Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks J: Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011, 365 (5): 395-409.
Article
PubMed
Google Scholar
Godoy MC, Naidich DP: Subsolid Pulmonary Nodules and the Spectrum of Peripheral Adenocarcinomas of the Lung: Recommended Interim Guidelines for Assessment and Management. Radiology. 2009, 253 (3): 606-622. 10.1148/radiol.2533090179.
Article
PubMed
Google Scholar
Lee HY, Lee KS: Ground-glass opacity nodules: histopathology, imaging evaluation, and clinical implications. J Thorac Imaging. 2011, 26 (2): 106-118. 10.1097/RTI.0b013e3181fbaa64.
Article
PubMed
Google Scholar
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, et al: International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011, 6 (2): 244-285. 10.1097/JTO.0b013e318206a221.
Article
PubMed
PubMed Central
Google Scholar
Takeuchi T, Tomida S, Yatabe Y, Kosaka T, Osada H, Yanagisawa K, Mitsudomi T, Takahashi T: Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Thorac Oncol. 2006, 24 (11): 1679-1688.
CAS
Google Scholar
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I: Gefitinib or chemotherapy for non–small-cell lung cancer with mutated EGFR. N Engl J Med. 2010, 362 (25): 2380-2388. 10.1056/NEJMoa0909530.
Article
CAS
PubMed
Google Scholar
Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T: Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010, 11 (2): 121-128. 10.1016/S1470-2045(09)70364-X.
Article
CAS
PubMed
Google Scholar
Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, Zhang S, Wang J, Zhou S, Ren S, Lu S, Zhang L, Hu C, Luo Y, Chen L, Ye M, Huang J, Zhi X, Zhang Y, Xiu Q, Ma J, Zhang L, You C: Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011, 12 (8): 735-742. 10.1016/S1470-2045(11)70184-X.
Article
CAS
PubMed
Google Scholar
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S-i, Watanabe H, Kurashina K, Hatanaka H: Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer. Nature. 2007, 448 (7153): 561-566. 10.1038/nature05945.
Article
CAS
PubMed
Google Scholar
Kwak EL, Bang Y-J, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou S-HI, Dezube BJ, Jänne PA, Costa DB: Anaplastic lymphoma kinase inhibition in non–small-cell lung cancer. N Engl J Med. 2010, 363 (18): 1693-1703. 10.1056/NEJMoa1006448.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shaw AT, Kim D-W, Nakagawa K, Seto T, Crinó L, Ahn M-J, De Pas T, Besse B, Solomon BJ, Blackhall F: Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013, 368 (25): 2385-2394. 10.1056/NEJMoa1214886.
Article
CAS
PubMed
Google Scholar
Ettinger DS, Akerley W, Borghaei H, Chang AC, Cheney RT, Chirieac LR, D’Amico TA, Demmy TL, Ganti AKP, Govindan R: Non–Small Cell Lung Cancer. J Natl Compr Cancer Netw. 2012, 10 (10): 1236-1271.
CAS
Google Scholar
Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar J-S, Squire J: Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagn. 2013, 15 (4): 415-453. 10.1016/j.jmoldx.2013.03.001.
Article
CAS
PubMed
Google Scholar
Aoki T, Hanamiya M, Uramoto H, Hisaoka M, Yamashita Y, Korogi Y: Adenocarcinomas with Predominant Ground-Glass Opacity: Correlation of Morphology and Molecular Biomarkers. Radiology. 2012, 264 (2): 590-596. 10.1148/radiol.12111337.
Article
PubMed
Google Scholar
Chung J-H, Choe G, Jheon S, Sung S-W, Kim TJ, Lee KW, Lee JH, Lee C-T: Epidermal growth factor receptor mutation and pathologic-radiologic correlation between multiple lung nodules with ground-glass opacity differentiates multicentric origin from intrapulmonary spread. J Thorac Oncol. 2009, 4 (12): 1490-1495. 10.1097/JTO.0b013e3181bc9731.
Article
PubMed
Google Scholar
Yoshida Y, Kokubu A, Suzuki K, Kuribayashi H, Tsuta K, Matsuno Y, Kusumoto M, Kanai Y, Asamura H, Hirohashi S: Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity. Jpn J Clin Oncol. 2007, 37 (12): 907-912. 10.1093/jjco/hym139.
Article
PubMed
Google Scholar
Yano M, Sasaki H, Kobayashi Y, Yukiue H, Haneda H, Suzuki E, Endo K, Kawano O, Hara M, Fujii Y: Epidermal growth factor receptor gene mutation and computed tomographic findings in peripheral pulmonary adenocarcinoma. J Thorac Oncol. 2006, 1 (5): 413-416. 10.1097/01243894-200606000-00006.
Article
PubMed
Google Scholar
Okada M, Nishio W, Sakamoto T, Uchino K, Tsubota N: Discrepancy of computed tomographic image between lung and mediastinal windows as a prognostic implication in small lung adenocarcinoma. Ann Thorac Surg. 2003, 76 (6): 1828-1832. 10.1016/S0003-4975(03)01077-4.
Article
PubMed
Google Scholar
Goldstraw P: The 7th Edition of TNM in Lung Cancer: what now?. J Thorac Oncol. 2009, 4 (6): 671-673. 10.1097/JTO.0b013e31819e7814.
Article
PubMed
Google Scholar
Kim HJ, Lee KY, Kim Y-C, Kim K-S, Lee SY, Jang TW, Lee MK, Shin K-C, Lee GH, Lee JC: Detection and comparison of peptide nucleic acid-mediated real-time polymerase chain reaction clamping and direct gene sequencing for epidermal growth factor receptor mutations in patients with non-small cell lung cancer. Lung Cancer. 2012, 75 (3): 321-325. 10.1016/j.lungcan.2011.08.005.
Article
PubMed
Google Scholar
Lee HJ, Xu X, Kim H, Jin Y, Sun P, Kim JE, Chung J-H: Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor. Korean J Pathol. 2013, 47 (1): 52-60. 10.4132/KoreanJPathol.2013.47.1.52.
Article
PubMed
PubMed Central
Google Scholar
Paik JH, Choe G, Kim H, Choe J-Y, Lee HJ, Lee C-T, Lee JS, Jheon S, Chung J-H: Screening of anaplastic lymphoma kinase rearrangement by immunohistochemistry in non-small cell lung cancer: correlation with fluorescence in situ hybridization. J Thorac Oncol. 2011, 6 (3): 466-472. 10.1097/JTO.0b013e31820b82e8.
Article
PubMed
Google Scholar
Paik JH, Choi C-M, Kim H, Jang SJ, Choe G, Kim DK, Kim HJ, Yoon H, Lee C-T, Jheon S: Clinicopathologic implication of ALK rearrangement in surgically resected lung cancer: a proposal of diagnostic algorithm for ALK-rearranged adenocarcinoma. Lung Cancer. 2012, 76 (3): 403-409. 10.1016/j.lungcan.2011.11.008.
Article
PubMed
Google Scholar
Kim H, Shim HS, Kim L, Kim T-J, Kwon KY, Lee GK, Chung J-H: Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: a Proposal of the Korean Cardiopulmonary Pathology Study Group. Korean J Pathol. 2014, 48: 1-9. 10.4132/KoreanJPathol.2014.48.1.1.
Article
PubMed
PubMed Central
Google Scholar
Choi H, Paeng JC, Kim D-W, Lee JK, Park CM, Kang KW, Chung J-K, Lee DS: Metabolic and metastatic characteristics of ALK–rearranged lung adenocarcinoma on FDG PET/CT. Lung Cancer. 2013, 79 (3): 242-247. 10.1016/j.lungcan.2012.11.021.
Article
PubMed
Google Scholar
Koh Y, Kim D-W, Kim TM, Lee S-H, Jeon YK, Chung DH, Kim Y-W, Heo DS, Kim W-H, Bang Y-J: Clinicopathologic characteristics and outcomes of patients with anaplastic lymphoma kinase-positive advanced pulmonary adenocarcinoma: suggestion for an effective screening strategy for these tumors. J Thorac Oncol. 2011, 6 (5): 905-912. 10.1097/JTO.0b013e3182111461.
Article
PubMed
Google Scholar
Aoki T, Tomoda Y, Watanabe H, Nakata H, Kasai T, Hashimoto H, Kodate M, Osaki T, Yasumoto K: Peripheral Lung Adenocarcinoma: Correlation of Thin-Section CT Findings with Histologic Prognostic Factors and Survival. Radiology. 2001, 220 (3): 803-809. 10.1148/radiol.2203001701.
Article
CAS
PubMed
Google Scholar
Takashima S, Maruyama Y, Hasegawa M, Yamanda T, Honda T, Kadoya M, Sone S: CT findings and progression of small peripheral lung neoplasms having a replacement growth pattern. Am J Roentgenol. 2003, 180 (3): 817-826. 10.2214/ajr.180.3.1800817.
Article
Google Scholar
Fukui T, Yatabe Y, Kobayashi Y, Tomizawa K, Ito S, Hatooka S, Matsuo K, Mitsudomi T: Clinicoradiologic characteristics of patients with lung adenocarcinoma harboring EML4-ALK fusion oncogene. Lung Cancer. 2012, 77 (2): 319-325. 10.1016/j.lungcan.2012.03.013.
Article
PubMed
Google Scholar
Rodig SJ, Mino-Kenudson M, Dacic S, Yeap BY, Shaw A, Barletta JA, Stubbs H, Law K, Lindeman N, Mark E: Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009, 15 (16): 5216-5223. 10.1158/1078-0432.CCR-09-0802.
Article
CAS
PubMed
PubMed Central
Google Scholar
Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H: RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012, 18 (3): 378-381. 10.1038/nm.2658.
Article
CAS
PubMed
Google Scholar
Wang Z, Zhang X, Bai H, Zhao J, Zhuo M, An T, Duan J, Yang L, Wu M, Wang S: EML4-ALK rearrangement and its clinical significance in Chinese patients with advanced non-small cell lung cancer. Oncology. 2012, 83 (5): 248-256. 10.1159/000341381.
Article
CAS
PubMed
Google Scholar
Pillai RN, Ramalingam SS: The Biology and Clinical Features of Non–small Cell Lung Cancers with EML4-ALK Translocation. Curr Oncol Rep. 2012, 14 (2): 105-110. 10.1007/s11912-012-0213-4.
Article
CAS
PubMed
Google Scholar
Jokoji R, Yamasaki T, Minami S, Komuta K, Sakamaki Y, Takeuchi K, Tsujimoto M: Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma. J Clin Pathol. 2010, 63 (12): 1066-1070. 10.1136/jcp.2010.081166.
Article
PubMed
Google Scholar
Yoshida A, Tsuta K, Nakamura H, Kohno T, Takahashi F, Asamura H, Sekine I, Fukayama M, Shibata T, Furuta K: Comprehensive histologic analysis of ALK-rearranged lung carcinomas. Am J Surg Pathol. 2011, 35 (8): 1226-1234. 10.1097/PAS.0b013e3182233e06.
Article
PubMed
Google Scholar
Park J, Yamaura H, Yatabe Y, Hosoda W, Kondo C, Shimizu J, Horio Y, Yoshida K, Tanaka K, Oguri T, Kobayashi Y, Hida H: Anaplastic lymphoma kinase gene rearrangements in patients with advanced-stage non-small-cell lung cancer: CT characteristics and response to chemotherapy. Cancer Med. 2014, 3 (1): 118-123. 10.1002/cam4.172.
Article
CAS
PubMed
Google Scholar
Yatabe Y, Kosaka T, Takahashi T, Mitsudomi T: EGFR mutation is specific for terminal respiratory unit type adenocarcinoma. Am J Surg Pathol. 2005, 29 (5): 633-639. 10.1097/01.pas.0000157935.28066.35.
Article
PubMed
Google Scholar
Park WY, Kim MH, Shin DH, Lee JH, Choi KU, Kim JY, Park DY, Lee CH, Sol MY: Ciliated adenocarcinomas of the lung: a tumor of non-terminal respiratory unit origin. Mod Pathol. 2012, 25 (9): 1265-1274. 10.1038/modpathol.2012.76.
Article
PubMed
Google Scholar
Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, Mun M-y, Sakao Y, Okumura S, Nakagawa K: EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod Pathol. 2009, 22 (4): 508-515. 10.1038/modpathol.2009.2.
Article
CAS
PubMed
Google Scholar
Li Y, Li Y, Yang T, Wei S, Wang J, Wang M, Wang Y, Zhou Q, Liu H, Chen J: Clinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer. PLoS One. 2013, 8 (1): e52093-10.1371/journal.pone.0052093.
Article
CAS
PubMed
PubMed Central
Google Scholar
Takahashi T, Kobayashi M, Yoshizawa A, Menju T, Nakayama E: Clinicopathologic features of non-small-cell lung cancer with EML4–ALK fusion gene. Ann Surg Oncol. 2010, 17 (3): 889-897. 10.1245/s10434-009-0808-7.
Article
PubMed
Google Scholar
Kim H, Jang SJ, Chung DH, Yoo SB, Sun P, Jin Y, Nam KH, Paik JH, Chung JH: A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype. PLoS One. 2013, 8 (10): e76999-10.1371/journal.pone.0076999.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kang HJ, Lim HJ, Park JS, Cho YJ, Yoon HI, Chung JH, Lee JH, Lee CT: Comparison of clinical characteristics between patients with ALK-positive and EGFR-positive lung adenocarcinoma. Respir Med. 2014, 108 (2): 388-394. 10.1016/j.rmed.2013.11.020.
Article
PubMed
Google Scholar
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non–small-cell lung cancer to gefitinib. N Engl J Med. 2004, 350 (21): 2129-2139. 10.1056/NEJMoa040938.
Article
CAS
PubMed
Google Scholar
Huang Y-s, Yang J-j, Zhang X-c, Yang X-n, Huang Y-j, Xu C-r, Zhou Q, Wang Z, Su J, Wu Y: Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer. Chin Med J. 2011, 124 (16): 2457-2460.
PubMed
Google Scholar
Kim HR, Ahn JR, Lee JG, Bang DH, Ha S-J, Hong YK, Kim SM, Nam KC, Rha SY, Soo RA: The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma. Yonsei Med J. 2013, 54 (4): 865-874. 10.3349/ymj.2013.54.4.865.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T: Mutations of the epidermal growth factor receptor gene in lung cancer biological and clinical implications. Cancer Res. 2004, 64 (24): 8919-8923. 10.1158/0008-5472.CAN-04-2818.
Article
CAS
PubMed
Google Scholar
Liam C-K, Wahid MIA, Rajadurai P, Cheah Y-K, Ng TS-Y: Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma in Malaysian Patients. J Thorac Oncol. 2013, 8 (6): 766-772. 10.1097/JTO.0b013e31828b5228.
Article
CAS
PubMed
Google Scholar
Sun P-L, Seol H, Lee HJ, Yoo SB, Kim H, Xu X, Jheon S, Lee C-T, Lee J-S, Chung J-H: High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas: Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features. J Thorac Oncol. 2012, 7 (2): 323-330. 10.1097/JTO.0b013e3182381515.
Article
CAS
PubMed
Google Scholar
Uramoto H, So T, Nagata Y, Kuroda K, Shigematsu Y, Baba T, So T, Takenoyama M, Hanagiri T, Yasumoto K: Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung. J Thorac Oncol. 2010, 5 (8): 1136-1142. 10.1097/JTO.0b013e3181e0b993.
Article
PubMed
Google Scholar
Hsu K-H, Chen K-C, Yang T-Y, Yeh Y-C, Chou T-Y, Chen H-Y, Tsai C-R, Chen C-Y, Hsu C-P, Hsia J-Y: Epidermal growth factor receptor mutation status in stage I lung adenocarcinoma with different image patterns. J Thorac Oncol. 2011, 6 (6): 1066-1072. 10.1097/JTO.0b013e31821667b0.
Article
PubMed
Google Scholar
Lee H-J, Kim YT, Kang CH, Zhao B, Tan Y, Schwartz LH, Persigehl T, Jeon YK, Chung DH: Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinomas: Relationship with CT Characteristics and Histologic Subtypes. Radiology. 2013, 268 (1): 254-264. 10.1148/radiol.13112553.
Article
PubMed
Google Scholar