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  1. NSCLC patients with EGFR mutation were at a higher incidence of developing brain metastasis (BM). Patients with BM are associated with high mortality. Reducing BM incidence becomes increasingly significant for...

    Authors: Wen Ouyang, Jing Yu, Yan Zhou, Jing Hu, Zhao huang, Junhong Zhang and Conghua Xie
    Citation: BMC Cancer 2020 20:699
    Content type: Research article Published on:

  2. The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look f...

    Authors: Vanina D. Heuser, Aida Kiviniemi, Laura Lehtinen, Sune Munthe, Bjarne Winther Kristensen, Jussi P. Posti, Jussi O. T. Sipilä, Ville Vuorinen, Olli Carpén and Maria Gardberg
    Citation: BMC Cancer 2020 20:710
    Content type: Research article Published on:

  3. It has previously been shown that bevacizumab, when added to chemotherapy, improved overall survival in several cancers. In glioblastoma multiforme (GBM), bevacizumab increased progression-free survival and it...

    Authors: Chiung-Chyi Shen, Wen-Yu Cheng, Chung-Hsin Lee, Xue-Jun Dai, Ming-Tsang Chiao, Yea-Jiuen Liang, Wan-Yu Hsieh, Tsuo-Fei Mao, Guo-Shi Lin, Shou-Ren Chen, Bai-Shuan Liu and Jun-Peng Chen
    Citation: BMC Cancer 2020 20:709
    Content type: Research article Published on:

  4. Studying entire dietary patterns is a promising alternative approach to overcome limitations of the single food or nutrient approach. We evaluated the relationship between the scores of 4 established Dietary A...

    Authors: Zeinab Heidari, Elahe Mohammadi, Vahideh Aghamohammadi, Saba Jalali, Arezoo Rezazadeh, Fatemeh Sedaghat, Mojan Assadi and Bahram Rashidkhani
    Citation: BMC Cancer 2020 20:708
    Content type: Research article Published on:

  5. A number of studies have reported hyperprogressive disease (HPD) in non-small cell lung cancer (NSCLC) after treatment with immune checkpoint inhibitor (ICI). This study aimed to summarize the incidence and su...

    Authors: Yan Chen, Junjie Hu, Fangfang Bu, Haiping Zhang, Ke Fei and Peng Zhang
    Citation: BMC Cancer 2020 20:707
    Content type: Research article Published on:

  6. Cervical cancer is the second leading type of female cancer in Ethiopia. Screening for cervical cancer is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) is n...

    Authors: Getnet Tesfaw, Yesuf Ahmed, Lealem Gedefaw, Lamessa Dube, Samson Godu, Kirubel Eshetu, Mesfin Nigussie, Haftamu Hailekiros, Moses Joloba, Gelila Goba and Alemseged Abdissa
    Citation: BMC Cancer 2020 20:706
    Content type: Research article Published on:

  7. This study aimed to comprehensively investigate the effect of spread through air spaces (STAS) on clinicopathologic features, molecular characteristics, immunohistochemical expression, and prognosis in lung ad...

    Authors: Meng Jia, Shili Yu, Jiaqi Yu, Yuemin Li, Hongwen Gao and Ping-Li Sun
    Citation: BMC Cancer 2020 20:705
    Content type: Research article Published on:

  8. The insulin-like growth factor 1 receptor (IGF1R) is suspected to be involved in colorectal carcinogenesis and has been associated with worse survival in colorectal cancer (CRC). We hypothesized that the alleg...

    Authors: Steffen M. Heckl, Marie Pellinghaus, Hans-Michael Behrens, Sandra Krüger, Stefan Schreiber and Christoph Röcken
    Citation: BMC Cancer 2020 20:704
    Content type: Research article Published on:

  9. Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the on...

    Authors: Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger and Tilman D. Rachner
    Citation: BMC Cancer 2020 20:703
    Content type: Research article Published on:

  10. Craniospinal irradiation (CSI) of childhood tumors with the RapidArc technique is a new method of treatment. Our objective was to compare the acute hematological toxicity pattern during 3D conformal radiothera...

    Authors: Zoltán Lőcsei, Róbert Farkas, Kornélia Borbásné Farkas, Klára Sebestyén, Zsolt Sebestyén, Zoltán Musch, Ágnes Vojcek, Noémi Benedek, László Mangel and Gábor Ottóffy
    Citation: BMC Cancer 2020 20:702
    Content type: Research article Published on:

  11. For loco-regionally advanced, but transorally resectable oropharyngeal cancer (OPSCC), the current standard of care includes surgical resection and risk-adapted adjuvant (chemo) radiotherapy, or definite chemo...

    Authors: Lara Bußmann, Simon Laban, Claus Wittekindt, Carmen Stromberger, Silke Tribius, Nikolaus Möckelmann, Arne Böttcher, Christian Stephan Betz, Jens Peter Klussmann, Volker Budach, Adrian Muenscher and Chia-Jung Busch
    Citation: BMC Cancer 2020 20:701
    Content type: Study protocol Published on:

  12. Advanced stage operable cancers of larynx are treated with total laryngectomy including thyroid resection in most of the cases, which may expose patient to hypothyroidism and hypoparathyroidism. The requiremen...

    Authors: Surendra Singh Baghel, Pawan Singhal, Namita Verma, Ritu Sehra, Rajeev Yadav, Sunita Agarwal, Man Prakash Sharma and D. P. Gupta
    Citation: BMC Cancer 2020 20:700
    Content type: Research article Published on:

  13. The end of active treatment is a period of high stress for young people with cancer, but limited literature exists about their information and support needs during this phase. This study aimed to understand th...

    Authors: Sarah Lea, Ana Martins, Lorna A. Fern, Matthew Bassett, Maria Cable, Gary Doig, Sue Morgan, Louise Soanes, Michael Whelan and Rachel M. Taylor
    Citation: BMC Cancer 2020 20:697
    Content type: Research article Published on:

  14. Between 30 and 50% of colon tumors have mutations in the Kirsten-ras (KRAS) gene, which have a large nutritional attributable risk. Despite its high frequency in colorectal cancer (CRC), data to support specific ...

    Authors: Achraf El Asri, Btissame Zarrouq, Khaoula El Kinany, Laila Bouguenouch, Karim Ouldim and Karima El Rhazi
    Citation: BMC Cancer 2020 20:696
    Content type: Review Published on:

  15. The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic mode...

    Authors: Cheng Peng, Natalie DuPre, Trang VoPham, Yujing J. Heng, Gabrielle M. Baker, Christopher A. Rubadue, Kimberly Glass, Abhijeet Sonawane, Oana Zeleznik, Peter Kraft, Susan E. Hankinson, A. Heather Eliassen, Jaime E. Hart, Francine Laden and Rulla M. Tamimi
    Citation: BMC Cancer 2020 20:695
    Content type: Research article Published on:

  16. Early diagnosis and continuous monitoring are necessary for an efficient management of cervical cancers (CC). Liquid biopsy, such as detecting circulating tumor DNA (ctDNA) from blood, is a simple, non-invasiv...

    Authors: Sun-Young Lee, Dong-Kyu Chae, Sung-Hun Lee, Yohan Lim, Jahyun An, Chang Hoon Chae, Byung Chul Kim, Jong Bhak, Dan Bolser and Dong-Hyu Cho
    Citation: BMC Cancer 2020 20:694
    Content type: Research article Published on:

  17. To identify modifiable risk factors that contribute to cancer holds important public health relevance for setting up prevention strategies. Therefore, the aim of this study was to estimate the proportion of ca...

    Authors: Leandro F. M. Rezende, Eliana Murata, Beatriz Giannichi, Luciana Yuki Tomita, Gabriela Arantes Wagner, Zila M. Sanchez, Carlos Celis-Morales and Gerson Ferrari
    Citation: BMC Cancer 2020 20:693
    Content type: Research article Published on:

  18. Differential DNA methylation panel derived from peripheral blood could serve as biomarkers of CRC susceptibility. However, most of the previous studies utilized post-diagnostic blood DNA which may be markers o...

    Authors: Justina Ucheojor Onwuka, Dapeng Li, Yupeng Liu, Hao Huang, Jing Xu, Ying Liu, Yuanyuan Zhang and Yashuang Zhao
    Citation: BMC Cancer 2020 20:692
    Content type: Research article Published on:

  19. Previous studies have shown that fibrinogen-to-albumin ratio (FAR) is a novel prognostic immune biomarker in various diseases. In this study, we investigated the role of FAR in the prognosis of patients with s...

    Authors: Qiang An, Wei Liu, Yujia Yang and Bing Yang
    Citation: BMC Cancer 2020 20:691
    Content type: Research article Published on:

  20. This study profiled the somatic genes mutations and the copy number variations (CNVs) in cerebrospinal fluid (CSF)-circulating tumor DNA (ctDNA) from patients with neoplastic meningitis (NM).

    Authors: Yue Zhao, Jun Ying He, Jun Zhao Cui, Zi-Qi Meng, Yue Li Zou, Xiao Su Guo, Xin Chen, Xueliang Wang, Li-Tian Yan, Wei Xin Han, Chunyan Li, Li Guo and Hui Bu
    Citation: BMC Cancer 2020 20:690
    Content type: Research article Published on:

  22. Although surgery is the definitive curative treatment for biliary tract cancer (BTC), outcomes after surgery alone have not been satisfactory. Adjuvant therapy with S-1 may improve survival in patients with BT...

    Authors: Osamu Itano, Yusuke Takemura, Norihiro Kishida, Eiji Tamagawa, Hiroharu Shinozaki, Ken Ikeda, Hidejiro Urakami, Shigenori Ei, Shigeo Hayatsu, Keiichi Suzuki, Tadayuki Sakuragawa, Masatsugu Ishii, Masaya Shito, Koichi Aiura, Hiroto Fujisaki, Kiminori Takano…
    Citation: BMC Cancer 2020 20:688
    Content type: Research article Published on:

  23. First-line treatment with FOLFOXIRI plus bevacizumab (BEV) is highly effective and regarded as one of the standards-of-care for patients with metastatic colorectal cancer (mCRC), despite the high incidence of ...

    Authors: Masaaki Miyo, Takeshi Kato, Takayuki Yoshino, Takeharu Yamanaka, Hideaki Bando, Hironaga Satake, Kentaro Yamazaki, Hiroya Taniguchi, Eiji Oki, Masahito Kotaka, Koji Oba, Yoshinori Miyata, Kei Muro, Yoshito Komatsu, Hideo Baba and Akihito Tsuji
    Citation: BMC Cancer 2020 20:687
    Content type: Study protocol Published on:

  24. In this study, we examined the differential associations of various proinflammatory and anti-inflammatory cytokines with depression severity from the development of breast cancer to subsequent chemotherapy tre...

    Authors: Bor-Show Tzang, Vincent Chin-Hung Chen, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Hsing-Ying Ho, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng and Yi-Lung Chen
    Citation: BMC Cancer 2020 20:686
    Content type: Research article Published on:

  25. Colorectal cancer (CRC) is a heterogeneous tumor having various genetic alterations. The current treatment options had limited impact on disease free survival due to therapeutic resistance. Novel anticancer ag...

    Authors: Khayal Al-Khayal, Mansoor-Ali Vaali-Mohammed, Mohammed Elwatidy, Thamer Bin Traiki, Omar Al-Obeed, Mohammad Azam, Zahid Khan, Maha Abdulla and Rehan Ahmad
    Citation: BMC Cancer 2020 20:685
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:834

  26. Nivolumab has changed the treatment of advanced gastric cancer (AGC). Nivolumab shows better outcomes compared to best supportive care among AGC patients who received at least two prior regimens. However, ther...

    Authors: Toshihiko Matsumoto, Yosuke Yamamoto, Yusuke Kuriona, Ukyo Okazaki, Shogo Kimura, Kou Miura, Takao Tsuduki, Takanori Watanabe, Yusuke Mastumoto and Masahiro Takatani
    Citation: BMC Cancer 2020 20:684
    Content type: Research article Published on:

  27. Immune checkpoint inhibitors (ICIs) reported remarkable achievements in several solid tumours. However, in metastatic colorectal cancer (mCRC) promising results are limited to patients with deficient mismatch ...

    Authors: Carlotta Antoniotti, Beatrice Borelli, Daniele Rossini, Filippo Pietrantonio, Federica Morano, Lisa Salvatore, Sara Lonardi, Federica Marmorino, Stefano Tamberi, Salvatore Corallo, Giampaolo Tortora, Francesca Bergamo, Di Stefano Brunella, Alessandra Boccaccino, Elisa Grassi, Patrizia Racca…
    Citation: BMC Cancer 2020 20:683
    Content type: Study protocol Published on:

  28. Long intergenic non-coding RNA 00511 (LINC00511) is highly expressed in diverse cancers and has a correlation with poor clinical outcomes for cancer patients. In view of contradictory data among published data...

    Authors: Yannick Luther Agbana, Manzama-Esso Abi, Yueli Ni, Guohang Xiong, Jing Chen, Fang Yun, Zihan Yi, Qiao Zhang, Zhe Yang, Yingmin Kuang and Yuechun Zhu
    Citation: BMC Cancer 2020 20:682
    Content type: Research article Published on:

  29. Iron is required for cellular metabolism, and rapidly proliferating cancer cells require more of this essential nutrient. Therefore, iron regulation may well represent a new avenue for cancer therapy. We have ...

    Authors: Shogo Amano, Seiji Kaino, Shuhei Shinoda, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida
    Citation: BMC Cancer 2020 20:681
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:582

  30. There is international interest in risk-stratification of breast screening programmes to allow women at higher risk to benefit from more frequent screening and chemoprevention. Risk-stratification also identif...

    Authors: Lorna McWilliams, Victoria G. Woof, Louise S. Donnelly, Anthony Howell, D. Gareth Evans and David P. French
    Citation: BMC Cancer 2020 20:680
    Content type: Research article Published on:

  31. The incidence of anal squamous cell carcinoma (SCC) has been steadily growing globally in the past decade. Clinical data on anal SCC from China are rare. We conducted this study to describe the clinical and ep...

    Authors: Yong Lu, Xiaohao Wang, Peiyang Li, Tao Zhang, Jiaming Zhou, Yufeng Ren, Yi Ding, Haihua Peng, Qichun Wei, Kaiyun You, Jason J. Ong, Christopher K. Fairley, Andrew E. Grulich, Meijin Huang, Yuanhong Gao and Huachun Zou
    Citation: BMC Cancer 2020 20:679
    Content type: Research article Published on:

  33. For patients with mid and distal rectal cancer, robust evidence on long-term outcome and causal treatment effects of transanal total mesorectal excision (TaTME) is lacking. This multicentre retrospective cohor...

    Authors: F. B. de Lacy, S. X. Roodbeen, J. Ríos, J. van Laarhoven, A. Otero-Piñeiro, R. Bravo, T. Visser, R. van Poppel, S. Valverde, R. Hompes, C. Sietses, A. Castells, W. A. Bemelman, P. J. Tanis and A. M. Lacy
    Citation: BMC Cancer 2020 20:677
    Content type: Research article Published on:

  34. Estrogen receptor (ER) positive breast cancer is often effectively treated with drugs that inhibit ER signaling, i.e., tamoxifen (TAM) and aromatase inhibitors (AIs). However, 30% of ER+ breast cancer patients...

    Authors: Maryam Soleimani Dodaran, Simone Borgoni, Emre Sofyalı, Pernette J. Verschure, Stefan Wiemann, Perry D. Moerland and Antoine H. C. van Kampen
    Citation: BMC Cancer 2020 20:676
    Content type: Research article Published on:

  35. Breast cancer clinical management requires the assessment of hormone receptors (estrogen (ER) and progesterone receptor (PR)), human epidermal growth factor receptor 2 (HER2) and cellular proliferation index K...

    Authors: Laura Rey-Vargas, Juan Carlos Mejía-Henao, María Carolina Sanabria-Salas and Silvia J. Serrano-Gomez
    Citation: BMC Cancer 2020 20:675
    Content type: Research article Published on:

  38. ALDH1A3 is a cancer stem cell marker in neoplasms including glioblastoma (GBM). However, the comprehensive role of ALDH1A3 in GBM remains unclear. This study attempted to investigate the expression of ALDH1A3 ...

    Authors: Chao Gan, Daniela Pierscianek, Nicolai El Hindy, Yahya Ahmadipour, Kathy Keyvani, Ulrich Sure and Yuan Zhu
    Citation: BMC Cancer 2020 20:672
    Content type: Research article Published on:

  39. To investigate whether there is a distinct difference in prognosis between hepatoid adenocarcinoma of the stomach (HAS) and non-hepatoid adenocarcinoma of the stomach (non-HAS) and whether HAS can benefit from...

    Authors: Kai Zhou, Anqiang Wang, Sheng Ao, Jiahui Chen, Ke Ji, Qifei He, Xin Ji, Xiaojiang Wu, Ji Zhang, Zhongwu Li, Zhaode Bu and Jiafu Ji
    Citation: BMC Cancer 2020 20:671
    Content type: Research article Published on:

  40. Patients with metastatic renal cell carcinoma (mRCC) treated with targeted systemic therapies have demonstrated favourable outcomes in randomised controlled trials, however real-world evidence is limited. Thus...

    Authors: Robert Hawkins, Kate Fife, Michael Hurst, Meng Wang, Niroshini Naicker, Sarah Nolasco, Tim Eisen, Athena Matakidou and Jason Gordon
    Citation: BMC Cancer 2020 20:670
    Content type: Research article Published on:

  41. Few studies have been designed to evaluate the short-term outcomes between robotic-assisted total gastrectomy (RATG) and laparoscopy-assisted total gastrectomy (LATG) for advanced gastric cancer (AGC). The pur...

    Authors: Changdong Yang, Yan Shi, Shaohui Xie, Jun Chen, Yongliang Zhao, Feng Qian, Yingxue Hao, Bo Tang and Peiwu Yu
    Citation: BMC Cancer 2020 20:669
    Content type: Research article Published on:

  42. As one of the most common cancers with high mortality in the world, we are still facing a huge challenge in the prevention and treatment of colon cancer. With the rapid development of high throughput technolog...

    Authors: Fuyan Hu, Qing Wang, Zhiyuan Yang, Zeng Zhang and Xiaoping Liu
    Citation: BMC Cancer 2020 20:668
    Content type: Research article Published on:

  43. Lymph node metastasis in the cervical region posterior to level V (PLV) can occurs in patients with nasopharyngeal carcinoma (NPC), but the significance of lymph node metastasis in this region and the delineat...

    Authors: Chaoyang Jiang, Hui Gao, Ling Zhang, Hua Li, Tao Zhang, Ji Ma and Bisheng Liu
    Citation: BMC Cancer 2020 20:667
    Content type: Research article Published on:

  44. This study aimed to establish a novel nomogram prognostic model to predict death probability for non-small cell lung cancer (NSCLC) patients who received surgery..

    Authors: Bo Jia, Qiwen Zheng, Jingjing Wang, Hongyan Sun, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Minglei Zhuo, Jianjie Li, Xue Yang, Jia Zhong, Hanxiao Chen, Yujia Chi, Xiaoyu Zhai and Ziping Wang
    Citation: BMC Cancer 2020 20:666
    Content type: Research article Published on:

  45. Based on its low toxicity, arginine starvation therapy has the potential to cure malignant tumors that cannot be treated surgically. The Arginine deiminase (ADI) gene has been identified to be an ideal cancer-...

    Authors: Qingyuan Feng, Xuzhao Bian, Xuan Liu, Ying Wang, Huiting Zhou, Xiaojing Ma, Chunju Quan, Yi Yao and Zhongliang Zheng
    Citation: BMC Cancer 2020 20:665
    Content type: Research article Published on:

  46. To compare adenocarcinoma (AC) and adenosquamous carcinoma (ASC) prognoses in patients with FIGO stage IB–IIA cervical cancer who underwent radical hysterectomy.

    Authors: Xiaojing Zhang, Zunfu Lv, Xiaoxian Xu, Zhuomin Yin and Hanmei Lou
    Citation: BMC Cancer 2020 20:664
    Content type: Research article Published on:

  47. Toremifene (TOR) is a selective oestrogen receptor modulator (SERM) and has comparable efficacy to that of tamoxifen (TAM) in breast cancer patients. Herein, we compared the safety of TOR to that of TAM in the...

    Authors: Jin Hong, Jiahui Huang, Lili Shen, Siji Zhu, Weiqi Gao, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen
    Citation: BMC Cancer 2020 20:663
    Content type: Research article Published on:

  48. Recent studies have highlighted the important role of long non-coding RNA SNHG16 in various human cancers. Here, we conducted a meta-analysis to investigate the effect of SNHG16 expression on clinicopathologic...

    Authors: Ruonan Jiao, Wei Jiang, Xin Wei, Mengpei Zhang, Si Zhao and Guangming Huang
    Citation: BMC Cancer 2020 20:662
    Content type: Research article Published on:

  49. Tumors are heterogeneous in nature, composed of different cell populations with various mutations and/or phenotypes. Using a single drug to encounter cancer progression is generally ineffective. To improve the...

    Authors: Vanessa Bellat, Alice Verchère, Sally A. Ashe and Benedict Law
    Citation: BMC Cancer 2020 20:661
    Content type: Research article Published on:

  50. LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women.

    Authors: Yi Zheng, Meng Wang, Shuqian Wang, Peng Xu, Yujiao Deng, Shuai Lin, Na Li, Kang Liu, Yuyao Zhu, Zhen Zhai, Ying Wu, Zhijun Dai and Gaixia Zhu
    Citation: BMC Cancer 2020 20:659
    Content type: Research article Published on:

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