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  1. Cervical cancer screening participation remains insufficient in most countries. Our aim was to evaluate whether offering a HPV self-sampling kit, either mailed directly to the woman’s home or using timely opt-...

    Authors: Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm and Berit Andersen
    Citation: BMC Cancer 2018 18:273
    Content type: Research article Published on:

  2. We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-bindin...

    Authors: Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen and Bjarne W. Kristensen
    Citation: BMC Cancer 2018 18:270
    Content type: Research article Published on:

  3. The introduction of targeted treatments for subsets of non-small cell lung cancer (NSCLC) has highlighted the importance of accurate molecular diagnosis to determine if an actionable genetic alteration is pres...

    Authors: Ales Ryska, Peter Berzinec, Luka Brcic, Tanja Cufer, Rafal Dziadziuszko, Maya Gottfried, Ilona Kovalszky, Włodzimierz Olszewski, Buge Oz, Lukas Plank and Jozsef Timar
    Citation: BMC Cancer 2018 18:269
    Content type: Research article Published on:

  4. Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi re...

    Authors: Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li and Xuejie Fei
    Citation: BMC Cancer 2018 18:255
    Content type: Research article Published on:

  5. In the original publication of this article [1], published on 8 February 2018, it was noticed that the acknowledgement of the source of the drug ADI-PEG20 was missing.

    Authors: Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed and Henrik Antti
    Citation: BMC Cancer 2018 18:268
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:167

  6. CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clini...

    Authors: Tao Jiang, Xiaofeng Xu, Meng Qiao, Xuefei Li, Chao Zhao, Fei Zhou, Guanghui Gao, Fengying Wu, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Changyun Zhai and Caicun Zhou
    Citation: BMC Cancer 2018 18:267
    Content type: Research article Published on:

  8. There is no international consensus up to which age women with a diagnosis of triple-negative breast cancer (TNBC) and no family history of breast or ovarian cancer should be offered genetic testing for germline

    Authors: Christoph Engel, Kerstin Rhiem, Eric Hahnen, Sibylle Loibl, Karsten E. Weber, Sabine Seiler, Silke Zachariae, Jan Hauke, Barbara Wappenschmidt, Anke Waha, Britta Blümcke, Marion Kiechle, Alfons Meindl, Dieter Niederacher, Claus R. Bartram, Dorothee Speiser…
    Citation: BMC Cancer 2018 18:265
    Content type: Research article Published on:

  9. Angiogenesis is a process of formation of new blood vessels and is an important criteria demonstrated by cancer cells. Over a period of time, these cancer cells infect the other parts of the healthy body by a ...

    Authors: Shailima Rampogu, Ayoung Baek, Amir Zeb and Keun Woo Lee
    Citation: BMC Cancer 2018 18:264
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1249

  10. High-grade chondrosarcoma, which has a high incidence of local recurrence and pulmonary metastasis despite surgical resection, is associated with poor prognosis. Therefore, new and effective adjuvant therapies...

    Authors: Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi and Masashi Neo
    Citation: BMC Cancer 2018 18:263
    Content type: Research article Published on:

  13. TIPE3 (TNFAIP8L3), a transfer protein for lipid second messengers, is upregulated in human lung cancer tissues. The most popular lung cancer is non-small cell lung cancer (NSCLC) with high incidences and low s...

    Authors: Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang and Qun Wang
    Citation: BMC Cancer 2018 18:260
    Content type: Research article Published on:

  14. Non-small-cell lung cancer (NSCLC) is characterized by abnormalities of numerous signaling proteins that play pivotal roles in cancer development and progression. Many of these proteins have been reported to b...

    Authors: Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu…
    Citation: BMC Cancer 2018 18:259
    Content type: Research article Published on:

  15. Several systemic treatments have been shown to increase survival for patients with metastatic castration-resistant prostate cancer. This study sought to characterize variation in use of the six “focus drugs” (...

    Authors: Megan E. V. Caram, Jason P. Estes, Jennifer J. Griggs, Paul Lin and Bhramar Mukherjee
    Citation: BMC Cancer 2018 18:258
    Content type: Research article Published on:

  16. After orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC), recurrent HCC mostly develops within 2 years. All cases of de novo HCC described so far occurred later than 2 years after OLT. Prev...

    Authors: Giuliano Ramadori, Patrizia Bosio, Federico Moriconi and Ihtzaz A. Malik
    Citation: BMC Cancer 2018 18:257
    Content type: Case report Published on:

  17. Cancer screening awareness and participation may be lower in low- and middle-income countries that lack established national screening programmes compared with those that do. We evaluated potential determinant...

    Authors: Sumadi L. Anwar, Gindo Tampubolon, Mieke Van Hemelrijck, Susanna H. Hutajulu, Johnathan Watkins and Wahyu Wulaningsih
    Citation: BMC Cancer 2018 18:208
    Content type: Research article Published on:

  18. Between 2003 and 2010 digital mammography (DM) gradually replaced screen-film mammography (SFM) in the Dutch breast cancer screening programme (BCSP). Previous studies showed increases in detection rate (DR) a...

    Authors: Valérie D. V. Sankatsing, Jacques Fracheboud, Linda de Munck, Mireille J. M. Broeders, Nicolien T. van Ravesteyn, Eveline A. M. Heijnsdijk, André L. M. Verbeek, Johannes D. M. Otten, Ruud M. Pijnappel, Sabine Siesling and Harry J. de Koning
    Citation: BMC Cancer 2018 18:256
    Content type: Research article Published on:

  19. Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast cancer. There are five major histologic subtypes of ovarian cancer and high grade serous cancer (...

    Authors: Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks and Gillian Mitchell
    Citation: BMC Cancer 2018 18:254
    Content type: Research article Published on:

  20. Gastro-intestinal stromal tumors (GISTs) are very rare tumors of the gastro-intestinal tract, originating from the interstitial cells of Cajal or a common cell precursor which both express type III tyrosine ki...

    Authors: Donatienne Van Weehaeghe, Olivier Gheysens, Vincent Vandecaveye, Patrick Schöffski, Koen Van Laere and Christophe M. Deroose
    Citation: BMC Cancer 2018 18:253
    Content type: Case report Published on:

  21. Oxaliplatin is a platinum derivative that has shown efficacy in advanced hepatocellular carcinoma. S-1 is an oral fluoropyrimidine that has substituted for 5-fluorouracil in many cancers. This was a multicente...

    Authors: Dae-Won Lee, Kyung-Hun Lee, Hee-Jun Kim, Tae-Yong Kim, Jin-Soo Kim, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im and Tae-You Kim
    Citation: BMC Cancer 2018 18:252
    Content type: Research article Published on:

  22. Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.

    Authors: Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao and Weimin Mao
    Citation: BMC Cancer 2018 18:251
    Content type: Research article Published on:

  24. In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers, drives AKT activity. Constitutive activation of the PI3K...

    Authors: Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès and Vincent Picco
    Citation: BMC Cancer 2018 18:249
    Content type: Research article Published on:

  25. As hybrid RNAs, transcription-induced chimeras (TICs) may have tumor-promoting properties, and some specific chimeras have become important diagnostic markers and therapeutic targets for cancer.

    Authors: Ye Tao, Neil Gross, Xiaojiao Fan, Jianming Yang, Maikun Teng, Xu Li, Guojun Li, Yang Zhang and Zhigang Huang
    Citation: BMC Cancer 2018 18:248
    Content type: Research article Published on:

  26. This study aimed to investigate the safety of sorafenib for the treatment of unresectable hepatocellular carcinoma in Chinese patients.

    Authors: Sheng-Long Ye, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu…
    Citation: BMC Cancer 2018 18:247
    Content type: Research article Published on:

  28. The aim of the present study was to evaluate the physical properties of “admixture paste”, which is a commercially available gel containing hinokitiol for use against severe stomatitis, and its characteristics...

    Authors: Ayumi Sakuramoto, Yoko Hasegawa, Kazuma Sugahara, Yoshiyuki Komoda, Kana Hasegawa, Shinichi Hikasa, Mai Kurashita, Junya Sakai, Masahiro Arita, Kazuhiro Yasukawa and Hiromitsu Kishimoto
    Citation: BMC Cancer 2018 18:245
    Content type: Research article Published on:

  29. Carers looking after someone with cancer often experience negative impacts on their own health. M-health interventions have been designed to provide information and support to patients and their carers. Howeve...

    Authors: Natalie Heynsbergh, Leila Heckel, Mari Botti and Patricia M. Livingston
    Citation: BMC Cancer 2018 18:244
    Content type: Research article Published on:

  30. Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only eff...

    Authors: Paula Fluxá, Daniel Rojas-Sepúlveda, María Alejandra Gleisner, Andrés Tittarelli, Pablo Villegas, Loreto Tapia, María Teresa Rivera, Mercedes Natalia López, Felipe Catán, Mario Uribe and Flavio Salazar-Onfray
    Citation: BMC Cancer 2018 18:243
    Content type: Research article Published on:

  31. In recent years management practices in relation to low-risk papillary microcarcinoma (PMC) have been evolving with increased awareness of the potential overdiagnosis and overtreatment of PMCs, and guidelines ...

    Authors: Brooke Nickel, Juan P. Brito, Ray Moynihan, Alexandra Barratt, Susan Jordan and Kirsten McCaffery
    Citation: BMC Cancer 2018 18:242
    Content type: Research article Published on:

  32. Preclinical studies have demonstrated that docetaxel and bevacizumab may act synergistically by decreasing endothelial cell proliferation and preventing circulating endothelial progenitor mobilization. The obj...

    Authors: Satoshi Ikeda, Terufumi Kato, Takashi Ogura, Akimasa Sekine, Tsuneyuki Oda, Noriyuki Masuda, Satoshi Igawa, Ken Katono, Sakiko Otani, Kouzo Yamada, Haruhiro Saito, Tetsuro Kondo, Yukio Hosomi, Yoshiro Nakahara, Masanori Nishikawa, Keiko Utumi…
    Citation: BMC Cancer 2018 18:241
    Content type: Research article Published on:

  33. It has been highlighted that the original manuscript [1] contains a typesetting error in the surname of Jesson Butcon. This was incorrectly captured as Jessica Butcon in the original manuscript which has since...

    Authors: Raymond Javan Chan, Patsy Yates, Qiuping Li, Hiroko Komatsu, Violeta Lopez, Myat Thandar, Selva Titus Chacko, Winnie Kwok Wei So, Kanaungnit Pongthavornkamol, Myungsun Yi, Pongpak Pittayapan, Jesson Butcon, David Wyld and Alex Molassiotis
    Citation: BMC Cancer 2018 18:240
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:715

  34. Immune checkpoint inhibitors (ICPIs) are being investigated in clinical trials for patients with glioblastoma. While these therapies hold great promise, management of the patients receiving such treatment can ...

    Authors: Surabhi Ranjan, Martha Quezado, Nancy Garren, Lisa Boris, Christine Siegel, Osorio Lopes Abath Neto, Brett J. Theeler, Deric M. Park, Edjah Nduom, Kareem A. Zaghloul, Mark R. Gilbert and Jing Wu
    Citation: BMC Cancer 2018 18:239
    Content type: Case report Published on:

  36. Histiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds of dogs, such as Bernese mountain dog. The purpose of this study was to fully characterize a no...

    Authors: Marilia Takada, Maciej Parys, Emmalena Gregory-Bryson, Paulo Vilar Saavedra, Matti Kiupel and Vilma Yuzbasiyan-Gurkan
    Citation: BMC Cancer 2018 18:237
    Content type: Research article Published on:

  37. Consumption of very hot (> 65 °C) beverages is probably associated with increased risk of oesophageal cancer. First associations were reported for yerba mate and it was initially believed that high content of ...

    Authors: Alex O. Okaru, Anke Rullmann, Adriana Farah, Elvira Gonzalez de Mejia, Mariana C. Stern and Dirk W. Lachenmeier
    Citation: BMC Cancer 2018 18:236
    Content type: Research article Published on:

  38. The immune system has a known role in the aetiology, progression and final treatment outcome of oral squamous cell cancers. The aim of this study was to evaluate the influence of radical surgery and radiothera...

    Authors: Tadej Dovšak, Alojz Ihan, Vojko Didanovič, Andrej Kansky, Miha Verdenik and Nataša Ihan Hren
    Citation: BMC Cancer 2018 18:235
    Content type: Research article Published on:

  39. There is no consensus regarding the optimal time to initiate adjuvant chemotherapy after surgery for stage III colon cancer, and the relevant postoperative complications that cause delays in adjuvant chemother...

    Authors: Peng Gao, Xuan-zhang Huang, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Yu Sun, Yu-meng Jiang and Zhen-ning Wang
    Citation: BMC Cancer 2018 18:234
    Content type: Research article Published on:

  41. In the original version of this article [1], published on 12 August 2017, the affiliations and author contributor details were not correct. In this Correction the incorrect affiliations and author contributor ...

    Authors: Yun Hee Lee, Jeong Won Lee and Hong Seok Jang
    Citation: BMC Cancer 2018 18:232
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:541

  42. Paclitaxel (PTX) is a potent anti-cancer drug commonly used for the treatment of advanced breast cancer (BCA) and melanoma. Toll-like receptor 4 (TLR4) promotes the production of pro-inflammatory cytokines ass...

    Authors: Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee and Chanitra Thuwajit
    Citation: BMC Cancer 2018 18:231
    Content type: Research article Published on:

  43. It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast st...

    Authors: Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström and Håkan Olsson
    Citation: BMC Cancer 2018 18:230
    Content type: Research article Published on:

  44. Gastroenterology Departments at hospitals within Australia receive thousands of General Practitioner (GP)-referral letters for gastrointestinal investigations every month. Many of these requests are for colono...

    Authors: Anton R. Lord, Lisa A. Simms, Allison Brown, Katherine Hanigan, Krupa Krishnaprasad, Belinda Schouten, Anthony R. Croft, Mark N. Appleyard and Graham L. Radford-Smith
    Citation: BMC Cancer 2018 18:229
    Content type: Research article Published on:

  45. Aspirin has been proposed as a novel adjuvant agent in colorectal cancer (CRC). Six observational studies have reported CRC-specific survival outcomes in patients using aspirin after CRC diagnosis but the resu...

    Authors: Ronan T. Gray, Helen G. Coleman, Carmel Hughes, Liam J. Murray and Chris R. Cardwell
    Citation: BMC Cancer 2018 18:228
    Content type: Research article Published on:

  46. Post-surgical prognosis is usually poor for combined hepatocellular cholangiocarcinoma (CHCC-CC), a rare primary liver cancer. Although midkine (MK) is a prognostic biomarker for several known cancers, it is n...

    Authors: Ming-Chun Ma, Yi-Ju Chen, Tai-Jan Chiu, Jui Lan, Chien-Ting Liu, Yi-Ching Chen, Hsin-Ho Tien and Yen-Yang Chen
    Citation: BMC Cancer 2018 18:227
    Content type: Research article Published on:

  47. The centralisation of specialist cancer surgical services across London Cancer and Greater Manchester Cancer, England, may significantly change how patients experience care. These centres are changing specialist ...

    Authors: Mariya Melnychuk, Cecilia Vindrola-Padros, Michael Aitchison, Caroline S. Clarke, Naomi J. Fulop, Claire Levermore, Satish B. Maddineni, Caroline M. Moore, Muntzer M. Mughal, Catherine Perry, Kathy Pritchard-Jones, Angus I. G. Ramsay, David Shackley, Jonathan Vickers and Stephen Morris
    Citation: BMC Cancer 2018 18:226
    Content type: Research article Published on:

  48. Programmed Death Ligand 1 (PD-L1) is a co-stimulatory and immune checkpoint protein. PD-L1 expression in non-small cell lung cancers (NSCLC) is a hallmark of adaptive resistance and its expression is often use...

    Authors: Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi and Shireen Vali
    Citation: BMC Cancer 2018 18:225
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:413

  49. The insulin receptor (INSR) and the insulin growth factor 1 receptor (IGF1R) play important roles in the etiology of both diabetes mellitus and breast cancer. We aimed to evaluate the expression of hormone and...

    Authors: Heleen K. Bronsveld, Marie L. De Bruin, Jelle Wesseling, Joyce Sanders, Ingrid Hofland, Vibeke Jensen, Marloes T. Bazelier, Bas ter Braak, Anthonius de Boer, Peter Vestergaard and Marjanka K. Schmidt
    Citation: BMC Cancer 2018 18:224
    Content type: Research article Published on:

  50. Cancer cell aggregation is a key process involved in the formation of clusters of circulating tumor cells. We previously reported that cell-cell adhesion proteins, such as E-cadherin, and desmosomal proteins a...

    Authors: Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun and Valérie Lobjois
    Citation: BMC Cancer 2018 18:221
    Content type: Research article Published on:

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