Caffo O, Doglioni C, Veronese S, Bonzanini M, Marchetti A, Buttitta F, Fina P, Leek R, Morelli L, Palma PD, Harris AL, Barbareschi M: Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up. Clin Cancer Res. 1996, 2 (9): 1591-1599.
CAS
PubMed
Google Scholar
Bonin SR, Pajak TF, Russell AH, Coia LR, Paris KJ, Flam MS, Sauter ER: Overexpression of p53 protein and outcome of patients treated with chemoradiation for carcinoma of the anal canal: a report of randomized trial RTOG 87-04. Radiation Therapy Oncology Group. Cancer. 1999, 85 (6): 1226-1233. 10.1002/(SICI)1097-0142(19990315)85:6<1226::AID-CNCR3>3.0.CO;2-B.
Article
CAS
PubMed
Google Scholar
Hayakawa K, Mitsuhashi N, Hasegawa M, Saito Y, Sakurai H, Ohno T, Maebayashi K, Ebara T, Hayakawa KY, Niibe H: The prognostic significance of immunohistochemically detected p53 protein expression in non-small cell lung cancer treated with radiation therapy. Anticancer Res. 1998, 18 (5B): 3685-3688.
CAS
PubMed
Google Scholar
Pomp J, Davelaar J, Blom J, van Krimpen C, Zwinderman A, Quint W, Immerzeel J: Radiotherapy for oesophagus carcinoma: the impact of p53 on treatment outcome. Radiother Oncol. 1998, 46 (2): 179-184. 10.1016/S0167-8140(97)00163-1.
Article
CAS
PubMed
Google Scholar
Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL: Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994, 78 (5): 761-771. 10.1016/S0092-8674(94)90462-6.
Article
CAS
PubMed
Google Scholar
Rolfe M, Chiu MI, Pagano M: The ubiquitin-mediated proteolytic pathway as a therapeutic area. J Mol Med. 1997, 75 (1): 5-17. 10.1007/s001090050081.
Article
CAS
PubMed
Google Scholar
Weissman AM: Regulating protein degradation by ubiquitination. Immunol Today. 1997, 18 (4): 189-198. 10.1016/S0167-5699(97)84666-X.
Article
CAS
PubMed
Google Scholar
Pajonk F, McBride WH: Ionizing radiation affects 26s proteasome function and associated molecular responses, even at low doses. Radiother Oncol. 2001, 59 (2): 203-212. 10.1016/S0167-8140(01)00311-5.
Article
CAS
PubMed
Google Scholar
Stempien-Otero A, Karsan A, Cornejo CJ, Xiang H, Eunson T, Morrison RS, Kay M, Winn R, Harlan J: Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis. J Biol Chem. 1999, 274 (12): 8039-8045. 10.1074/jbc.274.12.8039.
Article
CAS
PubMed
Google Scholar
Kueckelkorn U, Knuehl C, Boes-Fabian B, Drung I, Kloetzel PM: The effect of heat shock on 20S/26S proteasomes. Biol Chem. 2000, 381 (9-10): 1017-1023. 10.1515/BC.2000.125.
Google Scholar
Pajonk F, van Ophoven A, McBride WH: Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells. Cancer Res. 2005, 65 (11): 4836-4843.
Article
CAS
PubMed
Google Scholar
Glockzin S, von Knethen A, Scheffner M, Brune B: Activation of the cell death program by nitric oxide involves inhibition of the proteasome. J Biol Chem. 1999, 274 (28): 19581-19586. 10.1074/jbc.274.28.19581.
Article
CAS
PubMed
Google Scholar
Hasselgren PO, Fischer JE: The ubiquitin-proteasome pathway: review of a novel intracellular mechanism of muscle protein breakdown during sepsis and other catabolic conditions. Ann Surg. 1997, 225 (3): 307-316. 10.1097/00000658-199703000-00011.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tanaka K: Molecular biology of proteasomes. Mol Biol Rep. 1995, 21 (1): 21-26. 10.1007/BF00990966.
Article
CAS
PubMed
Google Scholar
Stohwasser R, Kloetzel PM: Cytokine induced changes in proteasome subunit composition are concentration dependent. Biol Chem. 1996, 377 (9): 571-577.
CAS
PubMed
Google Scholar
Nandi D, Woodward E, Ginsburg DB, Monaco JJ: Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits. EMBO J. 1997, 16 (17): 5363-5375. 10.1093/emboj/16.17.5363.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schmidt M, Kloetzel PM: Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme. FASEB J. 1997, 11 (14): 1235-1243.
CAS
PubMed
Google Scholar
Kloetzel PM, Soza A, Stohwasser R: The role of the proteasome system and the proteasome activator PA28 complex in the cellular immune response. Biol Chem. 1999, 380 (3): 293-297. 10.1515/BC.1999.040.
Article
CAS
PubMed
Google Scholar
Drexler HC: Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci U S A. 1997, 94 (3): 855-860. 10.1073/pnas.94.3.855.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu LW, Reid S, Ritchie A, Broxmeyer HE, Donner DB: The proteasome regulates caspase-dependent and caspase-independent protease cascades during apoptosis of MO7e hematopoietic progenitor cells. Blood Cells Mol Dis. 1999, 25 (1): 20-29. 10.1006/bcmd.1999.0223.
Article
CAS
PubMed
Google Scholar
Herrmann JL, Briones FJ, Brisbay S, Logothetis CJ, McDonnell TJ: Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53. Oncogene. 1998, 17 (22): 2889-2899. 10.1038/sj.onc.1202221.
Article
CAS
PubMed
Google Scholar
McDade TP, Perugini RA, Vittimberga FJJ, Callery MP: Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells. Surgery. 1999, 126 (2): 371-377. 10.1067/msy.1999.98785.
Article
CAS
PubMed
Google Scholar
Adams J, Palombella VJ, Sausville EA, Johnson J, Destree A, Lazarus DD, Maas J, Pien CS, Prakash S, Elliott PJ: Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999, 59 (11): 2615-2622.
CAS
PubMed
Google Scholar
Zhang XM, Lin H, Chen C, Chen BD: Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells. Biochem J. 1999, 340 (Pt 1): 127-133. 10.1042/0264-6021:3400127.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kitagawa H, Tani E, Ikemoto H, Ozaki I, Nakano A, Omura S: Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells. FEBS Lett. 1999, 443 (2): 181-186. 10.1016/S0014-5793(98)01709-8.
Article
CAS
PubMed
Google Scholar
Pajonk F, Pajonk K, McBride WH: Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition. Int J Radiat Oncol Biol Phys. 2000, 47 (4): 1025-1032. 10.1016/S0360-3016(00)00516-2.
Article
CAS
PubMed
Google Scholar
An B, Goldfarb RH, Siman R, Dou QP: Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ. 1998, 5 (12): 1062-1075. 10.1038/sj.cdd.4400436.
Article
CAS
PubMed
Google Scholar
Mortenson MM, Schlieman MG, Virudachalam S, Bold RJ: Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapy in the A549 non-small-cell lung cancer cell line. Cancer Chemother Pharmacol. 2004, 54 (4): 343-53. 10.1007/s00280-004-0811-4.
Article
CAS
PubMed
Google Scholar
Pasquini LA, Besio Moreno M, Adamo AM, Pasquini JM, Soto EF: Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells. J Neurosci Res. 2000, 59 (5): 601-611. 10.1002/(SICI)1097-4547(20000301)59:5<601::AID-JNR3>3.0.CO;2-1.
Article
CAS
PubMed
Google Scholar
Qiu JH, Asai A, Chi S, Saito N, Hamada H, Kirino T: Proteasome inhibitors induce cytochrome c-caspase-3-like protease- mediated apoptosis in cultured cortical neurons. J Neurosci. 2000, 20 (1): 259-265.
CAS
PubMed
Google Scholar
Han Z, Malik N, Carter T, Reeves WH, Wyche JH, Hendrickson EA: DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J Biol Chem. 1996, 271 (40): 25035-25040. 10.1074/jbc.271.40.25035.
Article
CAS
PubMed
Google Scholar
Song Q, Burrows SR, Smith G, Lees-Miller SP, Kumar S, Chan DW, Trapani JA, Alnemri E, Litwack G, Lu H, Moss DJ, Jackson S, Lavin MF: Interleukin-1 beta-converting enzyme-like protease cleaves DNA- dependent protein kinase in cytotoxic T cell killing. J Exp Med. 1996, 184 (2): 619-626. 10.1084/jem.184.2.619.
Article
CAS
PubMed
Google Scholar
Masdehors P, Omura S, Merle-Beral H, Mentz F, Cosset JM, Dumont J, Magdelenat H, Delic J: Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Br J Haematol. 1999, 105 (3): 752-757. 10.1046/j.1365-2141.1999.01388.x.
Article
CAS
PubMed
Google Scholar
Kane RC, Bross PF, Farrell AT, Pazdur R: Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy. Oncologist. 2003, 8 (6): 508-513. 10.1634/theoncologist.8-6-508.
Article
PubMed
Google Scholar
Maki RG, Kraft AS, Scheu K, Yamada J, Wadler S, Antonescu CR, Wright JJ, Schwartz GK: A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas. Cancer. 2005, 103 (7): 1431-1438. 10.1002/cncr.20968.
Article
CAS
PubMed
Google Scholar
Price N, Dreicer R: Phase I/II trial of bortezomib plus docetaxel in patients with advanced androgen-independent prostate cancer. Clin Prostate Cancer. 2004, 3 (3): 141-143.
Article
PubMed
Google Scholar
Papandreou CN, Daliani DD, Nix D, Yang H, Madden T, Wang X, Pien CS, Millikan RE, Tu SM, Pagliaro L, Kim J, Adams J, Elliott P, Esseltine D, Petrusich A, Dieringer P, Perez C, Logothetis CJ, Chatta G: Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer . J Clin Oncol. 2004, 22: 2108-21. 10.1200/JCO.2004.02.106.
Article
CAS
PubMed
Google Scholar
Blaney SM, Bernstein M, Neville K, Ginsberg J, Kitchen B, Horton T, Berg SL, Krailo M, Adamson PC: Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: a Children's Oncology Group study (ADVL0015). J Clin Oncol. 2004, 22 (23): 4804-4809. 10.1200/JCO.2004.12.185.
Article
CAS
PubMed
Google Scholar
Kondagunta GV, Drucker B, Schwartz L, Bacik J, Marion S, Russo P, Mazumdar M, Motzer RJ: Phase II trial of bortezomib for patients with advanced renal cell carcinoma. J Clin Oncol. 2004, 22 (18): 3720-3725. 10.1200/JCO.2004.10.155.
Article
CAS
PubMed
Google Scholar
Shah MH, Young D, Kindler HL, Webb I, Kleiber B, Wright J, Grever M: Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors. Clin Cancer Res. 2004, 10 (18 Pt 1): 6111-6118.
Article
CAS
PubMed
Google Scholar
Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001, 61 (7): 3071-3076.
CAS
PubMed
Google Scholar
Russo SM, Tepper JE, Baldwin ASJ, Liu R, Adams J, Elliott P, Cusack JCJ: Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys. 2001, 50 (1): 183-193. 10.1016/S0360-3016(01)01446-8.
Article
CAS
PubMed
Google Scholar
Pajonk F, Pajonk K, McBride W: Apoptosis and radiosensitization of Hodgkin’s cells by proteasome inhibition. Int J Radiat Oncol Biol Phys. 2000, 47 (4): 1025-1032. 10.1016/S0360-3016(00)00516-2.
Article
CAS
PubMed
Google Scholar
Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW: Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol. 1992, 12 (11): 5041-5049.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ihara M, Suwa A, Komatsu K, Shimasaki T, Okaichi K, Hendrickson EA, Okumura Y: Heat sensitivity of double-stranded DNA-dependent protein kinase (DNA- PK) activity. Int J Radiat Biol. 1999, 75 (2): 253-258. 10.1080/095530099140717.
Article
CAS
PubMed
Google Scholar
Enari M, Talanian RV, Wong WW, Nagata S: Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis. Nature. 1996, 380 (6576): 723-726. 10.1038/380723a0.
Article
CAS
PubMed
Google Scholar
Machiels BM, Henfling ME, Gerards WL, Broers JL, Bloemendal H, Ramaekers FC, Schutte B: Detailed analysis of cell cycle kinetics upon proteasome inhibition. Cytometry. 1997, 28 (3): 243-252. 10.1002/(SICI)1097-0320(19970701)28:3<243::AID-CYTO9>3.0.CO;2-E.
Article
CAS
PubMed
Google Scholar
Maity A, McKenna WG, Muschel RJ: The molecular basis for cell cycle delays following ionizing radiation: a review. Radiother Oncol. 1994, 31 (1): 1-13. 10.1016/0167-8140(94)90408-1.
Article
CAS
PubMed
Google Scholar
Hwang A, Muschel RJ: Radiation and the G2 phase of the cell cycle. Radiat Res. 1998, 150 (5 Suppl): S52-9.
Article
CAS
PubMed
Google Scholar
Lee DH, Goldberg AL: Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J Biol Chem. 1996, 271 (44): 27280-27284. 10.1074/jbc.271.44.27280.
Article
CAS
PubMed
Google Scholar
Teraoka H, Yumoto Y, Watanabe F, Tsukada K, Suwa A, Enari M, Nagata S: CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme. FEBS Lett. 1996, 393 (1): 1-6. 10.1016/0014-5793(96)00842-3.
Article
CAS
PubMed
Google Scholar
Dietrich C, Bartsch T, Schanz F, Oesch F, Wieser RJ: p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L- leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts. Proc Natl Acad Sci U S A. 1996, 93 (20): 10815-10819. 10.1073/pnas.93.20.10815.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hashemolhosseini S, Nagamine Y, Morley SJ, Desrivieres S, Mercep L, Ferrari S: Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J Biol Chem. 1998, 273 (23): 14424-14429. 10.1074/jbc.273.23.14424.
Article
CAS
PubMed
Google Scholar
Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K: Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci U S A. 1999, 96 (14): 7797-7802. 10.1073/pnas.96.14.7797.
Article
CAS
PubMed
PubMed Central
Google Scholar
Delic J, Masdehors P, Omura S, Cosset JM, Dumont J, Binet JL, Magdelenat H: The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis [see comments]. Br J Cancer. 1998, 77 (7): 1103-1107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sinclair WK, Morton RA: X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat Res. 1966, 29 (3): 450-474.
Article
CAS
PubMed
Google Scholar
Meyn RE, Stephens LC, Milas L: Programmed cell death and radioresistance. Cancer Metastasis Rev. 1996, 15 (1): 119-131. 10.1007/BF00049491.
Article
CAS
PubMed
Google Scholar
Weichselbaum RR, Little JB: The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process. Br J Cancer. 1982, 46 (4): 532-537.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rosenzweig KE, Youmell MB, Palayoor ST, Price BD: Radiosensitization of human tumor cells by the phosphatidylinositol3- kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res. 1997, 3 (7): 1149-1156.
CAS
PubMed
Google Scholar
Chernikova SB, Wells RL, Elkind MM: Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat Res. 1999, 151 (2): 159-166.
Article
CAS
PubMed
Google Scholar
Hsieh CL, Arlett CF, Lieber MR: V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem. 1993, 268 (27): 20105-20109.
CAS
PubMed
Google Scholar
Jeggo PA: Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res. 1998, 150 (5 Suppl): S80-91.
Article
CAS
PubMed
Google Scholar
Allalunis-Turner MJ, Lintott LG, Barron GM, Day RS, Lees-Miller SP: Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity. Cancer Res. 1995, 55 (22): 5200-5202.
CAS
PubMed
Google Scholar
Dikomey E, Borgmann K, Brammer I, Kasten-Pisula U: Molecular mechanisms of individual radiosensitivity studied in normal diploid human fibroblasts. Toxicology. 2003, 193 (1-2): 125-135. 10.1016/S0300-483X(03)00293-2.
Article
CAS
PubMed
Google Scholar
Olive PL, Banath JP, MacPhail HS: Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines. Cancer Res. 1994, 54 (14): 3939-3946.
CAS
PubMed
Google Scholar
Grimm LM, Goldberg AL, Poirier GG, Schwartz LM, Osborne BA: Proteasomes play an essential role in thymocyte apoptosis. Embo J. 1996, 15 (15): 3835-3844.
CAS
PubMed
PubMed Central
Google Scholar
Sadoul R, Fernandez PA, Quiquerez AL, Martinou I, Maki M, Schroter M, Becherer JD, Irmler M, Tschopp J, Martinou JC: Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. Embo J. 1996, 15 (15): 3845-3852.
CAS
PubMed
PubMed Central
Google Scholar
Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC: Advances in biology of multiple myeloma: clinical applications. Blood. 2004, 104 (3): 607-618. 10.1182/blood-2004-01-0037.
Article
CAS
PubMed
Google Scholar
Monney L, Otter I, Olivier R, Ozer HL, Haas AL, Omura S, Borner C: Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2. J Biol Chem. 1998, 273 (11): 6121-6131. 10.1074/jbc.273.11.6121.
Article
CAS
PubMed
Google Scholar