Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 2005, 55: 74-108. 10.3322/canjclin.55.2.74.
Article
PubMed
Google Scholar
Sano D, Myers JN: Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev. 2007, 26: 645-662. 10.1007/s10555-007-9082-y.
Article
CAS
PubMed
Google Scholar
Rusthoven K, Ballonoff A, Raben D, Chen C: Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer. 2008, 112: 345-351. 10.1002/cncr.23183.
Article
PubMed
Google Scholar
de Aguiar AF, Kowalski LP, de Almeida OP: Clinicopathological and immunohistochemical evaluation of oral squamous cell carcinoma in patients with early local recurrence. Oral Oncol. 2007, 43: 593-601. 10.1016/j.oraloncology.2006.07.003.
Article
PubMed
Google Scholar
Mucke T, Wagenpfeil S, Kesting MR, Holzle F, Wolff KD: Recurrence interval affects survival after local relapse of oral cancer. Oral Oncol. 2009, 45: 687-691. 10.1016/j.oraloncology.2008.10.011.
Article
PubMed
Google Scholar
Woolgar JA: Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2006, 42: 229-239. 10.1016/j.oraloncology.2005.05.008.
Article
PubMed
Google Scholar
Kureishy N, Sapountzi V, Prag S, Anilkumar N, Adams JC: Fascins, and their roles in cell structure and function. Bioessays. 2002, 24: 350-361. 10.1002/bies.10070.
Article
CAS
PubMed
Google Scholar
Bryan J, Edwards R, Matsudaira P, Otto J, Wulfkuhle J: Fascin, an echinoid actin-bundling protein, is a homolog of the Drosophila singed gene product. Proc Natl Acad Sci USA. 1993, 90: 9115-9119. 10.1073/pnas.90.19.9115.
Article
CAS
PubMed
PubMed Central
Google Scholar
Al-Alwan MM, Rowden G, Lee TD, West KA: Fascin is involved in the antigen presentation activity of mature dendritic cells. J Immunol. 2001, 166: 338-345.
Article
CAS
PubMed
Google Scholar
Cohan CS, Welnhofer EA, Zhao L, Matsumura F, Yamashiro S: Role of the actin bundling protein fascin in growth cone morphogenesis: localization in filopodia and lamellipodia. Cell Motil Cytoskeleton. 2001, 48: 109-120. 10.1002/1097-0169(200102)48:2<109::AID-CM1002>3.0.CO;2-G.
Article
CAS
PubMed
Google Scholar
Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M: Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. J Virol. 1994, 68: 7320-7328.
CAS
PubMed
PubMed Central
Google Scholar
Hashimoto Y, Skacel M, Adams JC: Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?. Int J Biochem Cell Biol. 2005, 37: 1787-1804. 10.1016/j.biocel.2005.05.004.
Article
CAS
PubMed
Google Scholar
Grothey A, Hashizume R, Ji H, Tubb BE, Patrick CW, Yu D, Mooney EE, McCrea PD: C-erbB-2/HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines. Oncogene. 2000, 19: 4864-4875. 10.1038/sj.onc.1203838.
Article
CAS
PubMed
Google Scholar
Grothey A, Hashizume R, Sahin AA, McCrea PD: Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer. Br J Cancer. 2000, 83: 870-873. 10.1054/bjoc.2000.1395.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hu W, McCrea PD, Deavers M, Kavanagh JJ, Kudelka AP, Verschraegen CF: Increased expression of fascin, motility associated protein, in cell cultures derived from ovarian cancer and in borderline and carcinomatous ovarian tumors. Clin Exp Metastasis. 2000, 18: 83-88. 10.1023/A:1026596609969.
Article
CAS
PubMed
Google Scholar
Goncharuk VN, Ross JS, Carlson JA: Actin-binding protein fascin expression in skin neoplasia. J Cutan Pathol. 2002, 29: 430-438. 10.1034/j.1600-0560.2002.290708.x.
Article
PubMed
Google Scholar
Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, et al: Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res. 2003, 63: 8614-8622.
CAS
PubMed
Google Scholar
Maitra A, Iacobuzio-Donahue C, Rahman A, Sohn TA, Argani P, Meyer R, Yeo CJ, Cameron JL, Goggins M, Kern SE, et al: Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47. Am J Clin Pathol. 2002, 118: 52-59. 10.1309/3PAM-P5WL-2LV0-R4EG.
Article
CAS
PubMed
Google Scholar
Iguchi T, Aishima S, Umeda K, Sanefuji K, Fujita N, Sugimachi K, Gion T, Taketomi A, Maehara Y, Tsuneyoshi M: Fascin expression in progression and prognosis of hepatocellular carcinoma. J Surg Oncol. 2009, 100: 575-579. 10.1002/jso.21377.
Article
PubMed
Google Scholar
Machesky LM, Li A: Fascin: Invasive filopodia promoting metastasis. Commun Integr Biol. 3: 263-270.
Pelosi G, Pasini F, Fraggetta F, Pastorino U, Iannucci A, Maisonneuve P, Arrigoni G, De Manzoni G, Bresaola E, Viale G: Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids. Lung Cancer. 2003, 42: 203-213. 10.1016/S0169-5002(03)00294-0.
Article
PubMed
Google Scholar
Hashimoto Y, Ito T, Inoue H, Okumura T, Tanaka E, Tsunoda S, Higashiyama M, Watanabe G, Imamura M, Shimada Y: Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma. Clin Cancer Res. 2005, 11: 2597-2605. 10.1158/1078-0432.CCR-04-1378.
Article
CAS
PubMed
Google Scholar
Hashimoto Y, Skacel M, Lavery IC, Mukherjee AL, Casey G, Adams JC: Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. BMC Cancer. 2006, 6: 241-10.1186/1471-2407-6-241.
Article
PubMed
PubMed Central
Google Scholar
Zhang H, Xu L, Xiao D, Xie J, Zeng H, Cai W, Niu Y, Yang Z, Shen Z, Li E: Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma. J Clin Pathol. 2006, 59: 958-964. 10.1136/jcp.2005.032730.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zigeuner R, Droschl N, Tauber V, Rehak P, Langner C: Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique. Urology. 2006, 68: 518-522. 10.1016/j.urology.2006.03.032.
Article
PubMed
Google Scholar
Puppa G, Maisonneuve P, Sonzogni A, Masullo M, Chiappa A, Valerio M, Zampino MG, Franceschetti I, Capelli P, Chilosi M, et al: Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma. Br J Cancer. 2007, 96: 1118-1126. 10.1038/sj.bjc.6603690.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen SF, Yang SF, Li JW, Nieh PC, Lin SY, Fu E, Bai CY, Jin JS, Lin CY, Nieh S: Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases. Histopathol. 2007, 51: 173-183. 10.1111/j.1365-2559.2007.02755.x.
Article
CAS
Google Scholar
Alam H, Kundu ST, Dalal SN, Vaidya MM: Loss of keratins 8 and 18 leads to alterations in alpha6beta4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line. J Cell Sci. 2011, 124: 2096-2106. 10.1242/jcs.073585.
Article
CAS
PubMed
Google Scholar
Raul U, Sawant S, Dange P, Kalraiya R, Ingle A, Vaidya M: Implications of cytokeratin 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype. Int J Cancer. 2004, 111: 662-668. 10.1002/ijc.20349.
Article
CAS
PubMed
Google Scholar
Alam H, Sehgal L, Kundu ST, Dalal SN, Vaidya MM: Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells. Mol Biol Cell. 2011, 22: 4068-4078. 10.1091/mbc.E10-08-0703.
Article
CAS
PubMed
PubMed Central
Google Scholar
Elbert M, Cohen D, Musch A: PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. Mol Biol Cell. 2006, 17: 3345-3355. 10.1091/mbc.E06-03-0193.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dua P, Ingle A, Gude RP: Suramin augments the antitumor and antimetastatic activity of pentoxifylline in B16F10 melanoma. Int J Cancer. 2007, 121: 1600-1608. 10.1002/ijc.22843.
Article
CAS
PubMed
Google Scholar
Heussen C, Dowdle EB: Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem. 1980, 102: 196-202. 10.1016/0003-2697(80)90338-3.
Article
CAS
PubMed
Google Scholar
Alam H, Gangadaran P, Bhate AV, Chaukar DA, Sawant SS, Tiwari R, Bobade J, Kannan S, D'Cruz A K, Kane S, Vaidya MM: Loss of Keratin 8 Phosphorylation Leads to Increased Tumor Progression and Correlates with Clinico-Pathological Parameters of OSCC Patients. PLoS One. 2011, 6: e27767-10.1371/journal.pone.0027767.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG: Role of fascin in filopodial protrusion. J Cell Biol. 2006, 174: 863-875. 10.1083/jcb.200603013.
Article
CAS
PubMed
PubMed Central
Google Scholar
Adams JC: Roles of fascin in cell adhesion and motility. Curr Opin Cell Biol. 2004, 16: 590-596. 10.1016/j.ceb.2004.07.009.
Article
CAS
PubMed
Google Scholar
Yamashiro S, Yamakita Y, Ono S, Matsumura F: Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell. 1998, 9: 993-1006.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kudo Y, Kitajima S, Ogawa I, Hiraoka M, Sargolzaei S, Keikhaee MR, Sato S, Miyauchi M, Takata T: Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin. Clin Cancer Res. 2004, 10: 5455-5463. 10.1158/1078-0432.CCR-04-0372.
Article
CAS
PubMed
Google Scholar
Laxmidevi LB, Angadi PV, Pillai RK, Chandreshekar C: Aberrant beta-catenin expression in the histologic differentiation of oral squamous cell carcinoma and verrucous carcinoma: an immunohistochemical study. J Oral Sci. 52: 633-640.
Wang L, Liu T, Wang Y, Cao L, Nishioka M, Aguirre RL, Ishikawa A, Geng L, Okada N: Altered expression of desmocollin 3, desmoglein 3, and beta-catenin in oral squamous cell carcinoma: correlation with lymph node metastasis and cell proliferation. Virchows Arch. 2007, 451: 959-966. 10.1007/s00428-007-0485-5.
Article
CAS
PubMed
Google Scholar
Hashimoto Y, Parsons M, Adams JC: Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis. Mol Biol Cell. 2007, 18: 4591-4602. 10.1091/mbc.E07-02-0157.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xie JJ, Xu LY, Zhang HH, Cai WJ, Mai RQ, Xie YM, Yang ZM, Niu YD, Shen ZY, Li EM: Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. Biochem Biophys Res Commun. 2005, 337: 355-362. 10.1016/j.bbrc.2005.09.055.
Article
CAS
PubMed
Google Scholar
Jawhari AU, Buda A, Jenkins M, Shehzad K, Sarraf C, Noda M, Farthing MJ, Pignatelli M, Adams JC: Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro. Am J Pathol. 2003, 162: 69-80. 10.1016/S0002-9440(10)63799-6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hwang JH, Smith CA, Salhia B, Rutka JT: The role of fascin in the migration and invasiveness of malignant glioma cells. Neoplasia. 2008, 10: 149-159. 10.1593/neo.07909.
Article
CAS
PubMed
Google Scholar
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY: Migrastatin analogues target fascin to block tumour metastasis. Nature. 464: 1062-1066.
Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S: Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature. 1980, 284: 67-68. 10.1038/284067a0.
Article
CAS
PubMed
Google Scholar
Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002, 2: 442-454. 10.1038/nrc822.
Article
CAS
PubMed
Google Scholar
Vignjevic D, Schoumacher M, Gavert N, Janssen KP, Jih G, Lae M, Louvard D, Ben-Ze'ev A, Robine S: Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res. 2007, 67: 6844-6853. 10.1158/0008-5472.CAN-07-0929.
Article
CAS
PubMed
Google Scholar
Friedl P: Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol. 2004, 16: 14-23. 10.1016/j.ceb.2003.11.001.
Article
CAS
PubMed
Google Scholar
Gumbiner BM: Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell. 1996, 84: 345-357. 10.1016/S0092-8674(00)81279-9.
Article
CAS
PubMed
Google Scholar
Hynes RO, Lander AD: Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell. 1992, 68: 303-322. 10.1016/0092-8674(92)90472-O.
Article
CAS
PubMed
Google Scholar
Lyons AJ, Jones J: Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma. Int J Oral Maxillofac Surg. 2007, 36: 671-679. 10.1016/j.ijom.2007.04.002.
Article
CAS
PubMed
Google Scholar
Adams JC: Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1. J Cell Sci. 1995, 108 (Pt 5): 1977-1990.
CAS
PubMed
Google Scholar
Adams JC, Clelland JD, Collett GD, Matsumura F, Yamashiro S, Zhang L: Cell-matrix adhesions differentially regulate fascin phosphorylation. Mol Biol Cell. 1999, 10: 4177-4190.
Article
CAS
PubMed
PubMed Central
Google Scholar
Anilkumar N, Parsons M, Monk R, Ng T, Adams JC: Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. Embo J. 2003, 22: 5390-5402. 10.1093/emboj/cdg521.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ortiz CM, Ito T, Hashimoto Y, Nagayama S, Iwai A, Tsunoda S, Sato F, Martorell M, Garcia JA, Perez A, Shimada Y: Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines. Diagn Pathol. 2010, 5: 41-10.1186/1746-1596-5-41.
Article
PubMed
PubMed Central
Google Scholar
Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, et al: Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. Br J Cancer. 2003, 88: 537-547. 10.1038/sj.bjc.6600731.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wagner EF, Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 2009, 9: 537-549. 10.1038/nrc2694.
Article
CAS
PubMed
Google Scholar
Roberts PJ, Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007, 26: 3291-3310. 10.1038/sj.onc.1210422.
Article
CAS
PubMed
Google Scholar
Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002, 2: 489-501. 10.1038/nrc839.
Article
CAS
PubMed
Google Scholar
Rao JS: Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer. 2003, 3: 489-501. 10.1038/nrc1121.
Article
CAS
PubMed
Google Scholar
Westermarck J, Kahari VM: Regulation of matrix metalloproteinase expression in tumor invasion. Faseb J. 1999, 13: 781-792.
CAS
PubMed
Google Scholar
Lev DC, Onn A, Melinkova VO, Miller C, Stone V, Ruiz M, McGary EC, Ananthaswamy HN, Price JE, Bar-Eli M: Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo. J Clin Oncol. 2004, 22: 2092-2100. 10.1200/JCO.2004.11.070.
Article
CAS
PubMed
Google Scholar
Lim J, Kim JH, Paeng JY, Kim MJ, Hong SD, Lee JI, Hong SP: Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol. 2005, 58: 1199-1205. 10.1136/jcp.2004.024786.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shingaki S, Takada M, Sasai K, Bibi R, Kobayashi T, Nomura T, Saito C: Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am J Surg. 2003, 185: 278-284. 10.1016/S0002-9610(02)01378-8.
Article
PubMed
Google Scholar
Massano J, Regateiro FS, Januario G, Ferreira A: Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006, 102: 67-76. 10.1016/j.tripleo.2005.07.038.
Article
PubMed
Google Scholar
Ferlito A, Rinaldo A, Robbins KT, Leemans CR, Shah JP, Shaha AR, Andersen PE, Kowalski LP, Pellitteri PK, Clayman GL, et al: Changing concepts in the surgical management of the cervical node metastasis. Oral Oncol. 2003, 39: 429-435. 10.1016/S1368-8375(03)00010-1.
Article
PubMed
Google Scholar
Woolgar JA, Rogers SN, Lowe D, Brown JS, Vaughan ED: Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol. 2003, 39: 130-137. 10.1016/S1368-8375(02)00030-1.
Article
CAS
PubMed
Google Scholar
Greenberg JS, El Naggar AK, Mo V, Roberts D, Myers JN: Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. Cancer. 2003, 98: 508-515. 10.1002/cncr.11526.
Article
PubMed
Google Scholar
Lo WL, Kao SY, Chi LY, Wong YK, Chang RC: Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. J Oral Maxillofac Surg. 2003, 61: 751-758. 10.1016/S0278-2391(03)00149-6.
Article
PubMed
Google Scholar
Lee TK, Poon RT, Man K, Guan XY, Ma S, Liu XB, Myers JN, Yuen AP: Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma. Cancer Lett. 2007, 254: 308-315. 10.1016/j.canlet.2007.03.017.
Article
CAS
PubMed
Google Scholar