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  1. ICIs have remarkably affected the treatment strategies for numerous malignancies, including lung cancer. However, only a fraction of patients experience durable responses to ICIs; thus, there is an urgent need...

    Authors: Zhenzhen Liu, Yuzhu Diao and Xiaoling Li
    Citation: BMC Cancer 2022 22:824
    Content type: Research Published on:

  2. As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of inna...

    Authors: Xin Zhang, Jia-rui Yuan, Xin Wang, Shuang Fu, Rui-tao Wang and Guang-yu Wang
    Citation: BMC Cancer 2022 22:823
    Content type: Research Published on:

  5. Initial systemic therapy for patients with metastatic colorectal cancer (mCRC) is usually based on two- or three-drug chemotherapy regimens with fluoropyrimidine (5-fluorouracil (5-FU) or capecitabine), oxalip...

    Authors: G. Sommerhäuser, A. Kurreck, S. Stintzing, V. Heinemann, L. Fischer von Weikersthal, T. Dechow, F. Kaiser, M. Karthaus, I. Schwaner, M. Fuchs, A. König, C. Roderburg, I. Hoyer, M. Quante, A. Kiani, S. Fruehauf…
    Citation: BMC Cancer 2022 22:820
    Content type: Study protocol Published on:

  6. U.S. professional organizations have provided conflicting recommendations on annual vs. biennial mammography screening. Potential harms of more frequent screening include increased anxiety and costs of false p...

    Authors: Vicky Ro, Tarsha Jones, Thomas Silverman, Julia E. McGuinness, Ashlee Guzman, Jacquelyn Amenta, Rita Kukafka and Katherine D. Crew
    Citation: BMC Cancer 2022 22:819
    Content type: Research article Published on:

  7. The mTOR signaling pathway plays an important role in cancer. As a master regulator, the status of MTOR affects pathway activity and the efficacy of mTOR inhibitor therapy. However, little research has been perfo...

    Authors: Chenxing Wang, Batuer Aikemu, Yanfei Shao, Sen Zhang, Guang Yang, Hiju Hong, Ling Huang, Hongtao Jia, Xiao Yang, Minhua Zheng, Jing Sun and Jianwen Li
    Citation: BMC Cancer 2022 22:818
    Content type: Research article Published on:

  8. Urothelial carcinoma (UC) is among the most prevalent malignancies. The muscle-invasive bladder cancer (MIBC) shows an invasive feature and has poor prognosis, while the non-muscle invasive bladder cancer (NMI...

    Authors: Qiongqiong Lin, Lu Pei, Zhiguang Zhao, Xiaoping Zhuang and Haide Qin
    Citation: BMC Cancer 2022 22:817
    Content type: Research Published on:

  9. The endothelial activation and stress index (EASIX) score has been reported to predict overall survival (OS) in hematological cancers. However, it has not been validated as a prognostic marker for diffuse larg...

    Authors: Sungwoo Park, Se-Il Go and Gyeong-Won Lee
    Citation: BMC Cancer 2022 22:816
    Content type: Research Published on:

  10. Renin-angiotensin system inhibitors (RASIs) are widely used in the treatment of hypertension. However, their impact on the outcome of the combined treatment of rectal cancer is poorly understood. The aim of th...

    Authors: Marcin Zeman, Władysław Skałba, Agata Małgorzata Wilk, Alexander Jorge Cortez, Adam Maciejewski and Agnieszka Czarniecka
    Citation: BMC Cancer 2022 22:815
    Content type: Research Published on:

  11. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the adoptive immunotherapy of which is worth studying. CD133, a kind of cancer stem cell (CSC) antigen, together with glypican-3 (...

    Authors: Hezhi Wang, Xiaoxiao Wang, Xueshuai Ye, Yi Ju, Nana Cao, Shuqi Wang and Jianhui Cai
    Citation: BMC Cancer 2022 22:814
    Content type: Research Published on:

  12. Authors: Yozo Mitsui, Inik Chang, Shinichiro Fukuhara, Miho Hiraki, Naoko Arichi, Hiroaki Yasumoto, Hiroshi Hirata, Soichiro Yamamura, Varahram Shahryari, Guoren Deng, Darryn K. Wong, Shahana Majid, Hiroaki Shiina, Rajvir Dahiya and Yuichiro Tanaka
    Citation: BMC Cancer 2022 22:813
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2015 15:942

  13. Despite the understanding of the COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on its value to predict the survival and prognosis of digestive system tumor patients. Hence...

    Authors: Yonghua Guo, Meng Gao, Ye Yao, Jinghua Li, Xi Chen, Xingxing Wang, Zhang Chen, Yufeng Yuan and Weijie Ma
    Citation: BMC Cancer 2022 22:812
    Content type: Research Published on:

  14. Large type 3 and type 4 gastric cancers have extremely poor prognoses. To address this, neoadjuvant chemotherapy may be a promising approach. The phase III JCOG0501 study, conducted to confirm the superiority ...

    Authors: Shunji Endo, Tetsuji Terazawa, Masahiro Goto, Ryo Tanaka, Takeshi Kato, Kazumasa Fujitani, Hisato Kawakami, Daisuke Sakai, Yukinori Kurokawa, Toshimasa Tsujinaka, Toshio Shimokawa and Taroh Satoh
    Citation: BMC Cancer 2022 22:811
    Content type: Study protocol Published on:

  15. To assess the impact of PET/CT functional parameters on survival, locoregional, and distant failure according to the most distant level of lymph node [18F]FDG uptake in patients with locally advanced cervical can...

    Authors: Alejandra Martinez, Elodie Chantalat, Martina Aida Angeles, Gwénaël Ferron, Anne Ducassou, Manon Daix, Justine Attal, Sarah Bétrian, Amélie Lusque and Erwan Gabiache
    Citation: BMC Cancer 2022 22:810
    Content type: Research article Published on:

  16. Lung cancer is the leading cause of malignancy-related mortality and lung adenocarcinoma accounts for about 40% of lung malignancies. The aim of this study was to investigate the associations of intraflagellar...

    Authors: Lianfeng Li, Yaobing Chen, Wei Liao, Qimei Yu, Hui Lin, Yuqin Shi, Ling Zhang, Guoqing Fu, Zhenyu Wang, Xi Li, Xianrong Kong, Ting Zhou and Lingzhi Qin
    Citation: BMC Cancer 2022 22:809
    Content type: Research Published on:

  17. Identification of microsatellite instability high (MSI-H) colorectal cancer (CRC) is crucial for screening patients most likely to benefit from immunotherapy. We aim to investigate whether the metabolic charac...

    Authors: Jinling Song, Zhongwu Li, Lujing Yang, Maomao Wei, Zhi Yang and Xuejuan Wang
    Citation: BMC Cancer 2022 22:808
    Content type: Research Published on:

  18. Five-fluorouracil, folinic acid, oxaliplatin and irinotecan (FOLFOXIRI) regimen is used as the first-line treatment for metastatic colorectal cancer (mCRC). The use of capecitabine, an oral fluoropyrimidine pr...

    Authors: Xiu Liu, Kai Ou, Xiaoting Ma, Lizhen Gao, Qi Wang, Haizeng Zhang and Lin Yang
    Citation: BMC Cancer 2022 22:807
    Content type: Research Published on:

  19. For colorectal cancer, preoperative (neoadjuvant) chemotherapy is more effective than postoperative chemotherapy because it not only eradicates micrometastases more effectively but also reduces the risk of inc...

    Authors: Jiawei Zhang, Jiaxin Deng, Jiancong Hu, Qinghua Zhong, Juan Li, Mingli Su, Wei Liu, Miwei Lv, Tian Xu, Dezheng Lin and Xuefeng Guo
    Citation: BMC Cancer 2022 22:806
    Content type: Research Published on:

  20. The time interval from first symptom and sign until a cancer diagnosis significantly affects the prognosis. Therefore, recognising and acting on signs of cancer, such as anaemia, is essential. Evidence is spar...

    Authors: Astrid Boennelykke, Henry Jensen, Lene Sofie Granfeldt Østgård, Alina Zalounina Falborg, Anette Tarp Hansen, Kaj Sparle Christensen and Peter Vedsted
    Citation: BMC Cancer 2022 22:805
    Content type: Research Published on:

  21. RNA methylation refers to a form of methyl modification in RNA that modulates various epigenetic alterations. Mounting studies have focused on its potential mechanisms in cancer initiation and progression. How...

    Authors: Siyuan Lu, Jie Hua, Jiang Liu, Miaoyan Wei, Chen Liang, Qingcai Meng, Bo Zhang, Xianjun Yu, Wei Wang and Jin Xu
    Citation: BMC Cancer 2022 22:804
    Content type: Research Published on:

  22. Tobacco consumption, as a worldwide problem, is a risk factor for several types of cancer. In Vietnam, tobacco consumption in the form of waterpipe tobacco smoking is common. This prospective cohort study aime...

    Authors: Hung Xuan Le, Dung Thi Thuy Truong, Long Bao Tran, Phuoc Hong Le, Binh Uyen Duong Pham, Koji Wada, Shunya Ikeda, Ariuntuul Garidkhuu, Can Van Phan and Ngoan Tran Le
    Citation: BMC Cancer 2022 22:803
    Content type: Research Published on:

  23. Carrying a pathogenic BRCA1/2 variant increases greatly young women’s risk of developing breast cancer (BC). This study aimed to provide the first genetic data on BC in Mauritania.

    Authors: Selma Mohamed Brahim, Ekht Elbenina Zein, Crystel Bonnet, Cheikh Tijani Hamed, Malak Salame, Mohamed Vall Zein, Meriem Khyatti, Ahmedou Tolba and Ahmed Houmeida
    Citation: BMC Cancer 2022 22:802
    Content type: Research Published on:

  24. Log odds of positive lymph nodes (LODDS) is a novel lymph node (LN) descriptor that demonstrates promising prognostic value in many tumors. However, there is limited information regarding LODDS in patients wit...

    Authors: Qing Wang, Suyu Wang, Zhiyong Sun, Min Cao and Xiaojing Zhao
    Citation: BMC Cancer 2022 22:801
    Content type: Research Published on:

  25. Neuroendocrine neoplasias (NENs) are a rare type of malignancy that arise from the cells of the neuroendocrine system. Most patients present with advanced, unresectable disease, typically with metastases to th...

    Authors: Rohini Sharma, Susanna Slater, Joanne Evans, Maria Martinez, Caroline Ward, Hooshang Izadi, Florian Wernig and Rob Thomas
    Citation: BMC Cancer 2022 22:800
    Content type: Study protocol Published on:

  26. Head and neck squamous cell carcinoma (HNSCC) is one severe malignancy driven by complex cellular and signaling mechanisms. However, the roles of circular RNAs (circRNAs) in HNSCC’s development remains poorly ...

    Authors: Ronghao Sun, Yuqiu Zhou, Yongcong Cai, Chunyan Shui, Xu Wang and Jingqiang Zhu
    Citation: BMC Cancer 2022 22:799
    Content type: Research Published on:

  28. The inverse relationship between BMI and lung cancer diagnosis is well defined. However, few studies have examined the racial differences in these relationships. The purpose of this paper is to explore the rel...

    Authors: Joy Zhao, Julie A. Barta, Russell McIntire, Christine Shusted, Charnita Zeigler-Johnson and Hee-Soon Juon
    Citation: BMC Cancer 2022 22:797
    Content type: Research Published on:

  29. Multiple myeloma (MM) is an incurable plasma cell malignancy. Red cell distribution width (RDW) is a prognostic marker in various diseases, solid tumors, and hematologic neoplasms, but its prognostic significa...

    Authors: Xiaomin Chen, Jiayue Liu, Jialin Duan, Hao Xiong, Yang Liu, Xinwen Zhang and Chunlan Huang
    Citation: BMC Cancer 2022 22:796
    Content type: Research Published on:

  30. Advances in hematopoietic cell transplantation (HCT) have led to marked improvements in survival. However, adolescents and young adults (AYAs) who undergo HCT are at high risk of developing sarcopenia (loss of...

    Authors: Minkeun Song, Saro H. Armenian, Rusha Bhandari, Kyuwan Lee, Kirsten Ness, Mary Putt, Lanie Lindenfeld, Saro Manoukian, Kristin Wade, Anna Dedio, Tati Guzman, Isabella Hampton, Kimberly Lin, Joseph Baur, Shana McCormack and Sogol Mostoufi-Moab
    Citation: BMC Cancer 2022 22:795
    Content type: Study protocol Published on:

  31. Prostate cancer (PCa) is the second most common cancer in men worldwide. The standard non-surgical approach for localized PCa is radiotherapy (RT), but one of the limitations of high-dose RT is the potential i...

    Authors: Patrizia Gnagnarella, Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Ottavio de Cobelli, Maria Claudia Simoncini, Luiz Felipe Nevola Teixeira, Annarita Sabbatini, Gabriella Pravettoni, Harriet Johansson, Luigi Nezi, Paolo Muto, Valentina Borzillo, Egidio Celentano, Anna Crispo, Monica Pinto, Ernesta Cavalcanti…
    Citation: BMC Cancer 2022 22:794
    Content type: Study protocol Published on:

  32. Concurrent chemoradiotherapy is currently the standard of care for patients with locally advanced cervical cancer. However, even with the application of modern radiotherapy techniques, a considerable number of...

    Authors: Jie Chen, Chen Li, Yuanjie Cao, Li Zhu, Bailin Zhang, Jinqiang You, Hailing Hou, Jing Wang and Zhiyong Yuan
    Citation: BMC Cancer 2022 22:793
    Content type: Study protocol Published on:

  33. Pathophysiology of transformation of inflammatory lesions in chronic pancreatitis (CP) to pancreatic ductal adenocarcinoma (PDAC) is not clear.

    Authors: Vijayasarathy Ketavarapu, Vishnubhotla Ravikanth, Mitnala Sasikala, G. V. Rao, Ch. Venkataramana Devi, Prabhakar Sripadi, Murali Satyanarayana Bethu, Ramars Amanchy, H. V. V. Murthy, Stephen J. Pandol and D. Nageshwar Reddy
    Citation: BMC Cancer 2022 22:792
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:825

  35. The WNT signal pathway has myriad family members, which are broadly involved in embryonic development and human cancer. Over-activation of WNT-β-Catenin signaling promotes cancer cell proliferation and surviva...

    Authors: Cheng Chen, Lunan Luo, Changling Xu, Xia Yang, Ting Liu, Jingyue Luo, Wen Shi, Lu Yang, Yi Zheng and Jing Yang
    Citation: BMC Cancer 2022 22:790
    Content type: Research Published on:

  36. Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. The present study a...

    Authors: Anchuan Li, Tingxuan Huang, Rong Zheng, Pan Chi, Zhihua Li, Xiaozhong Wang and Benhua Xu
    Citation: BMC Cancer 2022 22:789
    Content type: Research Published on:

  37. Findings from numerous studies have revealed that ferroptosis is closely related to tumorigenesis and immune cell infiltration. Long non-coding RNAs (lncRNAs) are reportedly involved in the progression of vari...

    Authors: Chunhui Liu, Yue Gao, Jiaxuan Ni, Saisai Chen, Qiang Hu, Can Wang, Mingjin Hu and Ming Chen
    Citation: BMC Cancer 2022 22:788
    Content type: Research Published on:

  38. Periostin is an extracellular matrix protein that has been known to be implicated in fibrillogenesis and cell migration, including cancer metastasis. Periostin overexpression in cancer cells and/or intervening...

    Authors: Kosuke Miyai, Kazuki Kawamura, Keiichi Ito, Susumu Matsukuma and Hitoshi Tsuda
    Citation: BMC Cancer 2022 22:787
    Content type: Research Published on:

  40. More than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined. Previously, we observed notable RanBP17 RNA expression levels ...

    Authors: Robert Mandic, André Marquardt, Philip Terhorst, Uzma Ali, Annette Nowak-Rossmann, Chengzhong Cai, Fiona R. Rodepeter, Thorsten Stiewe, Bernadette Wezorke, Michael Wanzel, Andreas Neff, Boris A. Stuck and Michael Bette
    Citation: BMC Cancer 2022 22:785
    Content type: Research Published on:

  41. Central nervous system (CNS) tumors are a leading cause of cancer-related morbidity and mortality in children. Our aim is to characterize incidence trends of pediatric CNS tumors in Finland over the last three...

    Authors: Jad Abuhamed, Atte Nikkilä, Jani Raitanen, Wafa Alimam, Olli Lohi, Janne Pitkäniemi, Hannu Haapasalo and Anssi Auvinen
    Citation: BMC Cancer 2022 22:784
    Content type: Research Published on:

  44. The high rate of aseptic loosening of cemented stems has led to their frequent use in endoprosthetic reconstruction. However, problems, such as stem breakage and stress shielding at the insertion site, remain....

    Authors: Satoshi Tsukushi, Yoshihiro Nishida, Takeshi Hirose, Eiji Nakata, Rumi Nakagawa, Tomoki Nakamura, Jungo Imanishi, Akihito Nagano, Hironari Tamiya and Takafumi Ueda
    Citation: BMC Cancer 2022 22:781
    Content type: Research Published on:

  45. Long non-coding RNAs (lncRNAs) are widely involved in the pathogenesis of cancers. However, biological roles of lncRNAs in occurrence and progression of colorectal cancer (CRC) remain unclear. The current study a...

    Authors: Mingjie Li, Dandan Guo, Xijun Chen, Xinxin Lu, Xiaoli Huang and Yan’an Wu
    Citation: BMC Cancer 2022 22:780
    Content type: Research Published on:

  46. Hypopharyngeal cancer is a relatively rare malignancy with poor prognosis. Current chemotherapeutic algorithm is still far from personalized medicine, and the identification of the truly active therapeutic bio...

    Authors: Yumiko Kawata-Shimamura, Hidetaka Eguchi, Reika Kawabata-Iwakawa, Mitsuhiko Nakahira, Yasushi Okazaki, Tetsuya Yoda, Reidar Grénman, Masashi Sugasawa and Masahiko Nishiyama
    Citation: BMC Cancer 2022 22:779
    Content type: Research Published on:

  47. A major challenge in the treatment of liver cancer is that a large proportion of patients fail to achieve long-term disease control, with death from liver cancer cell migration and invasion. Acid-sensitive ion...

    Authors: Yinci Zhang, Jiaojiao Liang, Niandie Cao, Jiafeng Gao, Yinghai Xie, Shuping Zhou and Xiaolong Tang
    Citation: BMC Cancer 2022 22:778
    Content type: Research Published on:

  48. Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients with...

    Authors: Toshifumi Yamaguchi, Hisato Kawakami, Daisuke Sakai, Yukinori Kurokawa, Toshio Shimokawa, Masahiro Goto and Taroh Satoh
    Citation: BMC Cancer 2022 22:773
    Content type: Study protocol Published on:

  49. Reshaping the tumor microenvironment by novel immunotherapies represents a key strategy to improve cancer treatment. Nevertheless, responsiveness to these treatments is often correlated with the extent of T ce...

    Authors: Claudia Corrò, Nicolas C. Buchs, Matthieu Tihy, André Durham-Faivre, Philippe Bichard, Jean-Louis Frossard, Giacomo Puppa, Thomas McKee, Arnaud Roth, Thomas Zilli, Christelle Trembleau, Mariagrazia Di Marco, Valérie Dutoit, Pierre-Yves Dietrich, Frédéric Ris and Thibaud Koessler
    Citation: BMC Cancer 2022 22:772
    Content type: Study protocol Published on:

  50. To investigate the maximum tolerated dose (MTD) of apatinib delivered during and after intensity-modulated radiotherapy (IMRT) for unresectable hepatocellular carcinoma (HCC).

    Authors: Hongzhi Wang, Xianggao Zhu, Yuting Zhao, Dezuo Dong, Lijuan Li, Yong Cai, Yongheng Li and Weihu Wang
    Citation: BMC Cancer 2022 22:771
    Content type: Research article Published on:

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