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  1. It remains uncertain whether first-line treatment with upfront brain radiotherapy (RT) in combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is superior to EGFR-TKIs alone fo...

    Authors: Yaowen Song, Shuiyu Lin, Jun Chen and Jun Dang
    Citation: BMC Cancer 2023 23:1043
    Content type: Research Published on:

  3. Radio/chemotherapy and immune systems provide examples of hormesis, as tumours can be stimulated (or reduced) at low radio/chemical or antibody doses but inhibited (or stimulated) by high doses.

    Authors: Sanyi Tang, Shuo Li, Biao Tang, Xia Wang, Yanni Xiao and Robert A. Cheke
    Citation: BMC Cancer 2023 23:1040
    Content type: Research article Published on:

  4. The immune checkpoint HERV-H LTR-associating 2 (HHLA2) is expressed in kidney cancer and various other tumor types. Therapeutics targeting HHLA2 or its inhibitory receptor KIR3DL3 are being developed for solid...

    Authors: Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman and Kathleen M. Mahoney
    Citation: BMC Cancer 2023 23:1039
    Content type: Research Published on:

  5. In the last decades, an increasing incidence of testicular cancer has been observed in several countries worldwide. Although mortality rates have been variable in many countries, little information is availabl...

    Authors: Yuleizy Crispin-Rios, Mariafe Faura-Gonzales, J. Smith Torres-Roman, Carlos Quispe-Vicuña, Uriel S. Franco-Jimenez, Bryan Valcarcel, Andreas Stang and Katherine A. McGlynn
    Citation: BMC Cancer 2023 23:1038
    Content type: Research Published on:

  6. The emergence of image-based systems to improve diagnostic pathology precision, involving the intent to label sets or bags of instances, greatly hinges on Multiple Instance Learning for Whole Slide Images(WSIs...

    Authors: Rukhma Aftab, Yan Qiang, Juanjuan Zhao, Zia Urrehman and Zijuan Zhao
    Citation: BMC Cancer 2023 23:1037
    Content type: Research Published on:

  7. Given high rates of cancer mortality in Native communities, we examined how urban American Indian and Alaska Native elders talk about colorectal cancer (CRC) and CRC screening.

    Authors: Dedra S. Buchwald, Deborah R. Bassett, Emily R. Van Dyke, Raymond M. Harris, Jessica D. Hanson and Shin-Ping Tu
    Citation: BMC Cancer 2023 23:1036
    Content type: Research Published on:

  8. Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis and progression to acute myeloid leukemia, myelodysplasia-related (AML-MR). A major mechanism of pathog...

    Authors: Ashikh A. Seethy, Karthikeyan Pethusamy, Tushar Kushwaha, Gaurav Kumar, Joyeeta Talukdar, Rekha Chaubey, Udayakumar Dharmalingam Sundaram, Manoranjan Mahapatra, Renu Saxena, Ruby Dhar, Krishna K. Inampudi and Subhradip Karmakar
    Citation: BMC Cancer 2023 23:1035
    Content type: Research Published on:

  9. Cervical cancer is one of the most malignancies in women all over the world. Over 90% of cases occurred in low and middle-income countries with limited resources. Even though cervical cancer is preventable, th...

    Authors: Ketemaw Tsegaye, Asebe Hagos, Hailemichael Kindie, Amare Minyihun and Getachew Teshale
    Citation: BMC Cancer 2023 23:1034
    Content type: Research Published on:

  10. To compare the efficacy and safety of TACE combined with Donafenib and Toripalimab versus TACE combined with Sorafenib in the treatment of unresectable hepatocellular carcinoma (HCC), aiming to guide personali...

    Authors: Haohao Lu, Bin Liang, Xiangwen Xia and Chuansheng Zheng
    Citation: BMC Cancer 2023 23:1033
    Content type: Research Published on:

  11. Gastric cancer (GC) remains among the most common and most lethal cancers worldwide. Peritoneum is the most common site for distant dissemination. Standard treatment for GC peritoneal metastases (PM) is a syst...

    Authors: Martynas Luksta, Augustinas Bausys, Klaudija Bickaite, Rokas Rackauskas, Marius Paskonis, Raminta Luksaite-Lukste, Anastasija Ranceva, Rokas Stulpinas, Birute Brasiuniene, Edita Baltruskeviciene, Nadezda Lachej, Rasa Sabaliauskaite, Rimantas Bausys, Skaiste Tulyte and Kestutis Strupas
    Citation: BMC Cancer 2023 23:1032
    Content type: Study Protocol Published on:

  12. One-half of hormone receptor-positive (HR +) breast cancer (BC) patients have low expression of HER2 (HER2-low) and may benefit from trastuzumab deruxtecan (TDXd). This study aimed to identify parameters assoc...

    Authors: Didi Feldman, Liat Anabel Sinberger, Mali Salmon-Divon, Judith Ben-Dror, Shlomit Strulov Shachar and Amir Sonnenblick
    Citation: BMC Cancer 2023 23:1031
    Content type: Research Published on:

  13. Platelet (PLT) count at diagnosis plays an important role in cancer development and progression in solid tumors. However, it remains controversial whether PLT count at diagnosis influences therapeutic outcome ...

    Authors: Yujiao Zhang, Quan Wu, Baoyi Yuan, Yun Huang, Ling Jiang, Fang Liu, Ping Yan, Yongshuai Jiang, Jieyu Ye and Xuejie Jiang
    Citation: BMC Cancer 2023 23:1030
    Content type: Research Published on:

  14. Necroptosis has been reported to be involved in cancer progression and associated with cancer prognosis. However, the prognostic values of necroptosis-related genes (NRGs) in hepatocellular carcinoma (HCC) rem...

    Authors: Qiqi Tao, Zhichao Lang, Yifei Li, Yuxiang Gao, Lifan Lin, Zhengping Yu, Jianjian Zheng and Suhui Yu
    Citation: BMC Cancer 2023 23:1029
    Content type: Research Published on:

  15. The accurate assessment of axillary lymph node metastasis (LNM) in early-stage breast cancer (BC) is of great importance. This study aimed to construct an integrated model based on clinicopathology, ultrasound...

    Authors: Yan Li, Dong Han, Cong Shen and Xiaoyi Duan
    Citation: BMC Cancer 2023 23:1028
    Content type: Research Published on:

  16. Gastric cancer has a complex aetiology including genetic factors. Individual case-control studies of toll like receptor (TLR) 9 (-1237 T/C, -1486 T/C) polymorphisms in the gastric cancer risk were available, a...

    Authors: Yap Zi Qyi, Htar Htar Aung, Saint-Nway Aye, Wong Siew Tung and Cho Naing
    Citation: BMC Cancer 2023 23:1027
    Content type: Research Published on:

  17. Noninvasive and precise methods to estimate treatment response and identify hepatocellular carcinoma (HCC) patients who could benefit from transarterial chemoembolization (TACE) are urgently required. The pres...

    Authors: Ying Zhao, Jian Zhang, Nan Wang, Qihao Xu, Yuhui Liu, Jinghong Liu, Qinhe Zhang, Xinyuan Zhang, Anliang Chen, Lihua Chen, Liuji Sheng, Qingwei Song, Feng Wang, Yan Guo and Ailian Liu
    Citation: BMC Cancer 2023 23:1026
    Content type: Research Published on:

  18. The Wnt/β-catenin signaling pathway plays an important role in embryogenesis and tumorigenesis. In human cancer, abnormal activity of Wnt/β-catenin signaling pathway induces overexpressed of downstream genes, ...

    Authors: Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen and Chung-Liang Ho
    Citation: BMC Cancer 2023 23:1025
    Content type: Research Published on:

  19. Human leukocyte antigen-G (HLA-G) has been reported to be aberrantly expressed in colorectal cancer (CRC); however, its prognostic value remains controversial. Hence, our meta-analysis aims to assess the progn...

    Authors: Yingying Zhang, Siying He, Lisha Yu, Chao Shi, Yanyue Zhang and Shiyue Tang
    Citation: BMC Cancer 2023 23:1024
    Content type: Research Published on:

  20. ICIs have become the standard treatment for advanced NSCLC patients. Currently, PD-L1 is the most widely useful biomarker to predict ICI efficacy, but the sensitivity and specificity are limited. Therefore, th...

    Authors: Tongtong Zhang, Shuluan Li, Jianhua Chang, Yan Qin and Chao li
    Citation: BMC Cancer 2023 23:1023
    Content type: Research Published on:

  21. HPV16 and 18 are positively correlated with cervical carcinogenesis. However, HPV prevalence tends to vary according to region, nationality, and environment. The most prevalent high-risk (HR) HPV genotypes are...

    Authors: Nan Lv, Yue Zhao, Yiying Song, Mingyu Ji and Yunying Zhou
    Citation: BMC Cancer 2023 23:1022
    Content type: Research Published on:

  22. Bladder urothelial carcinoma (BLCA) is the most common genitourinary cancer and the prognosis of patients is often poor. However, studies of basement membrane-related genes (BM-related genes) in BLCA are less ...

    Authors: Yanze Li, Kai Xu, Ye Zhang, Hu Mao, Qiangmin Qiu, Zhiwei Yan, Xiuheng Liu, Yang Du and Zhiyuan Chen
    Citation: BMC Cancer 2023 23:1021
    Content type: Research Published on:

  24. Chimeric antigen receptor T (CAR-T) cell therapy, a new adoptive cell therapy, has been widely used to treat lymphoma patients. Immune checkpoint blockade may improve the cytotoxicity of CAR-T cells by reducin...

    Authors: Yuxin Zhou, Wenjing Mu, Chen Wang, Zipeng Zhuo, Yu Xin, Hongxu Li and Changsong Wang
    Citation: BMC Cancer 2023 23:1019
    Content type: Research Published on:

  25. Although the current European Association of Urology(EAU) guideline recommends that patients with intermediate-risk non-muscle-invasive bladder cancer (NMIBC) should accept intravesical chemotherapy or Calmett...

    Authors: Jian-Xin Chen, Wen-Ting Huang, Qing-Yun Zhang, Cheng-En Deng, Jue-ling Wei, Yuan-Liang Xie, Rui Lin, Guan-Zheng Feng, Guang-Lin Yang, Jun Long, Hao-Yuan Lu and Zeng-nan Mo
    Citation: BMC Cancer 2023 23:1018
    Content type: Research Published on:

  26. The use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research has been conducted on the overall survival (OS) of patients with varying tumor responses...

    Authors: Kang Wang, Yan-Jun Xiang, Hong-Ming Yu, Yu-Qiang Cheng, Jin-Kai Feng, Zong-Han Liu, Yun-Feng Shan, Yi-Tao Zheng, Qian-Zhi Ni and Shu-Qun Cheng
    Citation: BMC Cancer 2023 23:1017
    Content type: Research Published on:

  27. Nomogram is a graphic representation containing the expressed factor of the mathematical formula used to define a particular phenomenon. We aim to build and internally validate a nomogram to predict overall su...

    Authors: Hassan Abdelilah Tafenzi, Farah Choulli, Ganiou Adjade, Anas Baladi, Leila Afani, Mohammed El Fadli, Ismail Essaadi and Rhizlane Belbaraka
    Citation: BMC Cancer 2023 23:1016
    Content type: Research Published on:

  29. Efforts have been made to investigate the role of salvage radiotherapy (RT) in treating recurrent ovarian cancer (ROC). Stereotactic ablative radiation therapy (SABR) is a state-of-the-art therapy that uses in...

    Authors: Yong Bae Kim, Hwa Kyung Byun, Chan Woo Wee, Hojin Kim, Seyoung Kim, Gowoon Yang, Jina Kim, Sang Joon Park and Jung-Yun Lee
    Citation: BMC Cancer 2023 23:1014
    Content type: Study Protocol Published on:

  30. Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) rectal cancer. The purpose of thi...

    Authors: Kemin Ni, Yixiang Zhan, Zhaoce Liu, Zhen Yuan, Shuyuan Wang, Xuan-zhu Zhao, Hangyu Ping, Yaohong Liu, Wanting Wang, Suying Yan, Ran Xin, Qiurong Han, Qinghuai Zhang, Guoxun Li, Xipeng Zhang, Guihua Wang…
    Citation: BMC Cancer 2023 23:1013
    Content type: Research Published on:

  31. Detecting tumor progression of glioma continues to pose a formidable challenge. The role of fibroblast activation protein (FAP) in gliomas has been demonstrated to facilitate tumor progression. Glioma-circulat...

    Authors: Xiao-song Yang, Peng zhu, Rong-Xing Xie, Peng-fei Chen, Hong Liu, Xiao-Man Cheng, Zheng-Quan Zhu, Xiao-min Peng, Hai-bin Liu, Qun-Ying Yang, Jun-Qi Li and Ji Zhang
    Citation: BMC Cancer 2023 23:1012
    Content type: Research Published on:

  32. Immune checkpoint inhibitors (ICIs), including nivolumab, have been approved to treat esophageal cancer. However, these remedies are not fit for all patients with esophageal cancer; therefore, a predictive sur...

    Authors: Seiji Natsuki, Hiroaki Tanaka, Masaki Nishiyama, Sota Deguchi, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Shigeru Lee and Kiyoshi Maeda
    Citation: BMC Cancer 2023 23:1011
    Content type: Research Published on:

  33. Metastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some patients follow a less aggressive disease course, characterized by a l...

    Authors: Alessandro Ottaiano, Antonella De Luca, Mariachiara Santorsola, Giosuè Scognamiglio, Annabella Di Mauro, Paolo Chiodini, Matilde Lambiase, Alessandra Sacco, Antonella Petrillo, Vincenza Granata, Roberta Fusco, Edoardo Mercadante, Nicola Martucci, Giuseppe De Luca, Antonello La Rocca, Egidio Celentano…
    Citation: BMC Cancer 2023 23:1010
    Content type: Study Protocol Published on:

  34. To predict the very early recurrence (VER) of patients with intrahepatic cholangiocarcinoma (ICC) based on TLSs and MVI status, and further perform prognosis stratifications.

    Authors: Ying Xu, Zhuo Li, Yanzhao Zhou, Yi Yang, Jingzhong Ouyang, Lu Li, Zhen Huang, Feng Ye, Jianming Ying, Hong Zhao, Jinxue Zhou and Xinming Zhao
    Citation: BMC Cancer 2023 23:1009
    Content type: Research Published on:

  35. To clarify the relationship between p53 immunohistochemistry (IHC) staining and TP53 alterations (including mutations and deletions) in large B-cell lymphomas (LBCLs) and to explore the possibility of p53 IHC exp...

    Authors: Xinyi Li, Danju Luo, Liling Zhang, Qiuhui Li, Jun Fan, Jiwei Zhang, Bo Huang, Ming Yang, Xiu Nie, Xiaona Chang and Huaxiong Pan
    Citation: BMC Cancer 2023 23:1008
    Content type: Research Published on:

  36. CANT1, as calcium-activated protein nucleotidase 1, is a kind of phosphatase. It is overexpressed in some tumors and related to poor prognosis, but few studies explore its function and carcinogenic mechanism i...

    Authors: Ting Liu, Zhi-zhao Li, Lei Sun, Kun Yang, Jia-min Chen, Xiao-yi Han, Li-ming Qi, Xin-gang Zhou and Peng Wang
    Citation: BMC Cancer 2023 23:1007
    Content type: Research Published on:

  37. The use of regorafenib in the treatment of hepatocellular carcinoma (HCC) is widespread. Albumin-Bilirubin (ALBI) has been shown to be a potential prognostic marker for regorafenib treatment, but its prognosti...

    Authors: Huilin Xu, Dedong Cao, Dingjie Zhou, Nan Zhao, Xixian Tang, Vishalkumar G. Shelat, Hrishikesh Samant, Sanjaya K. Satapathy, Francisco Tustumi, Giuseppe Aprile, Anbing He, Ximing Xu and Wei Ge
    Citation: BMC Cancer 2023 23:1006
    Content type: Research Published on:

  38. SH2 domain containing 1A (SH2D1A) expression has been linked to cancer progression. However, the functions of SH2D1A in hepatocellular carcinoma (HCC) have not been reported.

    Authors: Qian-Ming Xiang, Ni Jiang, Yue-Feng Liu, Yuan-Biao Wang, De-An Mu, Rong Liu, Lu-Yun Sun, Wei Zhang, Qiang Guo and Kai Li
    Citation: BMC Cancer 2023 23:1005
    Content type: Research Published on:

  39. Brain metastases are the most common intracranial tumours. Variation exists in the use of stereotactic radiosurgery for patients with 10 or more brain metastases. Concerns include an increasing number of brain...

    Authors: Hamoun Rozati, Jiarong Chen and Matt Williams
    Citation: BMC Cancer 2023 23:1004
    Content type: Research Published on:

  40. N-myc downstream-regulated gene-1 (NDRG1) is well-described as a potent metastasis suppressor, but its role in human breast cancer remains controversial and unclear. Therefore, the present study utilized a sys...

    Authors: Kwuntida Kotepui, Manas Kotepui, Hideyuki J. Majima and Jitbanjong Tangpong
    Citation: BMC Cancer 2023 23:1003
    Content type: Research Published on:

  41. Genitourinary small cell carcinoma is rare, and has a poor prognosis. However, effective treatment options for this disease are limited. We present a study to assess the efficacy of chemotherapy alone or combi...

    Authors: Riqing Huang, Meiting Chen, Haifeng Li, Xin An, Cong Xue, Anqi Hu, Ditian Shu, Wei Yang, Fangjian Zhou, Dan Sui, Kai Yao, Yonghong Li, Zhiming Wu, Zhiyong Li, Zhuowei Liu and Yanxia Shi
    Citation: BMC Cancer 2023 23:1002
    Content type: Research Published on:

  42. Recent studies have shown that the high incidence and low cure rate of hepatocellular carcinoma (HCC) have not improved significantly. Surgery and liver transplantation are the mainstays of prolonging the surv...

    Authors: Weiwei Yuan, Yuanmin Xu, Zhiheng Wu, Yang Huang, Lei Meng, Shiping Dai, Songcheng Ying, Zhangming Chen and Aman Xu
    Citation: BMC Cancer 2023 23:1001
    Content type: Research Published on:

  43. Two ROS1 tyrosine kinase inhibitors have been approved for ROS1 fusion positive (ROS1+) non-small cell lung cancer (NSCLC) tumors. We performed a pan-tumor analysis of the incidence of ROS1 fusions to assess if m...

    Authors: Misako Nagasaka, Shannon S. Zhang, Yasmine Baca, Joanne Xiu, Jorge Nieva, Ari Vanderwalde, Jeffrey J. Swensen, David Spetzler, Wolfgang Michael Korn, Luis E. Raez, Stephen V. Liu and Sai-Hong Ignatius Ou
    Citation: BMC Cancer 2023 23:1000
    Content type: Research Published on:

  44. Little is known on how denosumab reduces skeletal-related events (SREs) by bone metastases from solid tumors. We sought to evaluate the effect of denosumab administration in patients with bone metastases from ...

    Authors: Kohei Mizuta, Hiromichi Oshiro, Ryo Katsuki, Yuichi Tsuha, Yusuke Aoki, Yasunori Tome and Kotaro Nishida
    Citation: BMC Cancer 2023 23:999
    Content type: Research Published on:

  45. We previously identified 16,772 colorectal cancer-associated hypermethylated DNA regions that were also detectable in precancerous colorectal lesions (preCRCs) and unrelated to normal mucosal aging. We have no...

    Authors: Sija Sajibu, Emanuel Sonder, Amit Tiwari, Stephany Orjuela, Hannah R. Parker, Olivier The Frans, Christoph Gubler, Giancarlo Marra and Mark D. Robinson
    Citation: BMC Cancer 2023 23:998
    Content type: Research Published on:

  46. Immunosuppression is a significant factor contributing to the poor prognosis of cancer. S100P, a member of the S100 protein family, has been implicated in various cancers. However, its role in the tumor microenvi...

    Authors: Weiwei Hao, Yanyan Zhang, Jingwen Dou, Pu Cui and Jicun Zhu
    Citation: BMC Cancer 2023 23:997
    Content type: Research Published on:

  47. Response of locally advanced gastric cancer (LAGC) to neoadjuvant therapy (NAT) may be associated with prognosis, but which of the clinical or pathological evaluation can accurately predict a favorable prognos...

    Authors: Chongyuan Sun, Penghui Niu, Xiaojie Zhang, Lulu Zhao, Wanqing Wang, Xiaoyi Luan, Xue Han, Yingtai Chen and Dongbing Zhao
    Citation: BMC Cancer 2023 23:996
    Content type: Research Published on:

  48. Endometrial carcinoma (EC) is a malignant tumor of the female reproductive tract that has been associated with increased morbidity and mortality. This study aimed to identify biomarkers and potential therapeut...

    Authors: Qirong Hao, Hongqin Wu, Erniao Liu and Lina Wang
    Citation: BMC Cancer 2023 23:995
    Content type: Research Published on:

  49. A national framework for population-based cancer registration was established in Russia in the late 1990s. Data comparability and validity analyses found substantial differences across ten population-based can...

    Authors: Anton Barchuk, Rustam Tursun-zade, Ekaterina Nazarova, Yuri Komarov, Ekaterina Tyurina, Yulia Tumanova, Alexey Belyaev and Ariana Znaor
    Citation: BMC Cancer 2023 23:994
    Content type: Research Published on:

  50. This study aimed to explore the potential interaction between dietary intake and genetics on incident colorectal cancer (CRC) and whether adherence to healthy dietary habits could attenuate CRC risk in individ...

    Authors: Tung Hoang, Sooyoung Cho, Ji-Yeob Choi, Daehee Kang and Aesun Shin
    Citation: BMC Cancer 2023 23:993
    Content type: Research Published on:

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