Fig. 1From: Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphisma Global gDNA methylation pattern and prognosis of rGBM patients under POH inhaled therapy. The majority of rGBM patients (67%) presented with hypomethylated phenotype compared to hypermethylated group (33%, p < 0.0001). b Multiple comparison tests at 25 weeks confirm survival advantage to gDNA hypermethylated patients (median survival = 88 weeks) in comparison to hypomethylated rGBM survivors above 25 weeks (median survival = 44 weeks; d = 0.639)Back to article page