The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

Table 3 Summary of multivariate cox proportional hazards models for LRFS and OS

Endpoints	Characteristic	HR	95% CI
LRFS
	Age (≤ 50 vs. > 50)	1.63	0.79–3.12
	T stage (T3 vs. T4)	0.72	0.15–3.34
	Overall stage (III vs. IVA-B)	4.01	0.91–17.68
	RTI (≤ 5 vs. > 5 days)	9.64	4.10–22.65
	Schedule (68 Gy/30 F vs. 70 Gy/33 F)	2.03	0.78–8.67
OS
	Age (≤ 50 vs. > 50)	2.06	1.24–3.44
	Sex (male vs. female)	0.54	0.28–1.07
	T stage (T3 vs. T4)	0.89	0.34–2.30
	N stage (N0–1 vs. N2–3)	1.99	1.13–3.52
	Overall stage (III vs. IVA-B)	2.64	1.07–6.56

Abbreviations: LRFS local relapse free survival, OS overall survival, HR hazard ratio, CI confident interval, RTI radiotherapy interruption

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