Chiorazzi N, Rai KR, Ferranini M: Chronic lymphocytic leukemia. N Engl J Med. 2005, 352: 805-815.
Article
Google Scholar
Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, DeLuca DS, Zhang L, Zhang W, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K, Tesar B, Sievers QL, Shefler E, Gabriel S, Hacohen N, Reed R, Meyerson M, Golub TR, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ: SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011, 365: 2497-2506.
Article
CAS
PubMed
PubMed Central
Google Scholar
Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, Buchbinder A, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N: IgV gene mutation status and CD 38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999, 94: 1840-1847.
CAS
PubMed
Google Scholar
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK: Unmutated IgV(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999, 94: 1848-1854.
CAS
PubMed
Google Scholar
Döhner H, Stielgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P: Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000, 343: 1910-1916.
Article
PubMed
Google Scholar
Sportoletti P, Baldoni S, Cavalli L, Del Papa B, Bonifacio E, Ciurnelli R, Bell AS, Di Tommaso A, Rosati E, Crescenzi B, Mecucci C, Screpanti I, Marconi P, Martelli MF, Di Ianni M, Falzetti F: Notch1 PEST domain mutation is an adverse prognostic factor in B-CLL. British Journal of Haematology. 2010, 151: 404-406.
Article
PubMed
Google Scholar
Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, Villamor N, Escaramis G, Jares P, Beà S, González-Díaz M, Bassaganyas L, Baumann T, Juan M, López-Guerra M, Colomer D, Tubío JM, López C, Navarro A, Tornador C, Aymerich M, Rozman M, Hernández JM, Puente DA, Freije JM, Velasco G, Gutiérrez-Fernández A, Costa D, Carrió A, Guijarro S, Enjuanes A: Whole genome sequencing identifies recurrent mutations in chronic lymphocytic leukemia. Nature. 2011, 475: 101-105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, Grunn A, Fangazio M, Capello D, Monti S, Cresta S, Gargiulo E, Forconi F, Guarini A, Arcaini L, Paulli M, Laurenti L, Larocca LM, Marasca R, Gattei V, Oscier D, Bertoni F, Mullighan CG, Foá R, Pasqualucci L, Rabadan R, Dalla-Favera R, Gaidano G: Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med. 2011, 208: 1389-1401.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, Marasca R, Laurenti L, Bruscaggin A, Cerri M, Monti S, Cresta S, Famà R, De Paoli L, Bulian P, Gattei V, Guarini A, Deaglio S, Capello D, Rabadan R, Pasqualucci L, Dalla-Favera R, Foà R, Gaidano G: Mutations of Notch1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood. 2012, 119: 521-529.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shedden K, Li Y, Quillette P, Malek SN: Characteristics of chronic lymphocytic leukemia with somatically acquired mutations in exon 34. Leukemia. 2011, 26: 1108-1110.
Article
PubMed
PubMed Central
Google Scholar
Mansouri L, Cahill N, Gunnarsson R, Smedby KE, Tjönnfjord E, Hjalgrim H, Juliusson G, Geisler C, Rosenquist R: NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia. 2013, 27: 512-514.
Article
CAS
PubMed
Google Scholar
Rosati E, Sabatini R, Rampino G, Tabilio A, Di Ianni M, Fettucciari K, Bartoli A, Coaccioli S, Screpanti I, Marconi P: Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood. 2009, 113: 856-865.
Article
CAS
PubMed
Google Scholar
Radtke F, Wilson A, Mancini SJC, Robson MacDonald H: Notch regulation of lymphocyte development and function. Nature Immunology. 2004, 5: 247-253.
Article
CAS
PubMed
Google Scholar
Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O’Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA: Notch1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. PNAS. 2006, 103: 18261-18266.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S: Gain-of-function mutations and copy number increases of Notch2 diffuse large B-cell lymphoma. Cancer Science. 2009, 100: 920-926.
Article
CAS
PubMed
Google Scholar
Hubmann R, Schwarzmeier JD, Sheta M, Hilgarth M, Duechler M, Dettke M, Berger R: Notch2 is involved in overexperssion of CD23 in B-cell chronic lymphocytic leukemia. Blood. 2002, 99: 3742-3747.
Article
CAS
PubMed
Google Scholar
Willander K, Ungerbäck J, Karlsson K, Fredrikson M, Söderkvist P, Linderholm M: MDM2 SNP309 promoter polymorphism, an independent prognostic factor in chronic lymphocytic leukemia. European Journal of Haematology. 2010, 85: 251-256.
Article
CAS
PubMed
Google Scholar
Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ: Guidelines for diagnosis and treatment of chronic lymphocytic leukemia: a report from an international workshop on chronic lymphocytic leukemia updating the national cancer institute working group 1996 guidelines. Blood. 2008, 111: 5446-5456.
Article
CAS
PubMed
PubMed Central
Google Scholar
Orita M, Suzuki Y, Sekiya T, Hayashi K: Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction. Genomics. 1989, 5: 874-879.
Article
CAS
PubMed
Google Scholar
van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, van Krieken JH, Droese J, González D, Bastard C, White HE, Spaargaren M, González M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA: Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003, 17: 2257-2317.
Article
CAS
PubMed
Google Scholar
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC: Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004, 306: 269-271.
Article
CAS
PubMed
Google Scholar
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J: The mutational landscape of head and neck squamous cell carcinoma. Science. 2011, 333: 1157-1160.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R: The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012, 209: 1537-1551.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kiel MJ, Velusamy T, Betz BL, Zhao L, Weigelin HG, Chiang MY, Huebner-Chan DR, Bailey NG, Yang DT, Bhagat G, Miranda RN, Bahler DW, Medeiros LJ, Lim MS, Elenitoba-Johnson KS: Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. J Exp Med. 2012, 209: 1553-1565.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zenz T, Kröber A, Scherer K, Häbe S, Bühler A, Benner A, Denzel T, Winkler D, Edelmann J, Schwänen C, Döhner H, Stilgenbauer S: Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood. 2008, 112: 3322-3329.
Article
CAS
PubMed
Google Scholar
Baletti V, Bottoni A, Palamarchuk A, Alder H, Rassenti LZ, Kipps TJ: Notch1 mutations in CLL associated with trisomy 12. Blood. 2012, 119: 329-331.
Article
Google Scholar
Del Guidice I, Rossi D, Chiaretti S, Marinelli M, Tavolaro S, Gabrielli S, Laurenti L, Marasca R, Rasi S, Fangazio M, Guarini A, Gaidano G, Foà R: Notch1 mutations in +12 chronic lymphocytic leukemia (CLL) confer and unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica. 2012, 97: 437-441.
Article
Google Scholar
Secchiero P, Melloni E, di Iasio MG, Tiribelli M, Rimondi E, Corallini F, Gattei V, Zauli G: Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of negative feedback antiapoptotic mechanism. Blood. 2009, 113: 4300-4308.
Article
CAS
PubMed
Google Scholar
Paolo Dotto G: Crosstalk of Notch with p53 and p63 in cancer growth control. Nature Rev. Cancer. 2009, 9: 587-595.
Article
Google Scholar
Rossi D, Rasi S, Spina V, Fangazio M, Monti S, Greco M, Ciardullo C, Famà R, Cresta S, Bruscaggin A, Laurenti L, Martini M, Musto P, Forconi F, Marasca R, Larocca LM, Foà R, Gaidano G: Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome. British Journal of Haematoloy. 2012, 158: 426-229.
Article
CAS
Google Scholar
Pospisilova S, Gonzalez D, Malcikova J, Trbusek M, Rossi D, Kater AP, Cymbalista F, Eichhorst B, Hallek M, Döhner H, Hillmen P, van Oers M, Gribben J, Ghia P, Montserrat E, Stilgenbauer S, Zenz T: ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia. 2012, 26: 1458-1461.
Article
CAS
PubMed
Google Scholar
Zenz T, Gribben JG, Hallek M, Döhner H, Keating MJ, Stielgenbauer S: Risk categories and refractory CLL in era of chemoimmunotherapy. Blood. 2012, 119: 4101-4107.
Article
CAS
PubMed
Google Scholar