Skip to main content
Download PDF

Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma

BMC Cancer volume 15, Article number: 429 (2015) Cite this article

Abstract

Background

Leucopenia or neutropenia during chemotherapy predicts better survival in several cancers. We aimed to assess whether leucopenia could be a biological measure of treatment and a marker of efficacy in advanced nasopharyngeal carcinoma (ANPC).

Methods

We retrospectively analyzed 3826 patients with ANPC who received chemoradiotherapy. Leucopenia was categorised on the basis of worst grade during treatment according to the National Cancer Institute Common Toxicity Criteria version 4.0: no leucopenia (grade 0), mild leucopenia (grade 1–2), and severe leucopenia (grade 3–4). Associations between leucopenia and survival were estimated by Cox proportional hazards model.

Results

Of the 3826 patients, 2511 (65.6 %) developed mild leucopenia (grade 1–2) and 807 (21.1 %) developed severe leucopenia (grade 3–4) during treatment; 508 (13.3 %) did not. A multivariate Cox model that included leucopenia determined that the hazard ratios (HR) of death for patients with mild and severe leucopenia were 0.69 [95 % confidence interval (95 %CI) 0.56-0.85, p < 0.001] and 0.75 (95 %CI 0.59-0.95, p = 0.019), respectively; the HR of distant metastasis for patients with mild and severe leucopenia were 0.77 (95 %CI 0.61-0.96, p = 0.023) and 0.99 (95 %CI 0.77-1.29, p = 0.995), respectively. Leucopenia had no effect on locoregional relapse.

Conclusions

Our results indicate that mild leucopenia during chemoradiotherapy is associated with improved overall survival and distant metastasis–free survival in ANPC. Mild leucopenia may indicate appropriate dosage of chemotherapy. We can identify the patients who may benefit from chemotherapy if they experienced leucopenia during the treatment. Prospective trials are required to assess whether dosing adjustments based on leucopenia may improve chemotherapy efficacy.

Peer Review reports

Background

Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. The incidence rate is as high as 20–30 per 100,000 populations in endemic areas of southern China and Southeast Asia [1–3]. Radiotherapy (RT) is the primary treatment, plus chemotherapy when needed according to clinical stage. With the development of diagnostic imaging, chemotherapy regimens, targeted drugs, and radiotherapeutic techniques, especially the application of IMRT (Intensity Modulated Radiation Therapy), survival of NPC has improved significantly [4–6]. However, 10–20 % of patients with advanced NPC (ANPC) develop distant metastasis after radical chemoradiotherapy, rendering distant metastases the main reason for treatment failure. To reduce the occurrence of distant metastasis, different timings of chemotherapy is recommended for ANPC according to NCCN (National Comprehensive Cancer Network) guidelines [7]. In 2014 version of NCCN guidelines , the categories of evidence for induction or adjuvant chemotherapy of NPC has changed [7]. Category of induction chemotherapy of NPC changed from category 2A to category 3. Category of adjuvant chemotherapy “cisplatin + RT followed by cisplatin/5-FU changed from category 1 to category 2A and “cisplatin + RT followed by carboplatin/5-FU changed from category 2A to category 2B.

Bone marrow suppression is a common adverse reaction of cytotoxic drugs and could be a biological measure of drug activity and might predict treatment efficacy [8, 9]. Leucopenia or neutropenia during treatment is a common phenomenon of bone marrow suppression. Some studies reported that leucopenia or neutropenia is a prognostic factor predicting better clinical outcome in several solid tumors, e.g., breast cancer [10–12], colorectal cancer [13, 14], advanced gastric cancer [15–17], lung cancer [18–20], and Hodgkin’s lymphoma [21]. Others have reported different results [22, 23]. However, the predictive (ie, estimation of the chance of benefit from chemotherapy) or prognostic (ie, estimation of the chance of survival) role of leucopenia in advanced nasopharyngeal carcinoma have not been established.

We aimed to investigate the association between leucopenia during treatment and survival of ANPC and to provide evidences, through rigorous statistical analysis of a large series of subjects with ANPC, of the utility of leukocyte count as a surrogate marker of drug efficacy.

Methods

Patients and methods

We retrospectively collected 3939 newly diagnosed ANPC patients from January 2005 to December 2010 treated in the Nasopharyngeal Carcinoma Department of Sun Yat-Sen University Cancer Center. 113 paitents were excluded owing to different reasons, abnormal liver function, abnormal kidney function, unsatisfactory blood sugar control and so on. 3826 patients were involved in the study. The Sun Yat-Sen University Cancer Center Institutional Review Board (IRB) and ethics committee reviewed and approved the study. The study was retrospective. Patient records were anonymized and de-identified prior to analysis.

Pretreatment evaluation included complete patient history, physical examination, hematology and biochemistry profiles, nasopharynx and neck magnetic resonance imaging (MRI), chest radiography, abdominal ultrasound, bone emission computed tomography (ECT), and chest or abdomen computed tomography (CT) when necessary.

Treatment

The treatment strategy for all patients was based on National Comprehensive Cancer Network Guidelines [24, 25]. All patients were treated with intensity-modulated RT (IMRT) or conventional RT (CRT) with chemotherapy; the radiation techniques and chemotherapy regimens have been described previously [26, 27].

Laboratory measurements

We performed leukocyte and neutrophil counts for all patients within two weeks before therapy and at least once weekly during treatment. The most severe grade of leucopenia was based on the lowest recorded leukocyte count for a given patient between the first day of treatment administration and 1 week after the end of treatment, and was graded according to the National Cancer Institute Common Toxicity Criteria version 4.0. Patients were classified as having no leucopenia (grade 0), mild leucopenia (grade 1–2), and severe leucopenia (grade 3–4). Indications for using granulocyte colony–stimulating factor (G-CSF) were not specified; it was generally used in grade 3–4 or febrile leucopenia, and was not used for prophylaxis.

Follow-up

Patients were regularly followed after RT until death or their last follow-up appointment. Clinic visits were scheduled every three months in the first three years, every six months during the fourth to fifth years, and once a year after the fifth year. Patients underwent physical examination and nasopharyngoscopy on each visit. Nasopharynx and neck MRI, chest radiography, abdominal ultrasound, and ECT were performed after RT or according to clinical indications. The follow-up duration was calculated from the first day of therapy to the day of death or the day of last examination.

Statistical analysis

We estimated the following endpoints (interval to the first defining event): overall survival (OS), locoregional relapse–free survival (LRFS), and distant metastasis–free survival (DMFS). Survival curves were estimated using the Kaplan-Meier method and compared using the log-rank test. Multivariate analyses were performed using the Cox proportional hazards model. We used chi-square tests and Kruskal–Wallis H tests to assess the statistical significance of associations between categorical variables and the three groups. All statistical tests were 2-tailed; p < 0.05 was considered statistically significant. All tests were conducted using IBM SPSS version 20.0.0 (IBM Corporation, Armonk, NY, USA).

Results

Patient characteristics

Table 1 lists the patient characteristics. We studied 3826 patients (2873 male; 953 female). The median age at diagnosis for male patients was 46 years (range 20–84 years); that for female patients was 44 years (range 20–76 years). CRT and IMRT were administered to 2583 and 1243 patients, respectively. Induction chemotherapy (IC) was administered to 1073 patients, concurrent chemotherapy (CC) to 1291 patients, IC plus CC (IC + CC) to 1255 patients, and CC plus adjuvant chemotherapy (CC + AC) to 207 patients. We administered <4 and ≥4 chemotherapy cycles to 2364 (61.8 %) and 1462 (38.2 %) patients, respectively. No significant differences were observed for age, T classification, N classification, and clinical stage. There were significant differences in pretreatment leukocyte count, type of chemotherapy, chemotherapy cycles, type of RT, sex, and paclitaxel use (yes or no) in the compared groups (all p < 0.05). Patients who developed leucopenia during treatment had lower pretreatment leukocyte counts (p < 0.001). More female patients developed leucopenia (female vs. male, 90.1 % vs. 85.3 %, p < 0.001); patients using paclitaxel were likely to develop severe leucopenia (31.4 % vs. 18.4 %, p < 0.001).

Table 1 Patient characteristics according to grade of leucopenia
Full size table

The median OS was 52.6 months (range 3.07–113.0 months); 10.9 % of patients (417/3826) developed locoregional relapse, 16.5 % (633/3826) developed distant metastases, and 19.0 % (727/3826) died. The 5-year OS, LRFS, and DMFS rates for the entire population were 80.70 %, 87.9 %, and 82.1 %, respectively.

During treatment, 2511 patients (65.6 %) developed mild leucopenia (grade 1–2) and 807 patients (21.1 %) developed severe leucopenia (grade 3–4); the remaining 508 (13.3 %) did not develop leucopenia.

Survival analyses including leucopenia

Table 2 shows the univariate analysis of the baseline and clinical characteristics as prognostic factors, including leucopenia. Kaplan–Meier curves according to severity of leucopenia showed that better OS and DMFS were predicted for patients with leucopenia and that leucopenia had no significant effect on LRFS (Fig. 1). The 5-year OS rate in patients with no leucopenia, mild leucopenia, and severe leucopenia was 75.5 %, 81.9 %, and 80.5 %, respectively (mild vs no leucopenia, p = 0.001; severe vs no leucopenia, p = 0.03; mild vs severe, p = 0.314). The 5-year DMFS rate in patients with no leucopenia, mild leucopenia, and severe leucopenia was 79.7 %, 83.7 %, and 78.9 %, respectively (mild vs. no leucopenia, p = 0.038; severe vs no leucopenia, p = 0.927; mild vs severe, p = 0.007). The 5-year LRFS rate in patients with no leucopenia, mild leucopenia, and severe leucopenia was 88.9 %, 87.4 %, and 88.6 %, respectively (all p > 0.05 for any two compared groups).

Table 2 Univariate analysis of survival for patients with ANPC
Full size table
Fig. 1
figure 1

Kaplan–Meier survival curves of (a) Overall Survival, (b) Locoregional Relapse-free Survival, and (c) Distant Metastasis-free Survival according to severity of leucopenia

Full size image

We performed multivariate analysis to investigate whether leucopenia could be a marker of improved OS and DMFS (Table 3). Leucopenia and other prognostic factors, i.e., age, sex, T classification, N classification, pathological type, type of chemotherapy, paclitaxel use, and type of RT were included in the multivariate analysis, which determined that leucopenia, sex, T classification, and N classification were independent prognostic factors for OS and DMFS. Compared to patients without leucopenia, the hazard ratios (HRs) of death for patients with mild and severe leucopenia were 0.69 [95 % confidence interval (95 %CI) 0.56-0.85, p < 0.001] and 0.75 (95 %CI 0.59-0.95, p = 0.019), respectively. The HR of distant metastasis for patients with mild and severe leucopenia were 0.77 (95 %CI 0.61-0.96, p = 0.023) and 0.99 (95 %CI 0.77-1.29, p = 0.995), respectively. When we compared patients with mild leucopenia to patients with severe leucopenia, the HRs of death and distant metastasis were 0.93 (95 %CI 0.77-1.11, p = 0.416) and 0.77 (95%CI 0.64-0.93, p = 0.006), respectively.

Table 3 Multivariate analysis of survival for patients with ANPC
Full size table

When pretreatment leukocyte count (≤10 × 109/L vs. >10 × 109/L) was included in the Cox model, leucopenia remained significant for OS (mild leucopenia: HR = 0.70, 95 %CI 0.57-0.86, p = 0.001; severe leucopenia: HR = 0.76, 95 %CI 0.59-0.97, p = 0.026) and DMFS (mild leucopenia: HR = 0.77, 95 %CI 0.61-0.96, p = 0.023; severe leucopenia: HR = 0.99, 95 %CI 0.77-1.30, p = 0.995).

Tables 2 and 3 depict the subgroup analysis results for patients who received <4 and ≥4 chemotherapy cycles. Mild and severe leucopenia tended to be associated with improved survival in patients who received <4 or ≥4 chemotherapy cycles.

Discussion

In this study, we found that survival was improved in patients who developed leucopenia during chemoradiotherapy for ANPC. Patients with mild leucopenia had better OS and DMFS than those with severe leucopenia. Leucopenia was an independent prognostic factor for OS and DMFS in patients who received <4 and ≥4 chemotherapy cycles. This is the first instance that has been reported in pretreated ANPC.

As far as we know, leucopenia or neutropenia indicates that the chemotherapeutic agent dose is sufficient to cause bone marrow suppression and an anti-tumor effect [8, 9]. The absence of leucopenia or neutropenia indicates an absent or weak biological effect of chemotherapy, likely indicating that the dose is too low. On the other hand, severe leucopenia may indicate overdosage. High-dose chemotherapy does not improve survival, and impairs patient quality of life [28]. We speculate that moderate-dose chemotherapy, as evidenced by moderate toxicity, is the optimal treatment, correlating with better survival than under- or overdosage. Colleoni et al. [29] found that patients who received level II doses (65-84 % of the prescribed dose) had longer disease-free survival (DFS) and OS than patients who received higher (level I: >85 % of the prescribed dose) or lower (level III: <65 % of the prescribed dose) doses (p = 0.07, p = 0.03, respectively). Additionally, Brunetto et al. reported that there was no difference in OS for patients whose dose had been reduced compared to patients whose dose had been maintained [30]. Nakatat al. [17] and Shitara et al. [15] both found that patients with mild neutropenia had better outcomes than those with severe neutropenia; others have reported that patients who developed grade 2–3 leucopenia or neutropenia had significantly better prognosis than those with grade 4 leucopenia or neutropenia [16, 17, 31]. Our results agree with these results. In other words, mild leucopenia or neutropenia might be a barometer of the appropriate chemotherapeutic dosage to obtain sufficient anti-tumor effect in a patient, leading to improved clinical outcome; however, severe leucopenia or neutropenia might be a marker of overdosage and suboptimal survival.

However, there are differing findings: Kim et al. [22] reported that neutropenia was not a significant prognostic indicator of improved progression-free survival and OS (p = 0.180, p = 0.698, respectively) in stage I-IIIB breast cancer. Kumpulainen et al. [23] drew a wholly different conclusion, where the 10-year DFS in FIGO (International Federation of Obstetrics and Gynecology) stage IC-IV disease was 45 % in patients with lower leukocyte counts (<2.5 × 109/L) and 66 % in patients with higher leukocyte counts (≥2.5 × 109/L) (p < 0.05). The probable reason is that the different disease stages might obscure the impact of leucopenia. Most studies and ours studied patients with advanced-stage disease.

Several reports have stated that pretreatment high leukocyte or neutrophil count might be a poor prognostic indicator and that leucopenia or neutropenia are less likely to occur during treatment [32, 33]. However, in our multivariate analysis, which included this factor, leucopenia remained significant for OS and DMFS.

Due to the retrospective nature of our study, there are some limitations. First, the chemotherapy regimens and dose varied. Second, patients were identified from 2005 to 2010, and the normal range of hematological profiles may have varied. Third, although G-CSF was not used for prophylaxis, it would nevertheless affect the severity of leucopenia. Fourth, we only analyzed leucopenia, a sign of myelosuppression. Taking hemoglobin and platelet inhibition into account might reflect the relationship between myelosuppression and prognosis more accurately.

Conclusions

Leucopenia during chemoradiotherapy of ANPC is strongly associated with better OS and DMFS; mild leucopenia indicates better survival than severe leucopenia. This may indicate that mild leucopenia is a surrogate marker for adequate chemotherapeutic dose. We can identify the patients who may benefit from chemotherapy if they experienced leucopenia during the treatment. The chemotherapy dose should not only depend on the body surface area, but also be based on its toxic effects. Prospective trials are required to assess whether dosing adjustments based on leucopenia may improve chemotherapy efficacy.

Abbreviations

ANPC:

Advanced nasopharyngeal carcinoma

CRT:

Conventional radiotherapy

IMRT:

Intensity modulated radiation therapy

NCCN:

National comprehensive cancer network

G-CSF:

Granulocyte colony-stimulating factor

MRI:

Magnetic resonance imaging

ECT:

Emission computed tomography

CT:

Computed tomography

IC:

Induction chemotherapy

CC:

Concurrent chemotherapy

AC:

Adjuvant chemotherapy

HR:

Hazard ratio

CI:

Confidence interval

OS:

Overall survival

DMFS:

Distant metastasis-free survival

LRFS:

Locoregional relapse–free survival

DFS:

Disease-free survival

FIGO:

International federation of obstetrics and gynecology

WHO:

World health organization

References

  1. Chen L, Mao Y, Xie F, Liu L, Sun Y, Tian L, et al. The seventh edition of the UICC/AJCC staging system for nasopharyngeal carcinoma is prognostically useful for patients treated with intensity-modulated radiotherapy from an endemic area in China. Radiother Oncol. 2012;104(3):331–7.

    Article  PubMed  Google Scholar 

  2. Perri F. Locally advanced nasopharyngeal carcinoma: current and emerging treatment strategies. World Journal of Clinical Oncology. 2011;2(12):377.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer. 2012;31(4):185–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Peng G, Wang T, Yang KY, Zhang S, Zhang T, Li Q, et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol. 2012;104(3):286–93.

    Article  PubMed  Google Scholar 

  5. Lai SZ, Li WF, Chen L, Luo W, Chen YY, Liu LZ, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys. 2011;80(3):661–8.

    Article  PubMed  Google Scholar 

  6. Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, et al. Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 2006;64(1):47–56.

    Article  CAS  PubMed  Google Scholar 

  7. Pfister DG, Spencer S, Brizel DM, Burtness B, Busse PM, Caudell JJ, et al. Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2014;12(10):1454–87.

    PubMed  Google Scholar 

  8. Kvinnsland S. The leucocyte nadir, a predictor of chemotherapy efficacy? Br J Cancer. 1999;80(11):1681.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gurney H. How to calculate the dose of chemotherapy. Br J Cancer. 2002;86(8):1297–302.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mayers C, Panzarella T, Tannock IF. Analysis of the prognostic effects of inclusion in a clinical trial and of myelosuppression on survival after adjuvant chemotherapy for breast carcinoma. Cancer. 2001;91(12):2246–57.

    Article  CAS  PubMed  Google Scholar 

  11. Poikonen P, Saarto T, Lundin J, Joensuu H, Blomqvist C. Leucocyte nadir as a marker for chemotherapy efficacy in node-positive breast cancer treated with adjuvant CMF. Br J Cancer. 1999;80(11):1763–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Saarto T, Blomqvist C, Rissanen P, Auvinen A, Elomaa I. Haematological toxicity: a marker of adjuvant chemotherapy efficacy in stage II and III breast cancer. Br J Cancer. 1997;75(2):301–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sunaga T, Suzuki S, Kogo M, Kurihara T, Kaji S, Koike N, et al. The association between neutropenia and prognosis in stage III colorectal cancer patients receiving adjuvant chemotherapy. Eur J Cancer Care. 2013:n/a-n/a.

  14. Shitara K, Matsuo K, Takahari D, Yokota T, Inaba Y, Yamaura H, et al. Neutropaenia as a prognostic factor in metastatic colorectal cancer patients undergoing chemotherapy with first-line FOLFOX. Eur J Cancer. 2009;45(10):1757–63.

    Article  CAS  PubMed  Google Scholar 

  15. Shitara K, Matsuo K, Takahari D, Yokota T, Shibata T, Ura T, et al. Neutropenia as a prognostic factor in advanced gastric cancer patients undergoing second-line chemotherapy with weekly paclitaxel. Ann Oncol. 2010;21(12):2403–9.

    Article  CAS  PubMed  Google Scholar 

  16. Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. Predictive value of chemotherapy-induced neutropenia for the efficacy of oral fluoropyrimidine S-1 in advanced gastric carcinoma. Br J Cancer. 2007;97(1):37–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Nakata B, Tsuji A, Mitachi Y, Yamamitsu S, Hirata K, Takeuchi T, et al. Moderate neutropenia with S-1 plus low-dose cisplatin may predict a more favourable prognosis in advanced gastric cancer. Clin Oncol-Uk. 2006;18(9):678–83.

    Article  CAS  Google Scholar 

  18. Jang SH, Kim SY, Kim JH, Park S, Hwang YI, Kim DG, et al. Timing of chemotherapy-induced neutropenia is a prognostic factor in patients with metastatic non-small-cell lung cancer: a retrospective analysis in gemcitabine-plus-platinum-treated patients. J Cancer Res Clin Oncol. 2013;139(3):409–17.

    Article  CAS  PubMed  Google Scholar 

  19. Pallis AG, Agelaki S, Kakolyris S, Kotsakis A, Kalykaki A, Vardakis N, et al. Chemotherapy-induced neutropenia as a prognostic factor in patients with advanced non-small cell lung cancer treated with front-line docetaxel–gemcitabine chemotherapy. Lung Cancer-J Iaslc. 2008;62(3):356–63.

    Article  CAS  Google Scholar 

  20. Di Maio M, Gridelli C, Gallo C, Shepherd F, Piantedosi FV, Cigolari S, et al. Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials. Lancet Oncol. 2005;6(9):669–77.

    Article  PubMed  Google Scholar 

  21. Klimm B, Reineke T, Haverkamp H, Behringer K, Eich HT, Josting A, et al. Role of hematotoxicity and sex in patients with Hodgkin’s lymphoma: an analysis from the German Hodgkin Study Group. J Clin Oncol. 2005;23(31):8003–11.

    Article  CAS  PubMed  Google Scholar 

  22. Kim J, Park J, Kim D, Kim J, Kim Y, Nam J, et al. Is chemotherapy-induced neutropenia a prognostic factor in patients with ovarian cancer? Acta Obstet Gyn Scan. 2010;89(5):623–8.

    Article  CAS  Google Scholar 

  23. Kumpulainen EJ, Hirvikoski PP, Johansson RT. Neutropenia during adjuvant chemotherapy of breast cancer is not a predictor of outcome. Acta Oncol. 2009;48(8):1204–6.

    Article  PubMed  Google Scholar 

  24. Forastiere AA, Ang KK, Brizel D, Brockstein BE, Burtness BA, Cmelak AJ, et al. Head and neck cancers. J Natl Compr Canc Netw. 2008;6(7):646–95.

    CAS  PubMed  Google Scholar 

  25. Forastiere AA, Ang K, Brizel D, Brockstein BE, Dunphy F, Eisele DW, et al. Head and neck cancers. J Natl Compr Canc Netw. 2005;3(3):316–91.

    PubMed  Google Scholar 

  26. Liang SB, Sun Y, Liu LZ, Chen Y, Chen L, Mao YP, et al. Extension of local disease in nasopharyngeal carcinoma detected by magnetic resonance imaging: improvement of clinical target volume delineation. Int J Radiat Oncol Biol Phys. 2009;75(3):742–50.

    Article  PubMed  Google Scholar 

  27. Ma J, Liu L, Tang L, Zong J, Lin A, Lu T, et al. Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: prognostic value and staging categories. Clin Cancer Res. 2007;13(5):1445–52.

    Article  CAS  PubMed  Google Scholar 

  28. Brandberg Y. Quality of life in women with breast cancer during the first year after random assignment to adjuvant treatment with marrow-supported high-dose chemotherapy with cyclophosphamide, thiotepa, and carboplatin or tailored therapy with fluorouracil, epirubicin, and cyclophosphamide: scandinavian breast group study 9401. J Clin Oncol. 2003;21(19):3659–64.

    Article  CAS  PubMed  Google Scholar 

  29. Colleoni M, Price K, Castiglione-Gertsch M, Goldhirsch A, Coates A, Lindtner J, et al. Dose–response effect of adjuvant cyclophosphamide, methotrexate, 5-fluorouracil (CMF) in node-positive breast cancer. International Breast Cancer Study Group. Eur J Cancer. 1998;34(11):1693–700.

    Article  CAS  PubMed  Google Scholar 

  30. Brunetto AT, Carden CP, Myerson J, Faria AL, Ashley S, Popat S, et al. Modest reductions in dose intensity and drug-induced neutropenia have no major impact on survival of patients with non-small cell lung cancer treated with platinum-doublet chemotherapy. J Thorac Oncol. 2010;5(9):1397–403.

    Article  PubMed  Google Scholar 

  31. Cameron DA, Massie C, Kerr G, Leonard RC. Moderate neutropenia with adjuvant CMF confers improved survival in early breast cancer. Br J Cancer. 2003;89(10):1837–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Chang H, Gao J, Xu BQ, Guo SP, Lu RB, Li G, et al. Haemoglobin, neutrophil to lymphocyte ratio and platelet count improve prognosis prediction of the TNM staging system in nasopharyngeal carcinoma: development and validation in 3237 patients from a single institution. Clin Oncol-Uk. 2013;25(11):639–46.

    Article  CAS  Google Scholar 

  33. He JR, Shen GP, Ren ZF, Qin H, Cui C, Zhang Y, et al. Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma. Head Neck. 2012;34(12):1769–76.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (No. 81201746), Planned Science and Technology Project of Guangdong Province (2012B031800092), Medical Science Foundation of Guangdong Province (No. B2012135), Cultivating Foundation of Education-bureau of Guangdong Province (No. LYM11001).

Author information

Authors and Affiliations

  1. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

    Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan & Fang-Yun Xie

  2. Department of Radiation Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

    Fang-Yun Xie

Authors
  1. Zhen Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yan-Ping Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pu-Yun OuYang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jie Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiao-Wen Lan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fang-Yun Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fang-Yun Xie.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SZ checked data, drafted the manuscript and performed the statistical analysis. OYPU, TJ and LXW collected the data. XFY participated in the design of the study. MYP conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript. Both Zhen Su and Yan-Ping Mao contributed equally to this manuscript.

Zhen Su and Yan-Ping Mao are contributed equally to this work

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Su, Z., Mao, YP., OuYang, PY. et al. Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma. BMC Cancer 15, 429 (2015). https://doi.org/10.1186/s12885-015-1442-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12885-015-1442-3

Keywords

BMC Cancer

ISSN: 1471-2407

Contact us