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Table 1 Patient characteristics and clinicopathological parameters in relation to response status.

From: Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy

   

HRCT

   

RCT

  
  

n

Responder n = 18

Non-Res ponder n = 13

p

n

Responder n = 21

Non-Res ponder n = 14

p

Age (year)

  

61 ± 8*

58 ± 12*

n.s.

 

59 ± 7

57 ± 10

n.s.

Gender

male

23

16

7

 

18

11

7

 
 

female

8

2

6

n.s.

17

10

7

n.s.

Infiltration depth

uT3

26

13

13

 

32

19

13

 
 

uT4

5

5

0

n.s.

3

2

1

n.s.

LN-involvement

uN0

14

8

6

 

9

6

3

 
 

uNpos

17

10

7

n.s.

26

15

11

n.s.

optimal HT 1

 

16

13

3

     

suboptimal HT 2

 

15

5

10

0.01

    

radiation dose

< 45.94 Gy

2

1

1

 

1

0

1

 
 

≥ 45.94 Gy

29

17

12

n.s.

34

21

13

n.s.

  1. HRCT: radiochemotherapy with heat shock/hyperthermia. RCT: radiochemotherapy without heat shock/hyperthermia. HT: local heat shock/hyperthermia. LN: lymph node
  2. * mean ± SEM . n.s.: p > 0.05.
  3. 1 optimal hyperthermia (temperature-time-interval above pre-defined value): cum min T90 ≥ 40.5°C ≥ 120 min; 2 suboptimal hyperthermia (temperature-time-interval below pre-defined value): cum min T90 ≥ 40.5°C < 120 min