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  1. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third most lethal cancer worldwide. The epithelial to mesenchymal transition (EMT) describes the transformation of well-differenti...

    Authors: Philipp Wittmann, Markus Grubinger, Christian Gröger, Heidemarie Huber, Wolfgang Sieghart, Markus Peck-Radosavljevic and Wolfgang Mikulits
    Citation: BMC Cancer 2015 15:909
    Content type: Research article Published on:

  2. The aim of this study was to detect the epidermal growth factor receptor (EGFR)-activating mutations and other oncogene alterations in patients with non-small-cell lung cancers (NSCLC) who experienced a treatm...

    Authors: Katsuhiro Masago, Shiro Fujita, Miho Muraki, Akito Hata, Chiyuki Okuda, Kyoko Otsuka, Reiko Kaji, Jumpei Takeshita, Ryoji Kato, Nobuyuki Katakami and Yukio Hirata
    Citation: BMC Cancer 2015 15:908
    Content type: Research article Published on:

  3. Disadvantaged populations face many barriers to cancer care, including limited support in navigating through the complexities of the healthcare system. Family members play an integral role in caring for patien...

    Authors: Olive Mbah, Jean G. Ford, Miaozhen Qiu, Jennifer Wenzel, Lee Bone, Janice Bowie, Ahmed Elmi, Jimmie L. Slade, Michele Towson and Adrian S. Dobs
    Citation: BMC Cancer 2015 15:907
    Content type: Study protocol Published on:

  4. BRF2 is a transcription factor required for synthesis of a small group of non-coding RNAs by RNA polymerase III. Overexpression of BRF2 can transform human mammary epithelial cells. In both breast and lung can...

    Authors: Jana Koo, Stephanie Cabarcas-Petroski, John L. Petrie, Nicole Diette, Robert J. White and Laura Schramm
    Citation: BMC Cancer 2015 15:905
    Content type: Research article Published on:

  5. Although postoperative adjuvant chemoradiotherapies prevent recurrence for some patients with ampullary cancer, the recurrence rate is as high as 29 % in patients with stage I cancer. In an effort to identify ...

    Authors: Cheng-Lin Wu, Ying-Jui Chao, Ta-Ming Yang, Yi-Ling Chen, Kung-Chao Chang, Hui-Ping Hsu, Yan-Shen Shan and Ming-Derg Lai
    Citation: BMC Cancer 2015 15:903
    Content type: Research article Published on:

  6. The purpose of this study was to review patient characteristics and evaluate the potential factors affecting prognosis in cases of brain metastasis (BM) from colorectal cancer (CRC).

    Authors: Xiao-Dong Gu, Yan-Tao Cai, Yi-Ming Zhou, Zhen-Yang Li, Jian-Bin Xiang and Zong-You Chen
    Citation: BMC Cancer 2015 15:902
    Content type: Research article Published on:

  7. AXL is a well-characterized, protumorigenic receptor tyrosine kinase that is highly expressed and activated in numerous human carcinomas and sarcomas, including aggressive subtypes of liposarcoma. However, the...

    Authors: Caitlin D. May, Jeannine Garnett, XiaoYan Ma, Sharon M. Landers, Davis R. Ingram, Elizabeth G. Demicco, Ghadah A. Al Sannaa, Tona Vu, Lixia Han, Yi Zhang, Christine M. Kivlin, Svetlana Bolshakov, Azad Abul Kalam, Juehui Liu, Fuguo Zhou, Dominique Broccoli…
    Citation: BMC Cancer 2015 15:901
    Content type: Research article Published on:

  8. Antiangiogenic treatments have been shown to increase blood perfusion and oxygenation in some experimental tumors, and to reduce blood perfusion and induce hypoxia in others. The purpose of this preclinical st...

    Authors: Jon-Vidar Gaustad, Trude G. Simonsen, Ragnhild Smistad, Catherine S. Wegner, Lise Mari K. Andersen and Einar K. Rofstad
    Citation: BMC Cancer 2015 15:900
    Content type: Research article Published on:

  9. Return-to-work (RTW)-interventions support cancer survivors in resuming work, but come at additional healthcare costs. The objective of this study was to assess the budget impact of a RTW-intervention, consist...

    Authors: Janne C. Mewes, Lotte M. G. Steuten, Iris F. Groeneveld, Angela G. E. M. de Boer, Monique H. W. Frings-Dresen, Maarten J. IJzerman and Wim H. van Harten
    Citation: BMC Cancer 2015 15:899
    Content type: Research article Published on:

  10. Irisin is a recently discovered myokine, involved in the browning of white adipose tissue. To date, its function has been mainly associated with energy homeostasis and metabolism, and it has been proposed as a...

    Authors: Xeni Provatopoulou, Georgia P. Georgiou, Eleni Kalogera, Vasileios Kalles, Maira A. Matiatou, Ioannis Papapanagiotou, Alexandros Sagkriotis, George C. Zografos and Antonia Gounaris
    Citation: BMC Cancer 2015 15:898
    Content type: Research article Published on:

  12. Disseminated tumor cells (DTCs) can be detected using ultrasensitive immunocytochemical assays and their presence in the bone marrow can predict the subsequent occurrence of overt metastasis formation and meta...

    Authors: Stefan Werner, Hauke Stamm, Mutiha Pandjaitan, Dirk Kemming, Benedikt Brors, Klaus Pantel and Harriet Wikman
    Citation: BMC Cancer 2015 15:896
    Content type: Research article Published on:

  17. Chondrosarcoma is characterized for its lack of response to conventional cytotoxic chemotherapy, propensity for developing lung metastases, and low rates of survival. Research within the field of development a...

    Authors: Birgit Lohberger, Andreas Leithner, Nicole Stuendl, Heike Kaltenegger, Werner Kullich and Bibiane Steinecker-Frohnwieser
    Citation: BMC Cancer 2015 15:891
    Content type: Research article Published on:

  18. To summarize data on long-term ipsilateral local recurrence (LR) and breast cancer death rate (BCDR) for patients with ductal carcinoma in situ (DCIS) who received different treatments.

    Authors: Kirsty E. Stuart, Nehmat Houssami, Richard Taylor, Andrew Hayen and John Boyages
    Citation: BMC Cancer 2015 15:890
    Content type: Research article Published on:

  19. Ovarian cancer is a possibly lethal gynecological malignancy and this study utilized phage display technology to screen and identify peptides that specifically bind to ovarian cancer cells and explored the eff...

    Authors: Cong Zhou, Jiali Kang, Xiaoxia Wang, Wei Wei and Wenyan Jiang
    Citation: BMC Cancer 2015 15:889
    Content type: Research article Published on:

  20. In humans, sex-determining region-Y (SRY) related high-mobility-group box 4 (SOX4) is linked to development and tumorigenesis. SOX4 is over-expressed in several cancers and has prognostic significance. This st...

    Authors: Tae Mi Yoon, Sun-Ae Kim, Wan Seok Cho, Dong Hoon Lee, Joon Kyoo Lee, Young-Lan Park, Kyung-Hwa Lee, Jae Hyuk Lee, Sun-Seog Kweon, Ik-Joo Chung, Sang Chul Lim and Young-Eun Joo
    Citation: BMC Cancer 2015 15:888
    Content type: Research article Published on:

  21. Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis ...

    Authors: Martin G. Belinsky, Lori Rink, Kathy Q. Cai, Stephen J. Capuzzi, Yen Hoang, Jeremy Chien, Andrew K. Godwin and Margaret von Mehren
    Citation: BMC Cancer 2015 15:887
    Content type: Research article Published on:

  22. USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. USP18 null mice in a FVB/N background develop tumors as early as 2 months ...

    Authors: Fadzai Chinyengetere, David J. Sekula, Yun Lu, Andrew J. Giustini, Aarti Sanglikar, Masanori Kawakami, Tian Ma, Sandra S. Burkett, Burton L. Eisenberg, Wendy A. Wells, Paul J. Hoopes, Elizabeth G. Demicco, Alexander J Lazar, Keila E. Torres, Vincent Memoli, Sarah J. Freemantle…
    Citation: BMC Cancer 2015 15:886
    Content type: Research article Published on:

  23. Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibil...

    Authors: Nicola J. Grant, Philip J. Coates, Yvonne L. Woods, Susan E. Bray, Nicholas A. Morrice, C. James Hastie, Douglas J. Lamont, Francis A. Carey and Calum Sutherland
    Citation: BMC Cancer 2015 15:885
    Content type: Research article Published on:

  24. Mucinous adenocarcinoma (MAC) represents 6-19 % of all colorectal carcinoma. It is associated with poorer response to chemotherapy and chemoradiotherapy.

    Authors: Karolina Vernmark, Maria Albertsson, Bergthor Björnsson, Thomas Gasslander, Per Sandström, Xiao-Feng Sun and Annika Holmqvist
    Citation: BMC Cancer 2015 15:884
    Content type: Case report Published on:

  25. The development of androgen resistance is a major limitation to androgen deprivation treatment in prostate cancer. We have developed an in vitro model of androgen-resistance to characterise molecular changes occu...

    Authors: Sujitra Detchokul, Aparna Elangovan, Edmund J. Crampin, Melissa J. Davis and Albert G. Frauman
    Citation: BMC Cancer 2015 15:883
    Content type: Research article Published on:

  26. Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the ...

    Authors: Murray J. Cutler, Erica L. Lowthers, Cynthia L. Richard, Dagmar M. Hajducek, Paul A. Spagnuolo and Jonathan Blay
    Citation: BMC Cancer 2015 15:882
    Content type: Research article Published on:

  27. We aimed to estimate the effect of alcohol consumption on breast cancer risk and to test whether overweight and obesity modifies this association.

    Authors: Aesun Shin, Sven Sandin, Marie Lof, Karen L. Margolis, Kyeezu Kim, Elisabeth Couto, Hans Olov Adami and Elisabete Weiderpass
    Citation: BMC Cancer 2015 15:881
    Content type: Research article Published on:

  28. Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. Sialyltransferase ST3GAL-1, which adds a sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms an important role in mod...

    Authors: Qi Bai, Li Liu, Yu Xia, Qilai Long, Jiajun Wang, Jiejie Xu and Jianming Guo
    Citation: BMC Cancer 2015 15:880
    Content type: Research article Published on:

  29. Adult Langerhans cell histiocytosis (LCH) is an orphan disease. Chemotherapy is usually reserved to patients presenting with single system multifocal (SS-m) or multisystem (MS) disease but due to the lack of r...

    Authors: Enrico Derenzini, Vittorio Stefoni, Cinzia Pellegrini, Letizia Gandolfi, Alessandro Broccoli, Beatrice Casadei, Federica Quirini, Lisa Argnani, Lorenzo Tonialini and Pier Luigi Zinzani
    Citation: BMC Cancer 2015 15:879
    Content type: Research article Published on:

  30. Despite demonstrated efficacy, acceptance of selective estrogen receptor modulators (SERMs), such as tamoxifen, for breast cancer risk reduction remains low. Delivering SERMs via local transdermal therapy (LTT...

    Authors: Lindsey C. Karavites, Subhashini Allu, Seema A. Khan and Karen Kaiser
    Citation: BMC Cancer 2015 15:878
    Content type: Research article Published on:

  31. CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high prevalence in the Netherlands. We performed copy number and gene expression profiling to investigate whether CHEK2*1100delC breast...

    Authors: Maarten P. G. Massink, Irsan E. Kooi, John W. M. Martens, Quinten Waisfisz and Hanne Meijers-Heijboer
    Citation: BMC Cancer 2015 15:877
    Content type: Research article Published on:

  32. Little is known about sex-specific trends in lung cancer mortality and years of potential life lost (YPLL) attributable to lung cancer over more than five decades. The aim of the present study was to describe ...

    Authors: Ulrich John and Monika Hanke
    Citation: BMC Cancer 2015 15:876
    Content type: Research article Published on:

  33. Evidence-based guidelines concerning the older head and neck cancer (HNCA) patient are lacking. Accurate patient selection for optimal care management is therefore challenging. We examined if geriatric assessm...

    Authors: Lies Pottel, Michelle Lycke, Tom Boterberg, Hans Pottel, Laurence Goethals, Fréderic Duprez, Sylvie Rottey, Yolande Lievens, Nele Van Den Noortgate, Kurt Geldhof, Véronique Buyse, Khalil Kargar-Samani, Véronique Ghekiere and Philip R. Debruyne
    Citation: BMC Cancer 2015 15:875
    Content type: Research article Published on:

  34. The enhancer of zeste-homolog 2 (EZH2) is involved in cancer development through gene silencing by trimethylation of lysine 27 of histone 3 (H3K27me3). The C/C genotype for the EZH2 rs3757441 single-nucleotide po...

    Authors: Lorenzo Fornaro, Pinuccia Faviana, Veronica De Gregorio, Caterina Vivaldi, Elisa Paolicchi, Gianluca Masi, Fotios Loupakis, Elisa Sensi, Cristiana Lupi, Gabriella Fontanini, Yuzhuo Wang, Romano Danesi, Alfredo Falcone and Francesco Crea
    Citation: BMC Cancer 2015 15:874
    Content type: Research article Published on:

  36. With the advent of new and more efficient anti-androgen drugs targeting androgen receptor (AR) in breast cancer (BC) is becoming an increasingly important area of investigation. This would potentially be most ...

    Authors: André Grogg, Mafalda Trippel, Katrin Pfaltz, Claudia Lädrach, Raoul A. Droeser, Nikola Cihoric, Bodour Salhia, Martin Zweifel and Coya Tapia
    Citation: BMC Cancer 2015 15:872
    Content type: Research article Published on:

  37. Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clo...

    Authors: Ömer Acar, Ezgi Özkurt, Gulfem Demir, Hilal Saraç, Can Alkan, Tarık Esen, Mehmet Somel and Nathan A. Lack
    Citation: BMC Cancer 2015 15:871
    Content type: Research article Published on:

  38. Colon cancer is the third most commonly diagnosed cancer and the second leading cause of cancer mortality worldwide. Chalcone and its derivatives are reported to exhibit anti-cancer effects in several cancer c...

    Authors: Shanmei Xu, Minxiao Chen, Wenbo Chen, Junguo Hui, Jiansong Ji, Shuping Hu, Jianmin Zhou, Yi Wang and Guang Liang
    Citation: BMC Cancer 2015 15:870
    Content type: Research article Published on:

  39. Tumor-suppressor genes are inactivated by methylation in several cancers including acute myeloid leukemia (AML). Src homology-2 (SH2)-containing protein-tyrosine phosphatase 1 (SHP-1) is a negative regulator of t...

    Authors: Hamid Ali Nagi Al-Jamal, Siti Asmaa Mat Jusoh, Rosline Hassan and Muhammad Farid Johan
    Citation: BMC Cancer 2015 15:869
    Content type: Research article Published on:

  40. Definitive, percutaneous irradiation of the prostate and the pelvic lymph nodes in high-risk prostate cancer is the alternative to prostatectomy plus lymphadenectomy. To date, the role of whole pelvis radiothe...

    Authors: Gregor Habl, Sonja Katayama, Matthias Uhl, Kerstin A. Kessel, Lutz Edler, Juergen Debus, Klaus Herfarth and Florian Sterzing
    Citation: BMC Cancer 2015 15:868
    Content type: Research article Published on:

  41. Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FI...

    Authors: Sarah L. Miles, Adam P. Fischer, Sandeep J. Joshi and Richard M. Niles
    Citation: BMC Cancer 2015 15:867
    Content type: Research article Published on:

  42. Prostate cancer is the most commonly diagnosed malignancy among men. The Discovery of new agents for the treatment of prostate cancer is urgently needed. Compound WZ35, a novel analog of the natural product cu...

    Authors: Xiuhua Zhang, Minxiao Chen, Peng Zou, Karvannan Kanchana, Qiaoyou Weng, Wenbo Chen, Peng Zhong, Jiansong Ji, Huiping Zhou, Langchong He and Guang Liang
    Citation: BMC Cancer 2015 15:866
    Content type: Research article Published on:

  43. The association between body mass index (BMI) at the time of breast cancer diagnosis and the prognosis of breast cancer patients remains controversial. Furthermore, the association between BMI and prognosis wi...

    Authors: Ye Won Jeon, Su Hwan Kang, Min Ho Park, Woosung Lim, Se Heun Cho and Young Jin Suh
    Citation: BMC Cancer 2015 15:865
    Content type: Research article Published on:

  44. Human primary myeloma (MM) cells do not survive in culture; current in vitro and in vivo systems for growing these cells are limited to coculture with a specific bone marrow (BM) cell type or growth in an immu...

    Authors: Rakesh Bam, Sharmin Khan, Wen Ling, Shelton S. Randal, Xin Li, Bart Barlogie, Ricky Edmondson and Shmuel Yaccoby
    Citation: BMC Cancer 2015 15:864
    Content type: Research article Published on:

  45. Metastasis to the pituitary gland is extremely rare and is often detected incidentally by symptoms associated with endocrine dysfunction. Breast and lung cancer are the most common primary metastasizing to pit...

    Authors: Tomoko Tanaka, Katsushi Hiramatsu, Takuto Nosaka, Yasushi Saito, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Tomoyuki Nemoto, Hiroyuki Suto, Tatsuya Yamamoto, Hirohiko Kimura and Yasunari Nakamoto
    Citation: BMC Cancer 2015 15:863
    Content type: Case report Published on:

  46. Argonaute 2 (AGO2), a central component of RNA-induced silencing complex, plays critical roles in cancer. We examined whether the single nucleotide polymorphisms (SNPs) of AGO2 were related to the risk of nasopha...

    Authors: Peiyao Li, Jinfeng Meng, Yun Zhai, Hongxing Zhang, Lixia Yu, Zhifu Wang, Xiaoai Zhang, Pengbo Cao, Xi Chen, Yuqing Han, Yang Zhang, Huipeng Chen, Yan Ling, Yuxia Li, Ying Cui, Jin-Xin Bei…
    Citation: BMC Cancer 2015 15:862
    Content type: Research article Published on:

  47. Squamous cell carcinoma of the head and neck (SCCHN) remains a prevalent and devastating disease. Recently, there has been an increase in SCCHN cases that are associated with high-risk human papillomavirus (HP...

    Authors: Bhavana V. Chapman, Abigail I. Wald, Parvez Akhtar, Ana C. Munko, Jingjing Xu, Sandra P. Gibson, Jennifer R. Grandis, Robert L. Ferris and Saleem A. Khan
    Citation: BMC Cancer 2015 15:861
    Content type: Research article Published on:

  48. Extramural tumor deposits (TDs) and extracapsular lymph node involvement (ECLNI) are considered to be poor prognostic factors in patients with T3–4, N0–2, M0 colorectal cancer (CRC). Although TDs are known to ...

    Authors: Tomoki Yamano, Shuho Semba, Masafumi Noda, Mie Yoshimura, Masayoshi Kobayashi, Michiko Hamanaka, Naohito Beppu, Aya Yano, Kiyoshi Tsukamoto, Nagahide Matsubara and Naohiro Tomita
    Citation: BMC Cancer 2015 15:859
    Content type: Research article Published on:

  49. Malignant pleural mesothelioma (MPM) is a rare disease with poor prognosis in spite of significant improvement in survival, due to new chemotherapy regimens. We describe here patients’ profiles and management ...

    Authors: C. Raynaud, L. Greillier, J. Mazieres, I. Monnet, B. Mastroianni, G. Robinet, G. Fraboulet, A. Dixmier, H. Berard, R. Lamy, J. Letreut, H. Lena, G. Oliviero, S. Botta, A. Vergnenegre, I. Borget…
    Citation: BMC Cancer 2015 15:857
    Content type: Research article Published on:

  50. The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constituti...

    Authors: Cholpon S. Djuzenova, Marcus Zimmermann, Astrid Katzer, Vanessa Fiedler, Luitpold V. Distel, Martin Gasser, Anna-Maria Waaga-Gasser, Michael Flentje and Bülent Polat
    Citation: BMC Cancer 2015 15:856
    Content type: Research article Published on:

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