The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

Table 2 Univariate analysis for LRFS and OS

Endpoints	Characteristic	HR	95% CI
LRFS
	Age (≤ 50 vs. > 50)	1.53	0.73–3.24
	Sex (male vs. female)	1.24	0.55–2.82
	T stage (T3 vs. T4)	2.23	1.01–4.92
	N stage (N0–1 vs. N2–3)	1.36	0.58–3.19
	Overall stage (III vs. IVA-B)	2.45	1.15–5.22
	RTI (≤ 5 vs. > 5 days)	6.14	2.84–13.22
	Schedule (68 Gy/30 F vs. 70 Gy/33 F)	1.99	0.90–4.40
OS
	Age (≤ 50 vs. > 50)	2.03	1.22–3.38
	Sex (male vs. female)	0.56	0.28–1.09
	T stage (T3 vs. T4)	2.09	1.23–3.54
	N stage (N0–1 vs. N2–3)	2.42	1.46–4.02
	Overall stage (III vs. IVA-B)	2.72	1.65–4.46
	RTI (≤ 5 vs. > 5 days)	1.48	0.87–2.50
	Schedule (68 Gy/30 F vs. 70 Gy/33 F)	1.29	0.72–2.31

Abbreviations: LRFS local relapse free survival, OS overall survival, HR hazard ratio, CI confidence interval, RTI radiotherapy interruption

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