Figure 1

VPA enhances the sensitivity of pancreatic cancer cells to NK cell-mediated lysis via a NKG2D-dependent mechanism. (A) VPA sensitized pancreatic cancer cells to NK cell-mediated lysis; * P < 0.05; ** P < 0.01. (B) Blockade of NKG2D attenuated the ability of VPA to sensitize pancreatic cancer cells to NK cell-mediated lysis; * P < 0.05 for VPA + IgG vs. VPA + NKG2D; ** P < 0.01 for VPA + IgG vs. VPA + NKG2D. Data are mean ± SD of a single experiment performed in triplicate, all results were reproducible in three independent experiments. E:T, effector/ target ratio.