- Research article
- Open Access
- Open Peer Review
Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French Sarcoma group
- Thanh-Khoa Huynh1, 15Email author,
- Pierre Meeus2,
- Philippe Cassier3,
- Olivier Bouché4,
- Sophie Lardière-Deguelte5,
- Antoine Adenis6,
- Thierry André7,
- Julien Mancini8,
- Olivier Collard9,
- Michael Montemurro10,
- Emmanuelle Bompas11,
- Maria Rios12,
- Nicolas Isambert13,
- Didier Cupissol14,
- Jean-Yves Blay3 and
- Florence Duffaud1
© Huynh et al.; licensee BioMed Central Ltd. 2014
- Received: 8 December 2012
- Accepted: 21 February 2014
- Published: 5 March 2014
Rectal and pararectal gastrointestinal stromal tumors (GISTs) are rare. The optimal management strategy for primary localized GISTs remains poorly defined.
We conducted a retrospective analysis of 41 patients with localized rectal or pararectal GISTs treated between 1991 and 2011 in 13 French Sarcoma Group centers.
Of 12 patients who received preoperative imatinib therapy for a median duration of 7 (2-12) months, 8 experienced a partial response, 3 had stable disease, and 1 had a complete response. Thirty and 11 patients underwent function-sparing conservative surgery and abdominoperineal resection, respectively. Tumor resections were mostly R0 and R1 in 35 patients. Tumor rupture occurred in 12 patients. Eleven patients received postoperative imatinib with a median follow-up of 59 (2.4-186) months. The median time to disease relapse was 36 (9.8-62) months. The 5-year overall survival rate was 86.5%. Twenty patients developed local recurrence after surgery alone, two developed recurrence after resection combined with preoperative and/or postoperative imatinib, and eight developed metastases. In univariate analysis, the mitotic index (≤5) and tumor size (≤5 cm) were associated with a significantly decreased risk of local relapse. Perioperative imatinib was associated with a significantly reduced risk of overall relapse and local relapse.
Perioperative imatinib therapy was associated with improved disease-free survival. Preoperative imatinib was effective. Tumor shrinkage has a clear benefit for local excision in terms of feasibility and function preservation. Given the complexity of rectal GISTs, referral of patients with this rare disease to expert centers to undergo a multidisciplinary approach is recommended.
- Abdominoperineal Resection
- Imatinib Treatment
- Tumor Rupture
- Multivisceral Resection
Gastrointestinal stromal tumors (GISTs) are rare but nonetheless represent the most common mesenchymal tumors of the gastrointestinal tract. The majority of GISTs arise in the stomach and small intestine , with an estimated annual incidence of 11 to 14.5 per million [2, 3]. Rectal/pararectal GISTs are very rare and represent only 3 to 5% of all GISTs. Their incidence is estimated at 0.45 per million per year . Few series of rectal GISTs have been reported in the literature, and the available reports are limited to a small number of cases [5–7].
Due to the rarity of rectal GISTs and the limited number of published studies, there is a paucity of data on how to optimally handle rectal GISTs. There is a tendency to treat rectal/pararectal GISTs as other GISTs, particularly as gastric GISTs. Management typically involves en bloc resection of the tumor, which avoids tumor rupture and obtains clear margins; there is no need for lymphadenectomy because lymphatic metastases are exceedingly rare. Nevertheless, rectal/pararectal GISTs have a high risk of recurrence (local recurrence or metastasis), ranging from 55% for tumors of >5 cm with a mitotic index (MI) of ≤5/50 HPF to 85% for tumors with an MI of >5/50 HPF regardless of size .
Surgery remains the only curative treatment for GISTs. However, because of the specific location of rectal GISTs, surgery is technically difficult and often extensive, possibly involving abdominoperineal or multivisceral resections, and raises the problem of sphincter preservation. Extensive surgery may result in considerable functional morbidity based on the tumor size, exact location of the tumor, and relationship of the tumor with vital pelvic structures (i.e., bladder, pelvic nerves, and anal sphincters). Therefore, the ability to shrink such a tumor in a safe and reliable manner is crucial to facilitate the performance of function-sparing surgical resection of disease.
Imatinib is a selective receptor tyrosine kinase inhibitor of the KIT and PDGFR-α receptor tyrosine kinases, which are pathophysiological drivers of GISTs. Imatinib is approved worldwide as a first-line systemic treatment for KIT-positive unresectable and/or metastatic GISTs and has revolutionized their treatment . Since 2005, several case reports and small series regarding use of preoperative “neoadjuvant” imatinib treatment for rectal GISTs have been published [10–14], and some larger series have been more recently published [15, 16]. These studies have shown that significant downstaging can be achieved with this targeted therapy, thus allowing conservative surgical procedures to be performed. More recently, imatinib treatment has been considered in the adjuvant setting to lower the risk of relapse . Published reports of patients with rectal GISTs treated since the approval of imatinib, which has dramatically changed the treatment options and prognosis for GISTs, are rare [15, 16].
We conducted a 19-year retrospective analysis of rectal/pararectal GISTs with the aim of reviewing the clinicopathological characteristics, diagnostic and treatment approaches, choice of surgical procedure, perioperative use of imatinib, patterns of failure, and early and long-term results including overall survival and event-free survival.
We collected data of adult patients with rectal/pararectal GISTs treated from November 1991 to March 2011 in 12 French Sarcoma Group institutions and the Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne. A standard data file was created to retrieve information on patient characteristics (gender, age at diagnosis, Eastern Cooperative Oncology Group [ECOG] performance status, and initial clinical symptoms), clinicopathological tumor characteristics, treatment approaches including surgical management and medical treatment (neoadjuvant and/or adjuvant imatinib), and patterns of failure (local recurrence or distant metastasis). Follow-up information was obtained during outpatient visits.
The diagnosis of GIST was confirmed by an experienced local pathologist using morphology and immunohistochemical staining for KIT (CD117) and CD34. Seven GISTs diagnosed as leiomyosarcoma before the year 2000 were reclassified as GISTs at the time of recurrence. Tumors were classified using standard risk assessment criteria using both the classification proposed by Fletcher (NIH consensus risk) , which is based on tumor size and number of mitoses, and the classification proposed by Miettinen , which is based on the MI, tumor size, and tumor site.
This was a retrospective minimal-risk review, and all patients consented to the use of their standard clinical data. Our institutional review board exempts such minimal-risk survey studies from requiring institutional review board approval according to French laws. The board of directors of the French Sarcoma Group approved the study.
Continuous variables are expressed as median (range), and categorical variables are expressed as percentages. We retrospectively analyzed all prognostic factors, including patient characteristics (sex, age, ECOG performance status), tumor characteristics (tumor site in rectum, tumor size, KIT, CD34, MI/50 HPF, NIH categories, Miettinen categories, necrosis, histological subtype, and mutational status), surgical management (type of procedure, radical vs conservative surgery, margins [R0 vs R1 vs R2 or R0 vs R1-R2 or R0-R1 vs R2], tumor rupture, surgery-related complications), and medical treatment (imatinib treatment group vs non-imatinib treatment group). Fisher’s exact test was used to compare percentages. Survival curves were plotted using the Kaplan–Meier method and compared with the log-rank test. Overall survival was calculated based on the interval from diagnosis to patient’s death or last follow-up. Local relapse-free survival was defined as the interval between diagnosis and any subsequent occurrence of a tumor in the same location. Event-free survival was defined as the interval between diagnosis and local relapse and/or distant metastasis. All statistical tests were two-sided, and the threshold for statistical significance was set at p = 0.05. Analyses were performed with SPSS software, version 17.0 (SPSS Inc., IL, USA).
Patient and disease characteristics
Patient and tumor characteristics
n = 41
Others (genito urinary, pelvic heaviness)
Rectum (Middle third/Lower third)
Tumor size (mm)
Abdominopelvic CT Scan
≤ 5/50 HPF
> 5/50 HPF
Mutation status (done on 12 cases)
KIT Exon 11 mutation in 10/12
KIT Exon 9 mutation in 1/12
KIT Exon 17 mutation in 1/12
None PDGFRA mutation
NIH risk categories
Very low risk
Miettinen risk categories
Insufficient data (unclassified)
During the period from November 1991 to March 2011, a total of 41 adult patients with localized rectal/pararectal GISTs were included in this review, including 4 patients reported in a separate therapeutic trial known as the French Sarcoma Group BFR 14 study . The median age at diagnosis was 60 years (range, 33-82 years). The staging of the primary tumor included abdominopelvic computed tomography (CT) in 21 patients (51%), pelvic magnetic resonance imaging (MRI) in 18 patients (44%), endorectal ultrasonography in 23 patients (56%), and positron emission tomography–CT in 6 patients (15%).
The median tumor size was 62 mm (range, 6-130 mm). GISTs were mostly located in the middle third (9 patients, 24%) and lower third (22 patients, 50%) of the rectum. Only seven GISTs (17%) were located in pararectal spaces (presacral space, ischiorectal fossa, rectovaginal space, and rectoprostatic space). Histologically, the tumors were predominantly spindle-cell type (n = 31, 76%). Immunohistochemically, 83% of the tumors were KIT (CD117)-positive, and 78% were CD34-positive. The mutational status was determined in only 12 cases and revealed KIT exon 11 mutations in 10 cases.
Results of treatment
n = 41 localized tumors
Quality of surgery
Primary surgery/Post imatinib surgery
Anastomotic leakage of coloanal anastomosis
Small bowel fistula with death
Pararectal abscess and anorectal fistula
Imatinib (IM) therapy group (400 mg/day)
No neoadjuvant IM group (immediate surgery)
Post operative IM
from « neoadjuvant group »
from « immediate surgery group »
Median duration preoperative IM (month)
Median duration post operative IM (month)
Efficacy of preoperative IM therapy
Stable disease/minor response
All patients underwent tumor resection. Twenty-five patients underwent surgery only. Imatinib was not given either because of the small tumor size or because it was not available at the time of diagnosis. A total of 16 patients underwent operations and received preoperative (n = 5), postoperative (n = 4), or preoperative and postoperative (n = 7) receptor tyrosine kinase inhibitor therapy with imatinib. Twenty-nine (70%) patients underwent surgery as the initial treatment, but 12 were treated with imatinib preoperatively because of the tumor size.
All patients underwent surgery. Different types of surgical procedures were performed. Local removal of the tumor was performed in 30 of 41 patients and involved anterior resection with coloanal or sus-anal anastomosis in 12 (29%) patients, transanal/trans-sacral/transvaginal resection in 7 (17%) patients, endoanal/endovaginal excision in 6 (14.6%) patients, and unspecified resection in 5 (12%) patients, resulting in 14 R0, 10 R1, and 4 R2 resections of 30 conservative surgeries and 2 unspecified resections. Abdominoperineal resection was performed in 11 of 41 (27%) patients, resulting in 8 of 11 R0, 3 of 11 R1, and no R2 resections. In proportion, sphincter-sparing surgery was performed in 61% of patients, and abdominoperineal resection was performed in 27% of patients. Abdominoperineal resection was more likely to result in negative margins than local surgery (8 of 11 vs 14 of 30, respectively; p < 0.05).
Seven patients (17%) experienced complications related to surgery: infection (n = 4), occlusion (n = 1), and disunity of the coloanal anastomosis (n = 2). Complications were fatal in one patient who died of a small bowel fistula. Tumor rupture occurred during surgery in nine patients (22%).
Preoperative imatinib therapy
Among the 41 patients, 12 (30%) received preoperative imatinib at 400 mg daily before surgical resection, with a median preoperative treatment period of 7 months (range, 2-12 months). All tumors except two were in the inferior third of the rectum. The tumor response was assessed every 2 to 3 months by CT and/or MRI. Of the 12 patients, 8 showed a partial response according to Response Evaluation Criteria in Solid Tumors (RECIST), 1 had a complete response, and 3 had stable disease or a minor response.
Two patients underwent abdominoperineal resection despite a partial response after imatinib therapy; all had negative margins and no postoperative complications. Ten patients underwent a sphincter-sparing surgery; all except one had negative margins (R0), and four of them had postoperative complications.
Postoperative imatinib therapy
According to their estimated risk of relapse, 11 (27%) patients were treated with imatinib postoperatively at 400 mg/day for a median duration of 7 months (range, 2-41 months). Seven after surgery performed after preoperative imatinib therapy and four after surgery only.
Patient outcomes (Table 3)
n = 41 localized tumors
In the « non imatinib treatment group »
In the « imatinib treatment group »
6/11 patients (54.5%) who underwent abdominoperineal resection (exclusively in « non IM group)
In the « non imatinib treatment group »
In the « imatinib treatment group »
Local relapse-free survival at 3 years
60.2% [CI95% = 45.8-79.1]
Local relapse-free survival at 5 years
42.1% [CI95% = 26.8-66.3]
DFS at 3 years
53.9% [CI95% = 39.3-73.8%]
DFS at 5 years
34.6% [CI95% = 19.9-60.2%]
OS at 3 years
97.5% [CI95% = 92.8-100%]
OS at 5 years
86.5% [CI95% = 74.9-100%]
Local recurrence occurred in 20 (49%) patients, including 18 (72%) in the non-imatinib treatment group and only 2 (16%) in the imatinib treatment group (p < 0.001). The median follow-up duration in the imatinib treatment group was 39 months (range, 5-81 months), and that in the non-imatinib treatment group was 68 months (range, 2-186 months).
Among the 20 local recurrences, 6 (54.6%) developed in the 11 patients who underwent abdominoperineal resection (exclusively in the non-imatinib treatment group), and 14 (46%) developed among the 30 patients who underwent local resection (2 who received imatinib and 12 who did not receive imatinib). Furthermore, these local recurrences developed in 8 of 22 patients after R0 resection, 9 of 13 patients after R1 resection, and 3 of 4 patients after R2 resection. Eight of 41 patients (20%) developed distant metastases: 6 (24%) in the non-imatinib treatment group and 2 (13%) in the imatinib treatment group (p = 0.448).
Survival analysis and prognostic factors
A tumor size of larger than 5 cm and an MI of higher than 5/50 HPF increased the risk of local recurrence, as expected with these known prognostic factors . A low MI (≤5/50 HPF) (p = 0.008) and imatinib treatment (p = 0.011) were associated with a significantly lower risk of overall relapse (local recurrence and distant metastasis), but had no impact on overall survival. Sex, age, NIH risk, Miettinen risk categories, tumor margins, tumor rupture, and tumor local control had no influence on event-free survival or overall survival in the univariate analysis. In the multivariate analysis, we could not demonstrate whether tumor size, MI, or NIH risk were independent factors.
Preoperative and/or postoperative imatinib treatment significantly reduced the risk of overall relapse (p = 0.011) and local relapse (p = 0.006) (Figure 2D), with a significant impact on disease-free survival but no demonstrable impact on overall survival.
GISTs are unusual tumors overall, while rectal GISTs are a particularly rare subtype, representing less than 5% of all GISTs. Few data are available on the presentation, management, and survival of patients with primary rectal GISTs.
Our retrospective study of 41 localized rectal GISTs over the last 20 years is, to our knowledge, one of the largest series currently reported in the literature. The two most recent and large series on primary rectal GISTs reported 39 cases from 2 referral departments for sarcomas/GIST surgeries over the last 8 years  and 32 cases from 6 surgical oncology and medical oncology departments in the Netherlands over the last 21 years .
Patient demographics showed a male predominance (71%), as already suggested in other series on primary rectal GISTs [8, 15, 16, 21], although most large epidemiological studies of GISTs overall have shown a well-balanced sex ratio with respect to incidence [2, 22]. The presentation and symptoms of these 41 rectal GISTs were not different from those commonly found for other rectal tumors despite the fact that the clinical presentation was sometimes misleading, with rectal GISTs causing genitourinary and gynecological symptoms because of compression or invasion of adjacent pelvic organs. Therefore, we agree with other authors [6, 16, 23] that pelvic/rectal GISTs should be integrated into the framework of differential diagnoses along with other submucosal rectal and pelvic tumors.
The mutational status was only determined in a subset of 12 patients, in whom KIT exon 11 mutations were demonstrated in 10, KIT exon 9 mutation in 1, and no mutation in 1. In this retrospective study, tumor mutational testing for the oncogenic KIT and/or PDGFRA genes was able to be performed in only 12 of 41 (29%) of these rare patients with rectal GISTs. Given the known challenges described below, obtaining evaluable tissues from patients identified over more than a decade is simply not feasible. In three patients who underwent resection of the primary tumor between 2000 and 2008, paraffin-embedded blocks were collected, but the quality of tumor material was insufficient to perform mutational testing because of technical challenges associated with these older blocks and the tissue fixation procedure. For nine other patients, resection of primary GISTs was performed before 1999, and the quality of the tissue specimen from the primary tumor was insufficient to determine the mutational status. Thus, despite our best efforts, retrospective mutational examination of any additional patients in our series is unfortunately not possible. However, our team believes that the information provided in this series is useful because tumor mutational testing is routinely performed in only a minority (approximately 5%) of GISTs worldwide. Nevertheless, the mutation frequency in rectal GISTs has not been specifically investigated [15, 16] except in Miettinen’s study , which found mutations in 18 of 29 (62%) of the cases evaluated, with a predominance of KIT exon 11 mutations, a lack of KIT exon 13 mutations, and only one KIT exon 9 mutation.
In our study, 56% of the patients were classified in the high-risk group according to the Miettinen classification , and 56% of patients relapsed after surgical resection of primary localized GISTs with disease-free survival rates of 53.9 and 34.6% at 3 and 5 years, respectively. This confirms the more aggressive behavior of rectal GISTs. These data also corroborated the results of Mussi et al. , Tsai et al. , and Miettinen et al. , who showed that the majority of rectal GISTs are large, demonstrate high-risk malignant behavior, and have a tendency to recur and metastasize. Furthermore, in three Korean studies, colorectal GISTs occurred predominantly in the rectum and tended to be classified as high-risk, which was the most important risk factor for recurrence [25–27].
The cornerstone in treatment for patients with localized GISTs is complete surgical resection with en bloc tumor removal and clear margins, avoiding tumor rupture. In our series, the relatively high rate of tumor rupture during surgical resection might be explained by several factors in this rare subset of patients with GIST. In particular, this is a particularly challenging anatomical location for primary GISTs, and the risk of rupture definitely seems higher than that in many other sites. In five of our patients, the large size of the primary tumor (8–10 cm) in this constrained anatomic space likely contributed to the risk of rupture. In another three patients, the surgical resection was performed by endoanal or transvaginal enucleation with resultant fragmentation of the tumor. Conversely, rectal GISTs are often large tumors. Therefore, they are a challenge for surgeons because of the confined pelvic space (anatomical location close to the anal sphincters, pelvic nerves, and bladder) and the fact that they are often adherent to the pelvic floor. As a consequence, rectal GISTs might require extensive surgery (e.g., abdominoperineal or multivisceral resection) to achieve complete surgical resection. Nevertheless, various conservative surgical procedures and approaches may be considered for rectal GISTs, including local excision, anterior resection, trans-sacral/anal/vaginal approaches, and laparoscopic approaches [28–30]. The choice of the procedure mainly depends on the tumor size and location in relation to the anorectal margin. In our series, only 11 (27%) patients underwent abdominoperineal resection, and 30 patients were eligible for conservative surgery with various surgical procedures.
Nevertheless, resections with clear margins (R0 resections) were more common with abdominoperineal procedures than with conservative surgery (8/11 and 14/30, respectively), but tumor recurrence occurred similarly in both groups of patients: in 6 of 11 patients (54%) after abdominoperineal surgery and in 11 of 30 patients (46.6%) after conservative surgery.
Because of the rarity of this disease, no prospective studies have compared radical surgery versus conservative surgery or local tumor excision, and only such a study could elucidate the value of this radical surgery. Khalifa et al.  reported that there was no difference in survival rates between local resection and abdominoperineal resection in patients with rectal sarcoma. We believe that local resection should be performed if microscopically clear margins can be safely achieved.
Preoperative imatinib therapy was administered to 12 (30%) of the patients in this series because of large GISTs, difficulty of complete tumor removal, and preservation of the anal sphincters. In all cases, it enabled a modification in tumor size and/or density. It also permitted the performance of conservative surgery in 8 of 12 patients (6 of these 8 tumors were located in the lower third of the rectum). Thus, this treatment was feasible, safe, and effective. Since 2005, several case reports or small series regarding the use of preoperative imatinib treatment for rectal GISTs have been published [10–13, 32–35]. All concluded that preoperative imatinib therapy has an important role in downsizing large rectal GISTs and in reducing the mitotic activity. Because these tumors are in the vicinity of pelvic structures (i.e., bladder, major pelvic nerves, and anal sphincters) and given that radical surgery may lead to considerable morbidity, downstaging might be beneficial in this situation, allowing function-sparing procedures and less invasive surgery while potentially improving tumor resectability. Preoperative treatment is thus a reasonable option for patients with locally advanced rectal GISTs that require abdominoperineal or multivisceral resection for complete tumor removal.
Controversy remains regarding the optimal duration of preoperative therapy. Our patients received preoperative imatinib for a median duration of 7 months (range, 2–10 months). In the EORTC phase III trial, the median time to best response was 4 months, but some responses were documented later . Similar observations have been made in case reports of preoperative imatinib in localized diseases . Therefore, it would be reasonable to plan a final surgery within 6 to 12 months of imatinib onset .
Interestingly in our series, 18 patients (72%) in the non-imatinib group and only 2 (16%) in the imatinib group developed local recurrence. We showed that preoperative and/or postoperative imatinib significantly reduced the risk of not only local recurrence (p = 0.006), but also overall relapse (p = 0.011), and significantly improved the disease-free survival with no impact on overall survival. These results are in accordance with those from Andtbacka et al.  on 16 locally advanced GISTs from several locations treated with preoperative imatinib and those from Tielen et al. on 32 rectal GISTs, 22 treated with preoperative imatinib and 10 with surgery only .
Based on these data, we suggest that a therapeutic strategy combining surgery with preoperative imatinib therapy should be systematically considered for patients with rectal GISTs, specifically for patients with larger tumors, marginally resectable tumors, or tumors close to the anal sphincters because imatinib may potentially increase the proportion of patients able to undergo conservative surgery rather than the more morbid abdominoperineal resection. Furthermore, according to the results of the ACOSOG Z9001 study and two recent Scandinavian studies [17, 39], the indication to continue imatinib in the postoperative setting for a duration of at least 1 year has been established in patients with high-risk GISTs, when incomplete surgical resection has occurred, or when tumor rupture has occurred. This should be systematically discussed with patients according to the risk of disease recurrence per the standard risk assessment criteria.
Due to the rarity of these tumors, these decisions require the multidisciplinary expertise of surgeons, medical oncologists, radiologists, and gastroenterologists in expert centers. Referral of patients with this rare disease to expert centers is recommended.
The authors wish to thank the patients, the patients’ families, and the surgeons. This study was supported by a NetSarc grant from the French INCa, RREPS grant from the French INCa, Eurosarc (HEALTH-F2-2011-278742), and Conticanet (FP6-018806).
- Mazur MT, Clark MB: Gastric stromal tumors: reapparaisal of histogenesis. Am J Surg Pathol. 1983, 7: 507-519. 10.1097/00000478-198309000-00001.View ArticlePubMedGoogle Scholar
- Tryggvason G, Gislason HG, Magnusson M, Jónasson JG: Gastrointestinal Stromal tumors in Iceland, 1990-2003: the Iceland Gist study, a population based incidence and patologic risk stratification study. Int J Cancer. 2005, 117: 289-293. 10.1002/ijc.21167.View ArticlePubMedGoogle Scholar
- Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B, Sablinska K, Kindblom LG: Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era: a population-based Study in Western Sweden. Cancer. 2005, 103: 821-829. 10.1002/cncr.20862.View ArticlePubMedGoogle Scholar
- Conlon KC, Casper ES, Brennan MF: Primary gastrointestinal sarcomas: analysis of pronostic variables. Ann Surg Oncol. 1995, 2: 26-31. 10.1007/BF02303698.View ArticlePubMedGoogle Scholar
- Tworek JA, Goldblum JR, Weiss SW, Greenson JK, Appelman HD: Stromal tumors of the anorectum: a clinicopathologic study of 22 cases. Am J Surg Pathol. 1999, 23: 946-954. 10.1097/00000478-199908000-00013.View ArticlePubMedGoogle Scholar
- Baik SH, Kim NK, Lee CH, Lee KY, Sohn SK, Cho CH, Kim H, Pyo HR, Rha SY, Chung HC: Gastrointestinal stromal tumor of the rectum: an analysis of seven cases. Surg Today. 2007, 37: 455-459. 10.1007/s00595-006-3424-1.View ArticlePubMedGoogle Scholar
- Li JC, Ng SS, Lo AW, Lee JF, Yiu RY, Leung KL: Outcome of radical excision of anorectal gastrointestinal stromal tumors in Hong Kong Chinese patients. Indian J Gastroenterol. 2007, 26: 33-35.PubMedGoogle Scholar
- Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH, Lasota J: Gastrointestinal stromal tumors intramural leïmyomas, and leïomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J Surg Pathol. 2001, 25: 1121-1123. 10.1097/00000478-200109000-00002.View ArticlePubMedGoogle Scholar
- Demetri GD, Von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H: Efficacy and safety of imatinib (STI 571) in advanced gastrointestinal stromal tumors. N Engl J Med. 2002, 347: 472-480. 10.1056/NEJMoa020461.View ArticlePubMedGoogle Scholar
- Lo SS, Papachistou GI, Finkelstein SD, Conroy WP, Schraut WH, Ramanathan RK: Neoadjuvant imatinib in gastrointestinal stromal tumor of the rectum: report of a case. Dis Colon Rectum. 2005, 48: 1316-1319. 10.1007/s10350-004-0922-3.View ArticlePubMedGoogle Scholar
- Shah JN, Sun W, Seethala RR, Livolsi VA, Fry RD, Ginsberg GG: Neoadjuvant therapy with imatinib mesylate for locally advanced GI stromal tumor. Gastrointest Endosc. 2005, 61: 625-627. 10.1016/S0016-5107(04)02642-2.View ArticlePubMedGoogle Scholar
- Ebihara Y, Okushiba S, Kawarada Y, Kitashiro S, Katoh H, Kondo S: Neoadjuvant imatinib in a gastrointestinal stromal tumor of the rectum: report of a case. Surg Today. 2008, 38: 174-177. 10.1007/s00595-007-3585-6.View ArticlePubMedGoogle Scholar
- Santos Fernandes G, de Castro Cotti GC, Feitas D, Cutait R, Hoff PM: Downstaging of rectal gastrointestinal stromal tumor by neoadjuvant imatinib therapy allowing for a conservative surgical approach. Clinics. 2009, 64: 819-821. 10.1590/S1807-59322009000800018.View ArticlePubMedPubMed CentralGoogle Scholar
- Wassenberg N, Nunoo-Mensah JW, Beart RW, Ker TS: Is there a role for neoadjuvant treatment with Gleevec for large rectal gastrointestinal stromal tumors?. Int J Colorectal Dis. 2007, 22: 981-982. 10.1007/s00384-006-0104-y.View ArticleGoogle Scholar
- Tielen R, Verhoef C, van Coevorden F, Reyners AK, van der Graaf WT, Bonenkamp JJ, van Etten B, de Wilt JH: Surgical management of rectal gastrointestinal stromal tumours. J Surg Oncol. 2012, doi:10.1002/jso.23223Google Scholar
- Jakob J, Mussi C, Ronellenfitsch U, Wardelmann E, Negri T, Gronchi A, Hohenberger P: Gastrointestinal stromal tumor of the rectum: results of surgical and multomodality therapy in the era of Imatinib. Ann Surg Oncol. 2013, 20: 586-10.1245/s10434-012-2647-1. online september 12View ArticlePubMedGoogle Scholar
- Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, Patel S, McCarter MD, Polikoff JA, Tan BR, Owzar K, American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team: Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumor: a randomised, double-blind, placebo-controlled trial. Lancet. 2009, 373: 1097-1104. 10.1016/S0140-6736(09)60500-6.View ArticlePubMedPubMed CentralGoogle Scholar
- Fletcher CD, Bermann JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O’Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW: Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002, 33: 459-465. 10.1053/hupa.2002.123545.View ArticlePubMedGoogle Scholar
- Miettinen M, Lasota J: Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006, 23: 70-83. 10.1053/j.semdp.2006.09.001.View ArticlePubMedGoogle Scholar
- Blay JY, Le Cesne A, Ray-Coquard I, Bui B, Duffaud F, Delbaldo C, Adenis A, Viens P, Rios M, Bompas E, Cupissol D, Guillemet C, Kerbrat P, Fayette J: Prospective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma Group. J Clin Oncol. 2007, 25 (9): 1107-1113. 10.1200/JCO.2006.09.0183.View ArticlePubMedGoogle Scholar
- Mussi C, Jakob J, Wardelmann E, Reichardt P, Casali PG, Fiore M, Collini P, Gronchi A, Hohenberger P: Gastrointestinal stromal tumor of rectum and rectovaginal space: a retrospective review. ASCO Ann Meet. 2008, Abstract n° 10560Google Scholar
- Goettsh G, Bos SD, Breekveldt-Potsma N, Casparie M, Herings RM, Hogendoorn PC: Incidence of gastrointestinal stromal tumors is underestimated: results of a nationwide study. Eur J Cancer. 2005, 41: 2868-2872. 10.1016/j.ejca.2005.09.009.View ArticleGoogle Scholar
- Yoon KJ, Kim NK, Lee KY, Min BS, Hur H, Kang J, Lee S: Efficacy of imatinib mesylate neoadjuvant treatment for a locally advanced rectal gastrointestinal stromal tumor. J Korean Soc Coloproctol. 2011, 27: 147-152. 10.3393/jksc.2011.27.3.147.View ArticlePubMedPubMed CentralGoogle Scholar
- Tsai MC, Lin JW, Lin SE, Chen HH, Lee CM, Hu TH: Prognostic analysis of rectal stromal tumors by reference of National Institute of Health risk categories and immunohistochemical studies. Dis Colon Rectum. 2008, 51: 1535-1543. 10.1007/s10350-008-9370-9.View ArticlePubMedGoogle Scholar
- Park KC, Kim HC, Park IJ, Yu CS, Kim JS, Kim JC: Clinicopathologic and immunohistochemical features of gastrointestinal stromal tumors (GISTs) in the colon & rectum. J Korean Soc Coloproctol. 2004, 20: 371-377.Google Scholar
- Choi SH, Kim SJ, Choi YJ, Min BS, Kim JS, Baik SH, Kim NK, Kang JG: Clinicopathologic analysis of gastrointestinal stromal tumors of the colon and rectum. J Korean Soc Coloproctol. 2009, 25: 323-333. 10.3393/jksc.2009.25.5.323.View ArticleGoogle Scholar
- Paek OJ, Kim YB, Oh SY, Suh KW: Gastrointestinal stromal tumors of the colon and rectum. J Korean Soc Coloproctol. 2009, 25: 318-322. 10.3393/jksc.2009.25.5.318.View ArticleGoogle Scholar
- Gervaz P, Huber O, Bucher P, Sappino P, Morel P: Trans-sacral approach for gastrointestinal stromal tumor of the lower rectum: old procedure for a new disease. Colorectal Dis. 2008, 10: 951-952.PubMedGoogle Scholar
- Hellan M, Maker VK: Transvaginal excision of a large rectal stromal tumor: an alternative. Am J Surg. 2006, 191: 121-123. 10.1016/j.amjsurg.2005.10.013.View ArticlePubMedGoogle Scholar
- Nakamura T, Ihara A, Mitomi H, Kokuba Y, Sato T, Ozawa H, Hatade K, Onozato W, Watanabe M: Gastrointestinal stromal tumor of the rectum resected by laparoscopic surgery: report of case. Surg Today. 2007, 37: 1004-1008. 10.1007/s00595-007-3509-5.View ArticlePubMedGoogle Scholar
- Khalifa AA, Bong WL, Rao VK, Williams MJ: Leïomyosarcoma of the rectum. Dis Colon Rectum. 1986, 29: 427-432. 10.1007/BF02555068.View ArticlePubMedGoogle Scholar
- Wang JP, Wang T, Huang MJ, Wang L, Kang L, Wu XJ: The role of neoadjuvant imatinib mesylate therapy in sphincter-preserving procedures for anorectal gastrointestinal stromal tumour. Am J Clin Oncol. 2011, 34: 314-316. 10.1097/COC.0b013e3181dea970.View ArticlePubMedGoogle Scholar
- Machlenkin S, Pinsk I, Tulchinsky H, Ziv Y, Sayfan J, Duek D, Rabau M, Walfisch S: The effect of neoadjuvant Imatinib therapy on outcome and survival after rectal gastrointestinal stromal tumour. Colorectal Dis. 2011, 13: 110-115.View ArticleGoogle Scholar
- Fiore M, Palassani E, Fumagalli E, Pilotti S, Tamborini E, Stacchiotti S, Pennacchioli E, Casali PG, Gronchi A: Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors (GIST). Eur J Surg Oncol. 2009, 35: 739-745. 10.1016/j.ejso.2008.11.005.View ArticlePubMedGoogle Scholar
- Eisenberg BL, Harris J, Blanke CD, Demetri GD, Heinrich MC, Watson JC, Hoffman JP, Okuno S, Kane JM, von Mehren M: Phase II trial neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. J Surg Oncol. 2009, 99: 42-47. 10.1002/jso.21160.View ArticlePubMedPubMed CentralGoogle Scholar
- Werweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay JY, Issels R, van Oosterom A, Hogendoorn PC, Van Glabbeke M, Bertulli R, Judson I: Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004, 364: 1127-1134. 10.1016/S0140-6736(04)17098-0.View ArticleGoogle Scholar
- Haller F, Detken S, Schulten HJ, Happel N, Gunawan B, Kuhlgatz J, Füzesi L: Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumours (GISTs) with respect to imatinib resistance caused by secondary KIT mutations. Ann Surg Oncol. 2007, 14: 526-532. 10.1245/s10434-006-9228-0.View ArticlePubMedGoogle Scholar
- Andbacka RH, Ng CS, Scaife CL, Cormier JN, Hunt KK, Pisters PW, Pollock RE, Benjamin RS, Burgess MA, Chen LL, Trent J, Patel SR, Raymond K, Feig BW: Surgical resection of gastrointestinal stromal tumors after treatment of imatinib. Ann Surg Oncol. 2007, 14: 14-24.View ArticleGoogle Scholar
- Joensuu H, Eriksson M, Hatrmann J, Hartmann JT, Pink D, Schütte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, Schlemmer M, Bauer S, Wardelmann E, Sarlomo-Rikala M, Nilsson B, Sihto H, Monge OR, Bono P, Kallio R, Vehtari A, Leinonen M, Alvegård T, Reichardt P: One versus three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA. 2012, 307: 1265-1272. 10.1001/jama.2012.347.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/156/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.