Hemmings BA, Restuccia DF: PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol. 2012, 4: a011189-
Article
PubMed
PubMed Central
Google Scholar
Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell. 2007, 129: 1261-1274. 10.1016/j.cell.2007.06.009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR: Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J. 1999, 344 (Pt 2): 427-431.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rena G, Guo S, Cichy SC, Unterman TG, Cohen P: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem. 1999, 274: 17179-17183. 10.1074/jbc.274.24.17179.
Article
CAS
PubMed
Google Scholar
Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T: Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem. 1999, 274: 17184-17192. 10.1074/jbc.274.24.17184.
Article
CAS
PubMed
Google Scholar
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999, 96: 857-868. 10.1016/S0092-8674(00)80595-4.
Article
CAS
PubMed
Google Scholar
Samuels Y, Velculescu VE: Oncogenic mutations of PIK3CA in human cancers. Cell Cycle (Georgetown, Tex). 2004, 3: 1221-1224. 10.4161/cc.3.10.1164.
Article
CAS
Google Scholar
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science (New York, NY). 2004, 304: 554-10.1126/science.1096502.
Article
CAS
Google Scholar
Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, et al: The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther. 2004, 3: 772-775. 10.4161/cbt.3.8.994.
Article
CAS
PubMed
Google Scholar
Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H: Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res. 2004, 64: 5048-5050. 10.1158/0008-5472.CAN-04-1170.
Article
CAS
PubMed
Google Scholar
Samuels Y, Diaz LA, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, et al: Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 2005, 7: 561-573. 10.1016/j.ccr.2005.05.014.
Article
CAS
PubMed
Google Scholar
Kang S, Bader AG, Vogt PK: Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A. 2005, 102: 802-807. 10.1073/pnas.0408864102.
Article
CAS
PubMed
PubMed Central
Google Scholar
Banning A, Tomasovic A, Tikkanen R: Functional aspects of membrane association of reggie/flotillin proteins. Curr Protein Pept Sci. 2011, 12: 725-735. 10.2174/138920311798841708.
Article
CAS
PubMed
Google Scholar
Kurrle N, John B, Meister M, Tikkanen R: Function of Flotillins in Receptor Tyrosine Kinase Signaling and Endocytosis: Role of Tyrosine Phosphorylation and Oligomerization. Protein Phosphorylation in Human Health. Edited by: Huang C. 2012, Rijeka, Croatia: InTech Publisher, http://dx.doi.org/10.5772/48598 ISBN 980-953-307-159-1
Google Scholar
Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF: Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997, 272: 13793-13802. 10.1074/jbc.272.21.13793.
Article
CAS
PubMed
Google Scholar
Amaddii M, Meister M, Banning A, Tomasovic A, Mooz J, Rajalingam K, Tikkanen R: Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling. J Biol Chem. 2012, 287: 7265-7278. 10.1074/jbc.M111.287599.
Article
CAS
PubMed
PubMed Central
Google Scholar
Babuke T, Ruonala M, Meister M, Amaddii M, Genzler C, Esposito A, Tikkanen R: Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell Signal. 2009, 21: 1287-1297. 10.1016/j.cellsig.2009.03.012.
Article
CAS
PubMed
Google Scholar
Dermine JF, Duclos S, Garin J, St-Louis F, Rea S, Parton RG, Desjardins M: Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. J Biol Chem. 2001, 276: 18507-18512. 10.1074/jbc.M101113200.
Article
CAS
PubMed
Google Scholar
Glebov OO, Bright NA, Nichols BJ: Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat Cell Biol. 2006, 8: 46-54. 10.1038/ncb1342.
Article
CAS
PubMed
Google Scholar
Santamaria A, Castellanos E, Gomez V, Benedit P, Renau-Piqueras J, Morote J, Reventos J, Thomson TM, Paciucci R: PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol. 2005, 25: 1900-1911. 10.1128/MCB.25.5.1900-1911.2005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Morrow IC, Rea S, Martin S, Prior IA, Prohaska R, Hancock JF, James DE, Parton RG: Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation. J Biol Chem. 2002, 277: 48834-48841. 10.1074/jbc.M209082200.
Article
CAS
PubMed
Google Scholar
Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR: CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 2000, 407: 202-207. 10.1038/35025089.
Article
CAS
PubMed
Google Scholar
Frick M, Bright NA, Riento K, Bray A, Merrified C, Nichols BJ: Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Curr Biol. 2007, 17: 1151-1156. 10.1016/j.cub.2007.05.078.
Article
CAS
PubMed
Google Scholar
Limpert AS, Karlo JC, Landreth GE: Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein. Mol Cell Biol. 2007, 27: 5686-5698. 10.1128/MCB.01109-06.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ludwig A, Otto GP, Riento K, Hams E, Fallon PG, Nichols BJ: Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol. 2010, 191: 771-781. 10.1083/jcb.201005140.
Article
CAS
PubMed
PubMed Central
Google Scholar
Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Luers G, Stuermer CA, Herzog V, Tikkanen R: Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression. Biochem J. 2004, 378: 509-518. 10.1042/BJ20031100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R: Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci. 2007, 120: 395-406. 10.1242/jcs.03336.
Article
CAS
PubMed
Google Scholar
Pust S, Dyve AB, Torgersen ML, van Deurs B, Sandvig K: Interplay between toxin transport and flotillin localization. PLoS One. 2010, 5: e8844-10.1371/journal.pone.0008844.
Article
PubMed
PubMed Central
Google Scholar
Pust S, Klokk TI, Musa N, Jenstad M, Risberg B, Erikstein B, Tcatchoff L, Liestol K, Danielsen HE, van Deurs B, Sandvig K: Flotillins as regulators of ErbB2 levels in breast cancer. Oncogene. 2012, 32 (29): 3443-3451.
Article
PubMed
Google Scholar
Tomasovic A, Traub S, Tikkanen R: Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS One. 2012, 7: e29739-10.1371/journal.pone.0029739.
Article
CAS
PubMed
PubMed Central
Google Scholar
Solis GP, Schrock Y, Hulsbusch N, Wiechers M, Plattner H, Stuermer CA: Reggies/flotillins regulate E-cadherin-mediated cell contact formation by affecting EGFR trafficking. Mol Biol Cell. 2012, 23: 1812-1825. 10.1091/mbc.E11-12-1006.
Article
CAS
PubMed
PubMed Central
Google Scholar
Meister M, Tomasovic A, Banning A, Tikkanen R: Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. Int J Mol Sci. 2013, 14: 4854-4884. 10.3390/ijms14034854.
Article
CAS
PubMed
PubMed Central
Google Scholar
Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, et al: Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene. 2012, 32 (41): 4989-4994.
Article
PubMed
Google Scholar
Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M: Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res. 2004, 64: 7361-7369. 10.1158/0008-5472.CAN-04-0823.
Article
CAS
PubMed
Google Scholar
Lin C, Wu Z, Lin X, Yu C, Shi T, Zeng Y, Wang X, Li J, Song L: Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clin Cancer Res. 2011, 17: 3089-3099. 10.1158/1078-0432.CCR-10-3068.
Article
CAS
PubMed
Google Scholar
Rickman DS, Millon R, De Reynies A, Thomas E, Wasylyk C, Muller D, Abecassis J, Wasylyk B: Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays. Oncogene. 2008, 27: 6607-6622. 10.1038/onc.2008.251.
Article
CAS
PubMed
Google Scholar
Zhu Z, Wang J, Sun Z, Sun X, Wang Z, Xu H: Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer. PLoS One. 2013, 8: e62365-10.1371/journal.pone.0062365.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kersting C, Tidow N, Schmidt H, Liedtke C, Neumann J, Boecker W, van Diest PJ, Brandt B, Buerger H: Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma. Lab Invest. 2004, 84: 582-587. 10.1038/labinvest.3700077.
Article
CAS
PubMed
Google Scholar
Cremona ML, Matthies HJ, Pau K, Bowton E, Speed N, Lute BJ, Anderson M, Sen N, Robertson SD, Vaughan RA, et al: Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci. 2011, 14: 469-477. 10.1038/nn.2781.
Article
CAS
PubMed
PubMed Central
Google Scholar
COSMIC catalogue of somatic mutations in cancer. http://cancer.sanger.ac.uk/cosmic,
Banning A, Regenbrecht CR, Tikkanen R: Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model. Cell Signal. 2013, DOI: 10.1016/j.cellsig.2013.11.001
Google Scholar
Wu J, Lee C, Yokom D, Jiang H, Cheang MC, Yorida E, Turbin D, Berquin IM, Mertens PR, Iftner T, et al: Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2. Cancer Res. 2006, 66: 4872-4879. 10.1158/0008-5472.CAN-05-3561.
Article
CAS
PubMed
Google Scholar
Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, et al: Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene. 2005, 24: 4281-4292. 10.1038/sj.onc.1208590.
Article
CAS
PubMed
Google Scholar
Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S: Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. Gene. 1988, 73: 499-507. 10.1016/0378-1119(88)90514-8.
Article
CAS
PubMed
Google Scholar
Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS: Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 2005, 65: 10992-11000. 10.1158/0008-5472.CAN-05-2612.
Article
CAS
PubMed
Google Scholar