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  1. The French West-Indies rank first for both prostate cancer incidence and mortality rates. Analyzing diagnostic and therapeutic procedures among patients with prostate cancer, using data from a population-based...

    Authors: Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Jonathan Macni, Thierry Almont, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung and Patrick Escarmant
    Citation: BMC Cancer 2018 18:1130
    Content type: Research article Published on:

  2. Interactions between the protein synthesis inhibitor homoharringtonine (HHT) and the proteasome inhibitor bortezomib were investigated in DLBCL and mantle cell lymphoma cells (MCL).

    Authors: Tri Nguyen, Rebecca Parker, Yu Zhang, Elisa Hawkins, Maciej Kmieciak, William Craun and Steven Grant
    Citation: BMC Cancer 2018 18:1129
    Content type: Research article Published on:

  3. The large-conductance, voltage-gated, calcium (Ca (2+))-activated potassium channel (BKCa) plays an important role in regulating Ca (2+) signaling and cell physiological function, and is aberrantly expressed i...

    Authors: Fenfen Wang, Qin Chen, Genping Huang, Xuedong Guo, Na Li, Yang Li and Baohua Li
    Citation: BMC Cancer 2018 18:1128
    Content type: Research article Published on:

  4. The ZOHé study was a prospective, non-interventional, multicentre study in France to assess the use of biosimilar filgrastim Zarzio® (Sandoz filgrastim) in routine clinical practice in patients at risk of neut...

    Authors: Henri Roché, Jean-Christophe Eymard, Abderraouf Radji, Alain Prevost, Rafik Diab, Michele Lamuraglia, Ravaka-Fatoma Soumoudronga, Isabelle Gasnereau and Alain Toledano
    Citation: BMC Cancer 2018 18:1127
    Content type: Research article Published on:

  5. Trifluridine/tipiracil (TAS-102, Lonsurf®), a novel oral anti-tumor agent combining an anti-neoplastic thymidine-based nucleoside analogue (trifluridine, FTD) with a thymidine phosphorylase inhibitor (tipiraci...

    Authors: Stefan Kasper, Jens Kisro, Martin Fuchs, Christian Müller, Armin Schulz-Abelius, Meinolf Karthaus, Mohammad-Reza Rafiyan and Alexander Stein
    Citation: BMC Cancer 2018 18:1124
    Content type: Research article Published on:

  6. Karyopherin β1 (Kpnβ1) is the main nuclear import protein involved in the transport of cargoes from the cytoplasm into the cell nucleus. Previous research has found Kpnβ1 to be significantly overexpressed in c...

    Authors: Sarah Carden, Pauline van der Watt, Alicia Chi, Aderonke Ajayi-Smith, Katie Hadley and Virna D. Leaner
    Citation: BMC Cancer 2018 18:1123
    Content type: Research article Published on:

  7. Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendoc...

    Authors: Ron Basuroy, Catherine Bouvier, John Keith Ramage, Maia Sissons and Raj Srirajaskanthan
    Citation: BMC Cancer 2018 18:1122
    Content type: Research article Published on:

  8. To compare dual energy CT iodine imaging and standardized iodine concentration before and after chemoradiotherapy (CRT) for esophageal cancer and evaluate the efficacy of CRT for EC by examining DECT iodine ma...

    Authors: Xiaomin Ge, Jingping Yu, Zhongling Wang, Yiqun Xu, Changjie Pan, Lu Jiang, Yanling Yang, Kai Yuan and Wei Liu
    Citation: BMC Cancer 2018 18:1120
    Content type: Research article Published on:

  9. Intracranial germinomas are one of the most radiosensitive tumors and are curable by radiotherapy (RT) alone. RT-only therapy without chemotherapy is effective. But, as patients with germinoma can expect long-...

    Authors: Kihwan Hwang, Kyu Sang Lee, Gheeyoung Choe, Byung-Gyu Cho and Chae-Yong Kim
    Citation: BMC Cancer 2018 18:1119
    Content type: Case report Published on:

  10. Gastric cancer is one of the most common malignant tumors worldwide. With the rapid aging of global population, the number of elderly patients with local advanced gastric cancer is increasing. Surgery is the e...

    Authors: Ziyu Li, Fei Shan, Xiangji Ying, Kan Xue and Jiafu Ji
    Citation: BMC Cancer 2018 18:1118
    Content type: Study protocol Published on:

  11. Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape o...

    Authors: Luca Bertamini, Jacopo Nanni, Giovanni Marconi, Mariachiara Abbenante, Valentina Robustelli, Francesco Bacci, Antonella Matti, Stefania Paolini, Chiara Sartor, Silvia Lo Monaco, Maria Chiara Fontana, Stefano De Polo, Michele Cavo, Antonio Curti, Giovanni Martinelli and Cristina Papayannidis
    Citation: BMC Cancer 2018 18:1117
    Content type: Case report Published on:

  12. With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following c...

    Authors: Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha and Sung Hoon Noh
    Citation: BMC Cancer 2018 18:1116
    Content type: Research article Published on:

  13. Intravascular lymphoma is a rare type of non-Hodgkin lymphoma mostly of B-cell lineage. A few cases of intravascular lymphoma have been found to be of NK/T-cell origin, mainly affecting the skin and central ne...

    Authors: Magda Zanelli, Maria Cecilia Mengoli, Rachele Del Sordo, Angelo Cagini, Loredana De Marco, Edoardo Simonetti, Giovanni Martino, Maurizio Zizzo and Stefano Ascani
    Citation: BMC Cancer 2018 18:1115
    Content type: Case report Published on:

  14. To identify potential therapeutic target in clear cell renal cell carcinoma (ccRCC), we performed a transcriptome analysis. Our analysis showed that fatty acid binding protein 7 (FABP7) has the highest mean di...

    Authors: Kazuhiro Nagao, Nachi Shinohara, Frank Smit, Mirjam de Weijert, Sander Jannink, Yuji Owada, Peter Mulders, Egbert Oosterwijk and Hideyasu Matsuyama
    Citation: BMC Cancer 2018 18:1114
    Content type: Research article Published on:

  15. Cancer has a lot of consequences on patients’ quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients’ partners and their relationship, such as distres...

    Authors: Charlotte Grégoire, Marie-Elisabeth Faymonville, Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Guy Jerusalem and Isabelle Bragard
    Citation: BMC Cancer 2018 18:1113
    Content type: Study protocol Published on:

  16. Sacral chordoma is a locally aggressive malignant tumour originating from ectopic notochordal cells. The natural history of sacral chordoma is a slow growing tumour arising at the midline of the lower sacrum t...

    Authors: Zi Hao Phang, Xue Yi Saw, Noreen Fadzlina Binti Mat Nor, Zolqarnain Bin Ahmad and Sa’adon Bin Ibrahim
    Citation: BMC Cancer 2018 18:1112
    Content type: Case report Published on:

  17. Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-ca...

    Authors: Leila Kaeid Sharaf, Mridul Sharma, Deepika Chandel and Geeta Shukla
    Citation: BMC Cancer 2018 18:1111
    Content type: Research article Published on:

  18. Earlier diagnosis is beneficial for the prognosis of hepatocellular carcinoma (HCC). Alpha fetoprotein (AFP) is the most widely used biomarker for HCC, but its sensitivity and specificity are only 60 and 90%, ...

    Authors: Chenghua Zhang, Ran Xia, Bo Zhang and Haibo Wang
    Citation: BMC Cancer 2018 18:1110
    Content type: Research article Published on:

  19. Various efforts to understand the relationship between biological information and disease have been done using many different types of highthroughput data such as genomics and metabolomics. However, informatio...

    Authors: Jaesik Jeong, Kwangok Seo and Eung-Sam Kim
    Citation: BMC Cancer 2018 18:1109
    Content type: Research article Published on:

  20. To compare the efficacy of low dose (27 mg) Bacillus Calmette-Guérin (BCG) and a full dose (81 mg) BCG immunotherapy for patients with intermediate and high-risk non-muscle invasive bladder cancer (NMIBC) afte...

    Authors: Zongren Wang, Han Xiao, Guangyan Wei, Ning Zhang, Mengchao Wei, Zebin Chen, Zhenwei Peng, Sui Peng, Shaopeng Qiu, Heping Li and Jianting Long
    Citation: BMC Cancer 2018 18:1108
    Content type: Research article Published on:

  21. Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most i...

    Authors: Liyong Zhang, Zhihong Li, Yehai Liu, Shuping Xu, Manuj Tandon, Brittany Appelboom, Courtney R. LaValle, Simion I. Chiosea, Lin Wang, Malabika Sen, Vivian W. Y. Lui, Jennifer R. Grandis and Q. Jane Wang
    Citation: BMC Cancer 2018 18:1107
    Content type: Research article Published on:

  22. RBM3 expression has been suggested as prognostic marker in several cancer types. The purpose of this study was to assess the prevalence and clinical significance of altered RBM3 expression in esophageal cancer.

    Authors: Katharina Grupp, Bianca Hofmann, Asad Kutup, Kai Bachmann, Dean Bogoevski, Nathaniel Melling, Faik Guntac Uzunoglu, Alexander Tarek El Gammal, Christina Koop, Ronald Simon, Stefan Steurer, Till Krech, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter, Jakob Izbicki…
    Citation: BMC Cancer 2018 18:1106
    Content type: Research article Published on:

  23. Cholangiocarcinoma, or bile duct cancer, is a gastrointestinal cancer with limited therapeutic options and a poor outcome. Studies have revealed that some major driver genes are associated with cholangiocarcin...

    Authors: Haibo Mou, Lanfang Yu, Qin Liao, Xuehua Hou, Yinfang Wu, Qiang Cui, Na Yan, Ruobing Ma, Lingjian Wang, Ming Yao and Kai Wang
    Citation: BMC Cancer 2018 18:1105
    Content type: Case report Published on:

  24. Given the high cure-rate for testicular cancer (TC) and the patients’ young age, comprehensive evaluation of health-related quality of life (HRQOL) is an important consideration in this patient population. The...

    Authors: Monika Sztankay, Neil K. Aaronson, Juan I. Arraras, Umberto Basso, Uros Bumbasirevic, Fabio Efficace, Johannes M. Giesinger, Colin D. Johnson, Marieke van Leeuwen, Anne S. Oberguggenberger, Roman Sosnowski, Teresa Young and Bernhard Holzner
    Citation: BMC Cancer 2018 18:1104
    Content type: Research article Published on:

  25. Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various can...

    Authors: Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang and Joon Oh Park
    Citation: BMC Cancer 2018 18:1103
    Content type: Research article Published on:

  26. The modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). The systemic inflammation score (SIS) has been ...

    Authors: Fang Wang, Wenzhuo He, Chang Jiang, Guifang Guo, Bin Ke, Qiangsheng Dai, Jianting Long and Liangping Xia
    Citation: BMC Cancer 2018 18:1102
    Content type: Research article Published on:

  27. Previous studies on cervical cancer reported a worse outcome for adenocarcinoma (AC) compared with squamous cell carcinoma (SCC). Nevertheless, standard treatment remains identical. Insight in the impact of hi...

    Authors: Karen Couvreur, Eline Naert, Emiel De Jaeghere, Philippe Tummers, Amin Makar, Pieter De Visschere, Mieke Van Bockstal, Jo Van Dorpe, Wilfried De Neve, Hannelore Denys and Katrien Vandecasteele
    Citation: BMC Cancer 2018 18:1101
    Content type: Research article Published on:

  28. In acute lymphoblastic leukemia (ALL), the presence of minimal residual disease (MRD) after induction/consolidation chemotherapy is a strong prognostic factor for subsequent relapse and mortality. Accordingly,...

    Authors: Arnaud Pigneux, Pau Montesinos, Ze Cong, Xinke Zhang, Anja K. Pownell, Heather Wieffer, Jan McKendrick and Monika Brüggemann
    Citation: BMC Cancer 2018 18:1100
    Content type: Research article Published on:

  29. To investigate the influence of fibroblast activation protein alpha (FAP) derived from cancer-associated fibroblasts (CAFs), as well as potential mechanism of epithelial mesenchymal transition (EMT), on gastri...

    Authors: Jiuyang Liu, Chaoqun Huang, Chunwei Peng, Fei Xu, Yan Li, Yonemura Yutaka, Bin Xiong and Xiaojun Yang
    Citation: BMC Cancer 2018 18:1099
    Content type: Research article Published on:

  30. Atypical Myeloproliferative Neoplasms (aMPN) share characteristics of MPN and Myelodysplastic Syndromes. Although abnormalities in cytokine signaling are common in MPN, the pathophysiology of atypical MPN stil...

    Authors: Pierre-Yves Dumas, Olivier Mansier, Valerie Prouzet-Mauleon, Junji Koya, Arnaud Villacreces, Philippe Brunet de la Grange, Damien Luque Paz, Audrey Bidet, Jean-Max Pasquet, Vincent Praloran, Franck Salin, Mineo Kurokawa, François-Xavier Mahon, Bruno Cardinaud and Eric Lippert
    Citation: BMC Cancer 2018 18:1098
    Content type: Research article Published on:

  31. Chronic myeloid leukemia can be effectively treated with BCR-ABL1 tyrosine kinase inhibitors. However, BCR-ABL1 mutations can develop and cause secondary resistance to these inhibitors. For each of the availab...

    Authors: Radowan Elnair and Ahmed Galal
    Citation: BMC Cancer 2018 18:1097
    Content type: Case report Published on:

  32. In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression wa...

    Authors: Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Monika Bauden, Yi Jiang and Roland Andersson
    Citation: BMC Cancer 2018 18:1096
    Content type: Research article Published on:

  33. Inter-patient heterogeneity in radiation-induced DNA damage responses is proposed to reflect intrinsic variations in tumour and normal tissue radiation sensitivity, but the prediction of phenotype by a molecul...

    Authors: Kevin Lee Min Chua, Eugenia Li Ling Yeo, Waseem Ahamed Shihabudeen, Sze Huey Tan, Than Than Shwe, Enya Hui Wen Ong, Paula Yeng Po Lam, Khee Chee Soo, Yoke Lim Soong, Kam Weng Fong, Terence Wee Kiat Tan, Joseph Tien Seng Wee and Melvin Lee Kiang Chua
    Citation: BMC Cancer 2018 18:1095
    Content type: Research article Published on:

  34. In patients with locally advanced rectal cancer treated by neoadjuvant chemoradiation, pathological complete response in the surgical specimen is associated with favourable long-term oncologic outcome. Based o...

    Authors: Claudio Belluco, Marco Forlin, Paolo Delrio, Daniela Rega, Maurizio Degiuli, Silvia Sofia, Matteo Olivieri, Salvatore Pucciarelli, Matteo Zuin, Giovanni De Manzoni, Alberto Di Leo, Stefano Scabini, Luigi Zorcolo and Angelo Restivo
    Citation: BMC Cancer 2018 18:1094
    Content type: Research article Published on:

  35. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcin...

    Authors: Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi and Xin Chen
    Citation: BMC Cancer 2018 18:1093
    Content type: Research article Published on:

  36. Development of chemo−/radioresistance is a major challenge for the current prostate cancer (CaP) therapy. We have previously demonstrated that epithelial cell adhesion molecule (EpCAM) is associated with CaP g...

    Authors: Jie Ni, Paul Cozzi, Julia Beretov, Wei Duan, Joseph Bucci, Peter Graham and Yong Li
    Citation: BMC Cancer 2018 18:1092
    Content type: Research article Published on:

  37. Survival rates of lung cancer remains poor and the impact of comorbidities on the prognosis is discussed. The objective of this study was to assess if the Charlson Comorbidity Index (CCI) was associated with 8...

    Authors: A. Seigneurin, P. Delafosse, B. Trétarre, A. S. Woronoff, M. Velten, P. Grosclaude, A. V. Guizard, B. Lapôtre-Ledoux, S. Bara, F. Molinié and M. Colonna
    Citation: BMC Cancer 2018 18:1091
    Content type: Research article Published on:

  38. Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX (PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be hypo...

    Authors: Daniel Riani Gotardelo, Lilia Coronato Courrol, Maria Helena Bellini, Flávia Rodrigues de Oliveira Silva and Carlos Roberto Jorge Soares
    Citation: BMC Cancer 2018 18:1090
    Content type: Research article Published on:

  39. This study aims to establish a radiomics analysis system for the diagnosis and clinical behaviour prediction of hepatocellular carcinoma (HCC) based on multi-parametric ultrasound imaging.

    Authors: Zhao Yao, Yi Dong, Guoqing Wu, Qi Zhang, Daohui Yang, Jin-Hua Yu and Wen-Ping Wang
    Citation: BMC Cancer 2018 18:1089
    Content type: Research article Published on:

  40. We conducted a meta-analysis to evaluate the relationship between the glutathione S-transferase μ1 (GSTM1)– and glutathione S-transferase θ1 (GSTT1)– null genotypes and susceptibility to bladder cancer.

    Authors: Tianbiao Zhou, Hong-Yan Li, Wei-Ji Xie, Zhiqing Zhong, Hongzhen Zhong and Zhi-Jun Lin
    Citation: BMC Cancer 2018 18:1088
    Content type: Research article Published on:

  41. Colorectal cancer (CRC) is the most common type of gastrointestinal cancer. CRC gene therapy mediated by adenovirus holds great promise for the treatment of malignancies. However, intravenous delivery of adeno...

    Authors: Fang-Rui Liu, Shuang Bai, Qiang Feng, Xin-Yan Pan, Shu-Ling Song, Hong Fang, Jing Cui and Ju-Lun Yang
    Citation: BMC Cancer 2018 18:1087
    Content type: Research article Published on:

  43. Invasive micropapillary carcinoma (IMPC) is an unusual and distinct subtype of invasive breast tumor with high propensity for regional lymph node metastases. This study was to identify risk factors accounting ...

    Authors: Fu-Gui Ye, Chen Xia, Ding Ma, Pei-Yang Lin, Xin Hu and Zhi-Ming Shao
    Citation: BMC Cancer 2018 18:1085
    Content type: Research article Published on:

  44. An increasing number of studies have identified spatial differences in colorectal cancer survival. However, little is known about the spatially varying effects of predictors in survival prediction modeling stu...

    Authors: Yu Tian, Jun Li, Tianshu Zhou, Danyang Tong, Shengqiang Chi, Xiangxing Kong, Kefeng Ding and Jingsong Li
    Citation: BMC Cancer 2018 18:1084
    Content type: Research article Published on:

  46. Recent breakthroughs in targeted therapy and immunotherapy have revolutionized the treatment of lung cancer, the leading cause of cancer-related deaths in the United States and worldwide. Here we provide an ov...

    Authors: Xingxiang Pu, Lin Wu, Dan Su, Weimin Mao and Bingliang Fang
    Citation: BMC Cancer 2018 18:1082
    Content type: Review Published on:

  47. Utility weight, a measure of health-related quality of life, is used in disease burden measurements and economic evaluations. In this study, we used the visual analogue scale (VAS) and standard gamble (SG) met...

    Authors: Eun-Jung Kim, Minsu Ock, Kyu-pyo Kim, Nuri Hyun Jung, Hyeon-Jeong Lee, Seon-Ha Kim and Min-Woo Jo
    Citation: BMC Cancer 2018 18:1081
    Content type: Research article Published on:

  48. The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who ...

    Authors: Seong Eun Kim, Younggon Jung, Tae Hoon Oh, Uh Jin Kim, Seung-Ji Kang, Hee-Chang Jang, Kyung-Hwa Park, Kyung-Hwa Lee and Sook In Jung
    Citation: BMC Cancer 2018 18:1080
    Content type: Case report Published on:

  49. Breast and cervical cancers represent a significant cause of morbidity and mortality among women. The purpose of this study was to analyse the survival and time trends in two of the most common female cancers ...

    Authors: Allini Mafra da Costa, Dana Hashim, José Humberto Tavares Guerreiro Fregnani and Elisabete Weiderpass
    Citation: BMC Cancer 2018 18:1079
    Content type: Research article Published on:

  50. The role of carcinoembryonic antigen (CEA) change patterns in tumor response and long-term outcome is unclear. This study aimed to investigate the correlation between changes in CEA levels and tumor response a...

    Authors: Ping Yu, Mingyi Zhou, Jinglei Qu, Lingyu Fu, Xuedan Li, Ruimei Cai, Bo Jin, Yuee Teng, Jing Liu, Jing Shi and Jingdong Zhang
    Citation: BMC Cancer 2018 18:1076
    Content type: Research article Published on:

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