- Research article
- Open Access
- Open Peer Review
The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis
BMC Cancer volume 18, Article number: 740 (2018)
Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local control for advanced T stage (T3–4) in the intensity-modulated radiation therapy (IMRT) era. We aim to evaluate whether RTI affects local control for T3–4 NPC treated with definitive IMRT.
In this observational prospective study, 447 T3–4 NPC patients treated with IMRT plus concurrent chemotherapy were included. All patients completed the planned radiotherapy course, and RTI was defined as the actual time taken to finish the prescribed course of radiotherapy minus the planned radiotherapy time. Receiver operating characteristic (ROC) curve was used for determined the cutoff point of RTI. The effects of RTI on local control were analyzed in multivariate analysis.
At 5 years, the local relapse-free survival (LRFS) and overall survival (OS) rates were 93.7 and 85.7%, respectively. The cutoff RTI for LRFS was 5.5 days by ROC curve. Compared to patients with RTI > 5 days, patients with RTI ≤ 5 days had a significantly lower rate of LRFS (97% vs. 83%; P < 0.001). In multivariate analysis, RTI was a risk factor independently associated with LRFS (HR = 9.64, 95% CI, 4.10–22.65), but not for OS (HR = 1.09, 95% CI, 0.84–1.64).
The current analysis demonstrates a significant correlation between prolonged RTI and local control in NPC, even when concurrent chemotherapy is used. We consider that attention to RTI seems to be warranted for patients with advanced T-stage NPC in the era of IMRT.
In Southern China, nasopharyngeal carcinoma (NPC) is a common malignancy [1, 2]. Radiotherapy is the mainstay of treatment of NPC given the anatomical restrictions and its radio-sensitivity . The tumor often present with bulky disease and located near multiple critical structures, leading to difficulties in achieving satisfactory local control using two dimensional radiotherapy. Several studies have reported a 5-year local relapse-free survival (LRFS) of 61–79% and overall survival (OS) of 59–69% using two dimensional radiotherapy [4, 5].
With advances in radiation technology, intensity-modulated radiotherapy (IMRT) has become the primary means of radiotherapy due to better treatment outcome. The phase II trial of RTOG 0225 conducted by Memorial Sloan-Kettering Cancer Center reported the excellent local control (2-year rate, 92.6%) for NPC in the era of IMRT . Additionally, Peng et al.  conducted a randomised study and found that IMRT had a significant improvement in local control of 7.7% (5-year rate) compared with two dimensional radiotherapy. However, approximately 8–10% patients still experience local relapse in the era of IMRT, which has become a major cause of treatment failure in NPC [8, 9].
Many prognostic factors may directly and/or indirectly affect the local control, including radiotherapy interruption (RTI), which is a significant independent factor in the local control of lung cancer , laryngeal cancer  and NPC [12, 13] using two dimensional radiotherapy. However, it remains unknown whether RTI still affects local control in the era of IMRT. Based on this knowledge, we, therefore, did an observational prospective study to identify the relationship between RTI and local control in patients with stage T3–4 stage NPC treated by definitive IMRT.
Between December 2009 and February 2012, we included a total of 447 NPC patients. Patients’ characteristics are listed in Additional file 1: Table S1. The eligibility criteria were as follows: (1) histologically proven NPC, (2) stage with T3 to T4, (3) no evidence of distant metastases, (4) treated by IMRT and finished the planned radiotherapy, (5) received concurrent chemotherapy, and (6) no prior history of malignancy. Patients were staged based on American Joint Committee on Cancer (AJCC) staging system (7th edition, 2009) . This study was approved by our center’s Institutional Review Board. The authenticity of this article has been validated by uploading the key raw data onto the Research Data Deposit public platform (www.researchdata. org.cn), and the approval Research Data Deposit number is RDDB2018000277.
Radiotherapy and chemotherapy
IMRT was administered to all patients included in the study. We delineated the target volumes using a previously described treatment protocol by Sun Yat-sen University Cancer Center , which is consistent with International Commission on Radiation Units (ICRU) and Measurements reports 62  and 83 . All patients received concurrent chemotherapy, which consisted of 80–100 mg/m2 cisplatin every 3 weeks or 40 mg/m2 weekly. Deviations from these guidelines were due to patient refusal or when organ dysfunction suggested intolerance to chemotherapy.
The definition of RTI
Radiation treatment time was calculated as the duration from start of radiotherapy to completion of the planned course. All patients were treated with a fraction daily for 5 days per week, and no planned interruption. Radiotherapy interruptions were allowed in the case of holidays, machinery faults, severe acute toxicity, and other causes. RTI was defined as the radiation treatment time minus the planned radiation time (assuming a Monday start).
During treatment, patients were observed at least one time a week. After treatment, patients were then evaluated once every 3 months in the first three years, once every 6 months for the following two years, and once every afterward. The end points contained LRFS and OS. We defined LRFS from the date of initial treatment to the date of the first nasopharynx recurrence; and OS was calculated from the date of initial treatment to death. Local relapses were diagnosed by biopsy, MRI, or both.
Receiver operating characteristic (ROC) curves were used to determine the RTI cutoff point for LRFS. Chi-square test was used to determine the differences in patients’ characteristics among groups. Survival rates were depicted by Kaplan–Meier curves and were compared by Log-rank tests. A Cox proportional hazards model was used to test the significant factors in multivariate analysis. A two-tailed P value < 0.05 was deemed statistically significant. We performed all analyses using R 3.1.2 software.
The ability of RTI to predict LRFS was shown by ROC curve (Fig. 1), and the best RTI cutoff for LRFS was 5.5 days (area 0.73; 95% CI, 0.63–0.82). Based on optimal cutoff point, all patients were divided into RTI ≤ 5 days group or RTI > 5 days group. The baseline characteristics of the two groups are listed in Table 1. There were no differences in terms of age, sex, pathologic features, T (tumor) stage, N (nodal) stage, overall stage or schedule dose (all P > 0.05). However, patients receiving a schedule dose of 70 Gy in 33 fractions (2.12 Gy/F) were significantly (P = 0.013) more likely to have a longer RTI (> 5 days) than patients who received a dose of 68 Gy in 30 F (2.27 Gy/F).
Overall, 342 (76.5%) patients finished their prescribed course of radiotherapy within 5 days of the scheduled time (range: 0–5 days), and 105 (23.5%) patients finished more than 5 days after the scheduled time (range: 6–29 days). The median follow-up was 59.8 months (range: 1.3–76.4 months). At their final follow-up visit, 95 patients had treatment failure because of local relapse (n = 28), nodal relapse (n = 15) or development of distant metastasis (n = 58). Six patients (1.3%) suffered at least two types of treatment failure and 64 patients (14.3%) did not survive. Salvage local treatment included nasopharyngectomy, chemotherapy or re-irradiation. In addition, 9 patients in the group of RTI ≤ 5 days and 16 patients in the group of RTI > 5 days received further treatment for local relapse, but this difference was not significant (P = 0.645).
Overall, the 5-year LRFS and OS rates were 93.7 and 85.7%, respectively. The 5-year LRFS of the RTI ≤ 5 days group and RTI > 5 days group were 97.1 and 82.9% respectively, a significant difference (P < 0.001, Fig. 2a). However, the 5-year OS rates were almost identical in both groups (RTI ≤ 5 vs > 5 days group: 87.1% vs 81.0%; P = 0.147, Fig. 2b). The 5-year LRFS rates for the 68 Gy/30F group and 70 Gy/33F groups were 94.0 and 93.3%, respectively (P = 0.962). The 5-year OS rates for the 68 Gy/30F group and 70 Gy/33F groups were also similar (85.6% vs 84.5%; P = 0.942).
Univariate analysis showed that T stage, overall stage and RTI were prognostic factors for LRFS; OS were significantly associated with age, N stage, T stage and overall stage (P < 0.05 for all; Table 2). In multivariate analysis, following parameters as variables were included: age (≤ 50 vs. > 50 years), sex (male vs. female), pathology (type I/II vs. type III), T stage (T3 vs. T4), N stage (N0–1 vs. N2–3), overall stage (III vs. IVA-B) and schedule dose (68 Gy/30 F vs. 70 Gy/33 F). The outcomes for LRFS and OS are presented in Table 3. Significant predictors of inferior OS included age > 50 years (HR = 2.06; 95% CI, 1.24–3.44), N2/3 nodal stage (HR = 1.99; 95% CI, 1.13–3.52) and stage IVA-B (HR = 2.64; 95% CI, 1.07–6.56). Only RTI > 5 days (HR = 9.64, 95% CI = 4.10–22.65) was significantly associated with inferior local control in multivariate analysis.
The effect of RTI on different T stages
Although no association was found between local control and T stage in multivariate analysis, the Kaplan-Meier model showed a significantly higher risk of local failure for T3 and T4 disease (94.8% vs. 89.2%, respectively; P = 0.042). In patients with T3 disease, the 5-year LRFS rates for patients with a RTI ≤ 5 vs. > 5 days were 97.4% vs. 82.1% (HR = 7.30; 95% CI, 2.77–19.21; P < 0.001; Fig. 3a). In patients with T4 disease, the 5-year LRFS rates for patients with a RTI ≤ 5 vs. > 5 days were 93.3% vs. 72.2% (HR = 4.52; 95% CI, 1.21–16.83; P = 0.014; Fig. 4a). Moreover, in patients with T3 disease, the 5-year rate of OS was 88.9% in the group of RTI ≤ 5 days and 84.1% in the group of RTI > 5 days (HR = 1.48; 95% CI, 0.79–2.79; P = 0.222; Fig. 3b) and for T4 stage the rates were 77.9 and 68.7%, respectively (HR = 1.53, 95% CI, 0.59–3.98; P = 0.382; Fig. 4b).
The effect of median RTI in patients with advanced T stage
The median RTI was 3 days (interquartile range: 1–7 days) for the entire cohort. Based on the cutoff point of median RTI, patients were divided into RTI ≤ 3 days group or RTI > 3 days group. Kaplan-Meier method estimates of survival based on the median threshold are shown in Additional file 2: Figure S1. In the log-rank test, RTI > 3 days was associated with inferior LRFS (HR, 4.14; 95% CI, 1.76–9.73; Additional file 2: Figure S1a). However, we did not observe any difference in OS between patients with RTI > 3 and RTI ≤ 3 days (85.0% vs 85.0%; P = 0.863; Additional file 2: Figure S1b). Thus, compared with OS, LRFS is potentially more likely to be impacted by RTI. After adjusting for the TNM stage and other variables, we failed to detect an association between RTI (HR, 3.64; 95% CI, 0.97–8.96) and LRFS. In contrast, we found age (HR, 2.06; 95% CI, 1.24–3.44), N stage (HR, 1.99; 95% CI, 1.13–3.52), and overall stage (HR, 2.64; 95% CI, 1.07–6.56) were significant prognostic factors for OS (Additional file 3: Table S2).
Local failure is one of the major treatment failures in NPC, especially for patients with T3–4 stage [18, 19]. Several important prognostic factors for local control have been identified, including radiation technique [7, 18], dose per fraction , the volume of tumor , T stage , daily fraction size , presence of Epstein–Barr virus (EBV) DNA , RTI  and chemotherapy schedule . Of all these factors, the volume of tumor was excluded in the current study due to the difficulty of measuring before treatment. Another potentially valuable prognostic factor is plasma EBV DNA, but the the large interlaboratory variability of EBV DNA enables the difficulty to apply in routine clinical practice. For this reason, we did not include.
In this study, all patients were treated with concurrent radiochemotherapy. Daily fraction size was 2.12 Gy or 2.27 Gy for patients with conventional fractionation. Given the relatively homogeneous in radiation technique, daily fraction size, beam energy, and chemotherapy in the current study, we take more attention to the effect of RTI on local control. Based on the ROC analysis, RTI was analyzed as a categorical variable (RTI either ≤5 or > 5 days) in the present study. The 5-year LRFS rate was 97% if radiotherapy was completed within 5 days of schedule, whereas it was only 83% for RTI > 5 days. Further analysis revealed that RTI was a significant prognostic factor for local control in the current study. However, some studies suggest that RTI may be less relevant for IMRT or chemotherapy in head and neck carcinoma . A recent retrospective analysis was conducted for 321 patients with various stages of localized NPC treated with doses ranging from 64 to 74 Gy over a time period of 5 to 9 weeks . The median RTI was 3 days and no relationship was found between survival outcomes and radiation treatment duration. However, this was likely due to a relatively narrow RTI window and analysis of radiotherapy time as a continuous variable.
Although we found that the 5-year OS rate was higher in the RTI ≤ 5 days group than in the RTI > 5 days group, we did not find a significant correlation between RTI and OS (P > 0.05). This could be due to a number reasons. First, OS is not only associated with RTI but also associated with age, sex, N stage, and overall stage, as well as the addition of chemotherapy and supportive care . In the present study, all patients received concurrent chemotherapy that may reduce the effect of RTI on OS. Moreover, salvage treatment after initial treatment failure may be influential. Recently, Chen et al.  reported a 2-year OS rate of 84.2% in locally relapse NPC using endoscopic nasopharyngectomy. Moreover, re-irradiation and chemotherapy were associated with satisfactory OS for patients with local recurrent disease . This might partially explain the significant difference in LRFS, but not OS for patients with RTI > or ≤ 5 days.
T stage is known to be a prognostic factor of local relapse of NPC patients . However, we did not find any difference between T3 and T4 disease in terms of local control. This is consistent with a previous study , which indicates that the current T-stage does not fully reflect local control in NPC patients after IMRT treatment in combination with chemotherapy. It is well recognized that serious acute side effects that could cause radiotherapy interruption, which have been confirmed to be highly detrimental in radiobiologic efficacy [32, 33]. In this study, we included patients with advanced T-stage, who were more likely to receive a higher radiation dose (> 69 Gy) in combination with a higher intensity of chemotherapy, and the incidence of serious acute side effects could be increased for this group of patients. Moreover, we found patients older than 50 years of age were generally more associated with prolonging RTI. Considering that older patients were more likely to have poor performance status, multiple comorbidities, and inadequate social support, our findings seem reasonable due to patients of older age might have a lower tolerance to intense treatment (RT and/or chemotherapy) .
An interesting finding of this study was that patients have a significant difference in distribution of RTI (RTI > or ≤ 5 days) when treated with different fraction size (70 Gy/33 F vs. 68 Gy/30 F). Although we did not observe a significant effect of fraction schedule on survival outcomes, patients treated with 70 Gy/33 F tended to have a longer RTI than patients treated with 68 Gy/30 F. One possible reason might be that patients with 70 Gy/33 F had a longer radiotherapy time in comparison with those treated with 68 Gy/30 F, and they were more likely to experience interruption due to severe acute toxicity, holidays, equipment failure, and other causes.
There are some limitations must be noted. First, the 5-year OS curves were not well defined in the groups of RTI ≤ 5 days and RTI > 5 days. The differences in OS between the two groups may be greater with larger sample size. Second, we failed to include data regarding other prognostic factors, such as the alcohol and/or smoking consumption status. However, no studies to date have demonstrated the effect of alcohol consumption or cigarette smoking on local control for NPC.
In this study, we described the long-term outcomes for patients with T3–4 stage NPC treated with definitive chemoradiotherapy in the IMRT era. Our results suggest that prolonged RTI > 5 days is an independent adverse prognostic factor on local control for this group of patients. We consider that attention to RTI seems to be warranted for patients with advanced T3–4 stage NPC.
American Joint Committee on Cancer
nodal gross tumor volume
primary gross tumor volume
intensity-modulated radiation therapy
local relapse-free survival
magnetic resonance imaging
planned target volume
receiver operating characteristic
Wei KR, Zheng RS, Zhang SW, Liang ZH, Ou ZX, Chen WQ. Nasopharyngeal carcinoma incidence and mortality in China in 2010. Chin J Cancer. 2014;33(8):381–7.
Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005;365:2041–54.
Levendag PC, Lagerwaard FJ, de Pan C, Noever I, van Nimwegen A, Wijers O, et al. High-dose, high-precision treatment options for boosting cancer of the nasopharynx. Radiother Oncol. 2002;63(1):67–74.
Tuan JK, Ha TC, Ong WS, Siow TR, Tham IW, Yap SP, et al. Late toxicities after conventional radiation therapy alone for nasopharyngeal carcinoma. Radiother Oncol. 2012;104:305–11.
Yeh SA, Tang Y, Lui CC, Huang YJ, Huang EY. Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone. Int J Radiat Oncol Biol Phys. 2005;62:672–9.
Lee N, Harris J, Garden AS, Straube W, Glisson B, Xia P, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol. 2009;27:3684–90.
Peng G, Wang T, Yang KY, Zhang S, Zhang T, Li Q, et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol. 2012;104:286–93.
Lee AW, Poon YF, Foo W, Law SC, Cheung FK, Chan DK, et al. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys. 1992;23(2):261–70.
Lee N, Xia P, Quivey JM, Sultanem K, Poon I, Akazawa C, et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys. 2002;53(1):12–22.
Machtay M, Hsu C, Komaki R, Sause WT, Swann RS, Langer CJ, et al. Effect of overall treatment time on outcomes after concurrent chemoradiation for locally advanced non-small-cell lung carcinoma: analysis of the radiation therapy oncology group (RTOG) experience. Int J Radiat Oncol Biol Phys. 2005;63(3):667–71.
Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys. 2006;64(1):77–82.
Kwong DL, Sham JS, Chua DT, Choy DT, Au GK, Wu PM. The effect of interruptions and prolonged treatment time in radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 1997;39(3):703–10.
Wu SX, Zhao C, Lu TX, Chen M, Xie FY, Cui NJ. Influence of prolonged overall treatment time and interruptions on outcome in continuous radiotherapy for nasopharyngeal carcinoma. Chin J Cancer. 2000;19(10):923–6.
Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC Cancer staging manual. 7th ed. New York: Springer; 2009.
Yao JJ, Yu XL, Zhang F, Zhang WJ, Zhou GQ, Tang LL, et al. Radiotherapy with neoadjuvant chemotherapy versus concurrent chemoradiotherapy for ascending-type nasopharyngeal carcinoma: a retrospective comparison of toxicity and prognosis. Chin J Cancer. 2017;36(1):26.
ICRU Report. Vol. 62: prescribing, recording, and reporting photon beam therapy. Maryland: International Commission on Radiation Units and Measurements; 1999.
ICRU Report. Vol. 83: prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT), Maryland: International Commission on Radiation Units and Measurements; 2010.
Johnson FM, Garden AS, Palmer JL, Shin DM, Morrison W, Papadimitrakopoulou V, et al. A phase I/II study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced T-stage nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2005;63(3):717–24.
Chen JL, Huang YS, Kuo SH, Chen YF, Hong RL, Ko JY, et al. Intensity-modulated radiation therapy for T4 nasopharyngeal carcinoma. Treatment results and locoregional recurrence. Strahlenther Onkol. 2013;189(12):1001–8.
Le QT, Fu KK, Kroll S, Ryu JK, Quivey JM, Meyler TS, et al. Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma. Int J Radiat Oncol Biol Phys. 1997;39(1):115–26.
Guo R, Sun Y, Yu XL, Yin WJ, Li WF, Chen YY, et al. Is primary tumor volume still a prognostic factor in intensity modulated radiation therapy for nasopharyngeal carcinoma? Radiother Oncol. 2012;104(3):294–9.
Schwaibold F, Scariato A, Nunno M, Wallner PE, Lustig RA, Rouby E, et al. The effect of fraction size on control of early glottic cancer. Int J Radiat Oncol Biol Phys. 1988;14(3):451–4.
Lin JC, Wang WY, Chen KY, Wei YH, Liang WM, Jan JS, et al. Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma. N Engl J Med. 2004;350(24):2461–70.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, et al. Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 2006;64:47–56.
Kies MS, Haraf DJ, Rosen F, Stenson K, List M, Brockstein B, et al. Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. J Clin Oncol. 2001;19(7):1961–9.
Li PJ, Jin T, Luo DH, Shen T, Mai DM, Hu WH, et al. Effect of prolonged radiotherapy treatment time on survival outcomes after intensity-modulated radiation therapy in nasopharyngeal carcinoma. PLoS One. 2015;10(10):e0141332.
Xiao G, Cao Y, Qiu X, Wang W, Wang Y. Influence of gender and age on the survival of patients with nasopharyngeal carcinoma. BMC Cancer. 2013;13:226.
Chen MY, Wen WP, Guo X, Yang AK, Qian CN, Hua YJ, et al. Endoscopic nasopharyngectomy for locally recurrent nasopharyngeal carcinoma. Laryngoscope. 2009;119(3):516–22.
Zou X, Han F, Ma WJ, Deng MQ, Jiang R, Guo L, et al. Salvage endoscopic nasopharyngectomy and intensity-modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma. Head Neck. 2015;37(8):1108–15.
Sun X, Zeng L, Chen C, Huang Y, Han F, Xiao W, et al. Comparing treatment outcomes of different chemotherapy sequences during intensity modulated radiotherapy for advanced N-stage nasopharyngeal carcinoma patients. Radiat Oncol. 2013;8:265.
Sun Y, Tang LL, Chen L, Li WF, Mao YP, Liu LZ, et al. Promising treatment outcomes of intensity-modulated radiation therapy for nasopharyngeal carcinoma patients with N0 disease according to the seventh edition of the AJCC staging system. BMC Cancer. 2012;12:68. https://doi.org/10.1186/1471-2407-12-68.
Withers HR, Taylor JMG, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 1988;27:131–46.
Fowler JF, Chappell R. Non–small-cell lung tumors repopulate rapidly during radiation therapy [letter to the Editor]. Int J Radiat Oncol Biol Phys. 2000;46:516–7.
Xu GZ, Li L, Zhu XD. Effect of interrupted time during intensity modulated radiation therapy on survival outcomes in patients with nasopharyngeal cancer. Oncotarget. 2017;8(23):37817–25.
This work was supported by grants from the Science and Technology Project of Guangzhou City, China (No. 14570006), the National Natural Science Foundation of China (No.81372409), the Sun Yat-sen University Clinical Research 5010 Program (No.2012011), and the National Natural Science Foundation of China (No. 81402532). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Availability of data and materials
The authenticity of this article has been validated by uploading the key raw data onto the Research Data Deposit (RDD) public platform (www.researchdata.org.cn), with the approval RDD number as RDDB2018000277.
Ethics approval and consent to participate
This study was conducted in compliance with institutional policy to protect patients’ private information, and was approved by the Institutional Review Board of Sun Yat-sen University Cancer Center. As the current study was a retrospective assessment of routine data, the ethics committee of our Cancer Center waived the need for individual informed consent.
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Table S1. Patient characteristics. (DOC 26 kb)
Figure S1. Kaplan–Meier curves for patients with NPC patients stratified by RTI (≤3 vs > 3 days). (A) Local relapse-free survival, and (B) overall survival. (JPG 349 kb)
Table S2. Univariate and multivariate analysis of prognostic factors for LRFS and OS. (DOC 35 kb)
About this article
Cite this article
Yao, J., Jin, Y., Wang, S. et al. The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis. BMC Cancer 18, 740 (2018) doi:10.1186/s12885-018-4495-2
- Nasopharyngeal carcinoma
- Radiotherapy interruption
- Local control
- Concurrent chemoradiotherapy
- Advanced T stage