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  1. Azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic colon cancer and is a reliable model for identifying chemopreven...

    Authors: Angelo Pietro Femia, Cristina Luceri, Simona Toti, Augusto Giannini, Piero Dolara and Giovanna Caderni
    Citation: BMC Cancer 2010 10:194
    Content type: Research article Published on:

  2. Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP a...

    Authors: Adolfo Varona, Lorena Blanco, Itxaro Perez, Javier Gil, Jon Irazusta, José I López, M Luz Candenas, Francisco M Pinto and Gorka Larrinaga
    Citation: BMC Cancer 2010 10:193
    Content type: Research article Published on:

  3. Activator Protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in car...

    Authors: Verena Thewes, Francesca Orso, Richard Jäger, Dawid Eckert, Sabine Schäfer, Gregor Kirfel, Stephan Garbe, Daniela Taverna and Hubert Schorle
    Citation: BMC Cancer 2010 10:192
    Content type: Research article Published on:

  4. The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate ant...

    Authors: Andreas A Schnitzbauer, Carl Zuelke, Christian Graeb, Justine Rochon, Itxarone Bilbao, Patrizia Burra, Koert P de Jong, Christophe Duvoux, Norman M Kneteman, Rene Adam, Wolf O Bechstein, Thomas Becker, Susanne Beckebaum, Olivier Chazouillères, Umberto Cillo, Michele Colledan…
    Citation: BMC Cancer 2010 10:190
    Content type: Study protocol Published on:

  5. With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR

    Authors: Nancy Van Damme, Philippe Deron, Nadine Van Roy, Pieter Demetter, Alain Bols, Jo Van Dorpe, Filip Baert, Jean-Luc Van Laethem, Franki Speleman, Patrick Pauwels and Marc Peeters
    Citation: BMC Cancer 2010 10:189
    Content type: Research article Published on:

  6. There is strong evidence demonstrating that activation of epidermal growth factor receptors (EGFRs) leads to tumor growth, progression, invasion and metastasis. Erlotinib and gefitinib, two EGFR-targeted agent...

    Authors: Roque Diaz, Paul A Nguewa, Ricardo Parrondo, Carlos Perez-Stable, Irene Manrique, Miriam Redrado, Raul Catena, Maria Collantes, Ivan Peñuelas, Juan Antonio Díaz-González and Alfonso Calvo
    Citation: BMC Cancer 2010 10:188
    Content type: Research article Published on:

  7. The activation of signal transducer and activator of transcription 3 (Stat3) pathway correlates with tumor growth, survival, drug resistance and poor prognosis in osteosarcoma. To explore the potential therape...

    Authors: Keinosuke Ryu, Michiro Susa, Edwin Choy, Cao Yang, Francis J Hornicek, Henry J Mankin and Zhenfeng Duan
    Citation: BMC Cancer 2010 10:187
    Content type: Research article Published on:

  8. Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the cell. Bcl-2 has been investigated as ...

    Authors: Valsamo K Anagnostou, Frank J Lowery, Vassiliki Zolota, Vassiliki Tzelepi, Arun Gopinath, Camil Liceaga, Nikolaos Panagopoulos, Konstantina Frangia, Lynn Tanoue, Daniel Boffa, Scott Gettinger, Frank Detterbeck, Robert J Homer, Dimitrios Dougenis, David L Rimm and Konstantinos N Syrigos
    Citation: BMC Cancer 2010 10:186
    Content type: Research article Published on:

  9. Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a natural inhibitor of the matrix metalloproteinases (MMPs) which are proteolytic enzymes involved in degradation of extracellular matrix thereby favoring tu...

    Authors: Karina Dahl Steffensen, Marianne Waldstrøm, Rikke Kølby Christensen, Annette Bartels, Nils Brünner and Anders Jakobsen
    Citation: BMC Cancer 2010 10:185
    Content type: Research article Published on:

  10. Insulin-like growth factor-I receptor (IGFIR) has been shown to regulate the tumor development. The objective of the current study is to determine the association of IGFIR with lymph node metastasis and to exp...

    Authors: Chunhui Zhang, Li Hao, Liang Wang, Yichuan Xiao, Hailiang Ge, Zhenya Zhu, Yunbao Luo, Yi Zhang and Yanyun Zhang
    Citation: BMC Cancer 2010 10:184
    Content type: Research article Published on:

  11. The formation of metastases includes the separation of tumor cells from the primary tumor, cell migration into subendothelial tissue and cell proliferation in secondary organ. In this process, cell adhesion of...

    Authors: Walburgis Brenner, Silke Beitz, Elke Schneider, Frank Benzing, Ronald E Unger, Frederik C Roos, Joachim W Thüroff and Christian Hampel
    Citation: BMC Cancer 2010 10:183
    Content type: Research article Published on:

  12. Although chromosomal instability (CIN) has been detected in many kinds of human malignancies by means of various methods, there is no practical assessment for small clinical specimens. In this study, we evalua...

    Authors: Hiroaki Sato, Narikazu Uzawa, Ken-Ichiro Takahashi, Kunihiro Myo, Yoshio Ohyama and Teruo Amagasa
    Citation: BMC Cancer 2010 10:182
    Content type: Research article Published on:

  13. Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have bee...

    Authors: Maija Wolf, Miikka Korja, Ritva Karhu, Henrik Edgren, Sami Kilpinen, Kalle Ojala, Spyro Mousses, Anne Kallioniemi and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:181
    Content type: Research article Published on:

  14. To investigate the etiology of MLH1 promoter methylation in mismatch repair (MMR) mutation-negative early onset MSI-H colon cancer. As this type of colon cancer is associated with high ages, young patients bearin...

    Authors: Eddy HJ van Roon, Marjo van Puijenbroek, Anneke Middeldorp, Ronald van Eijk, Emile J de Meijer, Dianhdra Erasmus, Kim AD Wouters, Manon van Engeland, Jan Oosting, Frederik J Hes, Carli MJ Tops, Tom van Wezel, Judith M Boer and Hans Morreau
    Citation: BMC Cancer 2010 10:180
    Content type: Research article Published on:

  15. Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is eff...

    Authors: Gregory Riedlinger, Jonathan Adams, John R Stehle Jr, Michael J Blanks, Anne M Sanders, Amy M Hicks, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:179
    Content type: Research article Published on:

  16. Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers...

    Authors: Walid Sasi, Wen G Jiang, Anup Sharma and Kefah Mokbel
    Citation: BMC Cancer 2010 10:178
    Content type: Research article Published on:

  17. Metastasis formation is the leading cause of death among colon cancer patients. We established a new in-situ model of in vivo microscopy of the lung to analyse initiating events of metastatic tumor cell adhesi...

    Authors: Peter Gassmann, Mi-Li Kang, Soeren T Mees and Joerg Haier
    Citation: BMC Cancer 2010 10:177
    Content type: Research article Published on:

  18. Metastasis is a major cancer-related cause of death. Recent studies have described metastasis pathways. However, the exact contribution of each pathway remains unclear. Another key feature of a tumor is the pr...

    Authors: Michael Pierre, Benoît DeHertogh, Anthoula Gaigneaux, Bertrand DeMeulder, Fabrice Berger, Eric Bareke, Carine Michiels and Eric Depiereux
    Citation: BMC Cancer 2010 10:176
    Content type: Research article Published on:

  19. Advanced cancer is a multifactorial disease that demands treatments targeting multiple cellular pathways. Chinese herbal cocktail which contains various phytochemicals may target multiple dys-regulated pathway...

    Authors: Jean-San Chia, Jia-Ling Du, Wei-Bin Hsu, Andy Sun, Chun-Pin Chiang and Won-Bo Wang
    Citation: BMC Cancer 2010 10:175
    Content type: Research article Published on:

  20. Current frequent follow-up after treatment for breast cancer does not meet its intended aims, but does depend on expensive and scarce specialized knowledge for routine history taking and physical examinations....

    Authors: Merel L Kimman, Monique MF Bloebaum, Carmen D Dirksen, Ruud MA Houben, Philippe Lambin and Liesbeth J Boersma
    Citation: BMC Cancer 2010 10:174
    Content type: Research article Published on:

  21. Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription quant...

    Authors: Kah Hoong Chang, Pieter Mestdagh, Jo Vandesompele, Michael J Kerin and Nicola Miller
    Citation: BMC Cancer 2010 10:173
    Content type: Research article Published on:

  22. We have previously demonstrated that tumour islet infiltration by macrophages is associated with extended survival (ES) in NSCLC. We therefore hypothesised that patients with improved survival would have high ...

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding
    Citation: BMC Cancer 2010 10:172
    Content type: Research article Published on:

  23. The management of early breast cancer (BC) with skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) is not based on level-1 evidence. In this study, the oncological outcome, post-operative ...

    Authors: Sara Reefy, Neill Patani, Anne Anderson, Gwyne Burgoyne, Hisham Osman and Kefah Mokbel
    Citation: BMC Cancer 2010 10:171
    Content type: Research article Published on:

  24. The elevated expression of vascular endothelial growth factor C (VEGF-C) is correlated with clinical cervical cancer metastasis and patient survival, which is interpreted by VEGF-C functions to stimulate angio...

    Authors: Mian He, Yang Cheng, Wen Li, Qiongshan Liu, Junxiu Liu, Jinghe Huang and Xiaodong Fu
    Citation: BMC Cancer 2010 10:170
    Content type: Research article Published on:

  26. We reported increased levels of Phosphatidyl Inositol synthase (PI synthase), (enzyme that catalyses phosphatidyl inositol (PI) synthesis-implicated in intracellular signaling and regulation of cell growth) in...

    Authors: Jatinder Kaur, Meenakshi Sawhney, Siddartha DattaGupta, Nootan K Shukla, Anurag Srivastava and Ranju Ralhan
    Citation: BMC Cancer 2010 10:168
    Content type: Research article Published on:

  27. We performed multicenter study to define clinical characteristics of noncutaneous melanomas and to establish prognostic factors patients who received curative resection.

    Authors: Hyo Song Kim, Eun Kyoung Kim, Hyun Jung Jun, Sung Yong Oh, Keon Woo Park, Do Hyoung Lim, Soon Il Lee, Jung Han Kim, Kyoung Mee Kim, Dae Ho Lee and Jeeyun Lee
    Citation: BMC Cancer 2010 10:167
    Content type: Research article Published on:

  28. Subsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their resistance to apoptosis-inducing stimuli has been related to carcinoma recurrence and treatment ...

    Authors: Lisa J Harper, Daniela Elena Costea, Luke Gammon, Bilal Fazil, Adrian Biddle and Ian C Mackenzie
    Citation: BMC Cancer 2010 10:166
    Content type: Research article Published on:

  29. The prostate gland represents a multifaceted system in which prostate epithelia and stroma have distinct physiological roles. To understand the interaction between stroma and glandular epithelia, it is essenti...

    Authors: Jennifer L Gregg, Kathleen E Brown, Eric M Mintz, Helen Piontkivska and Gail C Fraizer
    Citation: BMC Cancer 2010 10:165
    Content type: Research article Published on:

  30. Lymphovascular invasion (LVI) and lymph node metastasis are conventional pathological factors associated with an unfavorable prognosis of urothelial carcinoma of the upper urinary tract (UC-UUT), but little is...

    Authors: Takao Kamai, Hiromichi Shirataki, Kimihiro Nakanishi, Nobutaka Furuya, Tsunehito Kambara, Hideyuki Abe, Tetsunari Oyama and Ken-Ichiro Yoshida
    Citation: BMC Cancer 2010 10:164
    Content type: Research article Published on:

  32. Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed.

    Authors: Li Tang, Gary R Zirpoli, Vijayvel Jayaprakash, Mary E Reid, Susan E McCann, Chukwumere E Nwogu, Yuesheng Zhang, Christine B Ambrosone and Kirsten B Moysich
    Citation: BMC Cancer 2010 10:162
    Content type: Research article Published on:

  33. Human cervical cancer oncoprotein 1 (HCCR-1), reported as a negative regulator of p53, is over-expressed in a variety of human cancers. However, it is yet unknown whether HCCR-1 plays any role in pancreatic ca...

    Authors: Zekuan Xu, Yi Zhang, Jiakai Jiang, Yang Yang, Ruihua Shi, Bo Hao, Zhihong Zhang, Zuhu Huang, Jin W Kim and Guoxin Zhang
    Citation: BMC Cancer 2010 10:161
    Content type: Research article Published on:

  34. Nasopharyngeal carcinoma associated gene 6 (NGX6) is down-regulated in most colon cancer cell lines and tumor tissues when compared with their normal tissue samples. As a novel suppress tumor gene, it could in...

    Authors: Minji Liu, Ya Peng, Xiaoyan Wang, Qin Guo, Shourong Shen and Guiyuan Li
    Citation: BMC Cancer 2010 10:160
    Content type: Research article Published on:

  35. Recently, extremely low frequency electromagnetic fields (ELF-EMF) have been studied with great interest due to their possible effects on human health. In this study, we evaluated the effect of 4.5 mT - 120 Hz...

    Authors: Mónica Noemí Jiménez-García, Jaime Arellanes-Robledo, Diana Ivette Aparicio-Bautista, Miguel Ángel Rodríguez-Segura, Saúl Villa-Treviño and Juan José Godina-Nava
    Citation: BMC Cancer 2010 10:159
    Content type: Research article Published on:

  36. Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) activity is a marker of osteoclast number and is elevated in breast cancer (BC) patients with extensive bone metastasis, which might in turn reflect the ...

    Authors: Yi-Ying Wu, Anthony J Janckila, Chih-Hung Ku, Cheng-Ping Yu, Jyh-Cherng Yu, Su-Hui Lee, Hsin-Yi Liu, Lung T Yam and Tsu-Yi Chao
    Citation: BMC Cancer 2010 10:158
    Content type: Research article Published on:

  37. Hypoxic microenvironments in tumors contribute to transformation, which may alter metabolism, growth, and therapeutic responsiveness. The α-enolase gene encodes both a glycolytic enzyme (α-enolase) and a DNA-b...

    Authors: Kara C Sedoris, Shelia D Thomas and Donald M Miller
    Citation: BMC Cancer 2010 10:157
    Content type: Research article Published on:

  38. Breast cancer is the most frequently diagnosed cancer in women. Intraepithelial lesions (IELs), such as usual ductal hyperplasia (UH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) are...

    Authors: Giovanni P Burrai, Sulma I Mohammed, Margaret A Miller, Vincenzo Marras, Salvatore Pirino, Maria F Addis, Sergio Uzzau and Elisabetta Antuofermo
    Citation: BMC Cancer 2010 10:156
    Content type: Research article Published on:

  39. The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and...

    Authors: Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson and Pamela S Douglas
    Citation: BMC Cancer 2010 10:155
    Content type: Study protocol Published on:

  40. Racial and ethnic disparities in breast cancer incidence, stage at diagnosis, survival and mortality are well documented; but few studies have reported on disparities in breast cancer treatment. This paper com...

    Authors: Parvin Yavari, Maria Cristina Barroetavena, T Greg Hislop and Chris D Bajdik
    Citation: BMC Cancer 2010 10:154
    Content type: Research article Published on:

  41. Large number of patients with colorectal liver metastasis show recurrent disease after curative surgical resection. Identification of these high-risk patients may guide therapeutic strategies. The aim of this ...

    Authors: F Jeroen Vogelaar, Wilma E Mesker, Arjen M Rijken, Gaby W van Pelt, Antonia M van Leeuwen, Hans J Tanke, Rob A Tollenaar and Gerrit J Liefers
    Citation: BMC Cancer 2010 10:153
    Content type: Research article Published on:

  42. Despite the large number of men diagnosed with localized prostate cancer, there is as yet no consensus concerning appropriate treatment. The purpose of this study was to describe the initial treatment patterns...

    Authors: Maria J Schymura, Amy R Kahn, Robert R German, Mei-Chin Hsieh, Rosemary D Cress, Jack L Finch, John P Fulton, Tiefu Shen and Erik Stuckart
    Citation: BMC Cancer 2010 10:152
    Content type: Research article Published on:

  43. The urokinase plasminogen activating system (uPAS) is implicated in neoplastic progression and high tissue levels of uPAS components correlate with a poor prognosis in different human cancers. Despite that, re...

    Authors: Salvatore Ulisse, Enke Baldini, Marcella Mottolese, Steno Sentinelli, Patrizia Gargiulo, Brancato Valentina, Salvatore Sorrenti, Anna Di Benedetto, Enrico De Antoni and Massimino D'Armiento
    Citation: BMC Cancer 2010 10:151
    Content type: Research article Published on:

  44. Sarcomas are rare malignant tumors. Accurate initial histological diagnosis is essential for adequate management. We prospectively assessed the medical management of all patients diagnosed with sarcoma in a Eu...

    Authors: Antoine Lurkin, Francoise Ducimetière, Dominique Ranchère Vince, Anne-Valérie Decouvelaere, Dominic Cellier, François N Gilly, Dimitri Salameire, Pierre Biron, Guy de Laroche, Jean Yves Blay and Isabelle Ray-Coquard
    Citation: BMC Cancer 2010 10:150
    Content type: Research article Published on:

  45. Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neu...

    Authors: Rene' G Feichtinger, Franz Zimmermann, Johannes A Mayr, Daniel Neureiter, Cornelia Hauser-Kronberger, Freimut H Schilling, Neil Jones, Wolfgang Sperl and Barbara Kofler
    Citation: BMC Cancer 2010 10:149
    Content type: Research article Published on:

  46. Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumours (PNETs) are the most common highly aggressive paediatric brain tumours. In spite of extensive research on these tumours, there are on...

    Authors: Kristiina Nordfors, Joonas Haapasalo, Miikka Korja, Anssi Niemelä, Jukka Laine, Anna-Kaisa Parkkila, Silvia Pastorekova, Jaromir Pastorek, Abdul Waheed, William S Sly, Seppo Parkkila and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:148
    Content type: Research article Published on:

  47. The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis. Previous case-control studies also revealed TP53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of c...

    Authors: Mang Xiao, Lei Zhang, Xinhua Zhu, Jun Huang, Huifen Jiang, Sunhong Hu and Yuehui Liu
    Citation: BMC Cancer 2010 10:147
    Content type: Research article Published on:

  48. Bacterial targeting of tumours is an important anti-cancer strategy. We previously showed that strain SL7838 of Salmonella typhimurium targets and kills cancer cells. Whether NO generation by the bacteria has a r...

    Authors: Yoram Barak, Frank Schreiber, Steve H Thorne, Christopher H Contag, Dirk deBeer and A Matin
    Citation: BMC Cancer 2010 10:146
    Content type: Research article Published on:

  49. Germline mutations in the BRCA1 gene predispose to the development of breast cancer, exhibiting a specific histological phenotype. Identification of possible hallmarks of these tumors is important for selectin...

    Authors: Marise R Heerma van Voss, Petra van der Groep, Jos Bart, Elsken van der Wall and Paul J van Diest
    Citation: BMC Cancer 2010 10:145
    Content type: Research article Published on:

  50. Despite evidence that breast cancer screening reduces morbidity and mortality, until recently most women have not undergone regular mammogram examinations in Korea. We aimed to identify factors associated with...

    Authors: Kiheon Lee, Hyung Taek Lim and Sang Min Park
    Citation: BMC Cancer 2010 10:144
    Content type: Research article Published on:

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