Table 1 Patient characteristics according to grade of leucopenia
From: Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma
Variable | All | Absent leucopenia | Mild leucopenia | Severe leucopenia | P value |
|---|---|---|---|---|---|
Total | 3826 | 508(13.3) | 2511(65.6) | 807(21.1) | |
Gender | <0.001 | ||||
male | 2873(75.1) | 421(82.9) | 1936(77.1) | 516(63.9) | |
female | 953(24.9) | 87(17.1) | 575(22.9) | 291(36.1) | |
Age(years) | 0.105 | ||||
<45 | 1982(51.8) | 242(47.6) | 1325(52.8) | 415(51.4) | |
> = 45 | 1844(48.2) | 266(52.4) | 1186(47.2) | 392(48.6) | |
Leukocyte count | <0.001 | ||||
= < 10 × 10^9/L | 3448(90.1) | 424(83.5) | 2278(90.7) | 746(92.4) | |
>10 × 10^9/L | 378(9.9) | 84(16.5) | 233(9.3) | 61(7.6) | |
Pathological type(WHO) | 0.692 | ||||
I | 83(2.2) | 11(2.2) | 55(2.2) | 17(2.1) | |
II | 203(5.3) | 23(4.5) | 143(5.7) | 37(4.6) | |
III | 3540(92.5) | 474(93.3) | 2313(92.1) | 753(93.3) | |
T-classification | 0.720 | ||||
T1 | 172(4.5) | 22(4.3) | 109(4.3) | 41(5.1) | |
T2 | 272(7.1) | 29(5.7) | 185(7.4) | 58(7.2) | |
T3 | 1871(48.9) | 271(53.3) | 1221(48.6) | 379(47.0) | |
T4 | 1511(39.5) | 186(36.6) | 996(39.7) | 329(40.8) | |
N-classification | 0.09 | ||||
N0 | 517(13.5) | 86(16.9) | 335(13.3) | 96(11.9) | |
N1 | 1978(51.7) | 252(49.6) | 1313(52.3) | 413(51.2) | |
N2 | 1043(27.3) | 133(26.2) | 680(27.1) | 230(28.5) | |
N3 | 288(7.5) | 37(7.3) | 183(7.3) | 68(8.4) | |
Clinical stage | 0.222 | ||||
III | 2094(54.7) | 295(58.1) | 1369(54.5) | 430(53.3) | |
IV | 1732(45.3) | 213(41.9) | 1142(45.5) | 377(46.7) | |
Radiotherapy | 0.004 | ||||
CRT | 2583(67.5) | 329(64.8) | 1741(69.3) | 513(63.6) | |
IMRT | 1243(32.5) | 179(35.2) | 770(30.7) | 294(36.4) | |
Chemotherapy | <0.001 | ||||
IC | 1073(28.0) | 198(39.0) | 697(27.8) | 178(22.1) | |
CC | 1291(33.7) | 202(39.8) | 878(35.0) | 211(26.1) | |
IC + CC | 1255(32.8) | 98(19.3) | 804(32.0) | 353(43.7) | |
CC + AC | 207(5.4) | 10(2.0) | 132(5.3) | 65(8.1) | |
Paclitaxel | <0.001 | ||||
NO | 3029(79.2) | 403(79.3) | 2069(82.4) | 557(69.0) | |
YES | 797(20.8) | 105(20.7) | 442(17.6) | 250(31.0) | |
Chemotherapy cycles | <0.001 | ||||
<4 | 2364(61.8) | 400(78.7) | 1575(62.7) | 389(48.2) | |
> = 4 | 1462(38.2) | 108(21.3) | 936(37.3) | 418(51.8) | |