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  1. Estrogens suppress tumor growth in prostate cancer which progresses despite anorchid serum androgen levels, termed castration resistant prostate cancers (CRPC), although the mechanisms are unclear. We hypothes...

    Authors: Bruce Montgomery, Peter S Nelson, Robert Vessella, Tom Kalhorn, David Hess and Eva Corey
    Citation: BMC Cancer 2010 10:244
    Content type: Research article Published on:

  2. Calretinin is one of the well-established immunohistochemical markers in the diagnostics of malignant mesothelioma (MM). Its utility as a diagnostic tool in human blood, however, is scarcely investigated. The ...

    Authors: Irina Raiko, Ingrid Sander, Daniel G Weber, Monika Raulf-Heimsoth, Adrian Gillissen, Jens Kollmeier, Arnaud Scherpereel, Thomas Brüning and Georg Johnen
    Citation: BMC Cancer 2010 10:242
    Content type: Technical advance Published on:

  3. The metastasis-promoting protein S100A4 activates the transcription factor NF-κB through the classical NF-κB activation pathway. The upstream signal transduction mechanisms leading to increased NF-κB activity ...

    Authors: Ida Grotterød, Gunhild M Mælandsmo and Kjetil Boye
    Citation: BMC Cancer 2010 10:241
    Content type: Research article Published on:

  4. Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is a powerful method for the analysis of gene expression. Target gene expression levels are usually normalized to a consistently...

    Authors: Hyun-Wook Rho, Byoung-Chan Lee, Eun-Seok Choi, Il-Ju Choi, Yeon-Su Lee and Sung-Ho Goh
    Citation: BMC Cancer 2010 10:240
    Content type: Research article Published on:

  6. Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-...

    Authors: Jairam Vanamala, Lavanya Reddivari, Sridhar Radhakrishnan and Chris Tarver
    Citation: BMC Cancer 2010 10:238
    Content type: Research article Published on:

  7. Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology a...

    Authors: Marcus Q Bernardini, Tsukasa Baba, Paula S Lee, Jason C Barnett, Gregory P Sfakianos, Angeles Alvarez Secord, Susan K Murphy, Edwin Iversen, Jeffrey R Marks and Andrew Berchuck
    Citation: BMC Cancer 2010 10:237
    Content type: Research article Published on:

  8. This study was designed to investigate an association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of gastric and colorectal cancer in the Korean population.

    Authors: Lian-Hua Cui, Min-Ho Shin, Sun-Seog Kweon, Hee Nam Kim, Hye-Rim Song, Jin-Mei Piao, Jin-Su Choi, Hyun Jeong Shim, Jun Eul Hwang, Hyeong-Rok Kim, Young-Kyu Park and Soo-Hyun Kim
    Citation: BMC Cancer 2010 10:236
    Content type: Research article Published on:

  9. The objective of this study was to develop a ligand-targeted photodynamic therapy (tPDT) by conjugating factor VII (fVII) protein with photosensitiser verteporfin in order to overcome the poor selectivity and ...

    Authors: Zhiwei Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu
    Citation: BMC Cancer 2010 10:235
    Content type: Research article Published on:

  10. Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and m...

    Authors: William N Rom, Judith D Goldberg, Doreen Addrizzo-Harris, Heather N Watson, Michael Khilkin, Alissa K Greenberg, David P Naidich, Bernard Crawford, Ellen Eylers, Daorong Liu and Eng M Tan
    Citation: BMC Cancer 2010 10:234
    Content type: Research article Published on:

  11. CDC25 phosphatases are important regulators of the cell cycle. Their abnormal expression detected in a number of tumors implies that their dysregulation is involved in malignant transformation. However, the ro...

    Authors: Zhihui Wang, Claes G Trope, Vivi Ann Flørenes, Zhenhe Suo, Jahn M Nesland and Ruth Holm
    Citation: BMC Cancer 2010 10:233
    Content type: Research article Published on:

  12. Length of hospital stay (LOS) is a surrogate marker for patients' well-being during hospital treatment and is associated with health care costs. Identifying pretreatment factors associated with LOS in surgical...

    Authors: Brenda Laky, Monika Janda, Srinivas Kondalsamy-Chennakesavan, Geoffrey Cleghorn and Andreas Obermair
    Citation: BMC Cancer 2010 10:232
    Content type: Research article Published on:

  14. Aberrations of allelic replication timing are epigenetic markers observed in peripheral blood cells of cancer patients. The aberrant markers are non-cancer-type-specific and are accompanied by increased levels...

    Authors: Arnon Nagler, Samuel Cytron, Maya Mashevich, Avital Korenstein-Ilan and Lydia Avivi
    Citation: BMC Cancer 2010 10:230
    Content type: Research article Published on:

  15. Exposure of cancer cells to chemotherapeutic agents may result in reduced sensitivity to structurally unrelated agents, a phenomenon known as multidrug resistance, MDR. The purpose of this study is to investig...

    Authors: Rosa S Schneiderman, Esther Shmueli, Eilon D Kirson and Yoram Palti
    Citation: BMC Cancer 2010 10:229
    Content type: Research article Published on:

  17. Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DN...

    Authors: Pei Woon Ang, Marie Loh, Natalia Liem, Pei Li Lim, Fabienne Grieu, Aparna Vaithilingam, Cameron Platell, Wei Peng Yong, Barry Iacopetta and Richie Soong
    Citation: BMC Cancer 2010 10:227
    Content type: Research article Published on:

  18. Some studies have indicated that reproductive factors affect the risk of histological types of breast cancer differently. The long-term protective effect of a childbirth is preceded by a short-term adverse eff...

    Authors: Grethe Albrektsen, Ivar Heuch and Steinar Ø Thoresen
    Citation: BMC Cancer 2010 10:226
    Content type: Research article Published on:

  20. During surgery for endometrial cancer, a pelvic lymphadenectomy with or without para-aortic lymphadenectomy is performed at least in patients with risk factors (stage I, grading 2 and/or histological subtypes ...

    Authors: Nina Bassarak, Thomas Blankenstein, Ansgar Brüning, Darius Dian, Florian Bergauer, Klaus Friese and Ioannis Mylonas
    Citation: BMC Cancer 2010 10:224
    Content type: Research article Published on:

  21. Breast cancer is not a single entity but a diverse group of entities. Advances in gene expression profiling and immunohistochemistry as its surrogate marker have led to the unmasking of new breast cancer molec...

    Authors: Dalal M Al Tamimi, Mohamed A Shawarby, Ayesha Ahmed, Ammar K Hassan and Amal A AlOdaini
    Citation: BMC Cancer 2010 10:223
    Content type: Research article Published on:

  22. The distinction between primary and secondary ovarian tumors may be challenging for pathologists. The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathologi...

    Authors: Jean-Philippe Meyniel, Paul H Cottu, Charles Decraene, Marc-Henri Stern, Jérôme Couturier, Ingrid Lebigot, André Nicolas, Nina Weber, Virginie Fourchotte, Séverine Alran, Audrey Rapinat, David Gentien, Sergio Roman-Roman, Laurent Mignot and Xavier Sastre-Garau
    Citation: BMC Cancer 2010 10:222
    Content type: Research article Published on:

  23. Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variat...

    Authors: Shujie Wang, Yao Zhao, Zhenchao Ruan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, Yan Huang and Daru Lu
    Citation: BMC Cancer 2010 10:221
    Content type: Research article Published on:

  24. Tumor microenvironment is composed of tumor cells, fibroblasts, endothelial cells, and infiltrating immune cells. Tumor-associated immune cells may inhibit or promote tumor growth and progression. This study w...

    Authors: Fuqiang Dai, Lunxu Liu, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma and Zongbing You
    Citation: BMC Cancer 2010 10:220
    Content type: Research article Published on:

  25. The opposite effects of chemotherapy, which enhance the malignancy of treated cancers such as hepatocellular carcinoma (HCC), are not well understood. We investigated this phenomenon and corresponding mechanis...

    Authors: Wei Xiong, Zheng-Gang Ren, Shuang-Jian Qiu, Hui-Chuan Sun, Lu Wang, Bin-Bin Liu, Qi-Song Li, Wei Zhang, Xiao-Dong Zhu, Liang Liu, Wen-Quan Wang and Zhao-You Tang
    Citation: BMC Cancer 2010 10:219
    Content type: Research article Published on:

  27. Numerous hypermethylated genes have been reported in breast cancer, and the silencing of these genes plays an important role in carcinogenesis, tumor progression and diagnosis. These hypermethylated promoters ...

    Authors: Mercedes Zurita, Pedro C Lara, Rosario del Moral, Blanca Torres, José Luis Linares-Fernández, Sandra Ríos Arrabal, Joaquina Martínez-Galán, Francisco Javier Oliver and José Mariano Ruiz de Almodóvar
    Citation: BMC Cancer 2010 10:217
    Content type: Research article Published on:

  28. Rapid and effective treatment of cancer-induced bone pain remains a clinical challenge and patients with bone metastasis are more likely to experience severe pain. The voltage-gated sodium channel Nav1.8 plays...

    Authors: Xue-Rong Miao, Xiao-Fei Gao, Jing-Xiang Wu, Zhi-Jie Lu, Zhang-Xiang Huang, Xiao-Qing Li, Cheng He and Wei-Feng Yu
    Citation: BMC Cancer 2010 10:216
    Content type: Research article Published on:

  29. Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant inta...

    Authors: Gerald N DeLorenze, Lucie McCoy, Ai-Lin Tsai, Charles P Quesenberry Jr, Terri Rice, Dora Il'yasova and Margaret Wrensch
    Citation: BMC Cancer 2010 10:215
    Content type: Research article Published on:

  30. Data from the California Health Interview Survey (CHIS) indicate that levels and temporal trends in colorectal cancer (CRC) screening prevalence vary among Asian American groups; however, the reasons for these...

    Authors: Annette E Maxwell, Catherine M Crespi, Cynthia M Antonio and Peiyun Lu
    Citation: BMC Cancer 2010 10:214
    Content type: Research article Published on:

  31. Griseofulvin, an antifungal drug, has recently been shown to inhibit proliferation of various types of cancer cells and to inhibit tumor growth in athymic mice. Due to its low toxicity, griseofulvin has drawn ...

    Authors: Krishnan Rathinasamy, Bhavya Jindal, Jayant Asthana, Parminder Singh, Petety V Balaji and Dulal Panda
    Citation: BMC Cancer 2010 10:213
    Content type: Research article Published on:

  32. The calcium-permeable cation channel TRPM8 (melastatin-related transient receptor potential member 8) is over-expressed in several cancers. The present study aimed at investigating the expression, function and...

    Authors: Dechen Chodon, Arnaud Guilbert, Isabelle Dhennin-Duthille, Mathieu Gautier, Marie-Sophie Telliez, Henri Sevestre and Halima Ouadid-Ahidouch
    Citation: BMC Cancer 2010 10:212
    Content type: Research article Published on:

  33. We have studied the in vitro and in vivo utility of polyethylene glycol (PEG)-hydrogels for the development of an anticancer drug 5-fluorouracil (5-FU) delivery system.

    Authors: Hee Yi, Hee-Jung Cho, Soo-Min Cho, Dong-Goo Lee, AM Abd El-Aty, So-Jeong Yoon, Gun-Won Bae, Kwang Nho, Bokyung Kim, Chi-Ho Lee, Jin-Suk Kim, Michael G Bartlett and Ho-Chul Shin
    Citation: BMC Cancer 2010 10:211
    Content type: Research article Published on:

  34. Chemoprevention, which includes the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings, is an extremely promising strategy for cancer prevention. Ci...

    Authors: Soumya J Koppikar, Amit S Choudhari, Snehal A Suryavanshi, Shweta Kumari, Samit Chattopadhyay and Ruchika Kaul-Ghanekar
    Citation: BMC Cancer 2010 10:210
    Content type: Research article Published on:

  35. The sole effective option for patients with advanced HCC is sorafenib and there is an urgent need to develop new therapeutic approaches. Immunotherapy is a promising option that deserves major investigation. I...

    Authors: Tim F Greten, Alejandro Forner, Firouzeh Korangy, Gisele N'Kontchou, Nathalie Barget, Carmen Ayuso, Lars A Ormandy, Michael P Manns, Michel Beaugrand and Jordi Bruix
    Citation: BMC Cancer 2010 10:209
    Content type: Research article Published on:

  36. Melanoma usually presents as an initial skin lesion without evidence of metastasis. A significant proportion of patients develop subsequent local, regional or distant metastasis, sometimes many years after the...

    Authors: Maxine S Emmett, Kirsty E Symonds, Howard Rigby, Martin G Cook, Rebecca Price, Chris Metcalfe, Antonio Orlando and David O Bates
    Citation: BMC Cancer 2010 10:208
    Content type: Research article Published on:

  37. One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin. The efficacy of cisplatin therapy is often limited by the emergence o...

    Authors: Lawton J Stubbert, Jennifer M Smith and Bruce C McKay
    Citation: BMC Cancer 2010 10:207
    Content type: Research article Published on:

  38. Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. However, the knowledge in diagnostic modalities has progressed less. To identify new biomarkers for the early d...

    Authors: Zhiyu Zhang, Lijun Zhang, Yingqi Hua, Xiaofang Jia, Jian Li, Shuo Hu, Xia Peng, Pengyuan Yang, Mengxiong Sun, Fang Ma and Zhengdong Cai
    Citation: BMC Cancer 2010 10:206
    Content type: Research article Published on:

  39. A population of breast cancer patients exists who, for various reasons, never received adjuvant post-operative tamoxifen (TAM). This study was aimed to evaluate the role of late TAM in these patients.

    Authors: Andrea Veronesi, GianMaria Miolo, Maria D Magri, Diana Crivellari, Simona Scalone, Ettore Bidoli and Davide Lombardi
    Citation: BMC Cancer 2010 10:205
    Content type: Research article Published on:

  40. One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome M...

    Authors: Olga A Patutina, Nadezda L Mironova, Nelly A Popova, Vasily I Kaledin, Valery P Nikolin, Valentin V Vlassov and Marina A Zenkova
    Citation: BMC Cancer 2010 10:204
    Content type: Research article Published on:

  41. Angiogenesis is a multistep process in which many growth factors and cytokines have an essential role. Vascular endothelial growth factor (VEGF) is a potent angiogenic agent that acts as a specific mitogen for...

    Authors: Kyung A Kwon, Sung Hyun Kim, Sung Yong Oh, Suee Lee, Jin-Yeong Han, Kyeong Hee Kim, Ri Young Goh, Hong Jo Choi, Ki Jae Park, Mee Sook Roh, Hyo-Jin Kim, Hyuk-Chan Kwon and Jong Hoon Lee
    Citation: BMC Cancer 2010 10:203
    Content type: Research article Published on:

  42. Human osteosarcoma is the most common pediatric bone tumor. There is limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis, and a lack of good diagnostic as well as prognostic c...

    Authors: Bekim Sadikovic, Paul Thorner, Susan Chilton-MacNeill, Jeff W Martin, Nilva K Cervigne, Jeremy Squire and Maria Zielenska
    Citation: BMC Cancer 2010 10:202
    Content type: Research article Published on:

  43. Seladin-1 overexpression exerts a protective mechanism against apoptosis. Seladin-1 mRNA is variably expressed in normal human tissues. Adrenal glands show the highest levels of seladin-1 expression, which are...

    Authors: Lisa Simi, Francesca Malentacchi, Paola Luciani, Stefania Gelmini, Cristiana Deledda, Rosaria Arvia, Massimo Mannelli, Alessandro Peri and Claudio Orlando
    Citation: BMC Cancer 2010 10:201
    Content type: Research article Published on:

  44. Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating factor receptor (PAF-R)-mediated pathways. In the ...

    Authors: Soraya I de Oliveira, Luciana NS Andrade, Ana C Onuchic, Sueli Nonogaki, Patrícia D Fernandes, Mônica C Pinheiro, Ciro BS Rohde, Roger Chammas and Sonia Jancar
    Citation: BMC Cancer 2010 10:200
    Content type: Research article Published on:

  45. About 80% of patients with GIST would experience tumor recurrence or metastasis after radical resection. The most common site of the metastasis is the liver. Imatinib mesylate has been proved effective for adv...

    Authors: Jiang Zhu, Yu Yang, Lin Zhou, Ming Jiang and Mei Hou
    Citation: BMC Cancer 2010 10:199
    Content type: Research article Published on:

  46. Multiple myeloma (MM) is characterized by a strong dependence of the tumor cells on their microenvironment, which produces growth factors supporting survival and proliferation of myeloma cells (MMC). In the pa...

    Authors: Karène Mahtouk, Jérôme Moreaux, Dirk Hose, Thierry Rème, Tobias Meißner, Michel Jourdan, Jean François Rossi, Steven T Pals, Hartmut Goldschmidt and Bernard Klein
    Citation: BMC Cancer 2010 10:198
    Content type: Research article Published on:

  47. Coactivator-associated arginine methyltransferase 1 (CARM1) functions as a transcriptional coactivator of androgen receptor (AR)-mediated signaling. Correspondingly, overexpression of CARM1 has been associated...

    Authors: Young-Rang Kim, Byung Kook Lee, Ra-Young Park, Nguyen Thi Xuan Nguyen, Jeong A Bae, Dong Deuk Kwon and Chaeyong Jung
    Citation: BMC Cancer 2010 10:197
    Content type: Research article Published on:

  48. Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and genetic similarities. While chRCC is a malignant tumor, oncocytoma is usu...

    Authors: Min-Han Tan, Chin Fong Wong, Hwei Ling Tan, Ximing J Yang, Jonathon Ditlev, Daisuke Matsuda, Sok Kean Khoo, Jun Sugimura, Tomoaki Fujioka, Kyle A Furge, Eric Kort, Sophie Giraud, Sophie Ferlicot, Philippe Vielh, Delphine Amsellem-Ouazana, Bernard Debré…
    Citation: BMC Cancer 2010 10:196
    Content type: Research article Published on:

  49. Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor a...

    Authors: Michael R Green, Paul Jardine, Peter Wood, Jeremy Wellwood, Rod A Lea, Paula Marlton and Lyn R Griffiths
    Citation: BMC Cancer 2010 10:195
    Content type: Technical advance Published on:

  50. Recent reports suggest increase in estrogen receptor (ER), progesterone receptor (PR) negative breast cancer yet little is known about histology or receptor status of breast cancer in Indian/Pakistani women.in...

    Authors: Madhuri Kakarala, Laura Rozek, Michele Cote, Samadhi Liyanage and Dean E Brenner
    Citation: BMC Cancer 2010 10:191
    Content type: Research article Published on:

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