Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 2009, 59: 225-249. 10.3322/caac.20006.
Article
PubMed
Google Scholar
Köbel M, Kalloger SE, Huntsman DG, Santos J, Swenerton KD, Seidman JD, Gilks CB: Differences in Tumor Type in Low versus High Stage Ovarian Carcinomas. Int J Gynecol Pathol. 2010, 29: 203-11. 10.1097/PGP.0b013e3181c042b6.
Article
PubMed
Google Scholar
Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, et al: Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet. 2001, 68: 700-710. 10.1086/318787.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chan KY, Ozcelik H, Cheung AN, Ngan HY, Khoo US: Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. Cancer Res. 2002, 62: 4151-4156.
CAS
PubMed
Google Scholar
Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX: Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999, 3: 389-395. 10.1016/S1097-2765(00)80466-9.
Article
CAS
PubMed
Google Scholar
Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003, 12: 1087-1099. 10.1016/S1097-2765(03)00424-6.
Article
CAS
PubMed
Google Scholar
Moynahan ME, Chiu JW, Koller BH, Jasin M: Brca1 controls homology-directed DNA repair. Mol Cell. 1999, 4: 511-518. 10.1016/S1097-2765(00)80202-6.
Article
CAS
PubMed
Google Scholar
Snouwaert JN, Gowen LC, Latour AM, Mohn AR, Xiao A, DiBiase L, Koller BH: BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene. 1999, 18: 7900-7907. 10.1038/sj.onc.1203334.
Article
CAS
PubMed
Google Scholar
Moynahan ME, Pierce AJ, Jasin M: BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell. 2001, 7: 263-272. 10.1016/S1097-2765(01)00174-5.
Article
CAS
PubMed
Google Scholar
Patel KJ, Yu VP, Lee H, Corcoran A, Thistlethwaite FC, Evans MJ, Colledge WH, Friedman LS, Ponder BA, Venkitaraman AR: Involvement of Brca2 in DNA repair. Mol Cell. 1998, 1: 347-357. 10.1016/S1097-2765(00)80035-0.
Article
CAS
PubMed
Google Scholar
Venkitaraman AR: Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol. 2009, 4: 461-487. 10.1146/annurev.pathol.3.121806.151422.
Article
CAS
PubMed
Google Scholar
Kobel M, Huntsman D, Gilks CB: Critical molecular abnormalities in high-grade serous carcinoma of the ovary. Expert Rev Mol Med. 2008, 10: e22-10.1017/S146239940800077X.
Article
PubMed
Google Scholar
Fabarius A, Hehlmann R, Duesberg PH: Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy. Cancer Genet Cytogenet. 2003, 143: 59-72. 10.1016/S0165-4608(03)00003-7.
Article
CAS
PubMed
Google Scholar
Kronenwett U, Huwendiek S, Ostring C, Portwood N, Roblick UJ, Pawitan Y, Alaiya A, Sennerstam R, Zetterberg A, Auer G: Improved grading of breast adenocarcinomas based on genomic instability. Cancer Res. 2004, 64: 904-909. 10.1158/0008-5472.CAN-03-2451.
Article
CAS
PubMed
Google Scholar
Holland AJ, Cleveland DW: Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 2009, 10: 478-487. 10.1038/nrm2718.
Article
CAS
PubMed
PubMed Central
Google Scholar
Press JZ, De LA, Boyd N, Young S, Troussard A, Ridge Y, Kaurah P, Kalloger SE, Blood KA, Smith M, et al: Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. BMC Cancer. 2008, 8: 17-10.1186/1471-2407-8-17.
Article
PubMed
PubMed Central
Google Scholar
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, et al: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005, 434: 917-921. 10.1038/nature03445.
Article
CAS
PubMed
Google Scholar
Pradhan M, Abeler VM, Danielsen HE, Trope CG, Risberg BA: Image cytometry DNA ploidy correlates with histological subtypes in endometrial carcinomas. Mod Pathol. 2006, 19: 1227-1235. 10.1038/modpathol.3800641.
Article
CAS
PubMed
Google Scholar
Pradhan M, Davidson B, Trope CG, Danielsen HE, Abeler VM, Risberg B: Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas--an image cytometric DNA ploidy analysis of 307 cases with histogenetic implications. Virchows Arch. 2009, 454: 677-683. 10.1007/s00428-009-0778-y.
Article
CAS
PubMed
Google Scholar
Eisen MB, Spellman PT, Brown PO, Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 1998, 95: 14863-14868. 10.1073/pnas.95.25.14863.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001, 98: 5116-5121. 10.1073/pnas.091062498.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lamber EP, Horwitz AA, Parvin JD: BRCA1 Represses Amphiregulin Gene Expression. Cancer Res. 2010, 70: 996-1005. 10.1158/0008-5472.CAN-09-2842.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gudmundsdottir K, Ashworth A: The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene. 2006, 25: 5864-5874. 10.1038/sj.onc.1209874.
Article
CAS
PubMed
Google Scholar
Tirkkonen M, Johannsson O, Agnarsson BA, Olsson H, Ingvarsson S, Karhu R, Tanner M, Isola J, Barkardottir RB, Borg A, et al: Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. Cancer Res. 1997, 57: 1222-1227.
CAS
PubMed
Google Scholar
Koul A, Malander S, Loman N, Pejovic T, Heim S, Willen R, Johannsson O, Olsson H, Ridderheim M, Borg AA: BRCA1 and BRCA2 mutations in ovarian cancer: Covariation with specific cytogenetic features. Int J Gynecol Cancer. 2000, 10: 289-295. 10.1046/j.1525-1438.2000.010004289.x.
Article
PubMed
Google Scholar
Vang R, Shih I, Kurman RJ: Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol. 2009, 16: 267-282. 10.1097/PAP.0b013e3181b4fffa.
Article
PubMed
PubMed Central
Google Scholar
Chiang JW, Karlan BY, Cass L, Baldwin RL: BRCA1 promoter methylation predicts adverse ovarian cancer prognosis. Gynecol Oncol. 2006, 101: 403-410. 10.1016/j.ygyno.2005.10.034.
Article
CAS
PubMed
Google Scholar
Levine DA, Federici MG, Reuter VE, Boyd J: Cell proliferation and apoptosis in BRCA-associated hereditary ovarian cancer. Gynecol Oncol. 2002, 85: 431-434. 10.1006/gyno.2002.6646.
Article
CAS
PubMed
Google Scholar
Jazaeri AA, Yee CJ, Sotiriou C, Brantley KR, Boyd J, Liu ET: Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers. J Natl Cancer Inst. 2002, 94: 990-1000.
Article
CAS
PubMed
Google Scholar
Tone AA, Begley H, Sharma M, Murphy J, Rosen B, Brown TJ, Shaw PA: Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma. Clin Cancer Res. 2008, 14: 4067-4078. 10.1158/1078-0432.CCR-07-4959.
Article
CAS
PubMed
Google Scholar
Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, O'Connell JX, Zhu S, Fero M, Sherlock G, Pollack JR, Brown PO, Botstein D, van de RM: Molecular characterisation of soft tissue tumours: a gene expression study. Lancet. 2002, 359: 1301-1307. 10.1016/S0140-6736(02)08270-3.
Article
CAS
PubMed
Google Scholar
Subramanian S, West RB, Corless CL, Ou W, Rubin BP, Chu KM, Leung SY, Yuen ST, Zhu S, Hernandez-Boussard T, Montgomery K, Nielsen TO, Patel RM, Goldblum JR, Heinrich MC, Fletcher JA, van de RM: Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene. 2004, 23: 7780-7790. 10.1038/sj.onc.1208056.
Article
CAS
PubMed
Google Scholar
Lee CH, Subramanian S, Beck AH, Espinosa I, Senz J, Zhu SX, Huntsman D, van de RM, Gilks CB: MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary. PLoS One. 2009, 4: e7314-10.1371/journal.pone.0007314.
Article
PubMed
PubMed Central
Google Scholar
Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG: Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res. 2010, 3: 48-61. 10.1158/1940-6207.CAPR-09-0078.
Article
CAS
Google Scholar
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, et al: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009, 361: 123-134. 10.1056/NEJMoa0900212.
Article
CAS
PubMed
Google Scholar
Turner N, Tutt A, Ashworth A: Targeting the DNA repair defect of BRCA tumours. Curr Opin Pharmacol. 2005, 5: 388-393. 10.1016/j.coph.2005.03.006.
Article
CAS
PubMed
Google Scholar
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T: Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005, 434: 913-917. 10.1038/nature03443.
Article
CAS
PubMed
Google Scholar