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Correction to: Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations

Correction to: BMC Cancer (2018) 18:264

https://doi.org/10.1186/s12885-018-4050-1

Following publication of the original article [1], the authors reported errors in Fig. 3, Fig. 14a, Fig. 18, Fig. 19b, Additional file 3 and Additional file 7. The title of Additional file 9 contains a typing error and is correctly given below.

Fig. 3
figure1

Most active compound (IC50 = 0.2) mapped to all the features

Fig. 14
figure2

a Molecular interaction between the reference- protein (purple). Green dotted lines indicate the hydrogen bonds. The residues are represented in orange stick model

Fig. 18
figure3

Binding mode assessment of compounds. The co-crystal is represented in gray, reference is denoted in green and the Hit in orange. All the three follow the same pattern

Fig. 19
figure4

b Intermolecular interactions between the ligand and the protein. Green dotted lines represent the hydrogen bonds. The protein residues are indicated in cyan

The following typing errors have been identified:

Page noColumn/paragraphlinePresent wordChange to
1Abstract/results2ofabove
21/22CyclicCyclin
22/13VEGFRVEGFR-2
122/13prognosisprogression
122/110formfrom
19Above conclusions4Cyc919Cys919
102/11320 ps20 ns
102/11525 ps25 ns
132/16fourfive
Table 5/ referencevan der Waals interactionsasn900leu1044Asn900, Ile1044
Fig 1030 ps30 ns
Fig 16refrencereference

Further to this, in Table 1, HyP is incorrectly represented as HyB and Hy-Ali as HyAli/HY-Ali. The corrected Table 1 can be found here.

Table 2 Table 1

These corrections do not alter the context of the manuscript.

Reference

  1. 1.

    Rampogu S, et al. Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations. BMC Cancer. 2018;18:264. https://doi.org/10.1186/s12885-018-4050-1.

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Correspondence to Keun Woo Lee.

Supplementary information

Additional file 3.

2D interaction representation of the reference compound and 4AG8. Detailed molecular interactions of the reference compound.

Additional file 7.

2D interaction representation of the reference compound and 1URW. Molecular interaction details of the reference compound.

Additional file 9.

Active sites comparison. Comparison of the active site residues of 4AG8 and 1URW.

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Rampogu, S., Baek, A., Zeb, A. et al. Correction to: Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations. BMC Cancer 19, 1249 (2019). https://doi.org/10.1186/s12885-019-6378-6

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