Yang HH, Hu N, Wang C, Ding T, Dunn BK, Goldstein AM, Taylor PR, Lee MP. Influence of genetic background and tissue types on global DNA methylation patterns. PLoS One. 2010;5(2):–e9355.
Cadieux B, Ching T-T, VandenBerg SR, Costello JF. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, Methylenetetrahydrofolate Reductase allele status, and increased proliferation. Cancer Res. 2006;66(17):8469–76.
Article
CAS
PubMed
Google Scholar
Cartron P-F, Hervouet E, Debien E, Olivier C, Pouliquen D, Menanteau J, Loussouarn D, A. Martin S, Campone M, Vallette FM: Folate supplementation limits the tumourigenesis in rodent models of gliomagenesis. Eur J Cancer 2012, 48(15):2431–2441.
Martinez R, Esteller M. The DNA methylome of glioblastoma multiforme. Neurobiol Dis. 2010;39(1):40–6.
Article
CAS
PubMed
Google Scholar
Körber V, Yang J, Barah P, Wu Y, Stichel D, Gu Z, Fletcher MNC, Jones D, Hentschel B, Lamszus K, et al. Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis. Cancer Cell. 2019;35(4):692–704 e612.
Article
PubMed
CAS
Google Scholar
Nishi N, Kawai S, Yonezawa T, Fujimoto K, Masui K. Early appearance of high grade glioma on magnetic resonance imaging. Neurol Med Chir. 2009;49(1):8–12.
Article
Google Scholar
Young RM, Jamshidi A, Davis G, Sherman JH. Current trends in the surgical management and treatment of adult glioblastoma. Ann Transl Med. 2015;3(9):121.
PubMed
PubMed Central
Google Scholar
Landy HJ, Lee TT, Potter P, Feun L, Markoe A. Early MRI findings in high grade glioma. J Neuro-Oncol. 2000;47(1):65–72.
Article
CAS
Google Scholar
Chang K, Zhang B, Guo X, Zong M, Rahman R, Sanchez D, Winder N, Reardon DA, Zhao B, Wen PY, et al. Multimodal imaging patterns predict survival in recurrent glioblastoma patients treated with bevacizumab. Neurooncology. 2016;18(12):1680–7.
CAS
Google Scholar
Delgado-López PD, Corrales-García EM. Survival in glioblastoma: a review on the impact of treatment modalities. Clin Transl Oncol. 2016;18(11):1062–71.
Article
PubMed
CAS
Google Scholar
Rajesh Y, Pal I, Banik P, Chakraborty S, Borkar SA, Dey G, Mukherjee A, Mandal M. Insights into molecular therapy of glioma: current challenges and next generation blueprint. Acta Pharmacol Sin. 2017;38(5):591–613.
Article
CAS
PubMed
PubMed Central
Google Scholar
Iwamoto F, Abrey L, Beal K, Gutin P, Rosenblum M, Reuter V, DeAngelis L, Lassman A. Patterns of relapse and prognosis after bevacizumab failure in recurrent glioblastoma. Neurology. 2009;73(15):1200–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lemée J-M, Clavreul A, Menei P. Intratumoral heterogeneity in glioblastoma: don't forget the peritumoral brain zone. Neurooncology. 2015;17(10):1322–32.
Google Scholar
Peppicelli S, Andreucci E, Ruzzolini J, Laurenzana A, Margheri F, Fibbi G, Del Rosso M, Bianchini F, Calorini L. The acidic microenvironment as a possible niche of dormant tumor cells. Cell Mol Life Sci. 2017;74(15):2761–71.
Article
CAS
PubMed
Google Scholar
Qazi MA, Vora P, Venugopal C, Sidhu SS, Moffat J, Swanton C, Singh SK. Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma. Ann Oncol. 2017;28(7):1448–56.
Article
CAS
PubMed
Google Scholar
Da Fonseca C, Teixeira RM, Silva JC, Fischer JS, Meirelles OC, Landeiro JA, Quirico-Santos T. Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. Anticancer Res. 2013;33(12):5625–31.
Google Scholar
da Fonseca CO, Simao M, Lins IR, Caetano RO, Futuro D, Quirico-Santos T. Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. J Cancer Res Clin Oncol. 2011;137(2):287–93.
Article
PubMed
CAS
Google Scholar
da Fonseca CO, Schwartsmann G, Fischer J, Nagel J, Futuro D, Quirico-Santos T, Gattass CR. Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. Surg Neurol. 2008;70(3):259–66 discussion 266-257.
Article
PubMed
Google Scholar
Gomes AC, Mello AL, Ribeiro MG, Garcia DG, Da Fonseca CO, Salazar MDA, Schönthal AH, Quirico-Santos T. Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals. Arch Immunol Ther Exp. 2017;65(4):285–97.
Article
CAS
Google Scholar
Loutrari H, Hatziapostolou M, Skouridou V, Papadimitriou E, Roussos C, Kolisis FN, Papapetropoulos A. Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther. 2004;311(2):568–75.
Article
CAS
PubMed
Google Scholar
Pavlova NN, Thompson CB. The emerging hallamarks of cancer metabolism. Cell Metab. 2016;23(1):27–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Carlsson SK, Brothers SP, Wahlestedt C. Emerging treatment strategies for glioblastoma multiforme. EMBO Mol Med. 2014;6(11):1359–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cheng T-YD, Makar KW, Neuhouser ML, Miller JW, Song X, Brown EC, Beresford SAA, Zheng Y, Poole EM, Galbraith RL, et al. Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative observational study. Cancer. 2015;121(20):3684–91.
Article
CAS
PubMed
Google Scholar
Kinnaird A, Zhao S, Wellen KE, Michelakis ED. Metabolic control of epigenetics in cancer. Nat Rev Cancer. 2016;16:694.
Article
CAS
PubMed
Google Scholar
Newman AC, Maddocks ODK. One-carbon metabolism in cancer. Br J Cancer. 2017;116(12):1499–504.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alexander BM, Cloughesy TF. Adult Glioblastoma. J Clin Oncol. 2017;35(21):2402–9.
Article
CAS
PubMed
Google Scholar
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuve LP, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111–3.
Article
CAS
PubMed
Google Scholar
Raichle ME. The restless brain: how intrinsic activity organizes brain function. Philos Trans R Soc Lond B Biol Sci. 2015;370(1668):20140172.
Article
PubMed
PubMed Central
Google Scholar
Faria G, Silva E, Da Fonseca C, Quirico-Santos T. Circulating cell-free DNA as a prognostic and molecular marker for patients with brain tumors under perillyl alcohol-based therapy. Int J Mol Sci. 2018;19(6):1610.
Article
PubMed Central
CAS
Google Scholar
Wang J, Bettegowda C. Applications of DNA-based liquid biopsy for central nervous system neoplasms. J Mol Diagn. 2017;19(1):24–34.
Article
CAS
PubMed
Google Scholar
Zukiel R, Nowak S, Barciszewska A-M, Gawronska I, Keith G, Barciszewska MZ. A simple epigenetic method for the diagnosis and classification of brain Tumors11Polish Committee of Scientific Research Project (M. Barciszewska). Mol Cancer Res. 2004;2(3):196–202.
CAS
PubMed
Google Scholar
Jones MJ, Goodman SJ, Kobor MS. DNA methylation and healthy human aging. Aging Cell. 2015;14(6):924–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Parker NR, Hudson AL, Khong P, Parkinson JF, Dwight T, Ikin RJ, Zhu Y, Cheng ZJ, Vafaee F, Chen J. Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma. Sci Rep. 2016;6:22477.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mutchinick OM, MaA L, Luna L, Waxman J, Babinsky VE, Group RC. High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab. 1999;68(4):461–7.
Article
CAS
PubMed
Google Scholar
Sullivan GM, Feinn R. Using effect size—or why the P value is not enough. J Graduate Med Educ. 2012;4(3):279–82.
Article
Google Scholar
Lenhard WL, A. Calculation of effect sizes. Dettelbach: Psychometrica. 2016. Retrieved from: https://www.psychometrica.de/effect_size.html. https://doi.org/10.13140/RG.2.2.17823.92329.
Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126(5):1763–8.
Article
PubMed
Google Scholar
Barciszewska A-M, Nowak S, Naskręt-Barciszewska MZ. The degree of global DNA hypomethylation in peripheral blood correlates with that in matched tumor tissues in several neoplasia. PLoS One. 2014;9(3):–e92599.
Kuchiba A, Iwasaki M, Ono H, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Tsugane S, Yoshida T. Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women. Br J Cancer. 2014;110(11):2765–71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Miranda-Morales E, Meier K, Sandoval-Carrillo A, Salas-Pacheco J, Vázquez-Cárdenas P, Arias-Carrión O. Implications of DNA methylation in Parkinson's disease. Front Mol Neurosci. 2017;10:225.
Article
PubMed
PubMed Central
CAS
Google Scholar
Klekner Á, Szivos L, Virga J, Árkosy P, Bognár L, Birkó Z, Nagy B. Significance of liquid biopsy in glioblastoma–A review. J Biotechnol. 2019;298:82–7.
Article
CAS
PubMed
Google Scholar
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74.
CAS
PubMed
Google Scholar
Netea-Maier RT, Smit JW, Netea MG. Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship. Cancer Lett. 2018;413:102–9.
Article
CAS
PubMed
Google Scholar
Wishart DS. Metabolomics for investigating physiological and pathophysiological processes. Physiol Rev. 2019;99(4):1819–75.
Article
CAS
PubMed
Google Scholar
Kondo Y, Katsushima K, Ohka F, Natsume A, Shinjo K. Epigenetic dysregulation in glioma. Cancer Sci. 2014;105(4):363–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krushkal J, Zhao Y, Hose C, Monks A, Doroshow JH, Simon R. Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment. Clin Epigenetics. 2016;8:73.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bethke L, Webb E, Murray A, Schoemaker M, Feychting M, Lonn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, et al. Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma. Cancer Epidemiol Biomark Prev. 2008;17(5):1195–202.
Article
CAS
Google Scholar
Da Costa DM, De Lima GPV, Faria MHG, Rabenhorst SHB. Polymorphisms of folate pathway enzymes (Methylenetetrahydrofolate Reductase and Thymidylate synthase) and their relationship with thymidylate synthase expression in human astrocytic tumors. DNA Cell Biol. 2012;31(1):57–66.
Article
PubMed
CAS
Google Scholar
Izmirli M. A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk. Mol Biol Rep. 2013;40(1):625–37.
Article
CAS
PubMed
Google Scholar
Stern LL, Mason JB, Selhub J, Choi S-W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the Methylenetetrahydrofolate Reductase gene. Cancer Epidemiol Biomark Prev. 2000;9(8):849–53.
CAS
Google Scholar
Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64(3):169–72.
Article
CAS
PubMed
Google Scholar
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131(6):803–20.
Article
PubMed
Google Scholar
Gomes AC, Mello AL, Ribeiro MG, Garcia DG, Da Fonseca CO, Salazar MD, Schonthal AH, Quirico-Santos T. Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals. Arch Immunol Ther Exp. 2017;65(4):285–97.