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  1. The main study objectives were: to establish a nationwide voluntary collaborative network of breast centres with independent data analysis; to define suitable quality indicators (QIs) for benchmarking the qual...

    Authors: Sara Y Brucker, Claudia Schumacher, Christoph Sohn, Mahdi Rezai, Michael Bamberg and Diethelm Wallwiener
    Citation: BMC Cancer 2008 8:358
    Content type: Research article Published on:

  2. The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT) in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not as...

    Authors: Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellaro, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise and José Andres Yunes
    Citation: BMC Cancer 2008 8:357
    Content type: Research article Published on:

  3. Recent reviews claiming smokeless tobacco increases pancreatic cancer risk appear not to have considered all available epidemiological evidence; nor were meta-analyses included. We present a systematic review ...

    Authors: Zheng Sponsiello-Wang, Rolf Weitkunat and Peter N Lee
    Citation: BMC Cancer 2008 8:356
    Content type: Research article Published on:

  4. Little is known about the effect of migrant status on childhood cancer survival. We studied cancer survival among children of Turkish descent in the German Cancer Childhood Registry, one of the largest childho...

    Authors: Claudia Spix, Jacob Spallek, Peter Kaatsch, Oliver Razum and Hajo Zeeb
    Citation: BMC Cancer 2008 8:355
    Content type: Research article Published on:

  6. Recepteur d'origine nantais (RON) is a receptor tyrosine kinase that is activated by a serum-derived, macrophage stimulating protein (MSP) growth factor and is expressed in many malignant tumors. The aim of th...

    Authors: Donghui Zhou, Gang Pan, Chen Zheng, Jingjing Zheng, Liping Yian and Xiaodong Teng
    Citation: BMC Cancer 2008 8:353
    Content type: Research article Published on:

  7. Pancreatic cancer continues to have a 5-year survival of less than 5%. Therefore, more effective therapies are necessary to improve prognosis in this disease. Angiogenesis is required for tumor growth, and sub...

    Authors: Sean P Dineen, Laura A Sullivan, Adam W Beck, Andrew F Miller, Juliet G Carbon, Roni Mamluk, Henry Wong and Rolf A Brekken
    Citation: BMC Cancer 2008 8:352
    Content type: Research article Published on:

  8. The objectives of this retrospective study was to evaluate the efficacy of stereotactic body radiation therapy (SBRT) for small non-resectable hepatocellular carcinoma (HCC) and SBRT combined with transarteria...

    Authors: Byung Ock Choi, Ihl Bohng Choi, Hong Seok Jang, Young Nam Kang, Ji Sun Jang, Si Hyun Bae, Seung Kew Yoon, Gyu Young Chai and Ki Mun Kang
    Citation: BMC Cancer 2008 8:351
    Content type: Research article Published on:

  9. Reference genes, which are often referred to as housekeeping genes are frequently used to normalize mRNA levels between different samples in quantitative reverse transcription polymerase chain reaction (qRT-PC...

    Authors: Vito R Cicinnati, Qingli Shen, Georgios C Sotiropoulos, Arnold Radtke, Guido Gerken and Susanne Beckebaum
    Citation: BMC Cancer 2008 8:350
    Content type: Research article Published on:

  10. Disease progression of hepatocellular cancer (HCC) in patients eligible for liver transplantation (LTx) occurs in up to 50% of patients, resulting in withdrawal from the LTx waiting list. Transarterial chemoem...

    Authors: K Hoffmann, H Glimm, B Radeleff, G Richter, C Heining, I Schenkel, A Zahlten-Hinguranage, P Schirrmacher, J Schmidt, MW Büchler, D Jaeger, C von Kalle and P Schemmer
    Citation: BMC Cancer 2008 8:349
    Content type: Study protocol Published on:

  11. Thymidylate synthase (TS) is an important target for chemotherapeutic treatment of cancer and high expression of TS has been associated with poor prognosis or refractory disease in several cancers including co...

    Authors: Takashi Shirasaki, Shin-ichiro Maruya, Hiroki Mizukami, Seiji Kakehata, Hidekachi Kurotaki, Soroku Yagihashi and Hideichi Shinkawa
    Citation: BMC Cancer 2008 8:348
    Content type: Research article Published on:

  12. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. T...

    Authors: D Mendoza-Villanueva, J Diaz-Chavez, L Uribe-Figueroa, C Rangel-Escareão, A Hidalgo-Miranda, S March-Mifsut, G Jimenez-Sanchez, PF Lambert and P Gariglio
    Citation: BMC Cancer 2008 8:347
    Content type: Research article Published on:

  13. Serous epithelial ovarian tumors can be subdivided into benign (BOV), low malignant potential (LMP) or borderline and invasive (TOV) tumors. Although the molecular characteristics of serous BOV, LMP and low gr...

    Authors: Véronique Ouellet, Tak Hay Ling, Karine Normandin, Jason Madore, Christian Lussier, Véronique Barrès, Dimcho Bachvarov, Claudine Rancourt, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2008 8:346
    Content type: Research article Published on:

  14. Stage at diagnosis plays a significant role in colorectal cancer (CRC) survival. Understanding which factors contribute to a more advanced stage at diagnosis is vital to improving overall survival. Comorbidity...

    Authors: S Yousuf Zafar, Amy P Abernethy, David H Abbott, Steven C Grambow, Jennifer E Marcello, James E Herndon II, Krista L Rowe, Jane T Kolimaga, Leah L Zullig, Meenal B Patwardhan and Dawn T Provenzale
    Citation: BMC Cancer 2008 8:345
    Content type: Research article Published on:

  15. Spatial clustering of different diseases has received much less attention than single disease mapping. Besides chance or artifact, clustering of different cancers in a given area may depend on exposure to a sh...

    Authors: Tiziana Cassetti, Francesco La Rosa, Luca Rossi, Daniela D'Alò and Fabrizio Stracci
    Citation: BMC Cancer 2008 8:344
    Content type: Research article Published on:

  16. Diagnosis and prognosis in breast cancer are mainly based on histology and immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) material. Recently, gene expression analysis was shown to elucidate t...

    Authors: Martina Schobesberger, Anna Baltzer, Andrea Oberli, Andreas Kappeler, Mathias Gugger, Hana Burger and Rolf Jaggi
    Citation: BMC Cancer 2008 8:343
    Content type: Technical advance Published on:

  17. Tripeptide tyroserleutide (YSL) is a novel small molecule anti-tumor polypeptide that has been shown to inhibit the growth of human liver cancer cells. In this study, we investigated the effects of YSL plus do...

    Authors: Zhi-feng Zhu, Li-juan Chen, Rong Lu, Jing Jia, Yu Liang, Qiong Xu, Chun-lei Zhou, Li Wang, Song Wang and Zhi Yao
    Citation: BMC Cancer 2008 8:342
    Content type: Research article Published on:

  18. Different methods exist to estimate smoking attributable cancer mortality rates (Peto and Ezzati methods, as examples). However, the smoking attributable estimates using these methods cannot be generalized to ...

    Authors: Bruce N Leistikow, Zubair Kabir, Gregory N Connolly, Luke Clancy and Hillel R Alpert
    Citation: BMC Cancer 2008 8:341
    Content type: Research article Published on:

  19. Lymph nodes constitute the first site of metastasis for most malignancies, and the extent of lymph node involvement is a major criterion for evaluating patient prognosis. The CXC chemokine receptor 4 (CXCR4) h...

    Authors: Hironao Yasuoka, Masahiko Tsujimoto, Katsuhide Yoshidome, Masaaki Nakahara, Rieko Kodama, Tokio Sanke and Yasushi Nakamura
    Citation: BMC Cancer 2008 8:340
    Content type: Research article Published on:

  20. Given the large number of genes purported to be prognostic for breast cancer, it would be optimal if the genes identified are not confounded by the continuously changing systemic therapies. The aim of this stu...

    Authors: Andrew Tutt, Alice Wang, Charles Rowland, Cheryl Gillett, Kit Lau, Karen Chew, Hongyue Dai, Shirley Kwok, Kenneth Ryder, Henry Shu, Robert Springall, Paul Cane, Blair McCallie, Lauren Kam-Morgan, Steve Anderson, Horst Buerger…
    Citation: BMC Cancer 2008 8:339
    Content type: Research article Published on:

  21. Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin rece...

    Authors: Michael N Okobia, Clareann H Bunker, Seymour J Garte, Joseph M Zmuda, Emmanuel R Ezeome, Stanley N Anyanwu, Emmanuel E Uche, Lewis H Kuller, Robert E Ferrell and Emanuela Taioli
    Citation: BMC Cancer 2008 8:338
    Content type: Research article Published on:

  22. The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are there...

    Authors: Laure Voisin, Catherine Julien, Stéphanie Duhamel, Kailesh Gopalbhai, Isabelle Claveau, Marc K Saba-El-Leil, Ian Gaël Rodrigue-Gervais, Louis Gaboury, Daniel Lamarre, Mark Basik and Sylvain Meloche
    Citation: BMC Cancer 2008 8:337
    Content type: Research article Published on:

  23. In Catalonia (Spain) breast cancer mortality has declined since the beginning of the 1990s. The dissemination of early detection by mammography and the introduction of adjuvant treatments are among the possibl...

    Authors: Montserrat Rue, Misericordia Carles, Ester Vilaprinyo, Montserrat Martinez-Alonso, Josep-Alfons Espinas, Roger Pla and Pilar Brugulat
    Citation: BMC Cancer 2008 8:336
    Content type: Research article Published on:

  24. The hypoxia-inducible factor (HIF) has emerged as an attractive target for cancer therapy. The few publications addressing the prognostic significance of Hypoxia-Inducible Factor 1α (HIF-1α) cellular expressio...

    Authors: Alexandros Daponte, Maria Ioannou, Ilias Mylonis, George Simos, Marcos Minas, Ioannis E Messinis and George Koukoulis
    Citation: BMC Cancer 2008 8:335
    Content type: Research article Published on:

  25. Endothelin(ET) axis plays a key role in many tumor progression and metastasis via various mechanisms such as angiogenesis, mediating extracellular matrix degradation and inhibition of apoptosis. However, there...

    Authors: Wenjie Jiao, Jing Xu, Jinsheng Zheng, Yi Shen, Lesheng Lin and Jian Li
    Citation: BMC Cancer 2008 8:334
    Content type: Research article Published on:

  26. Mucin alterations are a common feature of esophageal neoplasia, and alterations in MUC2 mucin have been associated with tumor progression in the esophagus. Bile acids have been linked to esophageal adenocarcin...

    Authors: JianTao Wu, Jun Gong, Juan Geng and YinXue Song
    Citation: BMC Cancer 2008 8:333
    Content type: Research article Published on:

  27. Recombinant granulocyte colony-stimulating factors (G-CSFs) such as Filgrastim are used to treat chemotherapy-induced neutropenia. We investigated a new G-CSF, XM02, and compared it to Neupogen™ after myelotox...

    Authors: A del Giglio, A Eniu, D Ganea-Motan, E Topuzov and H Lubenau
    Citation: BMC Cancer 2008 8:332
    Content type: Research article Published on:

  28. Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. ...

    Authors: Ester Vilaprinyo, Rosa Gispert, Montserrat Martínez-Alonso, Misericòrdia Carles, Roger Pla, Josep-Alfons Espinàs and Montserrat Rué
    Citation: BMC Cancer 2008 8:331
    Content type: Research article Published on:

  29. Measuring quality of life in breast cancer patients is of importance in assessing treatment outcomes. This study examined the impact of breast cancer diagnosis and its treatment on quality of life of women wit...

    Authors: Ali Montazeri, Mariam Vahdaninia, Iraj Harirchi, Mandana Ebrahimi, Fatemeh Khaleghi and Soghra Jarvandi
    Citation: BMC Cancer 2008 8:330
    Content type: Research article Published on:

  30. Protein tyrosine phosphatases (PTPs) like their antagonizing protein tyrosine kinases are key regulators of signal transduction thereby assuring normal control of cellular growth and differentiation. Increasin...

    Authors: Sebastian Korff, Stefan M Woerner, Yan P Yuan, Peer Bork, Magnus von Knebel Doeberitz and Johannes Gebert
    Citation: BMC Cancer 2008 8:329
    Content type: Research article Published on:

  31. A recent study has shown that phosphorylated c-Jun (p-c-Jun) interacts with TCF4 to form a complex that cooperatively enhances their transcriptional activity in the presence of β-Catenin, and that their intera...

    Authors: Kayoko Takeda, Ichiro Kinoshita, Yasushi Shimizu, Yusuke Ohba, Tomoo Itoh, Yoshihiro Matsuno, Toshiaki Shichinohe and Hirotoshi Dosaka-Akita
    Citation: BMC Cancer 2008 8:328
    Content type: Research article Published on:

  32. Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs. In addition, the WTH3 gene promot...

    Authors: Kegui Tian, Yuezeng Wang, Yu Huang, Boqiao Sun, Yuxin Li and Haopeng Xu
    Citation: BMC Cancer 2008 8:327
    Content type: Research article Published on:

  33. Sporadic colorectal cancers (CRC) are multifactorial diseases resulting from the combined effects of numerous genetic, environmental and behavioral risk factors. Genetic association studies have suggested low-...

    Authors: Sébastien Küry, Bruno Buecher, Sébastien Robiou-du-Pont, Catherine Scoul, Hélène Colman, Tanguy Le Neel, Claire Le Houérou, Roger Faroux, Jean Ollivry, Bernard Lafraise, Louis-Dominique Chupin, Véronique Sébille and Stéphane Bézieau
    Citation: BMC Cancer 2008 8:326
    Content type: Research article Published on:

  36. Prognostic factors are defined as biological or clinical measurement associated with overall survival and/or disease-free survival. Previous studies have shown that patients with estrogen receptor (ER) positiv...

    Authors: Takayoshi Kiba, Takashi Inamoto, Tsutomu Nishimura, Masaya Ueno, Kazuhiro Yanagihara, Satoshi Teramukai, Hironori Kato, Masakazu Toi and Masanori Fukushima
    Citation: BMC Cancer 2008 8:323
    Content type: Research article Published on:

  37. Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen re...

    Authors: Sara Wedrén, Lovisa Lovmar, Keith Humphreys, Cecilia Magnusson, Håkan Melhus, Ann-Christine Syvänen, Andreas Kindmark, Ulf Landegren, Maria Lagerström Fermér, Fredrik Stiger, Ingemar Persson, John A Baron and Elisabete Weiderpass
    Citation: BMC Cancer 2008 8:322
    Content type: Research article Published on:

  38. The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the associa...

    Authors: Björn Lindkvist, Dorthe Johansen, Anders Borgström and Jonas Manjer
    Citation: BMC Cancer 2008 8:321
    Content type: Research article Published on:

  39. Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown. To investigate the significance...

    Authors: Nektaria Simiantonaki, Marios Taxeidis, Caren Jayasinghe, Ursula Kurzik-Dumke and Charles James Kirkpatrick
    Citation: BMC Cancer 2008 8:320
    Content type: Research article Published on:

  40. Granulosa cell tumours (GCTs) are frequently seen in menopausal women and are relatively indolent. Although the physiological properties of normal granulosa cells have been studied extensively, little is known...

    Authors: Misa Imai, Miho Muraki, Kiyoshi Takamatsu, Hidekazu Saito, Motoharu Seiki and Yuji Takahashi
    Citation: BMC Cancer 2008 8:319
    Content type: Research article Published on:

  41. Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters. It remains unclear ...

    Authors: Stacey L Hembruff, Monique L Laberge, David J Villeneuve, Baoqing Guo, Zachary Veitch, Melanie Cecchetto and Amadeo M Parissenti
    Citation: BMC Cancer 2008 8:318
    Content type: Research article Published on:

  42. Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 1...

    Authors: Krisztián Bácsi, Erika Hitre, János P Kósa, Henrik Horváth, Áron Lazáry, Péter L Lakatos, Bernadett Balla, Barna Budai, Péter Lakatos and Gábor Speer
    Citation: BMC Cancer 2008 8:317
    Content type: Research article Published on:

  43. Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntar...

    Authors: Jihyeung Ju, Bonnie Nolan, Michelle Cheh, Mousumi Bose, Yong Lin, George C Wagner and Chung S Yang
    Citation: BMC Cancer 2008 8:316
    Content type: Research article Published on:

  44. Transcriptional profiling of prostate cancer (PC) has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal ab...

    Authors: Raquel Bermudo, David Abia, Berta Ferrer, Iracema Nayach, Alberto Benguria, Ángel Zaballos, Javier del Rey, Rosa Miró, Elías Campo, Carlos Martínez-A, Ángel R Ortiz, Pedro L Fernández and Timothy M Thomson
    Citation: BMC Cancer 2008 8:315
    Content type: Research article Published on:

  45. Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma ...

    Authors: Esther H Lips, Ronald van Eijk, Eelco JR de Graaf, Jan Oosting, Noel FCC de Miranda, Tom Karsten, Cornelis J van de Velde, Paul HC Eilers, Rob AEM Tollenaar, Tom van Wezel and Hans Morreau
    Citation: BMC Cancer 2008 8:314
    Content type: Research article Published on:

  46. Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed ...

    Authors: Adrien Daigeler, Ludger Klein-Hitpass, Ansgar Michael Chromik, Oliver Müller, Jörg Hauser, Heinz-Herbert Homann, Hans-Ulrich Steinau and Marcus Lehnhardt
    Citation: BMC Cancer 2008 8:313
    Content type: Research article Published on:

  47. Heat shock protein 90 (Hsp90) overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications. The purpose of this study is to evaluate the immunohistochemica...

    Authors: Flora Zagouri, Afrodite Nonni, Theodoros N Sergentanis, Christos A Papadimitriou, Nikolaos V Michalopoulos, Andreas C Lazaris, Efstratios Patsouris and George C Zografos
    Citation: BMC Cancer 2008 8:312
    Content type: Research article Published on:

  48. The ageing of the population is expected to bring an enormous growth in demand for oncological health care. In order to anticipate and respond to future trends, cancer care needs to be critically evaluated. Th...

    Authors: Ron Pritzkuleit, Annika Waldmann, Heiner Raspe and Alexander Katalinic
    Citation: BMC Cancer 2008 8:311
    Content type: Research article Published on:

  49. Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim o...

    Authors: Do Kyung Lee, Seok Jang, Mi Jin Kim, Jung Hyun Kim, Myung Jun Chung, Kyung Jae Kim and Nam Joo Ha
    Citation: BMC Cancer 2008 8:310
    Content type: Research article Published on:

  50. Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins.

    Authors: Tatsuya Toyama, Hiroko Yamashita, Naoto Kondo, Katsuhiro Okuda, Satoru Takahashi, Hidefumi Sasaki, Hiroshi Sugiura, Hirotaka Iwase and Yoshitaka Fujii
    Citation: BMC Cancer 2008 8:309
    Content type: Research article Published on:

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