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Table 1 Patient characteristics according to grade of leucopenia

From: Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma

Variable All Absent leucopenia Mild leucopenia Severe leucopenia P value
Total 3826 508(13.3) 2511(65.6) 807(21.1)  
Gender      <0.001
male 2873(75.1) 421(82.9) 1936(77.1) 516(63.9)  
female 953(24.9) 87(17.1) 575(22.9) 291(36.1)  
Age(years)      0.105
<45 1982(51.8) 242(47.6) 1325(52.8) 415(51.4)  
> = 45 1844(48.2) 266(52.4) 1186(47.2) 392(48.6)  
Leukocyte count     <0.001
= < 10 × 10^9/L 3448(90.1) 424(83.5) 2278(90.7) 746(92.4)  
>10 × 10^9/L 378(9.9) 84(16.5) 233(9.3) 61(7.6)  
Pathological type(WHO)     0.692
I 83(2.2) 11(2.2) 55(2.2) 17(2.1)  
II 203(5.3) 23(4.5) 143(5.7) 37(4.6)  
III 3540(92.5) 474(93.3) 2313(92.1) 753(93.3)  
T-classification      0.720
T1 172(4.5) 22(4.3) 109(4.3) 41(5.1)  
T2 272(7.1) 29(5.7) 185(7.4) 58(7.2)  
T3 1871(48.9) 271(53.3) 1221(48.6) 379(47.0)  
T4 1511(39.5) 186(36.6) 996(39.7) 329(40.8)  
N-classification      0.09
N0 517(13.5) 86(16.9) 335(13.3) 96(11.9)  
N1 1978(51.7) 252(49.6) 1313(52.3) 413(51.2)  
N2 1043(27.3) 133(26.2) 680(27.1) 230(28.5)  
N3 288(7.5) 37(7.3) 183(7.3) 68(8.4)  
Clinical stage      0.222
III 2094(54.7) 295(58.1) 1369(54.5) 430(53.3)  
IV 1732(45.3) 213(41.9) 1142(45.5) 377(46.7)  
Radiotherapy      0.004
CRT 2583(67.5) 329(64.8) 1741(69.3) 513(63.6)  
IMRT 1243(32.5) 179(35.2) 770(30.7) 294(36.4)  
Chemotherapy      <0.001
IC 1073(28.0) 198(39.0) 697(27.8) 178(22.1)  
CC 1291(33.7) 202(39.8) 878(35.0) 211(26.1)  
IC + CC 1255(32.8) 98(19.3) 804(32.0) 353(43.7)  
CC + AC 207(5.4) 10(2.0) 132(5.3) 65(8.1)  
Paclitaxel      <0.001
NO 3029(79.2) 403(79.3) 2069(82.4) 557(69.0)  
YES 797(20.8) 105(20.7) 442(17.6) 250(31.0)  
Chemotherapy cycles     <0.001
<4 2364(61.8) 400(78.7) 1575(62.7) 389(48.2)  
> = 4 1462(38.2) 108(21.3) 936(37.3) 418(51.8)  
  1. Abbreviations: CRT: conventional radiotherapy; IMRT: intensity modulated radiation therapy; IC: Induction chemotherapy; CC: concurrent chemotherapy; AC: adjuvant chemotherapy; WHO: world health organization