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  1. We aim to identify the multifaceted risk factors that can affect the development of severe radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) treated with curative high-dose radioth...

    Authors: Hakyoung Kim, Jeongeun Hwang, Sun Myung Kim, Juwhan Choi and Dae Sik Yang
    Citation: BMC Cancer 2023 23:992
    Content type: Research Published on:

  2. The purpose of this study was to develop and validate a radiomics nomogram for predicting thymidylate synthase (TYMS) status in hepatocellular carcinoma (HCC) by using Gd-DTPA contrast enhanced MRI.

    Authors: Zongren Ding, Yijun Wu, Guoxu Fang, Zhaowang Lin, Kongying Lin, Jun Fu, Qizhen Huang, Yanyan Tang, Wuyi You, Jingfeng Liu and Yongyi Zeng
    Citation: BMC Cancer 2023 23:991
    Content type: Research Published on:

  3. To investigate how Fusobacterium nucleatum (Fn) promotes oxidative stress and mediates proliferation and autophagy in hypopharyngeal squamous cell carcinoma (HPSCC).

    Authors: Hui-Ching Lau, Xiaohui Yuan, Huiying Huang, Ming Zhang, Chi-Yao Hsueh and Hongli Gong
    Citation: BMC Cancer 2023 23:990
    Content type: Research Published on:

  4. Long noncoding RNAs (lncRNAs) are considered key players in the formation and development of tumors. Herein, Gene Expression Profiling Interactive Analysis (GEPIA) was employed as a bioinformatics technology. ...

    Authors: Zhengang Wang, Yang Cui, Fanchen Wang, Lixia Xu, Yan Yan, Xiaoguang Tong and Hua Yan
    Citation: BMC Cancer 2023 23:989
    Content type: Research Published on:

  5. The machine learning models with dose factors and the deep learning models with dose distribution matrix have been used to building lung toxics models for radiotherapy and achieve promising results. However, f...

    Authors: Liming Sheng, Lei Zhuang, Jing Yang, Danhong Zhang, Ying Chen, Jie Zhang, Shengye Wang, Guoping Shan, Xianghui Du and Xue Bai
    Citation: BMC Cancer 2023 23:988
    Content type: Research Published on:

  6. Laparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks, such as motion restriction and difficulties in spatial perception. Rob...

    Authors: Rie Makuuchi, Masanori Terashima, Mitsumi Terada, Junki Mizusawa, Ryosuke Kita, Masanori Tokunaga, Takeshi Omori, Toshiyasu Ojima, Kazuhisa Ehara, Masaya Watanabe, Yoshitomo Yanagimoto, Souya Nunobe, Takahiro Kinoshita, Seiji Ito, Yasunori Nishida, Jun Hihara…
    Citation: BMC Cancer 2023 23:987
    Content type: Study Protocol Published on:

  7. Mitofusin 2 (MFN2) plays an important role in many tumors, but how its role in renal clear cell carcinoma needs further research.

    Authors: Bin Zhang, Dali Han, LiMing Yang, Yang He, Shujun Yang, Hongbo Wang, Xingxing Zhang, Yuelin Du, Wei Xiong, Hualan Ha and Panfeng Shang
    Citation: BMC Cancer 2023 23:986
    Content type: Research Published on:

  8. One of the causes of colon and gastric cancer is the dysregulation of carcinogenic genes, tumor inhibitors, and micro-RNA. The purpose of this study is to apply rs10811661 polymorphism in CDKN2A /B gene as an ...

    Authors: Maria Beihaghi, Reza Sahebi, Mohammad Reza Beihaghi, Raheleh Khosravi Nessiani, Majedeh Ramian Yarasmi, Sajad Gholamalizadeh, Fatemeh Shahabnavaie and Mitra shojaei
    Citation: BMC Cancer 2023 23:985
    Content type: Research Published on:

  9. Neoadjuvant chemotherapy (NAC) has been widely applied in operable breast cancer patients. This study aim to identify the predictive factors of overall survival(OS) and recurrence free survival (RFS) in breast...

    Authors: Danzhi Chen, Qinchuan Wang, Minjun Dong, Fei Chen, Aihua Huang, Cong Chen, Yi Lu, Wenhe Zhao and Linbo Wang
    Citation: BMC Cancer 2023 23:984
    Content type: Research Published on:

  10. Despite decades of effort to reduce racial cancer disparities, Black people continue to die at higher rates from cancer than any other U.S. racial group. Because prevention is a key to the cost-effective and l...

    Authors: Nao Hagiwara, Nadia Harika, Erin P. Carmany, Yongyun Shin, Susan Eggly, Shawn C. T. Jones and John Quillin
    Citation: BMC Cancer 2023 23:983
    Content type: Study Protocol Published on:

  11. About 10% of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations are harbored as uncommon mutations. This study aimed to explore the efficacy and safety of dacomitin...

    Authors: Xingxiang Pu, Yu Zhou, Yi Kong, Bolin Chen, Aifang Yang, Jia Li, Kang Li, Yan Xu and Lin Wu
    Citation: BMC Cancer 2023 23:982
    Content type: Research Published on:

  12. Chemotherapy is a well-known risk factor for sensorial and motor disturbances. Chemotherapy induced peripheral neuropathy (CIPN) which predominantly affects sensory nerves might cause a diminished fine motor f...

    Authors: Alper Tuğral, Zeynep Arıbaş, Murat Akyol and Yeşim Bakar
    Citation: BMC Cancer 2023 23:981
    Content type: Research Published on:

  13. Aponermin, a circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, is a potential death receptor 4/5-targeted antitumour candidate. Previous phase 1/2 studies have demonstrated the effic...

    Authors: Zhongjun Xia, Yun Leng, Baijun Fang, Yang Liang, Wei Li, Chengcheng Fu, Linhua Yang, Xiaoyan Ke, Hua Jiang, Jianyu Weng, Li Liu, Yaozhong Zhao, Xuejun Zhang, Zhongxia Huang, Aichun Liu, Qingzhi Shi…
    Citation: BMC Cancer 2023 23:980
    Content type: Research Published on:

  14. Weekly paclitaxel + ramucirumab (wPTX + RAM) therapy is recommended as the standard second-line chemotherapy regimen for unresectable advanced/recurrent gastric cancer (GC) or esophagogastric junction cancer. ...

    Authors: Katsuhiko Nara, Takehito Yamamoto, Hiroharu Yamashita, Koichi Yagi, Tappei Takada, Yasuyuki Seto and Hiroshi Suzuki
    Citation: BMC Cancer 2023 23:979
    Content type: Research Published on:

  15. Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative complexes at origins of replication. The role of CDC6 in the pathogenesis of in diffuse larger B-cell lymphoma (DLBCL) ...

    Authors: Mingfang Shen, Yunfeng Zhang, Lun Tang, Qinyan Fu, Jiawei Zhang, Yang Xu, Hui Zeng and Yuan Li
    Citation: BMC Cancer 2023 23:978
    Content type: Research Published on:

  16. This study surveyed circular RNA CCT3 in bladder cancer (BCa). We recruited 85 BCa patients and 40 normal controls (Normal) and collected clinical specimens for analysis. circRNA CCT3 expression was analyzed b...

    Authors: Lin Luo, Qingzhi Xie, Yunchou Wu, Ping Li, FuQiang Qin, Dunming Liao and KangNing Wang
    Citation: BMC Cancer 2023 23:977
    Content type: Research Published on:

  17. Current treatment of acute leukemia is based on anthracycline chemotherapy. Anthracyclines, despite improving patient survival, have serious cardiotoxicity and therefore cardiac monitoring should be a priority...

    Authors: Xi Zhou, Yue Weng, Tiantian Jiang, Wenxin Ou, Nan Zhang, Qian Dong and Xiaoqiong Tang
    Citation: BMC Cancer 2023 23:976
    Content type: Research Published on:

  18. Several factors contribute to delayed presentation with ovarian cancer (OC) symptoms including poor symptom awareness and barriers to seeking help. This study explored the anticipated time to seek medical advi...

    Authors: Mohamedraed Elshami, Sondos Al-Madhoun, Mohammed Alser, Ibrahim Al-Slaibi, Areej Yaseen, Aya Tuffaha, Hadeel Jabr, Sara Ubaiat, Salma Khader, Reem Khraishi, Inas Jaber, Zeina Abu Arafeh, Aya Alqattaa, Asmaa Abd El Hadi, Ola Barhoush, Maysun Hijazy…
    Citation: BMC Cancer 2023 23:975
    Content type: Research Published on:

  19. As a molecule controlling the assembly of central spindles and recruitment of midzone component, coiled-coil domain-containing protein 69 (CCDC69) plays an important role in multiple cancers. Currently, the re...

    Authors: Zhen Wang, Huiyang Ren, Guolian Zhu, Lei Zhang, Hongyi Cao and Bo Chen
    Citation: BMC Cancer 2023 23:974
    Content type: Research Published on:

  20. Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine, which is overexpressed and/or activated in multiple malignancies and is reported to be associated with tumor development and inf...

    Authors: Cong Zhao, Li Tong, Bin Liu, Fei Qi, Zhiyun Zhang, Yi Guo, Yanxia Liu, Ying Wang, Lina Zhang, Baohua Lu, Baolan Li and Tongmei Zhang
    Citation: BMC Cancer 2023 23:973
    Content type: Research Published on:

  21. In recent years, hyperthermia has been widely applied as a novel strategy for cancer treatment due to its multiple antitumour effects. In particular, the potential influences of hyperthermia on the tumour immu...

    Authors: Yin Huaqi, Dong Bingqi, Zhao Yanhui, Ma Yongkang, Zhao Shiming, Sun Zhenghui, Du Zheng, Peng Jiangshan and Yang Tiejun
    Citation: BMC Cancer 2023 23:972
    Content type: Research Published on:

  22. Cancer cells express immunosuppressive molecules, such as programmed death ligands (PD-L)1 and PD-L2, enabling evasion from the host’s immune system. Cancer cells synthesize and secrete acetylcholine (ACh), ac...

    Authors: Nyanbol Kuol, Janusz Godlewski, Zbigniew Kmiec, Sara Vogrin, Sarah Fraser, Vasso Apostolopoulos and Kulmira Nurgali
    Citation: BMC Cancer 2023 23:971
    Content type: Research Published on:

  23. CalliSpheres® is a microsphere that is already widely used for primary liver cancer treatment; however, its application in colorectal cancer liver metastasis (CRLM) is limited. The current study aimed to inves...

    Authors: Haitao Li, Xiaolin Zhang, Wenjiang Zhao, Fei Cai, Jia Qin and Jie Tian
    Citation: BMC Cancer 2023 23:970
    Content type: Research Published on:

  24. This study aimed to explore whether the addition of sarcopenia and visceral adiposity could improve the accuracy of model predicting progression-free survival (PFS) in hepatocellular carcinoma (HCC).

    Authors: Yao Liu, Sirui Fu, Xiangrong Yu, Jinxiong Zhang, Siyu Zhu, Yang Yang, Jianwen Huang, Hanlin Luo, Kai Tang, Youbing Zheng, Yujie Zhao, Xiaoqiong Chen, Meixiao Zhan, Xiaofeng He, Qiyang Li, Chongyang Duan…
    Citation: BMC Cancer 2023 23:969
    Content type: Research Published on:

  25. There is limited information of radical radiotherapy (RT) on lymphoepithelial carcinoma of salivary gland (LECSG) regarding to the rarity of the disease. We conducted this retrospective study that evaluated th...

    Authors: Xiaoshuang Niu, Peiyao Liu, Xiaoshen Wang and Chaosu Hu
    Citation: BMC Cancer 2023 23:968
    Content type: Research Published on:

  27. In case of locally advanced and/or non-metastatic unresectable esophageal cancer, definitive chemoradiotherapy (CRT) delivering 50 Gy in 25 daily fractions in combination with platinum-based regimen remains th...

    Authors: Anouchka Modesto, David Tougeron, Pierre Tremolières, Philippe Ronchin, Ariane Darut Jouve, Delphine Argo Leignel, Véronique Vendrely, Olivier Riou, Jérôme Martin-Babau, Samuel Le Sourd, Xavier Mirabel, Thomas Leroy, Florence Huguet, Lucile Montaigne, Isabelle Baumgaertner, Marion Deslandres…
    Citation: BMC Cancer 2023 23:966
    Content type: Study protocol Published on:

  28. Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but the extent to which the increased genetic risk can be mitigated by adhering to a healthy lifestyle remains unclear. We a...

    Authors: Qiangsheng He, Siqing Wu, Ying Zhou, Yuchen Liu, Bin Xia, Wenjing Li, Jinyu Zhao, Ningning Mi, Peng Xie, Xiwen Qin, Jinqiu Yuan and Yihang Pan
    Citation: BMC Cancer 2023 23:965
    Content type: Research Published on:

  29. The long-term dynamic recurrence hazard of locally advanced gastric cancer (LAGC) in the clinical setting of adjuvant chemotherapy (ACT) remains unclear.

    Authors: Dong Wu, Jun Lu, Zhen Xue, Qing Zhong, Bin-bin Xu, Hua-Long Zheng, Guo-sheng Lin, Li-li Shen, Jia Lin, Jiao-bao Huang, Davit Hakobyan, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao…
    Citation: BMC Cancer 2023 23:964
    Content type: Research Published on:

  31. The PACIFIC study has demonstrated that the administration of durvalumab following concurrent chemoradiotherapy can significantly improve both overall survival and progression-free survival rates in patients w...

    Authors: Zhenyi Yang, Wen Zhong, Yixuan Luo and Chunli Wu
    Citation: BMC Cancer 2023 23:962
    Content type: Research Published on:

  32. Cervical cancer is a public health problem. It is one of the leading causes of death in women worldwide and the second leading cause of female cancer-related deaths. Cervical cancer screening enables the detec...

    Authors: Tangut Misgun and Dereje Bayissa Demissie
    Citation: BMC Cancer 2023 23:961
    Content type: Research Published on:

  33. Antibody-drug conjugates (ADCs) that target human epidermal growth factor receptor 2 (HER2) are leading a new era of targeted cancer therapy. These drugs have also been associated with several fatal adverse ev...

    Authors: Zhiwen Fu, Chen Gao, Jiyi Xie, Cong Zhang, Shijun Li, Ming Gu and Chen Shi
    Citation: BMC Cancer 2023 23:960
    Content type: Research Published on:

  34. The Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcr...

    Authors: Yue Wang, Zheng Guo, Yueli Tian, Liang Cong, Yulu Zheng, Zhiyuan Wu, Guangle Shan, Yao Xia, Yahong Zhu, Xingang Li and Ying Song
    Citation: BMC Cancer 2023 23:959
    Content type: Research Published on:

  35. There are no standard third-line treatment options for metastatic pancreatic ductal adenocarcinoma (mPDAC). Trametinib in combination with hydroxychloroquine (HCQ) or CDK4/6 inhibitors for pancreatic adenocarc...

    Authors: Hui Tang, Yuping Ge, Tingting You, Xiaoyuan Li, Yingyi Wang, Yuejuan Cheng and Chunmei Bai
    Citation: BMC Cancer 2023 23:958
    Content type: Research Published on:

  36. Prostate cancer is a disease that seriously troubles men. However, there are some inevitable limitations in interventional therapy for prostate cancer patients at present, most of which are caused by low selec...

    Authors: Lan Huang, Buqing Ma, Chong Zhang, Jiaqi Shi, Rui Shen, Erci Zhang, Chenlei Lian, Cuifang Wang and Jieqing Liu
    Citation: BMC Cancer 2023 23:957
    Content type: Research Published on:

  37. MicroRNAs (miRNAs) have been reported to serve as potential biomarkers in bladder cancer and play important roles in cancer progression. This study aimed to investigate the biological role of miR-205-3p in bla...

    Authors: Zou Zhenhai, Cheng Qi, Zhang Shuchao, Wang Zhongqi, Song Xue, Geng Zhijun, Mei Zhijie, Liu Jianmin, Liu Beibei and Guo Yuanyuan
    Citation: BMC Cancer 2023 23:956
    Content type: Research Published on:

  38. The interruption of normal cell cycle execution acts as an important part to the development of leukemia. It was reported that microRNAs (miRNAs) were closely related to tumorigenesis and progression, and thei...

    Authors: Bei Xie, Lei Zhao, Zhewen Zhang, Cunmin Zhou, Ye Tian, Yingying Kang, Jing Chen, Hulai Wei and Linjing Li
    Citation: BMC Cancer 2023 23:955
    Content type: Research Published on:

  40. Small (< 4 cm) clear cell renal cell carcinoma (ccRCC) is the most common type of small renal cancer and its prognosis is poor. However, conventional radiological characteristics obtained by computed tomograph...

    Authors: Yankun Gao, Xia Wang, Xiaoying Zhao, Chao Zhu, Cuiping Li, Jianying Li and Xingwang Wu
    Citation: BMC Cancer 2023 23:953
    Content type: Research Published on:

  41. Mammographic density (MD) is a strong risk factor for breast cancer. We aimed to evaluate the association between MD and breast cancer related risk factors among average-risk women in rural China.

    Authors: Huijiao Yan, Wenhui Ren, Mengmeng Jia, Peng Xue, Zhifang Li, Shaokai Zhang, Lichun He and Youlin Qiao
    Citation: BMC Cancer 2023 23:952
    Content type: Research Published on:

  44. Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in mai...

    Authors: Marina Crespo-Bravo, Jeppe Thorlacius-Ussing, Neel I. Nissen, Rasmus S. Pedersen, Mogens K. Boisen, Maria Liljefors, Astrid Z. Johansen, Julia S. Johansen, Morten A. Karsdal and Nicholas Willumsen
    Citation: BMC Cancer 2023 23:949
    Content type: Research Published on:

  45. HER2-positive breast cancer (BC) invasiveness and drug-resistance issue is the critical treatment obstacle recently. We investigated the total and phosphorylated status EZH2 expression in database and BC tissu...

    Authors: Feng Yu, Lili Li, Mengwen Zhang and Shanshan Sun
    Citation: BMC Cancer 2023 23:948
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:1176

  47. Previous studies reported inconsistent results regarding the association between keratinocyte carcinoma (KC) and exogenous hormone therapy. This study aimed to investigate the association between the use of ex...

    Authors: Lin Li, Baoqiang Pei and Yanyan Feng
    Citation: BMC Cancer 2023 23:946
    Content type: Research Published on:

  48. Glioblastoma (GB) is the most aggressive of all primary brain tumours and due to its highly invasive nature, surgical resection is nearly impossible. Patients typically rely on radiotherapy with concurrent tem...

    Authors: Craig A. Vincent, Itzel Nissen, Soran Dakhel, Andreas Hörnblad and Silvia Remeseiro
    Citation: BMC Cancer 2023 23:945
    Content type: Research Published on:

  49. Pan-immune-inflammation value (PIV) is defined by the neutrophil, platelet, monocyte, and lymphocyte counts and is associated with immune-checkpoint inhibitor (ICI) therapy outcomes in advanced non-small cell ...

    Authors: Yiqun Chen, Lingyan Gong, Pengyang Gu, Yiwen Hua, Yingfang Sun, Songshi Ni, Xiaoyu Zhou and Zhiyuan Tang
    Citation: BMC Cancer 2023 23:944
    Content type: Research Published on:

  50. Nephrectomy, whether in the era of cytokine therapy or targeted therapy, has an important role in the treatment of metastatic renal cell carcinoma. With the advent of immunotherapy, immunotherapy combined with...

    Authors: Hanzhi Dong, Yuan Cao, Yan Jian, Jun Lei, Weimin Zhou, Xiaoling Yu, Xiquan Zhang, Zhiqiang Peng and Zhe Sun
    Citation: BMC Cancer 2023 23:943
    Content type: Research Published on:

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