze Shao, Tom K Hei and Yongliang Zhao
    Citation: BMC Cancer 2008 8:284
  29. Understanding risks is considered to be crucial for informed decision-making. Inaccurate risk perception is a common finding in women with a family history of breast cancer attending genetic counseling. As yet...

    Authors: Caroline F Ockhuysen-Vermey, Lidewij Henneman, Christi J van Asperen, Jan C Oosterwijk, Fred H Menko and Daniëlle RM Timmermans
    Citation: BMC Cancer 2008 8:283
  30. A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investiga...

    Authors: Fiona EM Paulin, Mary O'Neill, Gillian McGregor, Andrew Cassidy, Alison Ashfield, Clinton W Ali, Alastair J Munro, Lee Baker, Colin A Purdie, David P Lane and Alastair M Thompson
    Citation: BMC Cancer 2008 8:281
  31. Musashi1 (Msi1) is an RNA binding protein with a central role during nervous system development and stem cell maintenance. High levels of Msi1 have been reported in several malignancies including brain tumors ...

    Authors: Patricia C Sanchez-Diaz, Tarea L Burton, Suzanne C Burns, Jaclyn Y Hung and Luiz OF Penalva
    Citation: BMC Cancer 2008 8:280
  32. Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine produced physiologically by the uterus. Pathological secretion by tumours promotes growth and metastasis. High circulating VEGF levels ...

    Authors: Aoife J Lowery, Karl J Sweeney, Alan P Molloy, Emer Hennessy, Catherine Curran and Michael J Kerin
    Citation: BMC Cancer 2008 8:279
  33. Many women in Iran have a relatively high body mass index. To investigate whether the condition contributes to excess breast cancer cases, a case-control study was conducted to assess the relationships between...

    Authors: Ali Montazeri, Jila Sadighi, Faranak Farzadi, Farzaneh Maftoon, Mariam Vahdaninia, Mariam Ansari, Akram Sajadian, Mandana Ebrahimi, Shahpar Haghighat and Iraj Harirchi
    Citation: BMC Cancer 2008 8:278
  34. DNA microarray analysis has great potential to become an important clinical tool to individualize prognostication and treatment for breast cancer patients. However, with any emerging technology, there are many...

    Authors: Vietty Wong, Dong-Yu Wang, Keisha Warren, Supriya Kulkarni, Scott Boerner, Susan Jane Done and Wey Liang Leong
    Citation: BMC Cancer 2008 8:277
  35. The molecular mechanisms underlying melanoma tumor development and progression are still not completely understood. One of the new candidates that emerged from a recent gene expression profiling study is fatty ac...

    Authors: Ana Slipicevic, Kjersti Jørgensen, Martina Skrede, Anne Katrine Ree Rosnes, Gunhild Trøen, Ben Davidson and Vivi Ann Flørenes
    Citation: BMC Cancer 2008 8:276
  36. This retrospective study aims to determine: 1) the sensitivity of preoperative mammography (Mx) and ultrasound (US), and re-reviewed Mx to detect multifocal multicentric breast carcinoma (MMBC), defined by pat...

    Authors: Anna Bozzini, Giuseppe Renne, Lorenza Meneghetti, Giuseppe Bandi, Gabriela Santos, Anna Rita Vento, Simona Menna, Stefania Andrighetto, Giuseppe Viale, Enrico Cassano and Massimo Bellomi
    Citation: BMC Cancer 2008 8:275
  37. Metastasis to regional lymph nodes is a common step in the progression of cancer. Recent evidence suggests that tumor production of CXCR4 promotes lymph node metastasis. Nitric oxide (NO) may also increase met...

    Authors: Hironao Yasuoka, Rieko Kodama, Mitsuyoshi Hirokawa, Yuuki Takamura, Akira Miyauchi, Tokio Sanke and Yasushi Nakamura
    Citation: BMC Cancer 2008 8:274
  38. There is no biological or epidemiological data on the association between NOS3 promoter polymorphisms and prostate cancer. The polymorphisms in the promoter region of NOS3 gene may be responsible for variations i...

    Authors: Karina Marangoni, Thaíse G Araújo, Adriana F Neves and Luiz R Goulart
    Citation: BMC Cancer 2008 8:273
  39. Cyclin D1 is integral for the G1 to S phase of the cell cycle as it regulates cellular proliferation. A polymorphism in cyclin D1, 870 G>A, causes overexpression and supports uncontrollable cellular growth. Th...

    Authors: Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds, Mark McEvoy, John Attia, Michael Gilbert, Ute Hamann and Rodney J Scott
    Citation: BMC Cancer 2008 8:272
  40. Cancer incidence varies by socioeconomic group and these variations have been linked with environmental and lifestyle factors, differences in access to health care and health seeking behaviour. Socioeconomic v...

    Authors: Lorraine Shack, Catrina Jordan, Catherine S Thomson, Vivian Mak and Henrik Møller
    Citation: BMC Cancer 2008 8:271
  41. Deregulation of Stat5 in the mammary gland of transgenic mice causes tumorigenesis. Poorly differentiated carcinoma and highly differentiated papillary adenocarcinoma tumors evolve. To distinguish the genes an...

    Authors: Tali Eilon and Itamar Barash
    Citation: BMC Cancer 2008 8:270
  42. The human MutY homolog (hMYH), a DNA glycolsylase involved in the excision repair of oxidative DNA damage, is currently studied in colorectal cancer (CRC). We previously demonstrated a haplotype variant c.53C>T/c...

    Authors: Huimei Chen, Lizhi Xu, Qiufeng Qi, Yanweng Yao, Ming Zhu and Yaping Wang
    Citation: BMC Cancer 2008 8:269
  43. Overexpression of the bZip transcription factor, ATF3, in basal epithelial cells of transgenic mice under the control of the bovine cytokeratin-5 (CK5) promoter has previously been shown to induce epidermal hy...

    Authors: Aijin Wang, Stacey Arantes, Leqin Yan, Kaoru Kiguchi, Mark J McArthur, Aysegul Sahin, Howard D Thames, C Marcelo Aldaz and Michael C MacLeod
    Citation: BMC Cancer 2008 8:268
  44. The intermediate filament forming protein keratin 8 (K8) is a tumour-associated antigen, which was shown to be over-expressed in a variety of malignancies. Here, we present a study of K8 expression in squamous...

    Authors: Christoph Matthias, Brigitte Mack, Alexander Berghaus and Olivier Gires
    Citation: BMC Cancer 2008 8:267
  45. MicroRNAs (miRNAs), some of which function as oncogenes or tumor suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell death. MicroRNA miR-34 was recently found to be a...

    Authors: Qing Ji, Xinbao Hao, Yang Meng, Min Zhang, Jeffrey DeSano, Daiming Fan and Liang Xu
    Citation: BMC Cancer 2008 8:266
  46. Production of interferon (IFN)-γ is key to efficient anti-tumor immunity. The present study was set out to investigate effects of IFNγ on the release of the potent pro-angiogenic mediator IL-8 by human A549 lu...

    Authors: Kim A Boost, Christian D Sadik, Malte Bachmann, Bernhard Zwissler, Josef Pfeilschifter and Heiko Mühl
    Citation: BMC Cancer 2008 8:265
  47. The cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells....

    Authors: Matteo Pellegrini, Jerry C Cheng, Jon Voutila, Dejah Judelson, Julie Taylor, Stanley F Nelson and Kathleen M Sakamoto
    Citation: BMC Cancer 2008 8:264
  48. MYH11 (also known as SMMHC) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the MYH11 locus is one of the most frequent chromosomal aberrations found...

    Authors: Pia Alhopuro, Auli Karhu, Robert Winqvist, Kati Waltering, Tapio Visakorpi and Lauri A Aaltonen
    Citation: BMC Cancer 2008 8:263

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