Daniel PT, Schulze-Osthoff K, Belka C, Guner D: Guardians of cell death: the Bcl-2 family proteins. Essays Biochem. 2003, 39: 73-88.
Article
CAS
PubMed
Google Scholar
Sturm I, Kohne CH, Wolff G, Petrowsky H, Hillebrand T, Hauptmann S, Lorenz M, Dorken B, Daniel PT: Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol. 1999, 17 (5): 1364-1374.
CAS
PubMed
Google Scholar
Sturm I, Petrowsky H, Volz R, Lorenz M, Radetzki S, Hillebrand T, Wolff G, Hauptmann S, Dorken B, Daniel PT: Analysis of p53/BAX/p16(ink4a/CDKN2) in esophageal squamous cell carcinoma: high BAX and p16(ink4a/CDKN2) identifies patients with good prognosis. J Clin Oncol. 2001, 19 (8): 2272-2281.
CAS
PubMed
Google Scholar
Schelwies K, Sturm I, Grabowski P, Scherubl H, Schindler I, Hermann S, Stein H, Buhr HJ, Riecken EO, Zeitz M, Dorken B, Daniel PT: Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors. Int J Cancer. 2002, 99 (4): 589-596. 10.1002/ijc.10380.
Article
CAS
PubMed
Google Scholar
Mrozek A, Petrowsky H, Sturm I, Kraus J, Hermann S, Hauptmann S, Lorenz M, Dorken B, Daniel PT: Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability. Cell Death Differ. 2003, 10 (4): 461-467. 10.1038/sj.cdd.4401193.
Article
CAS
PubMed
Google Scholar
Rau B, Sturm I, Lage H, Berger S, Schneider U, Hauptmann S, Wust P, Riess H, Schlag PM, Dorken B, Daniel PT: Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. J Clin Oncol. 2003, 21 (18): 3391-3401. 10.1200/JCO.2003.07.077.
Article
CAS
PubMed
Google Scholar
von Haefen C, Wieder T, Gillissen B, Starck L, Graupner V, Dorken B, Daniel PT: Ceramide induces mitochondrial activation and apoptosis via a Bax- dependent pathway in human carcinoma cells. Oncogene. 2002, 21 (25): 4009-4019. 10.1038/sj.onc.1205497.
Article
CAS
PubMed
Google Scholar
von Haefen C, Gillissen B, Hemmati PG, Wendt J, Güner D, Mrozek A, Belka C, Dörken B, Daniel PT: Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway. Oncogene. 2004, 23 (50): 8320-8332. 10.1038/sj.onc.1207971.
Article
CAS
PubMed
Google Scholar
Friedrich K, Wieder T, Von Haefen C, Radetzki S, Janicke R, Schulze-Osthoff K, Dorken B, Daniel PT: Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance. Oncogene. 2001, 20 (22): 2749-2760. 10.1038/sj.onc.1204342.
Article
CAS
PubMed
Google Scholar
El-Deiry W, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994, 54 (5): 1169-1174.
CAS
PubMed
Google Scholar
Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993, 74 (4): 609-619. 10.1016/0092-8674(93)90509-O.
Article
CAS
PubMed
Google Scholar
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B: Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998, 282 (5393): 1497-1501. 10.1126/science.282.5393.1497.
Article
CAS
PubMed
Google Scholar
Waldman T, Lengauer C, Kinzler KW, Vogelstein B: Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature. 1996, 381 (6584): 713-716. 10.1038/381713a0.
Article
CAS
PubMed
Google Scholar
Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B: Role of BAX in the apoptotic response to anticancer agents. Science. 2000, 290 (5493): 989-992. 10.1126/science.290.5493.989.
Article
CAS
PubMed
Google Scholar
Radetzki S, Kohne CH, von Haefen C, Gillissen B, Sturm I, Dorken B, Daniel PT: The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines. Oncogene. 2002, 21 (2): 227-238. 10.1038/sj.onc.1205010.
Article
CAS
PubMed
Google Scholar
Daniel PT, Sturm I, Ritschel S, Friedrich K, Dorken B, Bendzko P, Hillebrand T: Detection of genomic DNA fragmentation during apoptosis (DNA ladder) and the simultaneous isolation of RNA from low cell numbers. Anal Biochem. 1999, 266 (1): 110-115. 10.1006/abio.1998.2929.
Article
CAS
PubMed
Google Scholar
Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer. 1981, 47 (1): 207-214.
Article
CAS
PubMed
Google Scholar
Tian H, Wittmack EK, Jorgensen TJ: p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. Cancer Res. 2000, 60 (3): 679-684.
CAS
PubMed
Google Scholar
Plisiecka-Halasa J, Karpinska G, Szymanska T, Ziolkowska I, Madry R, Timorek A, Debniak J, Ulanska M, Jedryka M, Chudecka-Glaz A, Klimek M, Rembiszewska A, Kraszewska E, Dybowski B, Markowska J, Emerich J, Pluzanska A, Goluda M, Rzepka-Gorska I, Urbanski K, Zielinski J, Stelmachow J, Chrabowska M, Kupryjanczyk J: P21(WAF1), P27(KIP1), TP53 and C-MYC analysis in 204 ovarian carcinomas treated with platinum-based regimens. Ann Oncol. 2003, 14 (7): 1078-1085. 10.1093/annonc/mdg299.
Article
CAS
PubMed
Google Scholar
Zirbes TK, Baldus SE, Moenig SP, Nolden S, Kunze D, Shafizadeh ST, Schneider PM, Thiele J, Hoelscher AH, Dienes HP: Prognostic impact of p21/waf1/cip1 in colorectal cancer. Int J Cancer. 2000, 89 (1): 14-18. 10.1002/(SICI)1097-0215(20000120)89:1<14::AID-IJC3>3.0.CO;2-L.
Article
CAS
PubMed
Google Scholar
Qiu H, Sirivongs P, Rothenberger M, Rothenberger DA, Garcia-Aguilar J: Molecular prognostic factors in rectal cancer treated by radiation and surgery. Dis Colon Rectum. 2000, 43 (4): 451-459. 10.1007/BF02237186.
Article
CAS
PubMed
Google Scholar
Kapranos N, Stathopoulos GP, Manolopoulos L, Kokka E, Papadimitriou C, Bibas A, Yiotakis J, Adamopoulos G: p53, p21 and p27 protein expression in head and neck cancer and their prognostic value. Anticancer Res. 2001, 21 (1B): 521-528.
CAS
PubMed
Google Scholar
Ahrendt SA, Brown HM, Komorowski RA, Zhu YR, Wilson SD, Erickson BA, Ritch PS, Pitt HA, Demeure MJ: p21WAF1 expression is associated with improved survival after adjuvant chemoradiation for pancreatic cancer. Surgery. 2000, 128 (4): 520-530. 10.1067/msy.2000.108052.
Article
CAS
PubMed
Google Scholar
Normand G, Hemmati PG, Verdoodt B, von Haefen C, Wendt J, Guner D, May E, Dorken B, Daniel PT: p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity. J Biol Chem. 2005, 280 (8): 7118-7130. 10.1074/jbc.M412330200.
Article
CAS
PubMed
Google Scholar
Hemmati PG, Normand G, Verdoodt B, von Haefen C, Hasenjager A, Guner D, Wendt J, Dorken B, Daniel PT: Loss of p21 disrupts p14(ARF)-induced G1 cell cycle arrest but augments p14(ARF)-induced apoptosis in human carcinoma cells. Oncogene. 2005
Google Scholar
Hemmati PG, Gillissen B, von Haefen C, Wendt J, Starck L, Guner D, Dorken B, Daniel PT: Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax- independent apoptosis. Oncogene. 2002, 21 (20): 3149-3161. 10.1038/sj.onc.1205458.
Article
CAS
PubMed
Google Scholar
Wendt J, Radetzki S, von Haefen C, Hemmati PG, Güner D, Schulze-Osthoff K, Dörken B, Daniel PT: Induction of p21CIP/WAF-1 and G2 arrest by ionising irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells. Oncogene. 2005, in revision
Google Scholar
Prokop A, Wrasidlo W, Lode H, Herold R, Lang F, Henze G, Dorken B, Wieder T, Daniel PT: Induction of apoptosis by enediyne antibiotic calicheamicin thetaII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner. Oncogene. 2003, 22 (57): 9107-9120. 10.1038/sj.onc.1207196.
Article
CAS
PubMed
Google Scholar
Gillissen B, Essmann F, Graupner V, Starck L, Radetzki S, Dorken B, Schulze-Osthoff K, Daniel PT: Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. Embo J. 2003, 22 (14): 3580-3590. 10.1093/emboj/cdg343.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hasenjager A, Gillissen B, Muller A, Normand G, Hemmati PG, Schuler M, Dorken B, Daniel PT: Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells. Oncogene. 2004, 23 (26): 4523-4535. 10.1038/sj.onc.1207594.
Article
PubMed
Google Scholar