Skip to main content

Articles

3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

Page 70 of 79

  1. Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Bec...

    Authors: Zacharie Segaoula, Aline Primot, Frederic Lepretre, Benoit Hedan, Emmanuel Bouchaert, Kevin Minier, Laurent Marescaux, François Serres, Sylvie Galiègue-Zouitina, Catherine André, Bruno Quesnel, Xavier Thuru and Dominique Tierny
    Citation: BMC Cancer 2018 18:1219
    Content type: Research article Published on:

  2. Macrophage migration inhibitory factor (MIF) is a widely expressed cytokine involved in a variety of cellular processes including cell cycle regulation and the control of proliferation. Overexpression of MIF h...

    Authors: Camila S Oliveira, Charles E de Bock, Timothy J Molloy, Elham Sadeqzadeh, Xin Yan Geng, Peter Hersey, Xu Dong Zhang and Rick F Thorne
    Citation: BMC Cancer 2014 14:630
    Content type: Research article Published on:

  3. Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor...

    Authors: Evi Michels, Jasmien Hoebeeck, Katleen De Preter, Alexander Schramm, Bénédicte Brichard, Anne De Paepe, Angelika Eggert, Geneviève Laureys, Jo Vandesompele and Frank Speleman
    Citation: BMC Cancer 2008 8:173
    Content type: Research article Published on:

  4. Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various e...

    Authors: Paulina Gil-Kulik, Ewa Dudzińska, Elżbieta Radzikowska-Büchner, Joanna Wawer, Mariusz Jojczuk, Adam Nogalski, Genowefa Anna Wawer, Marcin Feldo, Wojciech Kocki, Maria Cioch, Anna Bogucka-Kocka, Mansur Rahnama and Janusz Kocki
    Citation: BMC Cancer 2020 20:435
    Content type: Research article Published on:

  5. Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a f...

    Authors: Rui Niimi, Akihiko Matsumine, Takahiro Iino, Shigeto Nakazora, Tomoki Nakamura, Atsumasa Uchida and Akihiro Sudo
    Citation: BMC Cancer 2013 13:309
    Content type: Research article Published on:

  6. The relationship between the uptake of [18F]fluoroerythronitroimidazole ([18F]FETNIM), blood flow ([15O]H2O) and 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) and immunohistochemically determined biomarkers was evaluat...

    Authors: Tove J Grönroos, Kaisa Lehtiö, Karl-Ove Söderström, Pauliina Kronqvist, Jukka Laine, Olli Eskola, Tapio Viljanen, Reidar Grénman, Olof Solin and Heikki Minn
    Citation: BMC Cancer 2014 14:876
    Content type: Research article Published on:

  7. Myeloid ecotropic viral integration site 1 (MEIS1) protein plays a synergistic causative role in acute myeloid leukemia (AML). However, MEIS1 has also shown to be a potential tumor suppressor in some other can...

    Authors: Jie Zhu, Liang Cui, Axiang Xu, Xiaotao Yin, Fanglong Li and Jiangping Gao
    Citation: BMC Cancer 2017 17:176
    Content type: Research article Published on:

  8. Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedi...

    Authors: Junichi Yoshizawa, Satoshi Ishizone, Meguru Ikeyama and Jun Nakayama
    Citation: BMC Cancer 2017 17:368
    Content type: Case report Published on:

  9. Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown. This study aimed to retrospectively analyze treatment-related prognostic factors of nonspinal ES in Chinese adults.

    Authors: Jianjun Zhang, Yujing Huang, Yuanjue Sun, Aina He, Yan Zhou, Haiyan Hu, Yang Yao and Zan Shen
    Citation: BMC Cancer 2019 19:1168
    Content type: Research article Published on:

  10. Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proli...

    Authors: R. L. Ross, H. R. McPherson, L. Kettlewell, S. D. Shnyder, C. D. Hurst, O. Alder and M. A. Knowles
    Citation: BMC Cancer 2016 16:553
    Content type: Research article Published on:

  12. Hepatocellular (HCC) and cholangiocellular carcinomas (CCC) display an exceptionally poor prognosis. Especially for advanced disease no efficient standard therapy is currently available. Recently, somatostatin...

    Authors: Daniel Kaemmerer, Robin Schindler, Franziska Mußbach, Uta Dahmen, Annelore Altendorf-Hofmann, Olaf Dirsch, Jörg Sänger, Stefan Schulz and Amelie Lupp
    Citation: BMC Cancer 2017 17:896
    Content type: Research article Published on:

  14. Annexin A1 (ANXA1), a 37 kDa multifunctional protein, is over-expressed in tissues from patients of pancreatic carcinoma (PC) where the protein seems to be associated with malignant transformation and poor pro...

    Authors: Raffaella Belvedere, Valentina Bizzarro, Ada Popolo, Fabrizio Dal Piaz, Michele Vasaturo, Paola Picardi, Luca Parente and Antonello Petrella
    Citation: BMC Cancer 2014 14:961
    Content type: Research article Published on:

  15. CUL4A has been known for its oncogenic properties in various human cancers. However, its role in intrahepatic cholangiocarcinoma (iCCA) has not been explored.

    Authors: Gong -Kai Huang, Ting-Ting Liu, Shao-Wen Weng, Huey-Ling You, Yu-Ching Wei, Chang-Han Chen, Hock-Liew Eng and Wan-Ting Huang
    Citation: BMC Cancer 2017 17:395
    Content type: Research article Published on:

  16. Overweight/obesity are strongly implicated in breast cancer development, and weight gain post-diagnosis is associated with greater morbidity and all-cause mortality. The aim of this study was to describe the p...

    Authors: Carolyn Ee, Adele Elizabeth Cave, Dhevaksha Naidoo, Kellie Bilinski and John Boyages
    Citation: BMC Cancer 2020 20:113
    Content type: Research article Published on:

  17. Matrix metalloproteinase (MMP) is known to be involved in the initial and progressive stages of cancer development, and in the aggressive phenotypes of cancer. This study examines the association of single nucleo...

    Authors: Rishiho Nishizawa, Masaki Nagata, Arhab A Noman, Nobutaka Kitamura, Hajime Fujita, Hideyuki Hoshina, Takehiko Kubota, Manami Itagaki, Susumu Shingaki, Makoto Ohnishi, Hiroshi Kurita, Kouji Katsura, Chikara Saito, Hiromasa Yoshie and Ritsuo Takagi
    Citation: BMC Cancer 2007 7:187
    Content type: Research article Published on:

  18. The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth ...

    Authors: Chang Wei Feng, Li Dong Wang, Lian Hua Jiao, Bin Liu, Shu Zheng and Xin Ji Xie
    Citation: BMC Cancer 2002 2:8
    Content type: Research article Published on:

  19. In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer de...

    Authors: Ernesto Soto-Reyes, Rodrigo González-Barrios, Fernanda Cisneros-Soberanis, Roberto Herrera-Goepfert, Víctor Pérez, David Cantú, Diddier Prada, Clementina Castro, Félix Recillas-Targa and Luis A Herrera
    Citation: BMC Cancer 2012 12:40
    Content type: Research article Published on:

  20. Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variat...

    Authors: Shujie Wang, Yao Zhao, Zhenchao Ruan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, Yan Huang and Daru Lu
    Citation: BMC Cancer 2010 10:221
    Content type: Research article Published on:

  21. Neuron-Specific enolase (NSE) has been used as a typical tumor marker and shows a potential to diagnose malignant pleural effusion (MPE). The ability of NSE in diagnosing MPE has been investigated in many stud...

    Authors: Jing Zhu, Mei Feng, Liqun Liang, Ni Zeng, Chun Wan, Ting Yang, Yongchun Shen and Fuqiang Wen
    Citation: BMC Cancer 2017 17:590
    Content type: Research article Published on:

  22. Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we ...

    Authors: Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim and Je-Jung Lee
    Citation: BMC Cancer 2016 16:613
    Content type: Research article Published on:

  23. The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of t...

    Authors: Meghan Webb, Ethan D Emberley, Michael Lizardo, Salem Alowami, Gefei Qing, Abdullah Alfia'ar, Linda J Snell-Curtis, Yulian Niu, Alberto Civetta, Yvonne Myal, Robert Shiu, Leigh C Murphy and Peter H Watson
    Citation: BMC Cancer 2005 5:17
    Content type: Research article Published on:

  24. To compare efficacy and toxicity of nimotuzumab versus cisplatin (CDDP) concurrent with intensity modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).

    Authors: H. M. Li, P. Li, Y. J. Qian, X. Wu, L. Xie, F. Wang, H. Zhang and L. Liu
    Citation: BMC Cancer 2016 16:946
    Content type: Research article Published on:

  25. Meningioma, the most prevalent intracranial tumor, possesses a significant propensity for malignant transformation. Circular RNAs (circ-RNAs), a class of non-coding RNAs, have emerged as crucial players in tum...

    Authors: Yongkai Huang, Zhihui Wu, Zewei Peng, Anmin Liu, Wen Yuan, Deqing Han and Junmin Peng
    Citation: BMC Cancer 2024 24:345
    Content type: Research Published on:

  26. In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by the presence of distinctive gangliosides (sialic acid carrying glycosphingolipids). Ganglios...

    Authors: Cristina Tringali, Ilaria Silvestri, Francesca Testa, Paola Baldassari, Luigi Anastasia, Roberta Mortarini, Andrea Anichini, Alejandro López-Requena, Guido Tettamanti and Bruno Venerando
    Citation: BMC Cancer 2014 14:560
    Content type: Research article Published on:

  27. Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis. To explore possible contributors to the accu...

    Authors: Timo K Nykopp, Kirsi Rilla, Reijo Sironen, Markku I Tammi, Raija H Tammi, Kirsi Hämäläinen, Anna-Mari Heikkinen, Marja Komulainen, Veli-Matti Kosma and Maarit Anttila
    Citation: BMC Cancer 2009 9:143
    Content type: Research article Published on:

  28. Pemetrexed is an efficacious multi-targeted antifolate with acceptable toxicity for non-squamous non-small cell lung cancer (non-Sq NSCLC) and malignant pleural mesothelioma. Vitamin B12 and folic acid as prem...

    Authors: Yuichiro Takeda, Go Naka, Yuki Katsuya, Konomi Kobayashi, Manabu Suzuki, Masao Hashimoto, Satoshi Hirano and Yukari Uemura
    Citation: BMC Cancer 2023 23:800
    Content type: Research Published on:

  29. Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated....

    Authors: Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson and Patricia N Tonin
    Citation: BMC Cancer 2015 15:135
    Content type: Research article Published on:

  30. Radiotherapy failure is a significant clinical challenge due to the development of resistance in the course of treatment. Therefore, it is necessary to further study the radiation resistance mechanism of HCC. ...

    Authors: Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang and Long-Bang Chen
    Citation: BMC Cancer 2019 19:1075
    Content type: Research article Published on:

  31. The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate...

    Authors: Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo
    Citation: BMC Cancer 2017 17:617
    Content type: Research article Published on:

  32. Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge re...

    Authors: Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek and Ido Wolf
    Citation: BMC Cancer 2020 20:531
    Content type: Research article Published on:

  34. Carcinoma of the thyroid gland is an uncommon cancer, but the most frequent malignancy of the endocrine system. Most thyroid cancers are derived from the follicular cell. Follicular carcinoma (FTC) is consider...

    Authors: Patricia J McLaughlin, Ian S Zagon, Sunny S Park, Andrea Conway, Renee N Donahue and David Goldenberg
    Citation: BMC Cancer 2009 9:369
    Content type: Research article Published on:

  35. Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strong...

    Authors: Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki
    Citation: BMC Cancer 2015 15:82
    Content type: Research article Published on:

  36. Carbonic anhydrase IX (CA IX) is a transmembrane enzyme that is present in many types of solid tumors. Expression of CA IX is driven predominantly by the hypoxia-inducible factor (HIF) pathway and helps to mai...

    Authors: Zuzana Ditte, Peter Ditte, Martina Labudova, Veronika Simko, Filippo Iuliano, Miriam Zatovicova, Lucia Csaderova, Silvia Pastorekova and Jaromir Pastorek
    Citation: BMC Cancer 2014 14:358
    Content type: Research article Published on:

  37. Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify c...

    Authors: Eun-Shin Lee, Wonshik Han, Min Kyoon Kim, Jongjin Kim, Tae-kyung Yoo, Moo Hyun Lee, Kyung Hun Lee, Tae Yong Kim, Hyeong-Gon Moon, Seock-Ah Im, Dong-Young Noh and Eun Sook Lee
    Citation: BMC Cancer 2016 16:430
    Content type: Research article Published on:

  38. This phase I/II study aimed to determine the maximum tolerated dose (MTD) of nanoparticle albumin-bound paclitaxel (nab ®-paclitaxel) plus cisplatin as treatment for metastatic nasophar...

    Authors: Yan Huang, Wenhua Liang, Yunpeng Yang, Liping Zhao, Hongyun Zhao, Xuan Wu, Yuanyuan Zhao, Yang Zhang and Li Zhang
    Citation: BMC Cancer 2016 16:464
    Content type: Research article Published on:

  39. Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.

    Authors: Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao and Weimin Mao
    Citation: BMC Cancer 2018 18:251
    Content type: Research article Published on:

  40. CXCR2 chemokine ligands CXCL1, CXCL5 and CXCL6 were shown to be involved in chemoattraction, inflammatory responses, tumor growth and angiogenesis. Here, we comparatively analyzed their expression profile in r...

    Authors: Claudia Rubie, Vilma Oliveira Frick, Mathias Wagner, Jochen Schuld, Stefan Gräber, Brigitte Brittner, Rainer M Bohle and Martin K Schilling
    Citation: BMC Cancer 2008 8:178
    Content type: Research article Published on:

  41. Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development...

    Authors: Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang and Kailiang Zhang
    Citation: BMC Cancer 2020 20:815
    Content type: Research article Published on:

  42. For colorectal cancer, preoperative (neoadjuvant) chemotherapy is more effective than postoperative chemotherapy because it not only eradicates micrometastases more effectively but also reduces the risk of inc...

    Authors: Jiawei Zhang, Jiaxin Deng, Jiancong Hu, Qinghua Zhong, Juan Li, Mingli Su, Wei Liu, Miwei Lv, Tian Xu, Dezheng Lin and Xuefeng Guo
    Citation: BMC Cancer 2022 22:806
    Content type: Research Published on:

  43. Pathological response is an important marker for tumor aggressiveness in patients with esophageal squamous cell carcinoma (ESCC) who receive preoperative chemoradiation followed by esophagectomy. We aim to eva...

    Authors: Cheng-Che Tu, Po-Kuei Hsu, Ling-I Chien, Wan-Chen Liu, Chien-Sheng Huang, Chih-Cheng Hsieh, Han-Shui Hsu and Yu-Chung Wu
    Citation: BMC Cancer 2017 17:62
    Content type: Research article Published on:

  44. Patients with Ewing sarcoma family of tumors (ESFT) who are resistant even to salvage chemotherapy, have dismal prognoses and few therapeutic options. Because the docetaxel/irinotecan (DI) combination has not ...

    Authors: Jong Hyung Yoon, Mi Mi Kwon, Hyeon Jin Park, Seog Yun Park, Kun Young Lim, Jungnam Joo and Byung-Kiu Park
    Citation: BMC Cancer 2014 14:622
    Content type: Research article Published on:

  45. Leucopenia or neutropenia during chemotherapy predicts better survival in several cancers. We aimed to assess whether leucopenia could be a biological measure of treatment and a marker of efficacy in advanced ...

    Authors: Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan and Fang-Yun Xie
    Citation: BMC Cancer 2015 15:429
    Content type: Research article Published on:

  46. Intratumoral fibrosis was positively correlated with histological grade of renal clear cell carcinoma (ccRCC) and intratumoral inflammation. However, the association of intratumoral fibrosis with the immune in...

    Authors: Songchen Han, Wenbo Yang, Caipeng Qin, Yiqing Du, Mengting Ding, Huaqi Yin and Tao Xu
    Citation: BMC Cancer 2022 22:661
    Content type: Research Published on:

  47. Cutaneous melanoma is the most lethal skin cancer and its incidence in developed countries has dramatically increased over the past decades. Localized tumors are easily treated by surgery, but advanced melanom...

    Authors: Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian and Jean-Jacques Lebrun
    Citation: BMC Cancer 2015 15:200
    Content type: Research article Published on:

  48. Thymic epithelial tumors (TETs) are the most common primary neoplasms of the anterior mediastinum. Different risk subgroups of TETs have different prognosis and therapeutic strategies, therefore, preoperative ...

    Authors: Rongji Gao, Jian Zhou, Juan Zhang, Jianzhong Zhu, Tiantian Wang and Chengxin Yan
    Citation: BMC Cancer 2023 23:1158
    Content type: Research Published on:

  49. Immunodeficient murine models are usually used as the preclinical models of osteosarcoma. Such models do not effectively simulate the process of tumorigenesis and metastasis. Establishing a suitable animal mod...

    Authors: Mengyu Yao, Zehua Lei, Feng Peng, Donghui Wang, Mei Li, Guoqing Zhong, Hongwei Shao, Jielong Zhou, Chang Du and Yu Zhang
    Citation: BMC Cancer 2024 24:703
    Content type: Research Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us