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Table 1 Patient characteristics and clinicopathological parameters in relation to response status.

From: Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy

    HRCT     RCT   
   n Responder n = 18 Non-Res ponder n = 13 p n Responder n = 21 Non-Res ponder n = 14 p
Age (year)    61 ± 8* 58 ± 12* n.s.   59 ± 7 57 ± 10 n.s.
Gender male 23 16 7   18 11 7  
  female 8 2 6 n.s. 17 10 7 n.s.
Infiltration depth uT3 26 13 13   32 19 13  
  uT4 5 5 0 n.s. 3 2 1 n.s.
LN-involvement uN0 14 8 6   9 6 3  
  uNpos 17 10 7 n.s. 26 15 11 n.s.
optimal HT 1   16 13 3      
suboptimal HT 2   15 5 10 0.01     
radiation dose < 45.94 Gy 2 1 1   1 0 1  
  ≥ 45.94 Gy 29 17 12 n.s. 34 21 13 n.s.
  1. HRCT: radiochemotherapy with heat shock/hyperthermia. RCT: radiochemotherapy without heat shock/hyperthermia. HT: local heat shock/hyperthermia. LN: lymph node
  2. * mean ± SEM . n.s.: p > 0.05.
  3. 1 optimal hyperthermia (temperature-time-interval above pre-defined value): cum min T90 ≥ 40.5°C ≥ 120 min; 2 suboptimal hyperthermia (temperature-time-interval below pre-defined value): cum min T90 ≥ 40.5°C < 120 min