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  1. We have proposed a modified, completely intrafascial radical cysprostatectomy (RC) to treat bladder cancer patients with the aim of preserving the patients’ post-surgical urinary control and erectile function....

    Authors: Xiao Wang, Jia Guo, Lei Wang, Min Wang, Xiaodong Weng, Hui Chen and Xiuheng Liu
    Citation: BMC Cancer 2021 21:887
    Content type: Research Published on:

  2. Considering the clinical and genetic characteristics, acute lymphoblastic leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current standard diagnostics require various analyses encompa...

    Authors: Wencke Walter, Rabia Shahswar, Anna Stengel, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach and Claudia Haferlach
    Citation: BMC Cancer 2021 21:886
    Content type: Research Published on:

  3. Up to now, limited researches focused on the association between transcription factor 7-like 2 gene (TF7L2) gene single nucleotide polymorphisms (SNPs) and breast cancer (BC) risk. The aim of this study was to ev...

    Authors: Yang Wang, Xiaojuan Men, Yongxue Gu, Huidong Wang and Zhicai Xu
    Citation: BMC Cancer 2021 21:885
    Content type: Research Published on:

  4. Neuroligin1 (NLGN1) is a main component of excitatory glutamatergic synapses complex and is important for synapse assembly and function. The clinical value of NLGN1 in colorectal cancer (CRC) is not clear.

    Authors: Qian Yu, Xiaojie Wang, Yinghong Yang, Pan Chi, Jianping Huang, Shengliang Qiu, Xin Zheng and Xiaowen Chen
    Citation: BMC Cancer 2021 21:884
    Content type: Research Published on:

  5. To identify subgroups of female breast cancer patients with distinct self-reported employment interference (EI) profiles and determine which demographic, clinical, and symptom characteristics, and quality of l...

    Authors: Raymond Javan Chan, Bruce Cooper, Louisa Gordon, Nicolas Hart, Chia Jie Tan, Bogda Koczwara, Kord M. Kober, Alexandre Chan, Yvette P. Conley, Steven M. Paul and Christine Miaskowski
    Citation: BMC Cancer 2021 21:883
    Content type: Research Published on:

  8. Human papilloma virus infection and tobacco smoking are the major risk factors for cervical cancer. There are limited studies searching other risk factors for cervical cancer and the results are not consistent...

    Authors: Ji Young Kim, Dae Woo Lee, Min Jeong Kim, Jae Eun Shin, Yeun Joo Shin and Hae Nam Lee
    Citation: BMC Cancer 2021 21:880
    Content type: Research Published on:

  9. Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma, but some patients exhibit intrinsic resistance or develop acquired resistanc...

    Authors: Kana Oiwa, Naoko Hosono, Rie Nishi, Luigi Scotto, Owen A. O’Connor and Takahiro Yamauchi
    Citation: BMC Cancer 2021 21:879
    Content type: Research article Published on:

  10. Patterns of failure after treatment of oral and squamous cell carcinomas (OSCC) are diversified, with recurrences being one of the common causes. A special group of patients are sometimes encountered in the ou...

    Authors: Yue He, Zhonglong Liu, Surui Sheng, Weijin Gao, Xiao Tang, Xiaoguang Li and Chunyue Ma
    Citation: BMC Cancer 2021 21:878
    Content type: Research article Published on:

  11. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, have achieved good efficacy in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients, but eventual drug ...

    Authors: Wanjun Yu, Fei Ye, Xiao Yuan, Yali Ma, Chaoming Mao, Xiaoqin Li, Jian Li, Chunhua Dai, Fenhong Qian, Junrong Li, Xiujuan Fan, Yuepeng Zhou, Deqiang Wang, Zhenhong Guo, Huazhang An, Minghui Zhang…
    Citation: BMC Cancer 2021 21:877
    Content type: Study protocol Published on:

  12. m6A is the most prevalent and abundant form of mRNA modifications and is closely related to tumor proliferation, differentiation, and tumorigenesis. In this study, we try to conduct an effective prediction mod...

    Authors: Lianzi Wang, Shubing Zhang, Huimin Li, Yang Xu, Qiang Wu, Jilong Shen, Tao Li and Yuanhong Xu
    Citation: BMC Cancer 2021 21:876
    Content type: Research Published on:

  13. Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown contro...

    Authors: Guixin Wang, Shuhao Zhang, Meiling Wang, Lin Liu, Yaqian Liu, Lianjun Tang, He Bai and Haidong Zhao
    Citation: BMC Cancer 2021 21:875
    Content type: Research Published on:

  15. Leptomeningeal metastasis (LM) is a severe complication of advanced non-small cell lung cancer (NSCLC). This retrospective study aimed to investigate the potential use of osimertinib for preventing LM in patie...

    Authors: Xia Wang, Jing Cai, Zhimin Zeng and Anwen Liu
    Citation: BMC Cancer 2021 21:873
    Content type: Research Published on:

  16. Despite the progress in assessment and treatment of breast cancer, being diagnosed with it or receiving chemotherapy treatment is still conceived as a traumatic experience. Women develop negative thoughts abou...

    Authors: Aline HAJJ, Roula HACHEM, Rita KHOURY, Souheil HALLIT, Bashar ElJEBBAWI, Fady NASR, Fadi EL KARAK, Georges CHAHINE, Joseph KATTAN and Lydia RABBAA KHABBAZ
    Citation: BMC Cancer 2021 21:872
    Content type: Research Published on:

  18. Supervised physical activity interventions improve functional health during cancer survivorship, but remain costly and inaccessible for many. We previously reported on the benefits of a DVD-delivered physical ...

    Authors: Elizabeth A. Salerno, Neha P. Gothe, Jason Fanning, Lindsay L. Peterson, Graham A. Colditz and Edward McAuley
    Citation: BMC Cancer 2021 21:870
    Content type: Research article Published on:

  19. Although colorectal cancer (CRC) screening programs reduce CRC incidence and mortality, they are associated with risks in healthy subjects. However, the risk of overtreatment and overdiagnosis has not been det...

    Authors: Joaquín Cubiella, Antía González, Raquel Almazán, Elena Rodríguez-Camacho, Raquel Zubizarreta and Isabel Peña-Rey Lorenzo
    Citation: BMC Cancer 2021 21:869
    Content type: Research article Published on:

  20. Currently, no clinically useful biomarkers for radioresistance are available in head and neck squamous cell carcinoma (HNSCC). This study assesses the usefulness of Cell Line Microarray (CMA) method to enhance...

    Authors: Johannes Routila, Karri Suvila, Reidar Grénman, Ilmo Leivo, Jukka Westermarck and Sami Ventelä
    Citation: BMC Cancer 2021 21:868
    Content type: Research Published on:

  21. This investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction combination chemoradiotherapy and long-term maintenance therapy with temo...

    Authors: Kenichiro Asano, Toshio Fumoto, Masashi Matsuzaka, Seiko Hasegawa, Naoya Suzuki, Kenichi Akasaka, Kosuke Katayama, Akihisa Kamataki, Akira Kurose and Hiroki Ohkuma
    Citation: BMC Cancer 2021 21:867
    Content type: Research article Published on:

  22. Lymphovascular space invasion is an independent prognostic factor in early-stage cervical cancer. However, there is a lack of non-invasive methods to detect lymphovascular space invasion. Some researchers foun...

    Authors: Xiaoran Li, Chen Xu, Yang Yu, Yan Guo and Hongzan Sun
    Citation: BMC Cancer 2021 21:866
    Content type: Research article Published on:

  23. Cholangiocarcinoma (CCA) is an aggressive disease with poor prognosis. A molecular classification based on mutational, methylation and transcriptomic features could allow identifying tailored therapies to impr...

    Authors: Giuliana Cavalloni, Caterina Peraldo-Neia, Annamaria Massa, Carlo Bergamini, Alessandro Trentini, Giovanni De Rosa, Lorenzo Daniele, Fabiola Ciccosanti, Carlo Cervellati, Francesco Leone and Massimo Aglietta
    Citation: BMC Cancer 2021 21:865
    Content type: Research Published on:

  24. Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and 1-year local control estimated at 70 and 62% respectively. However...

    Authors: Angeline Ginzac, Guillaume Dupic, Lucie Brun, Ioana Molnar, Mélanie Casile, Xavier Durando, Pierre Verrelle, Jean-Jacques Lemaire, Toufic Khalil and Julian Biau
    Citation: BMC Cancer 2021 21:864
    Content type: Study protocol Published on:

  25. Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made from the spontaneous merging of pre-malignant (IMR90 E6E7, i.e. E6E7) an...

    Authors: Ariadna Brito, Candice Merle, Pauline Lagarde, Benjamin Faustin, Anne Devin, Lydia Lartigue and Frederic Chibon
    Citation: BMC Cancer 2021 21:863
    Content type: Research Published on:

  26. Here we evaluated the feasibility, efficacy, tolerability, and treatment-mediated immune modulation of neoadjuvant everolimus plus letrozole versus chemotherapy in treating postmenopausal patients with ER-posi...

    Authors: Wei Wu, Jiewen Chen, Heran Deng, Liang Jin, Zhanghai He, Nanyan Rao, Yan Nie, Yandan Yao, Yaping Yang, Fengxi Su and Jieqiong Liu
    Citation: BMC Cancer 2021 21:862
    Content type: Research Published on:

  27. To investigate the global expression profile of miRNAs, their impact on cellular signaling pathways, and their association with poor prognostic parameters in African-American (AA) patients with triple negative...

    Authors: Safaa Turkistani, Bruna M. Sugita, Paolo Fadda, Rafael Marchi, Ali Afsari, Tammey Naab, Victor Apprey, Robert L. Copeland Jr, Michael C. Campbell, Luciane R. Cavalli and Yasmine Kanaan
    Citation: BMC Cancer 2021 21:861
    Content type: Research Published on:

  28. The psychometric properties of the simplified Chinese version of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) have not been assessed. Therefore, we ai...

    Authors: Shan-Shan Yang, Lei Chen, Ying Liu, Hai-Jun Lu, Bo-Jie Huang, Ai-Hua Lin, Ying Sun, Jun Ma, Fang-Yun Xie and Yan-Ping Mao
    Citation: BMC Cancer 2021 21:860
    Content type: Research Published on:

  29. Afatinib is one of the standard treatments for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). However, data on the use of afatinib in patients with poor performa...

    Authors: Chiao-En Wu, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu and John Wen-Cheng Chang
    Citation: BMC Cancer 2021 21:859
    Content type: Research article Published on:

  30. Bladder cancer (BC) is a common malignancy neoplasm diagnosed in advanced stages in most cases. It is crucial to screen ideal biomarkers and construct a more accurate prognostic model than conventional clinica...

    Authors: Jianpeng Li, Jinlong Cao, Pan Li, Zhiqiang Yao, Ran Deng, Lijun Ying and Junqiang Tian
    Citation: BMC Cancer 2021 21:858
    Content type: Research Published on:

  31. Primary urethral carcinoma (PUC) is a rare genitourinary malignancy with a relatively poor prognosis. The aim of this study was to examine the impact of surgery on survival of patients diagnosed with PUC.

    Authors: Jie Wu, Yu-Chen Wang, Wen-Jie Luo, Bo-Dai, Ding-Wei Ye and Yi-Ping Zhu
    Citation: BMC Cancer 2021 21:857
    Content type: Research article Published on:

  32. PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have...

    Authors: Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan and Luigi Marchionni
    Citation: BMC Cancer 2021 21:856
    Content type: Research article Published on:

  33. Fatigue is one of the most common and burdensome symptoms experienced by cancer patients. In interventions intended to reduce fatigue in such patients, fatigability, or perception of fatigue contextualized to ...

    Authors: Min Kyeong Jang, Jeehee Han, Sung Hae Kim, Yun Hee Ko, Soo Yeon Kim and Sue Kim
    Citation: BMC Cancer 2021 21:855
    Content type: Research Published on:

  34. Although current therapy for patients with early-stage squamous cell carcinoma of the head and neck (SCCHN) is potentially curative, the recurrence rate is high. Patients with recurrent or metastatic (R/M) SCC...

    Authors: Prianka Singh, Bryan Bennett, Tom Bailey, Gavin Taylor-Stokes, Ivana Rajkovic, Marta Contente, Sharon Curtis and Chris Curtis
    Citation: BMC Cancer 2021 21:854
    Content type: Research Published on:

  35. Modified FOLFIRINOX and gemcitabine plus nab-paclitaxel (GEM-NAB) have been recommended as first-line therapies for advanced pancreatic cancer (PC). Due to the lack of evidence to directly compare them, we con...

    Authors: Jiayuan Chen, Qingling Hua, Haihong Wang, Dejun Zhang, Lei Zhao, Dandan Yu, Guoliang Pi, Tao Zhang and Zhenyu Lin
    Citation: BMC Cancer 2021 21:853
    Content type: Research article Published on:

  37. This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...

    Authors: Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R. Middleton and Graham P. Collins
    Citation: BMC Cancer 2021 21:851
    Content type: Research article Published on:

  38. Glioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a prevalence of approximately 2 per 10,000 people globally. The cell surface proteins or surfaceome serve as information gateway in ...

    Authors: Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Nurshahirah Ashikin Moidu, Bee Hong Soon and M. Aiman Mohtar
    Citation: BMC Cancer 2021 21:850
    Content type: Research article Published on:

  42. Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tu...

    Authors: Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams…
    Citation: BMC Cancer 2021 21:846
    Content type: Research article Published on:

  43. The understanding of molecular changes in mCRC during treatment could be used to personalise therapeutic strategies. The aim of our study was to explore the association of circulating tumour DNA (ctDNA) with c...

    Authors: Ning Jia, Lianpeng Chang, Xin Gao, Xiaohua Shi, Xuelin Dou, Mei Guan, Yajuan Shao, Ningning Li, Yuejuan Cheng, Hongyan Ying, Zhao Sun, Yanping Zhou, Lin Zhao, Jianfeng Zhou and Chunmei Bai
    Citation: BMC Cancer 2021 21:845
    Content type: Research Published on:

  44. Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in nume...

    Authors: Tianzao Huang, Yingxian Chen, Yile Zeng, Chaoyang Xu, Jinzhong Huang, Weipeng Hu, Xiangrong Chen and Huangde Fu
    Citation: BMC Cancer 2021 21:844
    Content type: Research article Published on:

  46. Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, an...

    Authors: Yunxiang Tang, Ruike Zhang, Yinan Li, Shuyu Xu, Hao Wang, Jingzhou Xu, Lei Xiao, Yajing Wang, Jing Du, Yujia Huang and Tong Su
    Citation: BMC Cancer 2021 21:842
    Content type: Research Published on:

  47. Body weight management was an important component in breast cancer survivorship care. The present study described the change patterns of body weight and waist-to-hip ratio (WHR) during the first 5 years of sur...

    Authors: Yuan-Yuan Lei, Suzanne C. Ho, Carol Kwok, Ashley Cheng, Ka Li Cheung, Roselle Lee, Frankie Mo and Winnie Yeo
    Citation: BMC Cancer 2021 21:839
    Content type: Research Published on:

  48. Tumor bed (TB) delineation based on preoperative magnetic resonance imaging (pre-MRI) fused with postoperative computed tomography (post-CT) were compared to post-CT only to define pre-MRI may aid in improving...

    Authors: Jie Jiang, Jinhu Chen, Wanhu Li, Yongqing Li, Yiru Chen, Zicheng Zhang, Chengxin Liu, Dan Han, Hongfu Sun, Baosheng Li and Wei Huang
    Citation: BMC Cancer 2021 21:838
    Content type: Research Published on:

  49. This study aimed to assess the clinical usefulness of 13N-ammonia and 11C- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary aden...

    Authors: Fangling Zhang, Qiao He, Ganhua Luo, Yali Long, Ruocheng Li, Lei Ding and Xiangsong Zhang
    Citation: BMC Cancer 2021 21:837
    Content type: Research Published on:

  50. Immunotherapy is a crucial therapeutic approach in oncology. However, most patients with head and neck squamous cell carcinoma (HNSCC) do not derive benefit from immunotherapy. Vascular endothelial growth fact...

    Authors: Chao Zhu, Liqun Gu, Zelong Liu, Jiang Li, Mianfeng Yao and Changyun Fang
    Citation: BMC Cancer 2021 21:836
    Content type: Research Published on:

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