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  1. Based on promising results from a Phase I study of hepatic arterial infusion chemotherapy using a combination of miriplatin and cisplatin powder (DDP-H) for unresectable hepatocellular carcinoma (UMIN-CTR00000...

    Authors: Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Hiroteru Kamimura, Tsutomu Kanefuji, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Satoshi Yamagiwa and Shuji Terai
    Citation: BMC Cancer 2017 17:322
    Content type: Research article Published on:

  2. The association between lymphovascular invasion and lymphatic or hematogenous metastasis has been suspected, with conflicting evidence. We have investigated the association between the risk of biochemical recu...

    Authors: Yong Jin Kang, Hyun-Soo Kim, Won Sik Jang, Jong Kyou Kwon, Cheol Yong Yoon, Joo Yong Lee, Kang Su Cho, Won Sik Ham and Young Deuk Choi
    Citation: BMC Cancer 2017 17:321
    Content type: Research article Published on:

  3. Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this stud...

    Authors: Silvia Delgado-García, Juan-Carlos Martínez-Escoriza, Alfonso Alba, Tina-Aurora Martín-Bayón, Hortensia Ballester-Galiana, Gloria Peiró, Pablo Caballero and Jose Ponce-Lorenzo
    Citation: BMC Cancer 2017 17:320
    Content type: Research article Published on:

  4. Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.

    Authors: Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck
    Citation: BMC Cancer 2017 17:319
    Content type: Research article Published on:

  5. eRAPID (electronic patient self-Reporting of Adverse-events: Patient Information and aDvice) is an internet based system for patients to self-report symptoms and side effects (adverse events or AE) of cancer t...

    Authors: Kate Absolom, Patricia Holch, Lorraine Warrington, Faye Samy, Claire Hulme, Jenny Hewison, Carolyn Morris, Leon Bamforth, Mark Conner, Julia Brown and Galina Velikova
    Citation: BMC Cancer 2017 17:318
    Content type: Study protocol Published on:

  6. To evaluate the procedures and complications of diaphragm peritonectomy (DP) and diaphragm full-thickness resection (DFTR) during primary cytoreduction for advanced stage epithelial ovarian cancer.

    Authors: Shuang Ye, Tiancong He, Shanhui Liang, Xiaojun Chen, Xiaohua Wu, Huijuan Yang and Libing Xiang
    Citation: BMC Cancer 2017 17:317
    Content type: Research article Published on:

  7. Exosomes or extracellular vesicles have the potential as a diagnostic marker for various diseases including cancer. In order to identify novel exosomal markers for prostate cancer (PC), we performed proteomic ...

    Authors: Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi and Masafumi Ito
    Citation: BMC Cancer 2017 17:316
    Content type: Research article Published on:

  8. To determine the proportion of “true” interval cancers and tumor characteristics of interval breast cancers prior to, during and after the transition from screen-film mammography screening (SFM) to full-field ...

    Authors: Rob M. G. van Bommel, Roy Weber, Adri C. Voogd, Joost Nederend, Marieke W. J. Louwman, Dick Venderink, Luc J. A. Strobbe, Matthieu J. C. Rutten, Menno L. Plaisier, Paul N. Lohle, Marianne J. H. Hooijen, Vivianne C.G. Tjan-Heijnen and Lucien E. M. Duijm
    Citation: BMC Cancer 2017 17:315
    Content type: Research article Published on:

  9. Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This placebo-controlled randomized phase II...

    Authors: T. Yokota, T. Ogawa, S. Takahashi, K. Okami, T. Fujii, K. Tanaka, S. Iwae, I. Ota, T. Ueda, N. Monden, K. Matsuura, H. Kojima, S. Ueda, K. Sasaki, Y. Fujimoto, Y. Hasegawa…
    Citation: BMC Cancer 2017 17:314
    Content type: Research article Published on:

  10. Thromboembolism (TE) is a serious complication in children with acute lymphoblastic leukemia (ALL). The incidence of symptomatic thromboembolism is as high as 14% and case fatality rate of ~15%. Further, devel...

    Authors: Uma H. Athale, Caroline Laverdiere, Trishana Nayiager, Yves-Line Delva, Gary Foster, Lehana Thabane and Anthony KC Chan
    Citation: BMC Cancer 2017 17:313
    Content type: Study protocol Published on:

  11. Ethnic differences in colon cancer (CC) care were shown in the United States, but results are not directly applicable to European countries due to fundamental healthcare system differences. This is the first s...

    Authors: M. Lamkaddem, M. A. G. Elferink, M. C. Seeleman, E. Dekker, C. J. A. Punt, O. Visser and M. L. Essink-Bot
    Citation: BMC Cancer 2017 17:312
    Content type: Research article Published on:

  12. The molecular profiles of tumors may inform the selection of appropriate targeted therapies. Circulating tumor cells (CTCs) reflect the real-time status of tumor genotypes. CTCs exhibit high genetic heterogene...

    Authors: Yuurin Kondo, Kazuhiko Hayashi, Kazuyuki Kawakami, Yukari Miwa, Hiroshi Hayashi and Masakazu Yamamoto
    Citation: BMC Cancer 2017 17:311
    Content type: Research article Published on:

  13. Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 al...

    Authors: Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo and Kirsi J. Granberg
    Citation: BMC Cancer 2017 17:310
    Content type: Research article Published on:

  14. Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin...

    Authors: Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi and Masatoshi Tagawa
    Citation: BMC Cancer 2017 17:309
    Content type: Research article Published on:

  15. Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC). Despite ...

    Authors: Valérie Fonteyne, Piet Dirix, Sara Junius, Elke Rammant, Piet Ost, Gert De Meerleer, Martijn Swimberghe and Karel Decaestecker
    Citation: BMC Cancer 2017 17:308
    Content type: Study protocol Published on:

  16. Glabridin (GLA), a major component extracted from licorice root, has anti-inflammatory and antioxidant activities, but few studies report its mechanism of inhibition of angiogenesis. This study was an extensio...

    Authors: Juan Mu, Dongmei Zhu, Zhaoxia Shen, Shilong Ning, Yun Liu, Juan Chen, Yuan Li and Zhong Li
    Citation: BMC Cancer 2017 17:307
    Content type: Research article Published on:

  17. Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is presumably due to differences in the molecular me...

    Authors: Kenneth M. K. Mark, Frederick S. Varn, Matthew H. Ung, Feng Qian and Chao Cheng
    Citation: BMC Cancer 2017 17:306
    Content type: Research article Published on:

  18. MicroRNAs are non-coding RNAs which regulate a variety of cellular functions in the development of tumors. Among the numerous microRNAs, microRNA-30a (miR-30a) is thought to play an important role in the proce...

    Authors: Minghao Xie, Huabo Qin, Qianxin Luo, Qunsheng Huang, Xiaosheng He, Zihuan Yang, Ping Lan and Lei Lian
    Citation: BMC Cancer 2017 17:305
    Content type: Research article Published on:

  19. Vascular invasion, including microvascular invasion (MVI) and portal vein tumor thrombus (PVTT), is associated with the postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to investigate the p...

    Authors: Xubiao Wei, Nan Li, Shanshan Li, Jie Shi, Weixing Guo, Yaxin Zheng and Shuqun Cheng
    Citation: BMC Cancer 2017 17:304
    Content type: Research article Published on:

  20. To characterize the expression of the membrane transporter NaPi2b and antigen targeted by the MX35 antibody in ovarian tumor samples. The current interest to develop monoclonal antibody based therapy of ovaria...

    Authors: Kristina Levan, Matin Mehryar, Constantina Mateoiu, Per Albertsson, Tom Bäck and Karin Sundfeldt
    Citation: BMC Cancer 2017 17:303
    Content type: Research article Published on:

  21. Interstitial lung diseases induced by anticancer agents (ILD-AA) are rare adverse effects of anticancer therapy. However, prognostic biomarkers for ILD-AA have not been identified in patients with advanced lun...

    Authors: Kota Nakamura, Motoyasu Kato, Takehito Shukuya, Keita Mori, Yasuhito Sekimoto, Hiroaki Ihara, Ryota Kanemaru, Ryo Ko, Rina Shibayama, Ken Tajima, Ryo Koyama, Naoko Shimada, Osamu Nagashima, Fumiyuki Takahashi, Shinichi Sasaki and Kazuhisa Takahashi
    Citation: BMC Cancer 2017 17:302
    Content type: Research article Published on:

  22. Annual low dose CT (LDCT) screening of individuals at high demographic risk reduces lung cancer mortality by more than 20%. However, subjects selected for screening based on demographic criteria typically have...

    Authors: Jiyoun Yeo, Erin L. Crawford, Xiaolu Zhang, Sadik Khuder, Tian Chen, Albert Levin, Thomas M. Blomquist and James C. Willey
    Citation: BMC Cancer 2017 17:301
    Content type: Research article Published on:

  24. Rapid and accurate cancer staging following diagnosis underpins patient management, in particular the identification of distant metastatic disease. Current staging guidelines recommend sequential deployment of...

    Authors: Stuart A. Taylor, Sue Mallett, Anne Miles, Sandy Beare, Gauraang Bhatnagar, John Bridgewater, Rob Glynne-Jones, Vicky Goh, Ashley M. Groves, Sam M. Janes, Dow Mu Koh, Steve Morris, Alison Morton, Neal Navani, Alf Oliver, Anwar R. Padhani…
    Citation: BMC Cancer 2017 17:299
    Content type: Study protocol Published on:

  25. We aimed to evaluate the potential benefits of the Leadership and Coaching for Health (LEACH) program on physical activity (PA), dietary habits, and distress management in cancer survivors.

    Authors: Young Ho Yun, Young Ae Kim, Myung Kyung Lee, Jin Ah Sim, Byung-Ho Nam, Sohee Kim, Eun Sook Lee, Dong-Young Noh, Jae-Young Lim, Sung Kim, Si-Young Kim, Chi-Heum Cho, Kyung Hae Jung, Mison Chun, Soon Nam Lee, Kyong Hwa Park…
    Citation: BMC Cancer 2017 17:298
    Content type: Research article Published on:

  26. The aim of the present study was to investigate the long-term survival outcomes and toxicities associated with our experienced early administration of adjuvant concurrent chemoradiotherapy (CCRT).

    Authors: Sang-Won Kim, Mison Chun, Hee-Sug Ryu, Suk-Joon Chang, Tae Wook Kong, Young-Taek Oh and Seung Hee Kang
    Citation: BMC Cancer 2017 17:297
    Content type: Research article Published on:

  27. Thyroglobulin measurement with fine-needle aspiration (Tg-FNA) is a sensitive method for detecting metastatic papillary thyroid carcinoma (PTC). However, the diagnostic threshold is not well established and th...

    Authors: Huan Zhao, Yong Wang, Min-jie Wang, Zhi-hui Zhang, Hai-rui Wang, Bing Zhang and Hui-qin Guo
    Citation: BMC Cancer 2017 17:296
    Content type: Research article Published on:

  28. Breast angiosarcoma is a rare malignancy with limited publications confined to small retrospective case reviews and case reports. Knowledge of this disease is limited because information from previous studies ...

    Authors: Ming Yin, Wenge Wang, Joseph J. Drabick and Harvey A. Harold
    Citation: BMC Cancer 2017 17:295
    Content type: Research article Published on:

  29. The theory of extravasated platelet aggregation in cancer lesions was recently introduced. We investigated the association of platelet aggregation in gastric cancer stroma with clinicopathological features, ch...

    Authors: Hiroto Saito, Sachio Fushida, Tomoharu Miyashita, Katsunobu Oyama, Takahisa Yamaguchi, Tomoya Tsukada, Jun Kinoshita, Hidehiro Tajima, Itasu Ninomiya and Tetsuo Ohta
    Citation: BMC Cancer 2017 17:294
    Content type: Research article Published on:

  30. Renal cell carcinoma (RCC) with sarcomatoid differentiation is a relatively rare tumor containing both carcinoma and sarcomatoid components. However, there has not been a systemic study on immunophenotypes of ...

    Authors: Wenjuan Yu, Yuewei Wang, Yanxia Jiang, Wei Zhang and Yujun Li
    Citation: BMC Cancer 2017 17:293
    Content type: Research article Published on:

  32. Women with breast cancer undergoing chemotherapy suffer from a number of symptoms and report receiving inadequate support from health care professionals. Innovative and easily accessible interventions are lack...

    Authors: Jiemin Zhu, Lyn Ebert, Xiangyu Liu and Sally Wai-Chi Chan
    Citation: BMC Cancer 2017 17:291
    Content type: Study protocol Published on:

  33. Impaired glucose metabolism–related genetic variants and traits likely interact with obesity and related lifestyle factors, influencing postmenopausal breast and colorectal cancer (CRC), but their interconnect...

    Authors: Su Yon Jung, Eric M. Sobel, Jeanette C. Papp and Zuo-Feng Zhang
    Citation: BMC Cancer 2017 17:290
    Content type: Research article Published on:

  34. We observed red autofluorescence emanating from bronchial cancer lesions using a sensitive color-fluorescence endoscopy system. We investigated to clarify the origin of the red autofluorescence.

    Authors: Yoshinobu Ohsaki, Takaaki Sasaki, Satoshi Endo, Masahiro Kitada, Shunsuke Okumura, Noriko Hirai, Yoshihiro Kazebayashi, Eri Toyoshima, Yasushi Yamamoto, Kaneyoshi Takeyama, Susumu Nakajima and Isao Sakata
    Citation: BMC Cancer 2017 17:289
    Content type: Research article Published on:

  35. Patients with unresectable malignant biliary obstruction have limited life expectancy because of limited stent patency and tumor progression. The aim of our study was to retrospectively evaluate the safety and...

    Authors: Wei Cui, Wenzhe Fan, Mingjian Lu, Yingqiang Zhang, Wang Yao, Jiaping Li and Yu Wang
    Citation: BMC Cancer 2017 17:288
    Content type: Research article Published on:

  36. Due to a lack of consensus on adjuvant treatments for pT1N1 gastric cancer, surgeons face a dilemma when deciding treatments for patients with pT1N1 gastric cancer after gastrectomy. The objective of this stud...

    Authors: Hyun Beak Shin, Ji Yeong An, Seung Hyoung Lee, Yoon Young Choi, Jong Won Kim, Soo Sang Sohn and Sung Hoon Noh
    Citation: BMC Cancer 2017 17:287
    Content type: Research article Published on:

  37. Although substantial evidence supports a 20–30% risk reduction of colon cancer, breast cancer, and endometrial cancer by physical activity (PA), the evidence for head and neck cancer (HNC) is limited. Three pu...

    Authors: Chen-Lin Lin, Wei-Ting Lee, Chun-Yen Ou, Jenn-Ren Hsiao, Cheng-Chih Huang, Jehn-Shyun Huang, Tung-Yiu Wong, Ken-Chung Chen, Sen-Tien Tsai, Sheen-Yie Fang, Tze-Ta Huang, Jiunn-Liang Wu, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Yu-Hsuan Lai…
    Citation: BMC Cancer 2017 17:286
    Content type: Research article Published on:

  38. Inflammation plays an important role in the pathogenesis of ovarian cancer. This study sought to investigate the association between the preoperative c-reactive protein/albumin ratio (CRP/Alb) and oncological ...

    Authors: Yubo Liu, Shengfu Chen, Chengyu Zheng, Miao Ding, Lan Zhang, Liangan Wang, Meiqing Xie and Jianhua Zhou
    Citation: BMC Cancer 2017 17:285
    Content type: Research article Published on:

  39. Breast cancer (BC) is the most frequent cancer occurring in women across the world. Its mortality rate in low-middle income countries (LMICs) is higher than in high-income countries (HICs), and in Indonesia BC...

    Authors: Hari Setyowibowo, Marit Sijbrandij, Aulia Iskandarsyah, Joke A. M. Hunfeld, Sawitri S. Sadarjoen, Dharmayanti F. Badudu, Drajat R. Suardi and Jan Passchier
    Citation: BMC Cancer 2017 17:284
    Content type: Study protocol Published on:

  41. The identification of four Consensus Molecular Subtypes (CMS1–4) of colorectal cancer forms a new paradigm for the design and evaluation of subtype-directed therapeutic strategies. The most aggressive subtype ...

    Authors: I. Ubink, H. J. Bloemendal, S. G. Elias, M. A. Brink, M. P. Schwartz, Y. C. W. Holierhoek, P. M. Verheijen, A. W. Boerman, R. H. J. Mathijssen, W. W. J. de Leng, R. A. de Weger, W. M. U. van Grevenstein, M. Koopman, M. P. Lolkema, O. Kranenburg and I. H. M. Borel Rinkes
    Citation: BMC Cancer 2017 17:282
    Content type: Study protocol Published on:

  42. Non-small cell lung cancer (NSCLC) harboring common epidermal growth factor receptor (EGFR) gene mutations (exon 19 deletion or exon 21 L858R) respond to EGFR tyrosine kinase inhibitors (EGFR-TKIs). The second...

    Authors: Masato Chiba, Yosuke Togashi, Eri Bannno, Yoshihisa Kobayashi, Yu Nakamura, Hidetoshi Hayashi, Masato Terashima, Marco A. De Velasco, Kazuko Sakai, Yoshihiko Fujita, Tetsuya Mitsudomi and Kazuto Nishio
    Citation: BMC Cancer 2017 17:281
    Content type: Research article Published on:

  43. Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis...

    Authors: Vivian Labovsky, Leandro Marcelo Martinez, Kevin Mauro Davies, María de Luján Calcagno, Hernán García-Rivello, Alejandra Wernicke, Leonardo Feldman, Ayelén Matas, María Belén Giorello, Francisco Raúl Borzone, Hosoon Choi, Scott C. Howard and Norma Alejandra Chasseing
    Citation: BMC Cancer 2017 17:280
    Content type: Research article Published on:

  44. Ultrasonography (US) is widely used as a standard surveillance tool for patients who are at a high risk of having hepatocellular carcinoma (HCC); however, conventional B-mode US appears to be insufficient in o...

    Authors: Ji Hoon Park, Mi-Suk Park, So Jung Lee, Woo Kyoung Jeong, Jae Young Lee, Min Jung Park, Kyunghwa Han, Chung Mo Nam, Seong Ho Park and Kyoung Ho Lee
    Citation: BMC Cancer 2017 17:279
    Content type: Study protocol Published on:

  45. Bevacizumab combined with chemotherapy produces clinical durable response in 25–30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this s...

    Authors: Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen and Ulrik Lassen
    Citation: BMC Cancer 2017 17:278
    Content type: Research article Published on:

  46. Arsenic is a widely distributed metalloid compound that has biphasic effects on cultured cells. In large doses, arsenic can be toxic enough to trigger cell death. In smaller amounts, non-toxic doses may promot...

    Authors: Yu-Ting Kao, Chin-Han Wu, Shan-Ying Wu, Sheng-Hui Lan, Hsiao-Sheng Liu and Ya-Shih Tseng
    Citation: BMC Cancer 2017 17:277
    Content type: Research article Published on:

  47. The purpose of this study is to investigate the most suitable first-line approach and the best combination treatment for primary mediastinal large B-cell lymphoma (PMLBCL) as they have been matter of debate fo...

    Authors: Alessandro Broccoli, Beatrice Casadei, Vittorio Stefoni, Cinzia Pellegrini, Federica Quirini, Lorenzo Tonialini, Alice Morigi, Miriam Marangon, Lisa Argnani and Pier Luigi Zinzani
    Citation: BMC Cancer 2017 17:276
    Content type: Research article Published on:

  48. F-18- fluorodeoxyglucose Positron emission tomography (18FDG-PET) has been widely used in clinical practice. However, the prognostic value of the pretreatment standardized uptake value (SUV) for patients with gas...

    Authors: Zhonghua Wu, Junhua Zhao, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Bin Ma and Zhenning Wang
    Citation: BMC Cancer 2017 17:275
    Content type: Research article Published on:

  49. To investigate the relationship between mammographic density measured in four quadrants of a breast with the location of the occurred cancer.

    Authors: Siwa Chan, Jeon-Hor Chen, Shunshan Li, Rita Chang, Darh-Cherng Yeh, Ruey-Feng Chang, Lee-Ren Yeh, Jessica Kwong and Min-Ying Su
    Citation: BMC Cancer 2017 17:274
    Content type: Research article Published on:

  50. Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids ...

    Authors: Marie K. Kirby, Ryne C. Ramaker, Brian S. Roberts, Brittany N. Lasseigne, David S. Gunther, Todd C. Burwell, Nicholas S. Davis, Zulfiqar G. Gulzar, Devin M. Absher, Sara J. Cooper, James D. Brooks and Richard M. Myers
    Citation: BMC Cancer 2017 17:273
    Content type: Research article Published on:

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