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  1. Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of mu...

    Authors: Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson and Rafat A Siddiqui
    Citation: BMC Cancer 2011 11:149
  2. Despite the recent publication of results from two randomized clinical trials, prostate specific antigen (PSA) screening for prostate cancer remains a controversial issue. There is lack of agreement across stu...

    Authors: David C Wheeler, Konrad M Szymanski, Amanda Black and David E Nelson
    Citation: BMC Cancer 2011 11:148
  3. Geographical variations in medical practice are expected to be small when the evidence about the effectiveness and safety of a particular technology is abundant. This would be the case of the prescription of c...

    Authors: Manuel Ridao-López, Sandra García-Armesto, Begoña Abadía-Taira, Salvador Peiró-Moreno and Enrique Bernal-Delgado
    Citation: BMC Cancer 2011 11:145
  4. Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effe...

    Authors: Seung Joon Lee, Candice Krauthauser, Victoria Maduskuie, Paul T Fawcett, James M Olson and Sigrid A Rajasekaran
    Citation: BMC Cancer 2011 11:144
  5. Optimizing treatment through microarray-based molecular subtyping is a promising method to address the problem of heterogeneity in breast cancer; however, current application is restricted to prediction of dis...

    Authors: Kuo-Jang Kao, Kai-Ming Chang, Hui-Chi Hsu and Andrew T Huang
    Citation: BMC Cancer 2011 11:143
  6. Cerebral metastases are a common cause of death in patients with melanoma. Systemic drug treatment of these metastases is rarely effective, and where possible surgical resection and/or stereotactic radiosurger...

    Authors: Gerald Fogarty, Rachael L Morton, Janette Vardy, Anna K Nowak, Catherine Mandel, Peta M Forder, Angela Hong, George Hruby, Bryan Burmeister, Brindha Shivalingam, Haryana Dhillon and John F Thompson
    Citation: BMC Cancer 2011 11:142

    The Update to this article has been published in Trials 2019 20:477

  7. Breast cancer is the leading cause of cancer mortality among women in Malaysia. Delayed diagnosis is preventable and has major effects on patients' prognosis and survival. The objectives of our study were to i...

    Authors: Bachok Norsa'adah, Krishna G Rampal, Mohd A Rahmah, Nyi N Naing and Biswa M Biswal
    Citation: BMC Cancer 2011 11:141
  8. Today, more than 70% of patients with primary node-negative breast cancer are cured by local therapy alone. Many patients receive overtreatment by adjuvant chemotherapy due to inadequate risk assessment. So fa...

    Authors: Eva J Kantelhardt, Martina Vetter, Marcus Schmidt, Corinne Veyret, Doris Augustin, Volker Hanf, Christoph Meisner, Daniela Paepke, Manfred Schmitt, Fred Sweep, Gunter von Minckwitz, Pierre-Marie Martin, Fritz Jaenicke, Christoph Thomssen and Nadia Harbeck
    Citation: BMC Cancer 2011 11:140
  9. A cross-talk between different receptor tyrosine kinases (RTKs) plays an important role in the pathogenesis of human cancers.

    Authors: Chen-Yun Yeh, Shin-Mei Shin, Hsuan-Heng Yeh, Tsung-Jung Wu, Jyh-Wei Shin, Tsuey-Yu Chang, Giri Raghavaraju, Chung-Ta Lee, Jung-Hsien Chiang, Vincent S Tseng, Yuan-Chii G Lee, Cheng-Huang Shen, Nan-Haw Chow and Hsiao-Sheng Liu
    Citation: BMC Cancer 2011 11:139
  10. Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas. In previous analyses, we were able to show that restoration of Smad4 expression in Smad4-deficient SW480 human colon carcinoma ...

    Authors: Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler and Stephan A Hahn
    Citation: BMC Cancer 2011 11:137
  11. Medulloblastoma is a highly malignant pediatric brain tumor that requires surgery, whole brain and spine irradiation, and intense chemotherapy for treatment. A more sophisticated understanding of the pathophys...

    Authors: Susan E Spiller, Naomi J Logsdon, Lindsey A Deckard and Harald Sontheimer
    Citation: BMC Cancer 2011 11:136
  12. The standard treatment for patients with advanced transitional cell carcinoma of the bladder is platin based chemotherapy. Only approximately 50% of the patients respond to chemotherapy. Therefore, molecular p...

    Authors: Iver Nordentoft, Lars Dyrskjøt, Julie S Bødker, Peter J Wild, Arndt Hartmann, Simone Bertz, Jan Lehmann, Torben F Ørntoft and Karin Birkenkamp-Demtroder
    Citation: BMC Cancer 2011 11:135
  13. The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing r...

    Authors: Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz and Peter E Huber
    Citation: BMC Cancer 2011 11:134
  14. There are large ethnic differences in cervical cancer survival in New Zealand that are only partly explained by stage at diagnosis. We investigated the association of comorbidity with cervical cancer survival,...

    Authors: Naomi Brewer, Barry Borman, Diana Sarfati, Mona Jeffreys, Steven T Fleming, Soo Cheng and Neil Pearce
    Citation: BMC Cancer 2011 11:132
  15. Chemotherapy dose delay and/or reduction lower relative total dose intensity (RTDI) and may affect short- and long-term outcome of metastatic breast cancer (MBC) patients.

    Authors: Sibylle Loibl, Tomas Skacel, Valentina Nekljudova, Hans Joachim Lück, Matthias Schwenkglenks, Thomas Brodowicz, Christoph Zielinski and Gunter von Minckwitz
    Citation: BMC Cancer 2011 11:131
  16. The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine ...

    Authors: Gali Soria, Maya Ofri-Shahak, Ilana Haas, Neora Yaal-Hahoshen, Leonor Leider-Trejo, Tal Leibovich-Rivkin, Polina Weitzenfeld, Tsipi Meshel, Esther Shabtai, Mordechai Gutman and Adit Ben-Baruch
    Citation: BMC Cancer 2011 11:130
  17. Oral (p.o.) chemotherapy treatments gained increasing importance in the palliative treatment of metastatic breast cancer (MBC). Aim of this survey was to evaluate the acceptance of p.o. treatment and patients'...

    Authors: Sarah Schott, Andreas Schneeweiss, Judith Reinhardt, Thomas Bruckner, Christoph Domschke, Christof Sohn and Michael H Eichbaum
    Citation: BMC Cancer 2011 11:129
  18. With the advances in modern radiotherapy (RT), many patients with head and neck cancer (HNC) can be effectively cured, and their health-related quality of life (HR-QoL) has become an important issue. In this s...

    Authors: Stephen Wan Leung, Tsair-Fwu Lee, Chih-Yen Chien, Pei-Ju Chao, Wen-Ling Tsai and Fu-Min Fang
    Citation: BMC Cancer 2011 11:128
  19. Mortality is high in patients with esophageal carcinoma as tumors are rarely detected before the disease has progressed to an advanced stage. Here, we sought to isolate cell-free DNA released into the plasma o...

    Authors: Immacolata Andolfo, Giuseppe Petrosino, Loredana Vecchione, Pasqualino De Antonellis, Mario Capasso, Donatella Montanaro, Marica Gemei, Giancarlo Troncone, Achille Iolascon, Michele Orditura, Fortunato Ciardiello, Fernando De Vita and Massimo Zollo
    Citation: BMC Cancer 2011 11:126
  20. We have previously demonstrated that both canine and human OSA cell lines, as well as 8 fresh canine OSA tumor samples, exhibit constitutive phosphorylation of STAT3, and that this correlates with enhanced exp...

    Authors: Stacey L Fossey, Misty D Bear, William C Kisseberth, Michael Pennell and Cheryl A London
    Citation: BMC Cancer 2011 11:125
  21. Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal formulation of irinotecan (Irinophore C™), and other...

    Authors: Maite Verreault, Dita Strutt, Dana Masin, Malathi Anantha, Andrew Yung, Piotr Kozlowski, Dawn Waterhouse, Marcel B Bally and Donald T Yapp
    Citation: BMC Cancer 2011 11:124
  22. The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the...

    Authors: Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart and Mark J Arends
    Citation: BMC Cancer 2011 11:123
  23. Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and a...

    Authors: Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura and Masahiko Watanabe
    Citation: BMC Cancer 2011 11:122
  24. Latexin, also known as endogenous carboxypeptidase inhibitor (CPI), has been found to inhibit mouse stem cell populations and lymphoma cell proliferation, demonstrating its potential role as a tumor suppressor...

    Authors: Yong Li, Zhuoma Basang, Huirong Ding, Zheming Lu, Tao Ning, Haoran Wei, Hong Cai and Yang Ke
    Citation: BMC Cancer 2011 11:121
  25. Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistanc...

    Authors: Philipp Lechler, Tobias Renkawitz, Valentina Campean, Sanjeevi Balakrishnan, Markus Tingart, Joachim Grifka and Jens Schaumburger
    Citation: BMC Cancer 2011 11:120
  26. KLK15 over-expression is reported to be a significant predictor of reduced progression-free survival and overall survival in ovarian cancer. Our aim was to analyse the KLK15 gene for putative functional single n...

    Authors: Jyotsna Batra, Christina M Nagle, Tracy O'Mara, Melanie Higgins, Ying Dong, Olivia L Tan, Felicity Lose, Lene Marie Skeie, Srilakshmi Srinivasan, Kelly L Bolton, Honglin Song, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Mary-Anne Kedda, Amanda B Spurdle…
    Citation: BMC Cancer 2011 11:119
  27. It is unclear whether individualized treatments based on biological factors have improved the prognosis of recurrent breast cancer. The purpose of this study is to evaluate the survival improvement of patients...

    Authors: Hideo Shigematsu, Hidetoshi Kawaguchi, Yoshiaki Nakamura, Kimihiro Tanaka, Satoko Shiotani, Chinami Koga, Sumiko Nishimura, Kenichi Taguchi, Kenichi Nishiyama and Shinji Ohno
    Citation: BMC Cancer 2011 11:118
  28. In patients with advanced hepatocellular carcinoma (HCC), combination chemotherapy using 5- fluorouracil, cisplatin, and mitoxantrone (FMP) could achieve a response rate > 20%, but the beneficial effect was co...

    Authors: Chau-Ting Yeh, Hui-Chin Chen, Chang-Mu Sung, Cheng-Lung Hsu, Chen-Chun Lin, Kuang-Tse Pan, Jeng-Hwei Tseng and Chien-Fu Hung
    Citation: BMC Cancer 2011 11:117
  29. Several naturally occurring cationic antimicrobial peptides (CAPs), including bovine lactoferricin (LfcinB), display promising anticancer activities. These peptides are unaffected by multidrug resistance mecha...

    Authors: Bodil Fadnes, Lars Uhlin-Hansen, Inger Lindin and Øystein Rekdal
    Citation: BMC Cancer 2011 11:116
  30. Many adjuvant trials have been undertaken in an attempt to reduce the risk of recurrence among patients who undergo surgical resection for locally advanced renal cancer. However, no clear benefit has been iden...

    Authors: Adolfo JO Scherr, Joao Paulo SN Lima, Emma C Sasse, Carmen SP Lima and André D Sasse
    Citation: BMC Cancer 2011 11:115
  31. Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based desig...

    Authors: Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth and Cheryl A London
    Citation: BMC Cancer 2011 11:112
  32. Metastasis to the seminal vesicle is extremely rare for hepatocellular carcinoma (HCC). To our knowledge, it has been not reported in literature. The purpose of the present paper was to report a case of metast...

    Authors: Li Gong, Minwen Zheng, Yanhong Li, Wendong Zhang, Wangjun Bu, Lifang Shi, Wei Zhang and Hong Yan
    Citation: BMC Cancer 2011 11:111
  33. Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical...

    Authors: B Leticia Rodriguez, Zhen Yu, Woon-Gye Chung, Richard Weiss and Zhengrong Cui
    Citation: BMC Cancer 2011 11:110
  34. Gastric cancer is the second most common cause of global cancer-related mortality. Although dedifferentiation predicts poor prognosis in gastric cancer, the molecular mechanism underlying dedifferentiation, wh...

    Authors: Min Wei, Zhiwei Wang, Hongliang Yao, Zhongyin Yang, Qing Zhang, Bingya Liu, Yingyan Yu, Liping Su, Zhenggang Zhu and Qinlong Gu
    Citation: BMC Cancer 2011 11:109
  35. Exosomes consist of membrane vesicles that are secreted by several cell types, including tumors and have been found in biological fluids. Exosomes interact with other cells and may serve as vehicles for the tr...

    Authors: Cristina Escrevente, Sascha Keller, Peter Altevogt and Júlia Costa
    Citation: BMC Cancer 2011 11:108
  36. As supplement to KRAS mutational analysis, BRAF and PIK3CA mutations as well as expression of PTEN may account for additional non-responders to anti-EGFR-MoAbs treatment. The aim of the present study was to inves...

    Authors: Karen-Lise G Spindler, Niels Pallisgaard, Jan Lindebjerg, Sanne K Frifeldt and Anders Jakobsen
    Citation: BMC Cancer 2011 11:107
  37. Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to pr...

    Authors: Sumiya Ishigami, Shinichi Ueno, Yuka Nishizono, Masataka Matsumoto, Hiroshi Kurahara, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Kita Yoshiaki, Yuko Kijima, Masaki Kitazono and Shoji Natsugoe
    Citation: BMC Cancer 2011 11:106
  38. Multikinase inhibitors (MKIs) sunitinib and sorafenib have become a standard of care for metastatic renal cell carcinoma (mRCC). This study assessed safety and treatment patterns for these agents in a real-wor...

    Authors: Camillo Porta, Chiara Paglino, Ilaria Imarisio, Cinzia Canipari, Kristina Chen, Maureen Neary and Mei Sheng Duh
    Citation: BMC Cancer 2011 11:105
  39. The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been repor...

    Authors: Keke Zhou, Dezhi Hu, Juan Lu, Weiwei Fan, Hongliang Liu, Hongyan Chen, Gong Chen, Qingyi Wei, Guhong Du, Ying Mao, Daru Lu and Liangfu Zhou
    Citation: BMC Cancer 2011 11:104
  40. The adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer. In this study we further investigate the relationship of PINCH...

    Authors: Jasmine Lööf, Johan Rosell, Charlotte Bratthäll, Siv Doré, Hans Starkhammar, Hong Zhang and Xiao-Feng Sun
    Citation: BMC Cancer 2011 11:103
  41. DNA methylation in the SHOX2 locus was previously used to reliably detect lung cancer in a group of critical controls, including 'cytologically negative' samples with no visible tumor cell content, at a high spec...

    Authors: Katja U Schneider, Dimo Dietrich, Michael Fleischhacker, Gunda Leschber, Johannes Merk, Frank Schäper, Henk R Stapert, Erik R Vossenaar, Sabine Weickmann, Volker Liebenberg, Christoph Kneip, Anke Seegebarth, Fikret Erdogan, Gudrun Rappold and Bernd Schmidt
    Citation: BMC Cancer 2011 11:102
  42. In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer devel...

    Authors: Kamel Rouissi, Islem Ben Bahria, Karim Bougatef, Raja Marrakchi, Nejla Stambouli, Khouloud Hamdi, Mohamed Cherif, Mohamed Riadh Ben Slama, Mohamed Sfaxi, Fethi Ben Othman, Mohamed Chebil, Amel Benammar Elgaaied and Slah Ouerhani
    Citation: BMC Cancer 2011 11:101
  43. Recently EBUS-TBNA, which has a sensitivity of 94.6%, specificity of 100% and diagnostic accuracy rate of 96.3% as previously reported, has been widely used for patients with mediastinal and hilar lymphadenopa...

    Authors: Ting Ye, Hong Hu, Xiaoyang Luo and Haiquan Chen
    Citation: BMC Cancer 2011 11:100

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