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  1. PTEN inactivation is the most frequent genetic aberration in endometrial cancer. One of the phosphatase-independent roles of PTEN is associated with homologous recombination (HR) in nucleus. Poly (ADP-ribose) ...

    Authors: Aki Miyasaka, Katsutoshi Oda, Yuji Ikeda, Osamu Wada-Hiraike, Tomoko Kashiyama, Atsushi Enomoto, Noriko Hosoya, Takahiro Koso, Tomohiko Fukuda, Kanako Inaba, Kenbun Sone, Yuriko Uehara, Reiko Kurikawa, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto…
    Citation: BMC Cancer 2014 14:179
    Content type: Research article Published on:

  2. NanoString’s Prosigna™ Breast Cancer Prognostic Gene Signature Assay is based on the PAM50 gene expression signature. The test outputs a risk of recurrence (ROR) score, risk category, and intrinsic subtype (Lu...

    Authors: Torsten Nielsen, Brett Wallden, Carl Schaper, Sean Ferree, Shuzhen Liu, Dongxia Gao, Garrett Barry, Naeem Dowidar, Malini Maysuria and James Storhoff
    Citation: BMC Cancer 2014 14:177
    Content type: Technical advance Published on:

  3. The inhibitor of apoptosis (IAP) protein Survivin and its splice variants are differentially expressed in breast cancer tissues. Our previous work showed Survivin is released from tumor cells via small membran...

    Authors: Salma Khan, Heather Ferguson Bennit, David Turay, Mia Perez, Saied Mirshahidi, Yuan Yuan and Nathan R Wall
    Citation: BMC Cancer 2014 14:176
    Content type: Research article Published on:

  5. Despite introduction of effective chemotherapy protocols, it has remained uncertain, if patients with colorectal cancer (CRC) liver metastases should receive adjuvant therapy. Clinical or molecular predictors ...

    Authors: Nuh N Rahbari, Christoph Reissfelder, Henning Schulze-Bergkamen, Dirk Jäger, Markus W Büchler, Jürgen Weitz and Moritz Koch
    Citation: BMC Cancer 2014 14:174
    Content type: Research article Published on:

  7. Tamoxifen, an endocrine therapy drug used to treat breast cancer, is designed to interrupt estrogen signaling by blocking the estrogen receptor (ER). However, many ER-positive patients are low reactive or resi...

    Authors: Ji Ma, Yan Guo, Suning Chen, Cuiping Zhong, Yan Xue, Yuan Zhang, Xiaofeng Lai, Yifang Wei, Shentong Yu, Jian Zhang and Wenchao Liu
    Citation: BMC Cancer 2014 14:172
    Content type: Research article Published on:

  8. While ovarian cancer is recognised as having identifiable early symptoms, understanding of the key determinants of symptom awareness and early presentation is limited. A population-based survey of ovarian canc...

    Authors: Kate E Brain, Stephanie Smits, Alice E Simon, Lindsay J Forbes, Chris Roberts, Iain J Robbé, John Steward, Ceri White, Richard D Neal and Jane Hanson
    Citation: BMC Cancer 2014 14:171
    Content type: Research article Published on:

  9. Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients with postmenopausal breast cancer. Preclinical and clinical studies have ...

    Authors: Jisun Kim, Woosung Lim, Eun-Kyu Kim, Min-Kyoon Kim, Nam-Sun Paik, Sang-Seol Jeong, Jung-han Yoon, Chan Heun Park, Sei Hyun Ahn, Lee Su Kim, Sehwan Han, Seok Jin Nam, Han-Sung Kang, Seung Il Kim, Young Bum Yoo, Joon Jeong…
    Citation: BMC Cancer 2014 14:170
    Content type: Study protocol Published on:

  10. Ewing’s sarcoma (ES) is the second most frequent primitive malignant bone tumor in adolescents with a very poor prognosis for high risk patients, mainly when lung metastases are detected (overall survival <15%...

    Authors: Guillaume Odri, Pui-Pui Kim, François Lamoureux, Céline Charrier, Séverine Battaglia, Jérôme Amiaud, Dominique Heymann, François Gouin and Françoise Redini
    Citation: BMC Cancer 2014 14:169
    Content type: Research article Published on:

  11. Pancreatic cancer is the third most common cancer related cause of death. Even in the 15% of patients who are eligible for surgical resection the outlook is dismal with less than 10% of patients surviving afte...

    Authors: Friedrich H Schmitz-Winnenthal, Thomas Schmidt, Monika Lehmann, Philipp Beckhove, Meinhard Kieser, Anthony D Ho, Peter Dreger and Markus W Büchler
    Citation: BMC Cancer 2014 14:168
    Content type: Study protocol Published on:

  12. Platelets play a fundamental role in maintaining hemostasis and have been shown to participate in hematogenous dissemination of tumor cells. Abundant platelets were detected in the tumor microenvironment outsi...

    Authors: Rong Li, Meiping Ren, Ni Chen, Mao Luo, Xin Deng, Jiyi Xia, Guang Yu, Jinbo Liu, Bing He, Xu Zhang, Zhuo Zhang, Xiao Zhang, Bing Ran and Jianbo Wu
    Citation: BMC Cancer 2014 14:167
    Content type: Research article Published on:

  13. This phase II study evaluated the efficacy and safety/tolerability of sunitinib plus trastuzumab in patients with HER2-positive advanced breast cancer (ABC).

    Authors: Thomas Bachelot, Jose A Garcia-Saenz, Sunil Verma, Maya Gutierrez, Xavier Pivot, Mark F Kozloff, Catherine Prady, Xin Huang, Reza Khosravan, Zhixiao Wang, Rossano Cesari, Vanessa Tassell, Kenneth A Kern, Jean-Yves Blay and Ana Lluch
    Citation: BMC Cancer 2014 14:166
    Content type: Research article Published on:

  14. Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, t...

    Authors: Jaehoon Jung, Hyo Young Kim, Jeehye Maeng, Moonhee Kim, Dong Hae Shin and Kyunglim Lee
    Citation: BMC Cancer 2014 14:165
    Content type: Research article Published on:

  15. Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncog...

    Authors: Dongjun Jeong, Suhak Heo, Tae Sung Ahn, Sookyoung Lee, Soyoung Park, Hyungjoo Kim, Doosan Park, Sang Byung Bae, Sung Soo Lee, Moon Soo Lee, Chang-Jin Kim and Moo Jun Baek
    Citation: BMC Cancer 2014 14:164
    Content type: Research article Published on:

  16. Lower breast cancer survival has been reported for Australian Aboriginal women compared to non-Aboriginal women, however the reasons for this disparity have not been fully explored. We compared the surgical tr...

    Authors: Rajah Supramaniam, Alison Gibberd, Anthony Dillon, David Eamon Goldsbury and Dianne L O’Connell
    Citation: BMC Cancer 2014 14:163
    Content type: Research article Published on:

  17. The effects of exposure to ultraviolet radiation are a significant concern in Australia which has one of the highest incidences of skin cancer in the world. Despite most skin cancers being preventable by encou...

    Authors: Cathy M Cleary, Katherine M White, Ross McD Young, Anna L Hawkes, Stuart Leske, Louise C Starfelt and Kylie Wihardjo
    Citation: BMC Cancer 2014 14:162
    Content type: Study protocol Published on:

  18. Cervical cancer is the first female cancer in Lao PDR, a low-income country with no national screening and prevention programs for this human papillomavirus (HPV) associated pathology. HIV-infected women have ...

    Authors: Chanvilay SICHANH, Fabrice QUET, Phetsavanh CHANTHAVILAY, Joeffroy DIENDERE, Vatthanaphone LATTHAPHASAVANG, Christophe LONGUET and Yves BUISSON
    Citation: BMC Cancer 2014 14:161
    Content type: Research article Published on:

  19. Resistance to 5-fluorouracil (5-FU) in patients with colorectal cancer prevents effective treatment and leads to unnecessary and burdensome chemotherapy. Therefore, prediction of 5-FU resistance is imperative.

    Authors: Ji-Won Park, Seung Cheol Kim, Won Ki Kim, Jun Pyu Hong, Kyung-Hee Kim, Hyun Yang Yeo, Jae Yong Lee, M Sun Kim, Jong Heon Kim, Se Young Yang, Dae Yong Kim, Jae Hwan Oh, Jae Youl Cho and Byong Chul Yoo
    Citation: BMC Cancer 2014 14:160
    Content type: Research article Published on:

  20. The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by the...

    Authors: Noelyn Hung, Yu-Jen Chen, Ahmad Taha, Magnus Olivecrona, Ronald Boet, Anna Wiles, Tracy Warr, Alisha Shaw, Ramona Eiholzer, Bruce C Baguley, Michael R Eccles, Antony W Braithwaite, Martin MacFarlane, Janice A Royds and Tania Slatter
    Citation: BMC Cancer 2014 14:159
    Content type: Research article Published on:

  21. In the present study we determined the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The infla...

    Authors: Tal Leibovich-Rivkin, Yulia Liubomirski, Tsipi Meshel, Anastasia Abashidze, Daphna Brisker, Hilla Solomon, Varda Rotter, Miguel Weil and Adit Ben-Baruch
    Citation: BMC Cancer 2014 14:158
    Content type: Research article Published on:

  23. Rectal and pararectal gastrointestinal stromal tumors (GISTs) are rare. The optimal management strategy for primary localized GISTs remains poorly defined.

    Authors: Thanh-Khoa Huynh, Pierre Meeus, Philippe Cassier, Olivier Bouché, Sophie Lardière-Deguelte, Antoine Adenis, Thierry André, Julien Mancini, Olivier Collard, Michael Montemurro, Emmanuelle Bompas, Maria Rios, Nicolas Isambert, Didier Cupissol, Jean-Yves Blay and Florence Duffaud
    Citation: BMC Cancer 2014 14:156
    Content type: Research article Published on:

  24. This randomized Phase III trial will evaluate whether the methylene blue-assisted technique is efficient for harvesting lymph nodes after radical surgery for gastric cancer.

    Authors: Toru Aoyama, Takaki Yoshikawa, Satoshi Morita, Junya Shirai, Hirohito Fujikawa, Kenichi Iwasaki, Tsutomu Hayashi, Takashi Ogata, Haruhiko Cho, Norio Yukawa, Takashi Oshima, Yasushi Rino, Munetaka Masuda and Akira Tsuburaya
    Citation: BMC Cancer 2014 14:155
    Content type: Study protocol Published on:

  25. Cancer cell adopts peculiar metabolic strategies aimed to sustain the continuous proliferation in an environment characterized by relevant fluctuations in oxygen and nutrient levels. Monocarboxylate transporte...

    Authors: Patrizia Sanità, Mattia Capulli, Anna Teti, Giuseppe Paradiso Galatioto, Carlo Vicentini, Paola Chiarugi, Mauro Bologna and Adriano Angelucci
    Citation: BMC Cancer 2014 14:154
    Content type: Research article Published on:

  26. Ki-67 is a nuclear protein involved in cell proliferation regulation, and its expression has been widely used as an index to evaluate the proliferative activity of lymphoma. However, its prognostic value for l...

    Authors: Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao and Liansheng Huang
    Citation: BMC Cancer 2014 14:153
    Content type: Research article Published on:

  27. Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells that will impair treatment efficacy. The objective of this study was to investigate if head and neck squa...

    Authors: Chann Lagadec, Erina Vlashi, Sunita Bhuta, Chi Lai, Paul Mischel, Martin Werner, Michael Henke and Frank Pajonk
    Citation: BMC Cancer 2014 14:152
    Content type: Research article Published on:

  28. Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM consists of surgery followed by radiotherapy and ...

    Authors: Lucio Tentori, Lucia Ricci-Vitiani, Alessia Muzi, Fabio Ciccarone, Federica Pelacchi, Roberta Calabrese, Daniele Runci, Roberto Pallini, Paola Caiafa and Grazia Graziani
    Citation: BMC Cancer 2014 14:151
    Content type: Research article Published on:

  29. Breast cancer has been poorly studied in women with intellectual disability (ID), which makes designing a policy for screening the nearly 70 million women with ID in the world difficult. As no data is availabl...

    Authors: Daniel Satgé, Eric-André Sauleau, William Jacot, Fernand Raffi, Bernard Azéma, Jean-Claude Bouyat and Nicolas El Hage Assaf
    Citation: BMC Cancer 2014 14:150
    Content type: Research article Published on:

  30. Chemokine receptor signaling pathways are implicated in the pathobiology of renal cell carcinoma (RCC). However, the clinical relevance of CXCR2 receptor, mediating the effects of all angiogenic chemokines, re...

    Authors: Anastasios Stofas, Georgia Levidou, Christina Piperi, Christos Adamopoulos, Georgia Dalagiorgou, Aristotelis Bamias, Alexandra Karadimou, George A Lainakis, Stefanos Papadoukakis, Konstantinos Stravodimos, Meletios-Athanasios Dimopoulos, Efstratios Patsouris, Hariklia Gakiopoulou and Penelope Korkolopoulou
    Citation: BMC Cancer 2014 14:149
    Content type: Research article Published on:

  31. The peritoneum is one of the most frequent sites of recurrent gastric carcinoma after curative treatment, despite the administration of pre- and/or postoperative systemic chemotherapy. Indeed, the prognosis of...

    Authors: Diane Goéré, Nathalie Gras-Chaput, Anne Aupérin, Caroline Flament, Christophe Mariette, Olivier Glehen, Laurence Zitvogel and Dominique Elias
    Citation: BMC Cancer 2014 14:148
    Content type: Study protocol Published on:

  32. Neuroendocrine carcinoma (NEC) of the breast is a rare type of carcinoma that has not been well studied or characterized. Of the limited number of studies reported in the literature, most are case reports. A f...

    Authors: Jun Wang, Bing Wei, Constance T Albarracin, Jianhua Hu, Susan C Abraham and Yun Wu
    Citation: BMC Cancer 2014 14:147
    Content type: Research article Published on:

  33. Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastro...

    Authors: Bin Peng, Xue Zhang, Fanfan Cao, Ying Wang, Limin Xu, Lu Cao, Chunxin Yang, Maoquan Li, Georges Uzan and Denghai Zhang
    Citation: BMC Cancer 2014 14:146
    Content type: Research article Published on:

  34. There is extensive evidence for the role of aberrant cell survival signaling mechanisms in cancer progression and metastasis. Akt is a major component of cell survival-signaling mechanisms in several types of ...

    Authors: Ekta Agarwal, Anathbandhu Chaudhuri, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain and Sanjib Chowdhury
    Citation: BMC Cancer 2014 14:145
    Content type: Research article Published on:

  35. The aim of this study was to examine the association of non-random X chromosome inactivation (XCI) and loss of heterozygosity (LOH) at Xq25 with breast cancer development.

    Authors: Hui-Tzu Chen, Yao-Chung Wu, Shou-Tung Chen, Hsien-Chang Tsai and Yi-Chih Chien
    Citation: BMC Cancer 2014 14:144
    Content type: Research article Published on:

  36. Significant bleeding may occur following endobronchial forceps biopsy or brushing of necrotic or hypervascular tumors in the airways. In some cases, methods such as endobronchial instillation of iced saline la...

    Authors: Adil Zamani
    Citation: BMC Cancer 2014 14:143
    Content type: Technical advance Published on:

  37. Maspin, which is classified as a tumor suppressor protein, is downregulated in many types of cancer. Several studies have suggested potential anti-proliferative activity of maspin as well as sensitizing activi...

    Authors: Magdalena Machowska, Katarzyna Wachowicz, Mirosław Sopel and Ryszard Rzepecki
    Citation: BMC Cancer 2014 14:142
    Content type: Research article Published on:

  38. The anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2; MDC-22), a novel derivative of aspirin, and evalu...

    Authors: Liqun Huang, Chi C Wong, Gerardo G Mackenzie, Yu Sun, Ka Wing Cheng, Kvetoslava Vrankova, Ninche Alston, Nengtai Ouyang and Basil Rigas
    Citation: BMC Cancer 2014 14:141
    Content type: Research article Published on:

  39. Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study...

    Authors: Long Huang, Ling-Min Liao, An-Wen Liu, Jian-Bing Wu, Xiao-Ling Cheng, Jia-Xin Lin and Min Zheng
    Citation: BMC Cancer 2014 14:140
    Content type: Research article Published on:

  40. Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors ...

    Authors: Roberta Ciarapica, Elena Carcarino, Laura Adesso, Maria De Salvo, Giorgia Bracaglia, Pier Paolo Leoncini, Alessandra Dall’Agnese, Federica Verginelli, Giuseppe M Milano, Renata Boldrini, Alessandro Inserra, Stefano Stifani, Isabella Screpanti, Victor E Marquez, Sergio Valente, Antonello Mai…
    Citation: BMC Cancer 2014 14:139
    Content type: Research article Published on:

  41. MicroRNA (miR)-182 is frequently upregulated in cancers, has generally been viewed as an oncogene and is possibly connected to angiogenesis. We aimed to explore what impact miR-182 has in non-small cell lung c...

    Authors: Helge Stenvold, Tom Donnem, Sigve Andersen, Samer Al-Saad, Lill-Tove Busund and Roy M Bremnes
    Citation: BMC Cancer 2014 14:138
    Content type: Research article Published on:

  42. Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and...

    Authors: Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli and Katia Scotlandi
    Citation: BMC Cancer 2014 14:137
    Content type: Research article Published on:

  43. To observe the primary tumor (PT) regression speed after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) and evaluate its prognostic significance.

    Authors: Ning Zhang, Shao-Bo Liang, Yan-Ming Deng, Rui-Liang Lu, Hai-Yang Chen, Hai Zhao, Zhi-Qian Lv, Shao-Qiang Liang, Lin Yang, Dong-Sheng Liu and Yong Chen
    Citation: BMC Cancer 2014 14:136
    Content type: Research article Published on:

  45. Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor ...

    Authors: Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang and Lin-Tao Jia
    Citation: BMC Cancer 2014 14:134
    Content type: Research article Published on:

  46. Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RAS mut) in acute myeloid leukaemia (AML), which has been associated with...

    Authors: Francianne Gomes Andrade, Juliana Montibeller Furtado-Silva, Bruno Alves de Aguiar Gonçalves, Luiz Claudio Santos Thuler, Thayana Conceição Barbosa, Mariana Emerenciano, André Siqueira and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2014 14:133
    Content type: Research article Published on:

  47. Among women, breast cancer (BC) is the leading cancer and the most common cause of cancer-related death between 30 and 69 years. Although lifestyle and diet are considered to have a role in global BC incidence...

    Authors: Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias and JC Mendes de Almeida
    Citation: BMC Cancer 2014 14:132
    Content type: Research article Published on:

  48. To evaluate the insulin receptor isoform mRNA expression status in non-small cell lung cancer (NSCLC) patients.

    Authors: Liyan Jiang, Wei Zhu, Katie Streicher, Chris Morehouse, Philip Brohawn, Xiaoxiao Ge, Zhengwei Dong, Xiaolu Yin, Guanshan Zhu, Yi Gu, Koustubh Ranade, Brandon W Higgs, Yihong Yao and Jiaqi Huang
    Citation: BMC Cancer 2014 14:131
    Content type: Research article Published on:

  49. Quantification of molecular cell processes is important for prognostication and treatment individualization of head and neck cancer (HNC). However, individual tumor comparison can show discord in upregulation ...

    Authors: Bianca AW Hoeben, Maud HW Starmans, Ralph TH Leijenaar, Ludwig J Dubois, Albert J van der Kogel, Johannes HAM Kaanders, Paul C Boutros, Philippe Lambin and Johan Bussink
    Citation: BMC Cancer 2014 14:130
    Content type: Research article Published on:

  50. Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC...

    Authors: Gloria D Coronado, William M Vollmer, Amanda Petrik, Josue Aguirre, Tanya Kapka, Jennifer DeVoe, Jon Puro, Tran Miers, Jennifer Lembach, Ann Turner, Jennifer Sanchez, Sally Retecki, Christine Nelson and Beverly Green
    Citation: BMC Cancer 2014 14:55
    Content type: Research article Published on:

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