Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ: Cancer statistics, 2005. CA Cancer J Clin. 2005, 55 (1): 10-30. Erratum in: CA Cancer J Clin. 2005; 55(4):259
Niederhuber JE, Brennan MF, Mench HR: The National Cancer Data Base Report on Pancreatic Cancer. Cancer. 1995, 76: 1671-7. 10.1002/1097-0142(19951101)76:9<1671::AID-CNCR2820760926>3.0.CO;2-R.
Ghaneh P, Costello E, Neoptolemos JP: Biology and management of pancreatic cancer. Gut. 2007, 56: 1134-52. 10.1136/gut.2006.103333.
Sarkar FH, Banerjee S, Li YW: Pancreatic cancer: Pathogenesis, prevention and treatment. Toxicol Appl Pharmacol. 2007, 224: 326-36. 10.1016/j.taap.2006.11.007.
Stefañska B, Arciemiuk M, Bontemps-Gracz MM, Dzieduszycka M, Kupiec A, Martelli S, Borowski E: Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h] cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line. Bioorg Med Chem. 2003, 11: 561-72. 10.1016/S0968-0896(02)00425-X.
Sahani DV, Shah ZK, Catalano OA, Boland GW, Brugge WR: Radiology of pancreatic adenocarcinoma: current status of imaging. J Gastroenterol Hepatol. 2008, 23: 23-33. 10.1111/j.1440-1746.2007.04868.x.
Cherng JM, Shieh DE, Chiang W, Chang MY, Chiang C: Chemopreventive effects of minor dietary constituents in common foods on human cancer cells. Biosci Biotechnol Biochem. 2007, 71: 1500-4. 10.1271/bbb.70008.
Feng R, Ni HM, Wang SY, Tourkova IL, Shurin MR, Harada H, Yin XM: Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J Biol Chem. 2007, 282: 13468-76. 10.1074/jbc.M610616200.
Aggarwal BB, Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006, 71: 1397-1421. 10.1016/j.bcp.2006.02.009.
Jagetia GC, Baliga MS, Malagi KJ, Sethukumar Kamath M: The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine. 2002, 9: 99-108. 10.1078/0944-7113-00095.
Kaur S, Arora S, Kaur K, Kumar S: The in vitro antimutagenic activity of Triphala- an Indian herbal drug. Food Chem Toxicol. 2002, 40: 527-34. 10.1016/S0278-6915(01)00101-6.
Singh DP, Govindarajan R, Rawat AK: High-performance liquid chromatography as a tool for the chemical standardization of Triphala-an Ayurvedic formulation. Phytochem Anal. 2008, 19: 164-8. 10.1002/pca.1032.
Deep G, Dhiman M, Rao AR, Kale RK: Chemopreventive potential of Triphala (a composite Indian drug) on benzo(a)pyrene induced forestomach tumorigenesis in murine tumor model system. J Exp Clin Cancer Res. 2005, 24: 555-63.
Sandhya T, Mishra KP: Cytotoxic response of breast cancer cell lines, MCF-7 and T 47D to triphala and its modification by antioxidants. Cancer Lett. 2006, 238: 304-13. 10.1016/j.canlet.2005.07.013.
Sandhya T, Lathika KM, Pandey BN, Mishra KP: Potential of traditional ayurvedic formulation, Triphala as a novel anticancer drug. Cancer Lett. 2006, 231: 206-214. 10.1016/j.canlet.2005.01.035.
Sandhya T, Lathika KM, Pandey BN, Bhilwade HN, Chaubey RC, Priyadarsini KI, Mishra KP: Protection against radiation oxidative damage in mice by Triphala. Mutation Res. 2006, 609: 17-25.
Furukawa T, Duguid WP, Rosenberg L, Viallet J, Galloway DA, Tsao MS: Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol. 1996, 148: 1763-70.
Ouyang H, Mou Lj, Luk C, Liu N, Karaskova J, Squire J, Tsao MS: Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol. 2000, 157: 1623-31.
Srivastava SK, Singh SV: Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells. Carcinogenesis. 2004, 25: 1701-9. 10.1093/carcin/bgh179.
Zhang R, Loganathan S, Humphreys I, Srivastava SK: Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells. J Nutr. 2006, 136: 2728-34.
Srivastava SK, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV: Allyl isothiocyanate, a natural constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis. 2003, 24: 1665-70. 10.1093/carcin/bgg123.
Liebermann DA, Hoffman B, Vesely D: p53 induced growth arrest versus apoptosis and its modulation by survival cytokines. Cell Cycle. 2007, 6: 166-70.
Lin T, Mak NK, Yang MS: MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Toxocology. 2008, 247: 145-153. 10.1016/j.tox.2008.02.017.
Persons DL, Yazlovitskaya EM, Pelling JC: Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin. J Biol Chem. 2000, 275: 35778-85. 10.1074/jbc.M004267200.
Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y, Kizaki M: Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at ser-15 residue by reactive species. Cancer Res. 2004, 64: 1071-8. 10.1158/0008-5472.CAN-03-1670.
Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz : Sulphoraphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem. 2005, 280: 19911-24. 10.1074/jbc.M412443200.
Dong LF, Swettenham E, Eliasson J, Wang XF, Gold M, Medunic Y, Stantic M, Low P, Prochazka L, Witting PK, Turanek J, Akporiaye ET, Ralph SJ, Neuzil J: Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress. Cancer Res. 2007, 67: 11906-13. 10.1158/0008-5472.CAN-07-3034.
Mclean L, Soto U, Agama K, Agama K, Francis J, Jimenez R, Pommier Y, Sowers L, Brantley E: Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells. Int J Cancer. 2008, 22: 1665-74. 10.1002/ijc.23244.
Lau AT, Wang Y, Chiu JF: Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic. J Cell Biochem. 2008, 104: 657-67. 10.1002/jcb.21655.
Ganguly A, Das B, Roy A, Sen N, Dasgupta SB, Mukhopadhayay S, Majumder HK: Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer Res. 2007, 67: 11848-58. 10.1158/0008-5472.CAN-07-1615.
Martirosyan A, Leonard S, Shi X, Griffith B, Gannett P, Strobl J: Action of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. Pharmacol Exp Ther. 2006, 317: 546-52. 10.1124/jpet.105.096891.
Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW: ATM mediates phosphorylation at multiple p53 sites, including Ser (46), in response to ionizing radiation. J Biol Chem. 2002, 277: 12491-4. 10.1074/jbc.C200093200.
Pabla N, Huang S, Mi QS, Damiel R, Dong Z: ATR-chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem. 2008, 283: 6572-83. 10.1074/jbc.M707568200.
Gottifredi V, Shieh S, Taya Y, Prives C: p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proc Natl Acad Sci USA. 2001, 98: 1036-41. 10.1073/pnas.021282898.
Wu SJ, Ng LT: MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food Chem Toxicol. 2007, 45: 2446-53. 10.1016/j.fct.2007.05.032.
Ma Y, Yu WD, Kong RX, Trump DL, Johnson CS: Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathway in 1,25D3-mediated apoptosis in squamous cell carcinoma cells. Cancer Res. 2006, 66: 8131-8. 10.1158/0008-5472.CAN-06-1333.
Singh S, Upadhyav AK, Ajay AK, Bhat MK: p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis. FEBS Lett. 2007, 581: 289-95. 10.1016/j.febslet.2006.12.035.
Jeon ES, Lee MJ, Sung SM, Kim JH: Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK. J Cell Biochem. 2007, 100: 1536-47. 10.1002/jcb.21141.
Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN: ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis. 2006, 27: 437-45. 10.1093/carcin/bgi251.
Choi YJ, Lim SY, Woo JH, Kim YH, Kwon YK, Suh SI, Lee SH, Choi WY, Kim JG, Lee IS, Park JW, Kwon TK: Sodium orthovanadate potentiates EGCG-induced apoptosis that is dependent on the ERK pathway. Biochem Biophys Res Commun. 2003, 305: 176-85. 10.1016/S0006-291X(03)00719-8.
Yu W, Liao QY, Hantash FM, Sanders BG, Kline K: Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res. 2001, 61: 6569-76.
Zhou Q, Meng D, Yan B, Jiang BH, Fang J: Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide. FEBS Lett. 2006, 580: 5161-6. 10.1016/j.febslet.2006.08.068.
Lee JS, Kim SY, Kwon CH, Kim YK: EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells. Arch Toxicol. 2006, 80: 337-46. 10.1007/s00204-005-0052-2.
Midwinter RG, Peskin AV, Vissers MC, Winterbourn CC: Extracellular oxidation by taurine chloramine activates ERK via the epidermal growth factor receptor. J Biol Chem. 2004, 279: 32205-11. 10.1074/jbc.M402070200.
Arany I, Megyesi JK, Kaneto H, Price PM, Safirstein RL: Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells. Am J Physiol Renal Physiol. 2004, 287: F543-9. 10.1152/ajprenal.00112.2004.
Höcker M, Rosenberg I, Xavier R, Henihan RJ, Wieham RJ, Wiedernmann B, Rosewicz S, Podolsky DK, Wanf TC: Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells. J Biol Chem. 1998, 273: 23046-54. 10.1074/jbc.273.36.23046.
Bodo J, Jakubikova J, Chalupa I, Bartosova Z, horakova K, Floch L, Sedlak J: Apoptotic effect of ethyl-4-isothiocyanatobutanoate is associated with DNA damage, proteasomal activity and induction of p53 and p21cip1/waf1. Apoptosis. 2006, 11: 1299-310. 10.1007/s10495-006-8760-5.
Lee JH, Kim KT: Regulation of cyclin-dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage-induced neuronal death. J Cell Physiol. 2007, 210: 784-97. 10.1002/jcp.20899.
Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ: ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem. 2002, 277: 12710-7. 10.1074/jbc.M111598200.
Baxer NN, Whitson BA, Tuttle TM: Trends in the treatment and outcome of pancreatic cancer in the United States. Ann Surg Oncol. 2007, 14: 1320-6. 10.1245/s10434-006-9249-8.
Rastogi T, Devesa S, Mangtani P, Mathew A, Cooper N, Kao R, Sinha R: Cancer incidence rates among south Asians in four geographic regions: India, Singapore, UK and US. Int J Epidemiol. 2007, 37: 147-60. 10.1093/ije/dym219.
Dhir V, Mohandas KM: Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol. 1999, 18: 24-8.
Dorai T, Aggarwal BB: Role of chemopreventive agents in cancer therapy. Cancer Lett. 2004, 215: 129-40. 10.1016/j.canlet.2004.07.013.
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M: Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. PNAS. 2008, 105: 11105-11109. 10.1073/pnas.0804226105.