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  1. Non-small-cell lung cancer (NSCLC) accounts for 85% of all lung cancers and is associated with a poor prognosis. Afatinib is an irreversible ErbB family blocker recommended in clinical guidelines as a first-li...

    Authors: Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu and Kwong Ng
    Citation: BMC Cancer 2018 18:352
    Content type: Research article Published on:

  2. Breast cancer survivors with excess weight are more likely to have negative breast cancer outcomes. Biomarkers related to insulin resistance may help explain this negative association. Weight loss is associate...

    Authors: Kim L. Dittus, Jean R. Harvey, Janice Y. Bunn, Nathan D. Kokinda, Karen M. Wilson, Jeff Priest and Richard E. Pratley
    Citation: BMC Cancer 2018 18:351
    Content type: Research article Published on:

  3. Cervical cancer (CC) is the fourth cause of mortality by neoplasia in women worldwide. The use of immunomarkers is an alternative tool to complement currently used algorithms for detection of cancer, and to im...

    Authors: Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López and Miguel A. Mendoza-Catalán
    Citation: BMC Cancer 2018 18:349
    Content type: Research article Published on:

  5. Innate lymphoid cells (ILC) are part of a heterogeneous family of haematopoietic effector cells which lack re-arranged antigen-specific receptors. They promote host defense and contribute to tissue and metabol...

    Authors: Maryam Salimi, Ruozheng Wang, Xuan Yao, Xi Li, Xiyan Wang, Yuhui Hu, Xumei Chang, Peiwen Fan, Tao Dong and Graham Ogg
    Citation: BMC Cancer 2018 18:341
    Content type: Research article Published on:

  6. The incidence and survival rates for colorectal cancer in Australia are among the highest in the world. With population growth and ageing there are increasing numbers of colorectal cancer survivors in the comm...

    Authors: Jane M. Young, Ivana Durcinoska, Katie DeLoyde and Michael J. Solomon
    Citation: BMC Cancer 2018 18:339
    Content type: Research article Published on:

  7. We conducted a phase I/Ib, open-label, single-arm trial to assess the safety, tolerability and optimal scheduling regimen of OTSGC-A24 cancer vaccine in patients with advanced gastric cancer.

    Authors: Raghav Sundar, Sun Young Rha, Hiroki Yamaue, Masahiro Katsuda, Koji Kono, Hyo Song Kim, Chan Kim, Kousaku Mimura, Ley-Fang Kua and Wei Peng Yong
    Citation: BMC Cancer 2018 18:332
    Content type: Research article Published on:

  8. Cyclooxygenase-2 (COX-2), the inducible COX form, is a bi-functional membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty acid) to form 2-series of prostaglandins known to be...

    Authors: Yi Xu, Xiaoyu Yang, Tao Wang, Liu Yang, Yu-Ying He, Keith Miskimins and Steven Y. Qian
    Citation: BMC Cancer 2018 18:330
    Content type: Research article Published on:

  9. Growth differentiation factor 15 (GDF15) has attracted much interest as a novel biomarker for epithelial ovarian carcinoma (EOC). Research focus has been directed at GDF15 as a diagnostic detection, while the ...

    Authors: Dan Zhao, Xiaobing Wang and Wei Zhang
    Citation: BMC Cancer 2018 18:328
    Content type: Research article Published on:

  10. The prognosis of patients with periampullary adenocarcinoma after pancreatoduodenectomy is diverse and not yet clearly illustrated. The aim of this study was to develop a nomogram to predict individual risk of...

    Authors: Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin and Shengping Li
    Citation: BMC Cancer 2018 18:327
    Content type: Research article Published on:

  11. Recent studies have shown that tumors with extensive tumor-infiltrating lymphocytes (TILs) have a higher probability of pathologic complete response, even in luminal/human epidermal growth factor 2 (HER2)-nega...

    Authors: Sung Gwe Ahn, Yoon Jin Cha, Soon June Bae, Chanik Yoon, Hak Woo Lee and Joon Jeong
    Citation: BMC Cancer 2018 18:320
    Content type: Research article Published on:

  12. Next-generation sequencing (NGS) is an efficient and sensitive method to detect mutations from ctDNA. Many features and clinical conditions could significantly affect the concordance between ctDNA and correspo...

    Authors: Nong Yang, Yi Li, Zhidong Liu, Hao Qin, Duanming Du, Xinkai Cao, Xiaoqing Cao, Jun Li, Dongge Li, Bo Jiang, Lincan Duan, Haiyan Yang, Zhenghua Zhang, Hao Lin, Jianying Li, Zhenhua Yang…
    Citation: BMC Cancer 2018 18:319
    Content type: Research article Published on:

  13. The primary objective was to determine human papilloma virus (HPV) clearance rate after cervical biopsy among women with persistent high-risk HPV infection compared with spontaneous HPV clearance rate in the a...

    Authors: K. U. Petry, J. Horn, A. Luyten and R. T. Mikolajczyk
    Citation: BMC Cancer 2018 18:318
    Content type: Research article Published on:

  14. C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are...

    Authors: Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata and Keiko Nohara
    Citation: BMC Cancer 2018 18:317
    Content type: Research article Published on:

  15. Age is an important prognostic factor in papillary thyroid cancer (PTC), with better survival observed in patients < 45 years of age, regardless of stage. Although the impact of increasing age on PTC-related s...

    Authors: Rondi M. Kauffmann, J. Blair Hamner, Philip H. G. Ituarte and John H. Yim
    Citation: BMC Cancer 2018 18:316
    Content type: Research article Published on:

  16. It is unclear whether germline breast cancer susceptibility gene mutations affect breast cancer related outcomes. We wanted to evaluate mutation patterns in 20 breast cancer susceptibility genes and correlate ...

    Authors: Yong Alison Wang, Jhih-Wei Jian, Chen-Fang Hung, Hung-Pin Peng, Chi-Fan Yang, Hung-Chun Skye Cheng and An-Suei Yang
    Citation: BMC Cancer 2018 18:315
    Content type: Research article Published on:

  17. We report the successful treatment of the patient with osimertinib 80 mg/day following disease progression and a discordance in the detection of a mechanism of resistance epithelial growth factor receptor (EGF...

    Authors: Isa Mambetsariev, Lalit Vora, Kim Wai Yu and Ravi Salgia
    Citation: BMC Cancer 2018 18:314
    Content type: Case report Published on:

  18. Recent studies have reported TIMs play an important role in tumors progression or regression, but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to investigate the prognos...

    Authors: Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu and Jiejie Xu
    Citation: BMC Cancer 2018 18:313
    Content type: Research article Published on:

  19. Typically, women in South Africa (SA) are diagnosed with breast cancer when they self-present with symptoms to health facilities. The aim of this study was to determine the pathway that women follow to breast ...

    Authors: Jennifer Moodley, Lydia Cairncross, Thurandrie Naiker and Deborah Constant
    Citation: BMC Cancer 2018 18:312
    Content type: Research article Published on:

  20. Everolimus was recently approved for the treatment of neuroendocrine tumors. However, its efficacy and tolerability in hemodialysis patients with end-stage renal disease is not established.

    Authors: M. P. Brizzi, A. La Salvia, M. Tampellini, C. Sonetto, M. Volante and G. V. Scagliotti
    Citation: BMC Cancer 2018 18:311
    Content type: Case report Published on:

  21. The VeriStrat test is a serum proteomic signature originally discovered in non-responders to second line gefitinib treatment and subsequently used to predict differential benefit from erlotinib versus chemothe...

    Authors: Mary Jo Fidler, Cristina L. Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi and Jeffrey A. Borgia
    Citation: BMC Cancer 2018 18:310
    Content type: Research article Published on:

  22. Despite the remarkable advances in the early diagnosis and treatment, overall 5-year survival rate of patients with pancreatic cancer is less than 10%. Gemcitabine (GEM), a cytidine nucleoside analogue and rib...

    Authors: Toshinori Ozaki, Meng Yu, Danjing Yin, Dan Sun, Yuyan Zhu, Youquan Bu and Meixiang Sang
    Citation: BMC Cancer 2018 18:309
    Content type: Review article Published on:

  24. Prediction of the outcome of sorafenib therapy using biomarkers is an unmet clinical need in patients with advanced hepatocellular carcinoma (HCC). The aim was to develop and validate a biomarker-based model f...

    Authors: Hwi Young Kim, Dong Hyeon Lee, Jeong-Hoon Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim and Jung-Hwan Yoon
    Citation: BMC Cancer 2018 18:307
    Content type: Research article Published on:

  25. Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR t...

    Authors: Julie A. Lynch, Brygida Berse, Merry Rabb, Paul Mosquin, Rob Chew, Suzanne L. West, Nicole Coomer, Daniel Becker and John Kautter
    Citation: BMC Cancer 2018 18:306
    Content type: Research article Published on:

  27. Liposarcomas are the second most common type of soft tissue sarcomas, 30–50% of these are of myxoid subtype. The aim of this retrospective study was to analyze the local control rate, the metastatic pattern an...

    Authors: Hans Roland Dürr, Jessica Rauh, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson and Alexander Klein
    Citation: BMC Cancer 2018 18:304
    Content type: Research article Published on:

  28. The expression of circular RNA (circRNA) may affect tumor progression. However, there have been no systemic meta-analysis for cancer diagnosis by using circRNAs in clinical till now. Herein, we aimed to collec...

    Authors: Miao Wang, Yuxi Yang, Jian Xu, Wen Bai, Xueli Ren and Huijian Wu
    Citation: BMC Cancer 2018 18:303
    Content type: Research article Published on:

  30. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare.

    Authors: Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone and Maria Abbondanza Pantaleo
    Citation: BMC Cancer 2018 18:301
    Content type: Case report Published on:

  31. Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse pr...

    Authors: Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani and Satoshi Ito
    Citation: BMC Cancer 2018 18:300
    Content type: Case report Published on:

  32. The WHO recognises that community pharmacists are the most accessible healthcare professionals to the general public. Most patients regularly visit community pharmacies for health information and also seek adv...

    Authors: Kofi Boamah Mensah, Frasia Oosthuizen and Adwoa Bemah Bonsu
    Citation: BMC Cancer 2018 18:299
    Content type: Research article Published on:

  33. Cervical cancer is one of the most easily preventable forms of female cancers if early screening and diagnosis is made. Low awareness level about the disease and risk factors, beliefs about the disease, poor a...

    Authors: Yitagesu Habtu, Samuel Yohannes and Tariku Laelago
    Citation: BMC Cancer 2018 18:298
    Content type: Research article Published on:

  34. Colorectal cancer (CRC) is the second most common cause of all cancer deaths in Europe and the Western world with a lifetime risk of approximately 5%. Despite several improvements in the treatment of patients ...

    Authors: Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther and Ulrike Stein
    Citation: BMC Cancer 2018 18:297
    Content type: Study protocol Published on:

  35. In patients with metastatic renal cell cancer, based on limited evidence, increased sunitinib exposure is associated with better outcome. The survival and toxicity data of patients receiving individualized dos...

    Authors: Anikó Maráz, Adrienn Cserháti, Gabriella Uhercsák, Éva Szilágyi, Zoltán Varga, János Révész, Renáta Kószó, Linda Varga and Zsuzsanna Kahán
    Citation: BMC Cancer 2018 18:296
    Content type: Research article Published on:

  36. Trastuzumab (Herceptin® [H]) is the standard of care for HER2-positive locally advanced/metastatic breast cancer and gastric/gastroesophageal junction (GEJ) cancer. However, there is a paucity of data availabl...

    Authors: Volkmar Müller, Michael Clemens, Jacek Jassem, Nedal Al-Sakaff, Petra Auclair, Eveline Nüesch, Debbie Holloway, Mona Shing and Yung-Jue Bang
    Citation: BMC Cancer 2018 18:295
    Content type: Research article Published on:

  38. Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome....

    Authors: Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi and Claudio Bassi
    Citation: BMC Cancer 2018 18:293
    Content type: Debate Published on:

  39. Genetic determinants of breast cancer (BC) remained largely unknown in the majority of Moroccan patients. The purpose of this study was to explore the association of ERCC2 and MTHFR polymorphisms with genetic sus...

    Authors: Hanaa Hardi, Rahma Melki, Zouhour Boughaleb, Tijani El Harroudi, Souria Aissaoui and Noureddine Boukhatem
    Citation: BMC Cancer 2018 18:292
    Content type: Research article Published on:

  40. Thyroid cancer is the most common malignant disease of the endocrine system. Previous studies indicate a rapid increase in the incidence of thyroid cancer in recent decades, and this increase has aroused the g...

    Authors: Lingbin Du, Youqing Wang, Xiaohui Sun, Huizhang Li, Xinwei Geng, Minghua Ge and Yimin Zhu
    Citation: BMC Cancer 2018 18:291
    Content type: Research article Published on:

  41. To compare the prevalence of nephrotoxicity between patients with a solitary-functioning kidney versus those with bilateral-functioning kidneys during the administration of cisplatin-based chemotherapy for adv...

    Authors: Takamitsu Inoue, Jun Miyazaki, Daishi Ichioka, Shintaro Narita, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Yoshiyuki Matsui, Keiko Fujie, Tomonori Habuchi and Hiroyuki Nishiyama
    Citation: BMC Cancer 2018 18:290
    Content type: Research article Published on:

  42. The nomogram of the Barcelona Clinic Liver Cancer (BCLC) for hepatocellular carcinoma (HCC) has been used for outcome prediction. Patients with BCLC stage C HCC often undergo anti-cancer therapy against curren...

    Authors: Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Cheng-Yuan Hsia, Praneeth Kudaravalli, Yun-Hsuan Lee, Yi-You Chiou, Ya-Ju Tsai, Yi-Hsiang Huang and Teh-Ia Huo
    Citation: BMC Cancer 2018 18:289
    Content type: Research article Published on:

  43. Epidemiological studies have clarified the potential associations between regular aspirin use and cancers. However, it remains controversial on whether aspirin use decreases the risk of cancers risks. Therefor...

    Authors: Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong and Zuxun Lu
    Citation: BMC Cancer 2018 18:288
    Content type: Research article Published on:

  44. Renal cell carcinoma (RCC) account for over 80% of renal malignancies. The most common type of RCC can be classified into three subtypes including clear cell, papillary and chromophobe. ccRCC (the Clear Cell R...

    Authors: Peng Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Yang, Shu-Peng Wang and Song Wu
    Citation: BMC Cancer 2018 18:287
    Content type: Research article Published on:

  45. The role of the hypoxia signaling pathway in the pathogenesis of pheochromocytoma/paraganglioma (PPGL)-polycythemia syndrome has been elucidated. Novel somatic mutations in hypoxia-inducible factor type 2A (HIF2A

    Authors: Ying Pang, Garima Gupta, Chunzhang Yang, Herui Wang, Thanh-Truc Huynh, Ziedulla Abdullaev, Svetlana D. Pack, Melanie J. Percy, Terence R. J. Lappin, Zhengping Zhuang and Karel Pacak
    Citation: BMC Cancer 2018 18:286
    Content type: Case report Published on:

  46. An ideal tumor marker should be capable of being detected at any stage of the disease. However, gastric cancer patients do not always have elevated serum carcinoembryonic antigen (CEA) levels, even in advanced...

    Authors: Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura and Yasunari Kawabata
    Citation: BMC Cancer 2018 18:285
    Content type: Research article Published on:

  47. Smurf2 E3 ubiquitin ligase physically associates with and regulate the stability of distinct cellular protein substrates. The multi-functional scaffold protein Connector enhancer of kinase suppressor of ras 2 ...

    Authors: Diana David, Arun Surendran, Jissa V. Thulaseedharan and Asha S. Nair
    Citation: BMC Cancer 2018 18:284
    Content type: Research article Published on:

  48. The intent of this pooled analysis as part of the German society for radiation oncology (DEGRO) stereotactic body radiotherapy (SBRT) initiative was to analyze the patterns of care of SBRT for liver oligometas...

    Authors: N. Andratschke, H. Alheid, M. Allgäuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, S. Gerum, M. Guckenberger, G. Hildebrandt, R. J. Klement, V. Lewitzki, C. Ostheimer, A. Papachristofilou, C. Petersen…
    Citation: BMC Cancer 2018 18:283
    Content type: Research article Published on:

  49. It has been highlighted that the original manuscript [1] contains a typesetting error regarding the authorship.

    Authors: Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A. L. Brown and M. J. Kerin
    Citation: BMC Cancer 2018 18:282
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:203

  50. The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and sum...

    Authors: D. Yao, L. Zhang, P. L. Wu, X. L. Gu, Y. F. Chen, L. X. Wang and X. Y. Huang
    Citation: BMC Cancer 2018 18:281
    Content type: Research article Published on:

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