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  1. Elucidating the activation pattern of molecular pathways across a given tumour type is a key challenge necessary for understanding the heterogeneity in clinical response and for developing novel more effective...

    Authors: Andrew E Teschendorff, Sergio Gomez, Alex Arenas, Dorraya El-Ashry, Marcus Schmidt, Mathias Gehrmann and Carlos Caldas
    Citation: BMC Cancer 2010 10:604
    Content type: Research article Published on:

  2. Very low density lipoprotein receptor (VLDLR) has been considered as a multiple function receptor due to binding numerous ligands, causing endocytosis and regulating cellular signaling. Our group previously re...

    Authors: Lei He, Yanjun Lu, Peng Wang, Jun Zhang, Chuanchang Yin and Shen Qu
    Citation: BMC Cancer 2010 10:601
    Content type: Research article Published on:

  3. This study aimed to show that SHOX2 DNA methylation is a tumor marker in patients with suspected lung cancer by using bronchial fluid aspirated during bronchoscopy. Such a biomarker would be clinically valuabl...

    Authors: Bernd Schmidt, Volker Liebenberg, Dimo Dietrich, Thomas Schlegel, Christoph Kneip, Anke Seegebarth, Nadja Flemming, Stefanie Seemann, Jürgen Distler, Jörn Lewin, Reimo Tetzner, Sabine Weickmann, Ulrike Wille, Triantafillos Liloglou, Olaide Raji, Martin Walshaw…
    Citation: BMC Cancer 2010 10:600
    Content type: Research article Published on:

  4. The genetic control of prostate cancer development is poorly understood. Large numbers of gene-expression datasets on different aspects of prostate tumorigenesis are available. We used these data to identify a...

    Authors: Ivan P Gorlov, Kanishka Sircar, Hongya Zhao, Sankar N Maity, Nora M Navone, Olga Y Gorlova, Patricia Troncoso, Curtis A Pettaway, Jin Young Byun and Christopher J Logothetis
    Citation: BMC Cancer 2010 10:599
    Content type: Research article Published on:

  5. Pancreatic cancer is the fourth leading cause of death in the US. Unlike other solid tumors such as testicular cancer which are now curable, more than 90% of pancreatic cancer patients die due to lack of respo...

    Authors: Zhaomin Li, Zizheng Dong, David Myer, Michele Yip-Schneider, Jianguo Liu, Ping Cui, C Max Schmidt and Jian-Ting Zhang
    Citation: BMC Cancer 2010 10:598
    Content type: Research article Published on:

  6. Several investigators have employed high throughput mitochondrial sequencing array (MitoChip) in clinical studies to search mtDNA for markers linked to cancers. In consequence, a host of somatic mtDNA mutation...

    Authors: Malliya Gounder Palanichamy and Ya-Ping Zhang
    Citation: BMC Cancer 2010 10:597
    Content type: Research article Published on:

  7. Prostate tumours are commonly poorly oxygenated which is associated with tumour progression and development of resistance to chemotherapeutic drugs and radiotherapy. Fibroblast growth factor 8b (FGF8b) is a mi...

    Authors: Johanna Tuomela, Tove J Grönroos, Maija P Valta, Jouko Sandholm, Aleksi Schrey, Jani Seppänen, Päivi Marjamäki, Sarita Forsback, Ilpo Kinnunen, Olof Solin, Heikki Minn and Pirkko L Härkönen
    Citation: BMC Cancer 2010 10:596
    Content type: Research article Published on:

  8. The anti-infective agent Taurolidine (TRD) has been shown to have cell death inducing properties, but the mechanism of its action is largely unknown. The aim of this study was to identify potential common targ...

    Authors: Ansgar M Chromik, Stephan A Hahn, Adrien Daigeler, Annegret Flier, Daniel Bulut, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Dirk Weyhe, Ulrich Mittelkötter and Waldemar Uhl
    Citation: BMC Cancer 2010 10:595
    Content type: Research article Published on:

  9. The prevalence of anxiety and depressive disorders in cancer patients and its associated factors in Pakistan is not known. There is a need to develop an evidence base to help introduce interventions as untreat...

    Authors: Nauman A Jadoon, Waqar Munir, Mohammad A Shahzad and Zeshan S Choudhry
    Citation: BMC Cancer 2010 10:594
    Content type: Research article Published on:

  10. Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-exp...

    Authors: Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei and Takashi Tamiya
    Citation: BMC Cancer 2010 10:593
    Content type: Research article Published on:

  11. Intrinsic to "Patient-Centered Care" is being respectful and responsive to individual patient preferences, expressed needs, and personal values. Establishing a patient's preferences for active and aggressive i...

    Authors: Vincent Maida, Jonathan Peck, Marguerite Ennis, Navjot Brar and Alexandria R Maida
    Citation: BMC Cancer 2010 10:592
    Content type: Research article Published on:

  12. Circulating cell-free microRNAs have been identified as potential cancer biomarkers. However, the existence and the potential application of cell-free miRNAs in effusion samples are still uncertain. In order t...

    Authors: Li Xie, Xi Chen, Lifeng Wang, Xiaoping Qian, Tingting Wang, Jia Wei, Lixia Yu, Yitao Ding, Chenyu Zhang and Baorui Liu
    Citation: BMC Cancer 2010 10:591
    Content type: Research article Published on:

  13. Lung cancer remains the leading cause of cancer-related mortality despite continuous efforts to find effective treatments. Data from the American Cancer Society indicate that while the overall incidence of lun...

    Authors: Dharmendra K Maurya, Chiyo Doi, Atsushi Kawabata, Marla M Pyle, Clay King, Zhihong Wu, Deryl Troyer and Masaaki Tamura
    Citation: BMC Cancer 2010 10:590
    Content type: Research article Published on:

  14. Electrotherapy effectiveness at different doses has been demonstrated in preclinical and clinical studies; however, several aspects that occur in the tumor growth kinetics before and after treatment have not y...

    Authors: Luis E Bergues Cabrales, Juan J Godina Nava, Andrés Ramírez Aguilera, Javier A González Joa, Héctor M Camué Ciria, Maraelys Morales González, Miriam Fariñas Salas, Manuel Verdecia Jarque, Tamara Rubio González, Miguel A O'Farril Mateus, Soraida C Acosta Brooks, Fabiola Suárez Palencia, Lisset Ortiz Zamora, María C Céspedes Quevedo, Sarah Edward Seringe, Vladimir Crombet Cuitié…
    Citation: BMC Cancer 2010 10:589
    Content type: Research article Published on:

  15. It is known that alpha-defensin expression is enhanced in colon cancer. However, the expression of human alpha defensin 6 (DEFA 6) in earlier stages, such as adenoma, has so far not yet been studied in a patie...

    Authors: Mariya Y Radeva, Franziska Jahns, Anne Wilhelm, Michael Glei, Utz Settmacher, Karl Otto Greulich and Henning Mothes
    Citation: BMC Cancer 2010 10:588
    Content type: Research article Published on:

  16. Only a few studies have addressed the molecular pathways specifically involved in carcinogenesis of the distal colon and rectum. We aimed to identify potential differences among genetic alterations in distal c...

    Authors: Manuela Pinheiro, Terje Ahlquist, Stine A Danielsen, Guro E Lind, Isabel Veiga, Carla Pinto, Vera Costa, Luís Afonso, Olga Sousa, Maria Fragoso, Lúcio Santos, Rui Henrique, Paula Lopes, Carlos Lopes, Ragnhild A Lothe and Manuel R Teixeira
    Citation: BMC Cancer 2010 10:587
    Content type: Research article Published on:

  17. Developing the right drugs for the right patients has become a mantra of drug development. In practice, it is very difficult to identify subsets of patients who will respond to a drug under evaluation. Most of...

    Authors: Erich P Huang, Jane Fridlyand, Nicholas Lewin-Koh, Peng Yue, Xiaoyan Shi, David Dornan and Bart Burington
    Citation: BMC Cancer 2010 10:586
    Content type: Research article Published on:

  18. Ovarian fibrosarcomas are very rare tumors, and therefore, few case studies have evaluated the prognostic factors of this disease. To our knowledge, this study represents the largest study to evaluate the clin...

    Authors: Long Huang, Ling-Min Liao, Hui-Yun Wang and Min Zheng
    Citation: BMC Cancer 2010 10:585
    Content type: Research article Published on:

  19. Lung cancer causes the highest rate of cancer-related deaths both in men and women. As many current treatment modalities are inadequate in increasing patient survival, new therapeutic strategies are required. ...

    Authors: Cigdem Aydin, Ahter D Sanlioglu, Atil Bisgin, Burcak Yoldas, Levent Dertsiz, Bahri Karacay, Thomas S Griffith and Salih Sanlioglu
    Citation: BMC Cancer 2010 10:584
    Content type: Research article Published on:

  20. Cisplatin-based chemotherapy, in combination with fluoropyrimidines or taxanes, have demonstrated efficacy against advanced gastric cancer (AGC). This retrospective study was performed with the data obtained f...

    Authors: Do Hyoung Lim, Se Hoon Park, Keon Woo Park, Jung Hun Kang, Sung Yong Oh, In Gyu Hwang, Jung Mi Kwon, Sang-Cheol Lee, Hui-Young Lee, Hyeong Su Kim, Ho Yeong Lim and Won Ki Kang
    Citation: BMC Cancer 2010 10:583
    Content type: Research article Published on:

  21. This study investigated potential prognostic factors in patients treated with whole-brain irradiation (WBI) alone for brain metastases from relatively radioresistant tumors such as malignant melanoma, renal ce...

    Authors: Thekla Meyners, Christine Heisterkamp, Jan-Dirk Kueter, Theo Veninga, Lukas JA Stalpers, Steven E Schild and Dirk Rades
    Citation: BMC Cancer 2010 10:582
    Content type: Research article Published on:

  22. Chemotherapy-induced anemia (CIA) is responsive to treatment with erythropoiesis-stimulating agents (ESAs) such as darbepoetin alfa. Administration of ESAs on a synchronous schedule with chemotherapy administr...

    Authors: Lee Schwartzberg, Ronald Burkes, Barry Mirtsching, Timothy Rearden, Peter Silberstein, Lorrin Yee, Amy Inamoto and Tom Lillie
    Citation: BMC Cancer 2010 10:581
    Content type: Research article Published on:

  23. Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...

    Authors: Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng and Zhao-You Tang
    Citation: BMC Cancer 2010 10:580
    Content type: Research article Published on:

  26. NORE1 (RASSF5) is a newly described member of the RASSF family with Ras effector function. NORE1 expression is frequently inactivated by aberrant promoter hypermethylation in many human cancers, suggesting that N...

    Authors: Chang Kyun Lee, Jin-Hee Lee, Min-Goo Lee, Seong-In Jeong, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Young Hwangbo, Jae-Jun Shim, Jae Young Jang, Kil Yeon Lee, Hyo Jong Kim and Sung-Gil Chi
    Citation: BMC Cancer 2010 10:577
    Content type: Research article Published on:

  27. Most patients with ovarian cancer are diagnosed with advanced stage disease (i.e., stage III-IV), which is associated with a poor prognosis. Differentially expressed genes (DEGs) in stage III serous ovarian carci...

    Authors: Yun-Sook Kim, Jin Hwan Do, Sumi Bae, Dong-Han Bae and Woong Shick Ahn
    Citation: BMC Cancer 2010 10:576
    Content type: Research article Published on:

  28. CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development o...

    Authors: Kefu Tang, Yang Li, Zhao Zhang, Yunmin Gu, Yuyu Xiong, Guoyin Feng, Lin He and Shengying Qin
    Citation: BMC Cancer 2010 10:575
    Content type: Research article Published on:

  29. Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Prev...

    Authors: Michelle MS Chew, Sook-Yee Gan, Alan SB Khoo and Eng-Lai Tan
    Citation: BMC Cancer 2010 10:574
    Content type: Research article Published on:

  30. An estimated 12% of females in the United States will develop breast cancer in their lifetime. Although, there are advances in treatment options including surgery and chemotherapy, breast cancer is still the s...

    Authors: Jeffrey C Miecznikowski, Dan Wang, Song Liu, Lara Sucheston and David Gold
    Citation: BMC Cancer 2010 10:573
    Content type: Research article Published on:

  31. The optimal protocol for 125I-transperineal prostatic brachytherapy (TPPB) in intermediate-risk prostate cancer (PCa) patients remains controversial. Data on the efficacy of combining androgen-deprivation therapy...

    Authors: Kenta Miki, Takayoshi Kiba, Hiroshi Sasaki, Masahito Kido, Manabu Aoki, Hiroyuki Takahashi, Keiko Miyakoda, Takushi Dokiya, Hidetoshi Yamanaka, Masanori Fukushima and Shin Egawa
    Citation: BMC Cancer 2010 10:572
    Content type: Study protocol Published on:

  32. Telomerase activation, a critical step in cell immortalization and oncogenesis, is partly regulated by alternative splicing. In this study, we aimed to use the Marek's disease virus (MDV) T-cell lymphoma model...

    Authors: Souheila Amor, Sylvie Remy, Ginette Dambrine, Yves Le Vern, Denis Rasschaert and Sylvie Laurent
    Citation: BMC Cancer 2010 10:571
    Content type: Research article Published on:

  33. Gallbladder cancer typically follows an aggressive course, with chemotherapy the standard of care for advanced disease; complete remissions are rarely encountered. The epidermal growth factor receptor (EGFR) i...

    Authors: Kabir Mody, Edward Strauss, Robert Lincer and Richard C Frank
    Citation: BMC Cancer 2010 10:570
    Content type: Case report Published on:

  34. Various studies reported remarkable high incidence rates of depression in cancer patients compared with the general population. Pancreatic cancer is still one of the malignancies with the worst prognosis and t...

    Authors: Martina Mayr and Roland M Schmid
    Citation: BMC Cancer 2010 10:569
    Content type: Debate Published on:

  35. Recent studies have suggested that the Src inhibitor dasatinib preferentially inhibits the growth of breast cancer cells of the basal-like subtype. To clarify this finding and further investigate combined anti...

    Authors: Junichi Kurebayashi, Naoki Kanomata, Takuya Moriya, Yuji Kozuka, Mika Watanabe and Hiroshi Sonoo
    Citation: BMC Cancer 2010 10:568
    Content type: Research article Published on:

  36. This phase II study investigated efficacy and safety of weekly alternating Bevacizumab (BEV)/Irinotecan (CPT-11) or Oxaliplatin (OHP) associated to weekly 5-Fluorouracil (5-FU) in first line treatment of metas...

    Authors: Gemma Bruera, Alessandra Santomaggio, Katia Cannita, Paola Lanfiuti Baldi, Marianna Tudini, Federica De Galitiis, Maria Mancini, Paolo Marchetti, Adelmo Antonucci, Corrado Ficorella and Enrico Ricevuto
    Citation: BMC Cancer 2010 10:567
    Content type: Research article Published on:

  37. The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα.

    Authors: Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi and Yoshinori Otsuki
    Citation: BMC Cancer 2010 10:566
    Content type: Research article Published on:

  38. Preclinical studies demonstrated that small chain RNA fragments accelerate the recovery of platelets numbers in animals exposed to high doses of chemotherapeutic drugs. There is anecdotal data supporting the s...

    Authors: Robert D Levin, MaryAnn Daehler, James F Grutsch, John L Hall, Digant Gupta and Christopher G Lis
    Citation: BMC Cancer 2010 10:565
    Content type: Research article Published on:

  39. Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics. The goal of this study was to investigate anatomical site-related s...

    Authors: Hye Sung Won, Myung Ah Lee, Eun-Seon Chung, Dong-Goo Kim, Young Kyoung You, Tae Ho Hong and In-Seok Lee
    Citation: BMC Cancer 2010 10:564
    Content type: Research article Published on:

  40. The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI)....

    Authors: Daniele Campa, Anika Hüsing, James D McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjønneland, Kim Overvad, Jakob Stegger, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher…
    Citation: BMC Cancer 2010 10:563
    Content type: Research article Published on:

  41. The Ras association domain family 1 (RASSF1) gene is a Ras effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative promoter selection and alternative mRNA splicing. RASSF1A is a tum...

    Authors: Mark E Reeves, Scott W Baldwin, Melissa L Baldwin, Shin-Tai Chen, Jeremy M Moretz, Robert J Aragon, Xinmin Li, Donna D Strong, Subburaman Mohan and Yousef G Amaar
    Citation: BMC Cancer 2010 10:562
    Content type: Research article Published on:

  42. Numerous studies reported genomic alterations in colorectal human tumors but few focused on rectal tumors with the specification of preoperative-treated or untreated tumors. The goals of this study were to lis...

    Authors: Benoît Romain, Agnès Neuville, Nicolas Meyer, Cécile Brigand, Serge Rohr, Anne Schneider, Marie-Pierre Gaub and Dominique Guenot
    Citation: BMC Cancer 2010 10:561
    Content type: Research article Published on:

  43. Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphobl...

    Authors: Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund and Christian Junghanss
    Citation: BMC Cancer 2010 10:560
    Content type: Research article Published on:

  44. Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of

    Authors: Emmalena Gregory-Bryson, Elizabeth Bartlett, Matti Kiupel, Schantel Hayes and Vilma Yuzbasiyan-Gurkan
    Citation: BMC Cancer 2010 10:559
    Content type: Research article Published on:

  45. The main objective of this meta-analysis was to determine the clinical benefit of concurrent chemoradiotherapy (CCRT) compared with radiation alone (RT) in the treatment of nasopharyngeal carcinoma (NPC) patie...

    Authors: Li Zhang, Chong Zhao, Bijesh Ghimire, Ming-Huang Hong, Qing Liu, Yang Zhang, Ying Guo, Yi-Jun Huang and Zhong-Zhen Guan
    Citation: BMC Cancer 2010 10:558
    Content type: Research article Published on:

  46. Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of ≤1 cm, including T1mic.

    Authors: Ji Hyun Kwon, Yu Jung Kim, Keun-Wook Lee, Do-Youn Oh, So Yeon Park, Jee Hyun Kim, Eui Kyu Chie, Sung-Won Kim, Seock-Ah Im, In-Ah Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Yung-Jue Bang and Sung Whan Ha
    Citation: BMC Cancer 2010 10:557
    Content type: Research article Published on:

  47. Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuatio...

    Authors: William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen and Zijie Sun
    Citation: BMC Cancer 2010 10:556
    Content type: Research article Published on:

  48. Polyamine metabolism has a critical role in cell death and proliferation representing a potential target for intervention in breast cancer (BC). This study investigates the expression of spermine oxidase (SMO)...

    Authors: Manuela Cervelli, Gabriella Bellavia, Emiliano Fratini, Roberto Amendola, Fabio Polticelli, Marco Barba, Rodolfo Federico, Fabrizio Signore, Giacomo Gucciardo, Rosalba Grillo, Patrick M Woster, Robert A Casero Jr and Paolo Mariottini
    Citation: BMC Cancer 2010 10:555
    Content type: Research article Published on:

  49. Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. Their expression is related ...

    Authors: Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix and Jelena Anacker
    Citation: BMC Cancer 2010 10:553
    Content type: Research article Published on:

  50. Cancer health disparities affecting low-income and minority patients are well documented. Root-causes are multifactorial, including diagnostic and treatment delays, social and financial barriers, and poor comm...

    Authors: Samantha Hendren, Jennifer J Griggs, Ronald M Epstein, Sharon Humiston, Sally Rousseau, Pascal Jean-Pierre, Jennifer Carroll, Amanat M Yosha, Starlene Loader and Kevin Fiscella
    Citation: BMC Cancer 2010 10:551
    Content type: Study protocol Published on:

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