Enzinger PC, Mayer RJ: Esophageal cancer. N Engl J Med. 2003, 349: 2241-2252. 10.1056/NEJMra035010.
Article
CAS
PubMed
Google Scholar
Thrift AP, Whiteman DC: The incidence of esophageal adenocarcinoma continues to rise: analysis of period and birth cohort effects on recent trends. Ann Oncol. 2012, 23: 3155-3162. 10.1093/annonc/mds181.
Article
CAS
PubMed
Google Scholar
Bosetti C, Levi F, Ferlay J, Garavello W, Lucchini F, Bertuccio P, Negri E, La Vecchia C: Trends in oesophageal cancer incidence and mortality in Europe. Int J Cancer. 2008, 122: 1118-1129.
Article
CAS
PubMed
Google Scholar
World Health Organization: Obesity: preventing and managing the global epidemic: report of a WHO consultation. World Health Organ Tech Rep Ser. 2000, 894: 1-253. i-xii
Google Scholar
Beddy P, Howard J, McMahon C, Knox M, de Blacam C, Ravi N, Reynolds JV, Keogan MT: Association of visceral adiposity with oesophageal and junctional adenocarcinomas. Br J Surg. 2010, 97: 1028-1034. 10.1002/bjs.7100.
Article
CAS
PubMed
Google Scholar
Ryan AM, Rowley SP, Fitzgerald AP, Ravi N, Reynolds JV: Adenocarcinoma of the oesophagus and gastric cardia: male preponderance in association with obesity. Eur J Cancer. 2006, 42: 1151-1158. 10.1016/j.ejca.2005.12.024.
Article
PubMed
Google Scholar
Yoon HH, Lewis MA, Shi Q, Khan M, Cassivi SD, Diasio RB, Sinicrope FA: Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma. J Clin Oncol. 2011, 29: 4561-4567. 10.1200/JCO.2011.37.1260.
Article
PubMed
PubMed Central
Google Scholar
Lysaght J, van der Stok EP, Allott EH, Casey R, Donohoe CL, Howard JM, McGarrigle SA, Ravi N, Reynolds JV, Pidgeon GP: Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue. Cancer Lett. 2011, 312: 62-72. 10.1016/j.canlet.2011.07.034.
Article
CAS
PubMed
Google Scholar
Ouchi N, Parker JL, Lugus JJ, Walsh K: Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011, 11: 85-97. 10.1038/nri2921.
Article
CAS
PubMed
PubMed Central
Google Scholar
Doyle SL, Donohoe CL, Lysaght J, Reynolds JV: Visceral obesity, metabolic syndrome, insulin resistance and cancer. Proc Nutr Soc. 2012, 71: 181-189. 10.1017/S002966511100320X.
Article
CAS
PubMed
Google Scholar
Harvey AE, Lashinger LM, Hursting SD: The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci. 2011, 1229: 45-52. 10.1111/j.1749-6632.2011.06096.x.
Article
CAS
PubMed
Google Scholar
Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, Vacchelli E, Michaud M, Zischka H, Castedo M, Kroemer G: Mitochondrial gateways to cancer. Mol Aspects Med. 2010, 31: 1-20. 10.1016/j.mam.2009.08.002.
Article
CAS
PubMed
Google Scholar
Warburg O: On the origin of cancer cells. Science. 1956, 123: 309-314. 10.1126/science.123.3191.309.
Article
CAS
PubMed
Google Scholar
Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser W: High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 2000, 60: 916-921.
CAS
PubMed
Google Scholar
Doyle SL, Bennett AM, Donohoe CL, Mongan AM, Howard JM, Lithander FE, Pidgeon GP, Reynolds JV, Lysaght J: Establishing computed tomography-defined visceral fat area thresholds for use in obesity-related cancer research. Nutr Res. 2013, 33: 171-179. 10.1016/j.nutres.2012.12.007.
Article
CAS
PubMed
Google Scholar
Baumgartner RN, Heymsfield SB, Roche AF, Bernardino M: Abdominal composition quantified by computed tomography. Am J Clin Nutr. 1988, 48: 936-945.
CAS
PubMed
Google Scholar
Fried SK, Moustaid-Moussa N: Culture of adipose tissue and isolated adipocytes. Methods Mol Biol. 2001, 155: 197-212.
CAS
PubMed
Google Scholar
World Health Organization: Physical status: the use and interpretation of anthropometry: report of a WHO expert committee. World Health Organ Tech Rep Ser. 1995, 854: 1-452.
Google Scholar
Seyfried TN, Shelton LM: Cancer as a metabolic disease. Nutr Metab (Lond). 2010, 7: 7-10.1186/1743-7075-7-7.
Article
Google Scholar
Kroemer G, Galluzzi L, Brenner C: Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007, 87: 99-163. 10.1152/physrev.00013.2006.
Article
CAS
PubMed
Google Scholar
Heerdt BG, Houston MA, Augenlicht LH: The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression. Cancer Res. 2005, 65: 9861-9867. 10.1158/0008-5472.CAN-05-2444.
Article
CAS
PubMed
Google Scholar
Houston MA, Augenlicht LH, Heerdt BG: Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity. Int J Cell Biol. 2011, 2011: 978583-
Article
PubMed
PubMed Central
Google Scholar
Allott EH, Lysaght J, Cathcart MC, Donohoe CL, Cummins R, McGarrigle SA, Kay E, Reynolds JV, Pidgeon GP: MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation. Mol Carcinog. 2013, 52: 144-154. 10.1002/mc.21840.
Article
PubMed
Google Scholar
Detmer SA, Chan DC: Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol. 2007, 8: 870-879. 10.1038/nrm2275.
Article
CAS
PubMed
Google Scholar
Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J. 2008, 22: 3264-3275. 10.1096/fj.08-106468.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chevrollier A, Loiseau D, Chabi B, Renier G, Douay O, Malthiery Y, Stepien G: ANT2 isoform required for cancer cell glycolysis. J Bioenerg Biomembr. 2005, 37: 307-316. 10.1007/s10863-005-8642-5.
Article
CAS
PubMed
Google Scholar
Lehninger AND, Cox MM: Lehninger Principles of Biochemistry Book. 2008, New York: W.H. Freeman, 5
Google Scholar
Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE: Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes. 2005, 54: 8-14. 10.2337/diabetes.54.1.8.
Article
CAS
PubMed
Google Scholar
Allott EH, Morine MJ, Lysaght J, McGarrigle SA, Donohoe CL, Reynolds JV, Roche HM, Pidgeon GP: Elevated tumor expression of PAI-1 and SNAI2 in obese esophageal adenocarcinoma patients and impact on prognosis. Clin Transl Gastroenterol. 2012, 3: e12-10.1038/ctg.2012.5.
Article
PubMed
PubMed Central
Google Scholar
Park J, Kusminski CM, Chua SC, Scherer PE: Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo. Am J Pathol. 2010, 177: 3133-3144. 10.2353/ajpath.2010.100595.
Article
CAS
PubMed
PubMed Central
Google Scholar
Groves AM, Win T, Haim SB, Ell PJ: Non-[18F]FDG PET in clinical oncology. Lancet Oncol. 2007, 8: 822-830. 10.1016/S1470-2045(07)70274-7.
Article
PubMed
Google Scholar
Gatenby RA, Gillies RJ: Why do cancers have high aerobic glycolysis?. Nat Rev Cancer. 2004, 4: 891-899. 10.1038/nrc1478.
Article
CAS
PubMed
Google Scholar
Bellance N, Benard G, Furt F, Begueret H, Smolkova K, Passerieux E, Delage JP, Baste JM, Moreau P, Rossignol R: Bioenergetics of lung tumors: alteration of mitochondrial biogenesis and respiratory capacity. Int J Biochem Cell Biol. 2009, 41: 2566-2577. 10.1016/j.biocel.2009.08.012.
Article
CAS
PubMed
Google Scholar
Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA: Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 2004, 64: 985-993. 10.1158/0008-5472.CAN-03-1101.
Article
CAS
PubMed
Google Scholar
Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J: Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma. PLoS One. 2014, 9: e100738-10.1371/journal.pone.0100738.
Article
PubMed
PubMed Central
Google Scholar
Pfeiffer T, Schuster S, Bonhoeffer S: Cooperation and competition in the evolution of ATP-producing pathways. Science. 2001, 292: 504-507. 10.1126/science.1058079.
Article
CAS
PubMed
Google Scholar
Groff JL, Stugard CE, Mays CJ, Koopmans HS, DiGirolamo M: Glucose metabolism in isolated rat adipocytes: estimate of total recovery by the product summation method. J Lab Clin Med. 1992, 119: 216-220.
CAS
PubMed
Google Scholar
Hirschhaeuser F, Sattler UG, Mueller-Klieser W: Lactate: a metabolic key player in cancer. Cancer Res. 2011, 71: 6921-6925. 10.1158/0008-5472.CAN-11-1457.
Article
CAS
PubMed
Google Scholar
Muto Y, Sato S, Watanabe A, Moriwaki H, Suzuki K, Kato A, Kato M, Nakamura T, Higuchi K, Nishiguchi S, Kumada H, Ohashi Y: Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatol Res. 2006, 35: 204-214.
CAS
PubMed
Google Scholar
Kawaguchi T, Nagao Y, Matsuoka H, Ide T, Sata M: Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease. Int J Mol Med. 2008, 22: 105-112.
PubMed
Google Scholar
Kawaguchi T, Shiraishi K, Ito T, Suzuki K, Koreeda C, Ohtake T, Iwasa M, Tokumoto Y, Endo R, Kawamura NH, Shiraki M, Habu D, Tsuruta S, Miwa Y, Kawaguchi A, Kakuma T, Sakai H, Kawada N, Hanai T, Takahashi SI, Kato A, Onji M, Takei Y, Kohgo Y, Seki T, Tamano M, Katayama K, Mine T, Sata M, Moriwaki H: Branched-chain amino acids prevent Hepatocarcinogenesis and prolong survival of patients with cirrhosis. Clin Gastroenterol Hepatol. 2014, 12: 1012-1018. 10.1016/j.cgh.2013.08.050.
Article
CAS
PubMed
Google Scholar
Hagiwara A, Nishiyama M, Ishizaki S: Branched-chain amino acids prevent insulin-induced hepatic tumor cell proliferation by inducing apoptosis through mTORC1 and mTORC2-dependent mechanisms. J Cell Physiol. 2012, 227: 2097-2105. 10.1002/jcp.22941.
Article
CAS
PubMed
Google Scholar
Yoshiji H, Noguchi R, Kitade M, Kaji K, Ikenaka Y, Namisaki T, Yoshii J, Yanase K, Yamazaki M, Tsujimoto T, Akahane T, Kawaratani H, Uemura M, Fukui H: Branched-chain amino acids suppress insulin-resistance-based hepatocarcinogenesis in obese diabetic rats. J Gastroenterol. 2009, 44: 483-491. 10.1007/s00535-009-0031-0.
Article
CAS
PubMed
Google Scholar
Cha JH, Bae SH, Kim HL, Park NR, Choi ES, Jung ES, Choi JY, Yoon SK: Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis. PLoS One. 2013, 8: e77899-10.1371/journal.pone.0077899.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rossner S, Bo WJ, Hiltbrandt E, Hinson W, Karstaedt N, Santago P, Sobol WT, Crouse JR: Adipose tissue determinations in cadavers–a comparison between cross-sectional planimetry and computed tomography. Int J Obes. 1990, 14: 893-902.
CAS
PubMed
Google Scholar