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  1. NKG2D (natural killer group 2, member D) is thought to play an important role in mediating the activation of anticancer immune response. Expression of NKG2D ligands (NKG2DLs) is pronounced in malignancies and ...

    Authors: Hanbyoul Cho, Joon-Yong Chung, Sunghoon Kim, Till Braunschweig, Tae Heung Kang, Jennie Kim, Eun Joo Chung, Stephen M Hewitt and Jae-Hoon Kim
    Citation: BMC Cancer 2014 14:957
  2. Cancer-associated fibroblasts and high mobility group box 1 (HMGB1) protein have been suggested to mediate cancer progression and chemotherapy resistance. The role of such fibroblasts in HMGB1 production in br...

    Authors: Kamolporn Amornsupak, Tonkla Insawang, Peti Thuwajit, Pornchai O-Charoenrat, Suzanne A Eccles and Chanitra Thuwajit
    Citation: BMC Cancer 2014 14:955
  3. The value of adjuvant chemotherapy in colorectal cancer is well studied, and guidelines have been established. Little is known about how treatment guidelines are implemented in the everyday clinical setting.

    Authors: Elinor Bexe Lindskog, Katrín Ásta Gunnarsdóttir, Kristoffer Derwinger, Yvonne Wettergren, Bengt Glimelius and Karl Kodeda
    Citation: BMC Cancer 2014 14:948
  4. The aim of this multicenter, retrospective study was to evaluate the efficacy and safety of metronomic oral cyclophosphamide (MOC) in heavily treated, relapsed ovarian cancer (ROC) patients.

    Authors: Gabriella Ferrandina, Giacomo Corrado, Floriana Mascilini, Paola Malaguti, Riccardo Samaritani, Mariagrazia Distefano, Valeria Masciullo, Alessia Di Legge, Antonella Savarese and Giovanni Scambia
    Citation: BMC Cancer 2014 14:947
  5. Sarcoid-like reaction is often seen in various types of carcinoma, not only in the primary tumor, but also in regional lymph nodes, and can occur at any time, not only at the time of diagnosis, but also after ...

    Authors: Yota Kawasaki, Kosei Maemura, Hiroshi Kurahara, Yuko Mataki, Satoshi Iino, Masahiko Sakoda, Shinichi Ueno, Hiroyuki Shinchi, Sonshin Takao and Shoji Natsugoe
    Citation: BMC Cancer 2014 14:946
  6. MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportu...

    Authors: Zongxiang Zhou, Manishha Patel, Nicholas Ng, Mindy H Hsieh, Anthony P Orth, John R Walker, Serge Batalov, Jennifer L Harris and Jun Liu
    Citation: BMC Cancer 2014 14:944
  7. Smoke-free policies shown to reduce population exposure to secondhand smoke (SHS) are the norm in hospitals in many countries around the world. Armenia, a transition economy in the South Caucasus, has one of t...

    Authors: Narine K Movsisyan, Varduhi Petrosyan, Arusyak Harutyunyan, Diana Petrosyan and Frances Stillman
    Citation: BMC Cancer 2014 14:943
  8. Breast cancer is a complex multifactorial genetic disease. Among other factors, race and, to an even greater extent, viruses are known to influence the development of this heterogeneous disease. It has been re...

    Authors: Alberto Cedro-Tanda, Alejandro Córdova-Solis, Teresa Juárez-Cedillo, Emmanuel Pina-Jiménez, Marta E Hernández-Caballero, Christian Moctezuma-Meza, Germán Castelazo-Rico, Alejandro Gómez-Delgado, Alejandro Cruz Monsalvo-Reyes, Fabio A Salamanca-Gómez, Diego J Arenas-Aranda and Normand García-Hernández
    Citation: BMC Cancer 2014 14:942
  9. The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/n...

    Authors: Maria D Cao, Santosh Lamichhane, Steinar Lundgren, Anna Bofin, Hans Fjøsne, Guro F Giskeødegård and Tone F Bathen
    Citation: BMC Cancer 2014 14:941
  10. Real-world evidence lacks for clinical effectiveness and clinical toxicity associated with platinum-based doublets in the first-line setting for advanced non-squamous non-small cell lung cancer (advNS-NSCLC) i...

    Authors: Yan Wang, Jianhua Chen, Shengqi Wu, Chenping Hu, Xiaoling Li, Yuqin Wang, Yicheng Yang, Narayan Rajan, Yun Chen, Yi Chen, Zhuanzhuan Luo and Wendong Chen
    Citation: BMC Cancer 2014 14:940
  11. Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not...

    Authors: Alessandra Fiorio Pla, Alessia Brossa, Michela Bernardini, Tullio Genova, Guillaume Grolez, Arnaud Villers, Xavier Leroy, Natalia Prevarskaya, Dimitra Gkika and Benedetta Bussolati
    Citation: BMC Cancer 2014 14:939
  12. Fibulin-5 has been considered as a tumor suppressor through inhibiting tumor growth and invasion. Reduced expression of Fibulin-5 is frequently observed in various human cancers. In this study, we investigate ...

    Authors: Kangsheng Tu, Changwei Dou, Xin Zheng, Chao Li, Wei Yang, Yingmin Yao and Qingguang Liu
    Citation: BMC Cancer 2014 14:938
  13. In patients with ovarian cancer relapsing at least 6 months after end of primary treatment, the addition of paclitaxel to platinum treatment has been shown to improve survival but at the cost of significant ne...

    Authors: Yun Wang, Jørn Herrstedt, Hanne Havsteen, Rene DePoint Christensen, Mansoor Raza Mirza, Bente Lund, Johanna Maenpaa and Gunnar Kristensen
    Citation: BMC Cancer 2014 14:937
  14. Breast cancer places a heavy burden on the Australian healthcare system, but information about the actual number of women living with breast cancer and their current or future health service needs is limited. ...

    Authors: Xue Qin Yu, Roberta De Angelis, Qingwei Luo, Clare Kahn, Nehmat Houssami and Dianne L O’Connell
    Citation: BMC Cancer 2014 14:936
  15. Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptible to endocrine therapy using antiestrogens. However, the majority of TNBCs express the membrane bound estrogen receptor GPR30. W...

    Authors: Rainer Girgert, Günter Emons and Carsten Gründker
    Citation: BMC Cancer 2014 14:935
  16. Although radiotherapy is a key component of curative-intent treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC), it can be associated with substantial pulmonary toxicity in some pat...

    Authors: Douglas A Hoover, Dante PI Capaldi, Khadija Sheikh, David A Palma, George B Rodrigues, A Rashid Dar, Edward Yu, Brian Dingle, Mark Landis, Walter Kocha, Michael Sanatani, Mark Vincent, Jawaid Younus, Sara Kuruvilla, Stewart Gaede, Grace Parraga…
    Citation: BMC Cancer 2014 14:934
  17. Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected popul...

    Authors: Lizet Sanchez, Patricia Lorenzo-Luaces, Carmen Viada, Yaima Galan, Javier Ballesteros, Tania Crombet and Agustin Lage
    Citation: BMC Cancer 2014 14:933
  18. Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown.

    Authors: Yuehua Han, Jun Ye, Dang Wu, Pin Wu, Zhigang Chen, Jian Chen, Shunliang Gao and Jian Huang
    Citation: BMC Cancer 2014 14:932
  19. It is unclear whether patients with few cerebral metastases benefit from whole-brain irradiation added to radiosurgery. Since primary tumors disseminating to the brain show different behavior, this question sh...

    Authors: Dirk Rades, Stefan Huttenlocher, Dagmar Hornung, Oliver Blanck and Steven E Schild
    Citation: BMC Cancer 2014 14:931
  20. Despite the preclinical outcomes and biologic significance of the presence of the human epidermal growth factor receptor-2 (HER2) extracellular domain (ECD), there is little evidence supporting the measurement...

    Authors: Sae Byul Lee, Jong Won Lee, Jong Han Yu, Beom Seok Ko, Hee Jeong Kim, Byung Ho Son, Gyungyub Gong, Hee Jin Lee, Sung-Bae Kim, Kyung Hae Jung, Jin-Hee Ahn, Woochang Lee, Joohon Sung and Sei-Hyun Ahn
    Citation: BMC Cancer 2014 14:929
  21. Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been r...

    Authors: Seunghwan Lim, Byoung Kwon Yoo, Hae-Suk Kim, Hannah L Gilmore, Yonghun Lee, Hyun-pil Lee, Seong-Jin Kim, John Letterio and Hyoung-gon Lee
    Citation: BMC Cancer 2014 14:928
  22. Disparities by race and neighborhood socioeconomic status exist for many colorectal cancer (CRC) outcomes, including screening use and mortality. We used population-based data to determine if disparities also ...

    Authors: Sandi L Pruitt, Nicholas O Davidson, Samir Gupta, Yan Yan and Mario Schootman
    Citation: BMC Cancer 2014 14:927
  23. Obesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts...

    Authors: Sarah E Jackson, Kate Williams, Andrew Steptoe and Jane Wardle
    Citation: BMC Cancer 2014 14:926
  24. FUSE binding protein1 (FBP1) is a transactivator of transcription of human c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very l...

    Authors: Updesh Dixit, Zhihe Liu, Ashutosh K Pandey, Ramesh Kothari and Virendra N Pandey
    Citation: BMC Cancer 2014 14:925
  25. Trastuzumab was registered in 2000 for the treatment of metastatic breast cancer, both as monotherapy and combination therapy with paclitaxel. In this prospective, non-interventional observation study, the 10-...

    Authors: Christian Jackisch, Winfried Schoenegg, Dietmar Reichert, Manfred Welslau, Johannes Selbach, Hanns-Detlev Harich, Hans Tesch, Tim Wohlfarth, Heidi Eustermann and Axel Hinke
    Citation: BMC Cancer 2014 14:924
  26. Glioblastoma (GBM) is the most common primary brain tumor and the most aggressive glial tumor. This tumor is highly heterogeneous, angiogenic, and insensitive to radio- and chemotherapy. Here we have investiga...

    Authors: Celina Garcia, Luiz Gustavo Dubois, Anna Lenice Xavier, Luiz Henrique Geraldo, Anna Carolina Carvalho da Fonseca, Ana Helena Correia, Fernanda Meirelles, Grasiella Ventura, Luciana Romão, Nathalie Henriques Silva Canedo, Jorge Marcondes de Souza, João Ricardo Lacerda de Menezes, Vivaldo Moura-Neto, Fernanda Tovar-Moll and Flavia Regina Souza Lima
    Citation: BMC Cancer 2014 14:923
  27. In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is...

    Authors: Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Teresa Mele, Sandra R Ramírez-Clavijo, Giorgio Scagliotti, Caterina Marchiò and Anna Sapino
    Citation: BMC Cancer 2014 14:922
  28. There is evidence that calcium (Ca2+) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation betwee...

    Authors: Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Sonia Liberati, Claudio Cardinali, Valerio Farfariello, Daniele Tomassoni, Wilma Quaglia, Alessandro Piergentili, Alessandro Bonifazi, Fabio Del Bello, Matteo Santoni, Gabriele Mammana, Lucilla Servi, Alessandra Filosa, Angela Gismondi…
    Citation: BMC Cancer 2014 14:921
  29. Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) is a truly novel protein, defining a new class of secreted factors. We have previously reported that ectopic overexpression of hHSS1 has a negative...

    Authors: Katiana S Junes-Gill, Chris E Lawrence, Christopher J Wheeler, Ryan Cordner, Tristan G Gill, Vernon Mar, Liron Shiri and Lena A Basile
    Citation: BMC Cancer 2014 14:920
  30. Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically ex...

    Authors: Christine M Friedenreich, Sarah MacLaughlin, Heather K Neilson, Frank Z Stanczyk, Yutaka Yasui, Aalo Duha, Brigid M Lynch, Ciara Kallal and Kerry S Courneya
    Citation: BMC Cancer 2014 14:919
  31. Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone
    Citation: BMC Cancer 2014 14:918
  32. MicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological processes such as apoptosis, development, aging and cancer. The aberrant expression of miRNAs may contribute t...

    Authors: Rui Yang, Yongjun Chen, Cong Tang, Hongbo Li, Bing Wang, Qun Yan, Junbo Hu and Shengquan Zou
    Citation: BMC Cancer 2014 14:917
  33. The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes
    Citation: BMC Cancer 2014 14:916
  34. Carfilzomib is a selective proteasome inhibitor approved in the United States in 2012 for the treatment of relapsed and refractory multiple myeloma. Although cardiopulmonary and vascular events have been repor...

    Authors: Ajai Chari and Daher Hajje
    Citation: BMC Cancer 2014 14:915
  35. Papillary thyroid cancer (PTC) often presents as multifocal. However, the association of multifocality with poor prognosis remains controversial. The aim of this retrospective study was to identify the charact...

    Authors: Ning Qu, Ling Zhang, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Qiang Shen, Yu Wang and Duan-shu Li
    Citation: BMC Cancer 2014 14:914
  36. The constituents of stable multiprotein complexes are known to dissociate from the complex to play independent regulatory roles. The components of translation elongation complex eEF1H (eEF1A, eEF1Bα, eEF1Bβ, e...

    Authors: Maryna Veremieva, Liudmyla Kapustian, Antonina Khoruzhenko, Valery Zakharychev, Boris Negrutskii and Anna El’skaya
    Citation: BMC Cancer 2014 14:913
  37. Chronic inflammation is a key feature of colorectal cancer (CRC), meaning that inflammatory biomarkers may be useful for its diagnosis. In particular, high neutrophil gelatinase-associated lipocalin (NGAL) exp...

    Authors: Laurence Duvillard, Pablo Ortega-Deballon, Abderrahmane Bourredjem, Marie-Lorraine Scherrer, Georges Mantion, Jean-Baptiste Delhorme, Sophie Deguelte-Lardière, Jean-Michel Petit and Claire Bonithon-Kopp
    Citation: BMC Cancer 2014 14:912
  38. Sphingosine-1-phosphate receptor-1 (S1PR1) and signal transducer and activator of transcription-3 (STAT3) play important roles in immune responses with potential oncogenic roles.

    Authors: Jin Ho Paik, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim and Yoon Kyung Jeon
    Citation: BMC Cancer 2014 14:911
  39. Accumulating evidences suggest that tumors are driven by a small population of cells, termed “cancer stem cells” (CSCs), which may be resistant to current therapeutic approaches. In breast carcinoma, the CSCs ...

    Authors: Refael Peleg, Marianna Romzova, Inga Kogan-Zviagin, Ron N Apte and Esther Priel
    Citation: BMC Cancer 2014 14:910
  40. Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related mortality in the world. MicroRNAs (miRNAs) are small, noncoding RNAs that play essential roles in vario...

    Authors: Xue-Wei Yang, Guan-Zhu Shen, Liang-Qi Cao, Xiao-Feng Jiang, He-Ping Peng, Gang Shen, De Chen and Ping Xue
    Citation: BMC Cancer 2014 14:909
  41. PREDICT (http://​www.​predict.​nhs.​uk) is a prognostication and treatment benefit tool for early breast cancer (EBC). The aim of this study was to incorporate t...

    Authors: Gordon C Wishart, Emad Rakha, Andrew Green, Ian Ellis, Hamid Raza Ali, Elena Provenzano, Fiona M Blows, Carlos Caldas and Paul DP Pharoah
    Citation: BMC Cancer 2014 14:908
  42. Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer...

    Authors: Niamh Lynam-Lennon, Ruth Connaughton, Eibhlin Carr, Ann-Marie Mongan, Naoimh J O’Farrell, Richard K Porter, Lorraine Brennan, Graham P Pidgeon, Joanne Lysaght, John V Reynolds and Jacintha O’Sullivan
    Citation: BMC Cancer 2014 14:907
  43. Everolimus was recently introduced as a second-line treatment for renal cell carcinoma (RCC) and many other cancers. Several prospective studies have shown that serum creatinine levels are increased in a signi...

    Authors: Sung Hae Ha, Ji Hyeon Park, Hye Ryoun Jang, Wooseong Huh, Ho-Yeong Lim, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Jung Eun Lee
    Citation: BMC Cancer 2014 14:906
  44. Persistent infection with high-risk (HR) human papillomavirus (HPV) causes cervical cancer, the fourth most frequent cancer in the Kingdom of Bahrain, with an annual incidence of four per 100,000 women. The ai...

    Authors: Khairya Moosa, Adel Salman Alsayyad, Wim Quint, Kusuma Gopala and Rodrigo DeAntonio
    Citation: BMC Cancer 2014 14:905
  45. Routine chemotherapy often cannot achieve good therapeutic effects because of multidrug resistance (MDR). MDR is frequently caused by the elevated expression of the MDR1 gene encoding P-glycoprotein (P-gp). E2...

    Authors: Lin-Hai Yan, Wei-Yuan Wei, Wen-Long Cao, Xiao-Shi Zhang, Yu-Bo Xie and Qiang Xiao
    Citation: BMC Cancer 2014 14:904
  46. Thyroid carcinoma is the leading cause of death among endocrine cancers second to carcinoma of the ovary. Now a day, the incidence of thyroid malignancy is increasing more rapidly than any other malignancy. Bu...

    Authors: Tadele Melak, Biniam Mathewos, Bamlaku Enawgaw and Debasu Damtie
    Citation: BMC Cancer 2014 14:899

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