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  1. In this retrospective study we evaluated the respective correlations and clinical relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global DNA hypomethylation in type I and type II ov...

    Authors: Sara Notaro, Daniel Reimer, Heidi Fiegl, Gabriel Schmid, Annamarie Wiedemair, Julia Rössler, Christian Marth and Alain Gustave Zeimet
    Citation: BMC Cancer 2016 16:589
    Content type: Research article Published on:

  2. The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with current...

    Authors: Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons and Lao H. Saal
    Citation: BMC Cancer 2016 16:587
    Content type: Research article Published on:

  3. Prostate cancer is one of the most common male cancers worldwide. Active Surveillance (AS) has been developed to allow men with lower risk disease to postpone or avoid the adverse side effects associated with ...

    Authors: Eimear Ruane-McAteer, Joe O’Sullivan, Sam Porter, Lionne Venderbos and Gillian Prue
    Citation: BMC Cancer 2016 16:586
    Content type: Study protocol Published on:

  4. KRAS mutation testing is mandatory in the management of metastatic colorectal cancer prior to treatment with anti-EGFR antibodies as patients whose tumors express mutant KRAS do not benefit from these agents. Alt...

    Authors: Elisabeth Mack, Kathleen Stabla, Jorge Riera-Knorrenschild, Roland Moll, Andreas Neubauer and Cornelia Brendel
    Citation: BMC Cancer 2016 16:585
    Content type: Research article Published on:

  5. In South and Southeast Asian, the majority of buccal squamous cell carcinoma (BSCC) can arise from oral submucous fibrosis (OSF). BSCCs develop in OSF that are often not completely resected, causing local rela...

    Authors: Wen Liu, Lijuan Zeng, Ning Li, Fei Wang, Canhua Jiang, Feng Guo, Xinqun Chen, Tong Su, Chunjiao Xu, Shanshan Zhang and Changyun Fang
    Citation: BMC Cancer 2016 16:584
    Content type: Research article Published on:

  6. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, and lncRNA taurine-upregulated gene 1 (TUG1) has been proven to be associated with several human cancers. However, the mechanisms of TUG1-involve...

    Authors: Pei-Chin Lin, Hsien-Da Huang, Chun-Chi Chang, Ya-Sian Chang, Ju-Chen Yen, Chien-Chih Lee, Wen-Hsin Chang, Ta-Chih Liu and Jan-Gowth Chang
    Citation: BMC Cancer 2016 16:583
    Content type: Research article Published on:

  7. NF-kB can function as an oncogene or tumor suppressor depending on cancer types. The role of NF-kB in low-grade serous ovarian cancer, however, has never been tested. We sought to elucidate the function of NF-...

    Authors: Xue Xiao, Gong Yang, Peng Bai, Shunping Gui, Tri M. Bui Nyuyen, Imelda Mercado-Uribe, Mei Yang, Juan Zou, Qintong Li, Jianguo Xiao, Bin Chang, Guangzhi Liu, He Wang and Jinsong Liu
    Citation: BMC Cancer 2016 16:582
    Content type: Research article Published on:

  8. Three-dimensional (3-D) cultures of cancer cells can potentially bridge the gap between 2-D drug screening and in vivo xenografts. The objective of this study was to characterize the cellular and extracellular...

    Authors: Surya P. Lamichhane, Neha Arya, Esther Kohler, Shengnan Xiang, Jon Christensen and V. Prasad Shastri
    Citation: BMC Cancer 2016 16:581
    Content type: Research article Published on:

  9. Total laryngectomy with or without adjuvant (chemo)radiation often induces speech, swallowing and neck and shoulder problems. Speech, swallowing and shoulder exercises may prevent or diminish these problems. T...

    Authors: Femke Jansen, Ingrid C. Cnossen, Simone E. J. Eerenstein, Veerle M. H. Coupé, Birgit I. Witte, Cornelia F. van Uden-Kraan, Patricia Doornaert, Weibel W. Braunius, Remco De Bree, José A. U. Hardillo, Jimmie Honings, György B. Halmos, C. René Leemans and Irma M. Verdonck-de Leeuw
    Citation: BMC Cancer 2016 16:580
    Content type: Study protocol Published on:

  10. Pancreatic cancer has a dire prognosis and is associated with a high mortality. Palliative patients have special needs and often seek help in integrative oncological concepts (IO) that combine conventional and...

    Authors: Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes and Friedemann Schad
    Citation: BMC Cancer 2016 16:579
    Content type: Research article Published on:

  11. Chemoresistance is one of the most leading causes for tumor progression and recurrence of bladder cancer. Reactive oxygen species (ROS) plays a key role in the chemosensitivity of cancer cells. In the present ...

    Authors: Xinxing Li, Haolu Wang, Juan Wang, Yuying Chen, Xiaobin Yin, Guiying Shi, Hui Li, Zhiqian Hu and Xiaowen Liang
    Citation: BMC Cancer 2016 16:578
    Content type: Research article Published on:

  12. To identify predictors of prolonged or shortened progression-free survival (PFS) and overall survival (OS) among patients with metastatic renal cell carcinoma (mRCC) who received first-line targeted therapies.

    Authors: Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee and Jinsoo Chung
    Citation: BMC Cancer 2016 16:577
    Content type: Research article Published on:

  13. Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response...

    Authors: Tomoka Kitao, Kenji Hirata, Katsumi Shima, Takashi Hayashi, Mitsunori Sekizawa, Toshiki Takei, Wataru Ichimura, Masao Harada, Keishi Kondo and Nagara Tamaki
    Citation: BMC Cancer 2016 16:576
    Content type: Research article Published on:

  14. Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibrobl...

    Authors: Maha A. Al-Rakan, Siti-Faujiah Hendrayani and Abdelilah Aboussekhra
    Citation: BMC Cancer 2016 16:575
    Content type: Research article Published on:

  15. Fibronectin is a mechanically sensitive protein which is organized in the extracellular matrix as a network of interacting fibrils. The lung tumor stroma is enriched for fibronectin which is thought to contrib...

    Authors: Christina Cho, Carol Horzempa, David Jones and Paula J. McKeown-Longo
    Citation: BMC Cancer 2016 16:574
    Content type: Research article Published on:

  16. Imatinib-resistant chronic myeloid leukemia (CML) patients receiving second-line tyrosine kinase inhibitor (TKI) therapy with dasatinib or nilotinib have a higher risk of disease relapse and progression and no...

    Authors: Simona Soverini, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Manuela Mancini, Luana Bavaro, Katerina Machova Polakova, Jana Linhartova, Alessandra Iurlo, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Michele Cavo, Michele Baccarani and Giovanni Martinelli
    Citation: BMC Cancer 2016 16:572
    Content type: Technical advance Published on:

  17. Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into diffe...

    Authors: Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie and Shuxin Huang
    Citation: BMC Cancer 2016 16:571
    Content type: Research article Published on:

  18. The role of microRNA-200 (miR-200) family members in the migration and invasion of breast cancer is controversial. This study investigated the mechanisms by which the miR-200 family members modulated the migra...

    Authors: Sul Ki Choi, Hoe Suk Kim, Tiefeng Jin, Eun Hye Hwang, Minji Jung and Woo Kyung Moon
    Citation: BMC Cancer 2016 16:570
    Content type: Research article Published on:

  19. Many factors contribute to socioeconomic status (SES), yet in most survival studies only income is used as a measure for determining SES. We used a complex, composite, census-based metric for socioeconomic dep...

    Authors: Ajit Auluck, Blake Byron Walker, Greg Hislop, Scott A. Lear, Nadine Schuurman and Miriam Rosin
    Citation: BMC Cancer 2016 16:569
    Content type: Research article Published on:

  22. Accumulating evidences have demonstrated that mesenchymal stem cells (MSC) could be recruited to the tumor microenvironment. Umbilical cord mesenchymal stem cells (UCMSC) were attractive vehicles for deliverin...

    Authors: Chang Liu, Yang Liu, Xiao-xi Xu, Xin Guo, Guang-wei Sun and Xiao-jun Ma
    Citation: BMC Cancer 2016 16:566
    Content type: Research article Published on:

  23. Collapsin response mediator proteins (CRMPs) were originally identified in the nervous system and are involved in neuronal development. Similar to CRMP1, CRMP4 has a shorter transcript encoding a short isoform...

    Authors: Haijian Guo and Bing Xia
    Citation: BMC Cancer 2016 16:565
    Content type: Research article Published on:

  24. Hyponatremia is prognostic of higher mortality in some cancers but has not been well studied in others. We used a longitudinal design to determine the incidence and prognostic importance of euvolemic and hyper...

    Authors: Jorge J. Castillo, Ilya G. Glezerman, Susan H. Boklage, Joseph Chiodo III, Beni A. Tidwell, Lois E. Lamerato and Kathy L. Schulman
    Citation: BMC Cancer 2016 16:564
    Content type: Research article Published on:

  25. Primary invasive Extramammary Paget’s vulvar disease is a rare tumor that is challenging to control. Wide surgical excision represents the standard treatment approach for Primary invasive Extramammary Paget’s ...

    Authors: Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias and George Kyrgias
    Citation: BMC Cancer 2016 16:563
    Content type: Debate Published on:

  26. Coffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma. We studied the impact of total coffee consu...

    Authors: Marko Lukic, Mie Jareid, Elisabete Weiderpass and Tonje Braaten
    Citation: BMC Cancer 2016 16:562
    Content type: Research article Published on:

  27. Colorectal cancer (CRC) is the third leading cause of cancer related deaths worldwide both in men and women. Our recent studies have indicated an association of heat shock protein 70–2 (HSP70-2) with bladder u...

    Authors: Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya and Anil Suri
    Citation: BMC Cancer 2016 16:561
    Content type: Research article Published on:

  28. SLC52A3 was recently identified as a susceptibility gene for esophageal squamous cell carcinoma (ESCC). However, associations between the single nucleotide polymorphisms (SNPs) rs13042...

    Authors: Hua-Zhen Tan, Zhi-Yong Wu, Jian-Yi Wu, Lin Long, Ji-Wei Jiao, Yu-Hui Peng, Yi-Wei Xu, Shan-Shan Li, Wei Wang, Jian-Jun Zhang, En-Min Li and Li-Yan Xu
    Citation: BMC Cancer 2016 16:560
    Content type: Research article Published on:

  29. Breast cancer is a complex heterogeneous disease where many distinct subtypes are found. Younger African American (AA) women often present themselves with aggressive form of breast cancer with unique biology w...

    Authors: Luis Martinez, Easter Thames, Jinna Kim, Gautam Chaudhuri, Rajan Singh and Shehla Pervin
    Citation: BMC Cancer 2016 16:559
    Content type: Research article Published on:

  30. Gynecologic cancer is one of the most common malignant diseases in working-age women. This study investigated whether several characteristics influence return to work after treatment of gynecologic cancer.

    Authors: Keiichiro Nakamura, Hisashi Masuyama, Takeshi Nishida, Junko Haraga, Naoyuki Ida, Masayuki Saijo, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki and Yuji Hiramatsu
    Citation: BMC Cancer 2016 16:558
    Content type: Research article Published on:

  31. Little is known about the relationship between preoperative body mass index and need for adjuvant radiation therapy (RT) following radical prostatectomy. The goal of this study was to evaluate the utility of b...

    Authors: Kosj Yamoah, Charnita M. Zeigler-Johnson, Abra Jeffers, Bruce Malkowicz, Elaine Spangler, Jong Y. Park, Alice Whittemore and Timothy R. Rebbeck
    Citation: BMC Cancer 2016 16:557
    Content type: Research article Published on:

  32. Diffusion Weighted (DW) Magnetic Resonance Imaging (MRI) has been studed in several cancers including cervical cancer. This study was designed to investigate the association of DW-MRI parameters with baseline ...

    Authors: Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda and Mitchell Kamrava
    Citation: BMC Cancer 2016 16:556
    Content type: Research article Published on:

  33. Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a poor prognosis, a subset...

    Authors: Jessica G. Cockburn, Robin M. Hallett, Amy E. Gillgrass, Kay N. Dias, T. Whelan, M. N. Levine, John A. Hassell and Anita Bane
    Citation: BMC Cancer 2016 16:555
    Content type: Research article Published on:

  34. The distinction between right-sided and left-sided colon cancer has recently received considerable attention due to differences regarding underlying genetic mutations. There is an ongoing debate if right- vers...

    Authors: Rene Warschkow, Michael C. Sulz, Lukas Marti, Ignazio Tarantino, Bruno M. Schmied, Thomas Cerny and Ulrich Güller
    Citation: BMC Cancer 2016 16:554
    Content type: Research article Published on:

  35. Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proli...

    Authors: R. L. Ross, H. R. McPherson, L. Kettlewell, S. D. Shnyder, C. D. Hurst, O. Alder and M. A. Knowles
    Citation: BMC Cancer 2016 16:553
    Content type: Research article Published on:

  36. Despite aggressive regimens, the clinical outcome of head and neck squamous cell carcinoma remains poor. The detection of circulating tumor cells could potentially improve the management of patients with disse...

    Authors: Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt and Gilles Dolivet
    Citation: BMC Cancer 2016 16:552
    Content type: Case report Published on:

  38. Platinum resistance is a major obstacle in the treatment of epithelial ovarian cancer (EOC). Activation of the AKT pathway promotes platinum resistance while inhibition of AKT sensitizes chemoresistant cells. ...

    Authors: Margaret E. Whicker, Z. Ping Lin, Ruth Hanna, Alan C. Sartorelli and Elena S. Ratner
    Citation: BMC Cancer 2016 16:550
    Content type: Research article Published on:

  39. The purpose of this study was to evaluate invasive and metastatic potential of urothelial cancer by investigating differential expression of various clock genes/proteins participating in the 24 h circadian rhy...

    Authors: Jorunn Litlekalsoy, Kari Rostad, Karl-Henning Kalland, Jens G. Hostmark and Ole Didrik Laerum
    Citation: BMC Cancer 2016 16:549
    Content type: Research article Published on:

  40. The cancer stem cells (CSCs), a small subpopulation of cells in tumor are responsible for the tumor initiation, growth, recurrence and metastasis of cancer, as well as resistance of cancers to drugs or radioth...

    Authors: Koji Harada, Tarannum Ferdous, Dan Cui, Yasuhiro Kuramitsu, Takuya Matsumoto, Eiji Ikeda, Hideyuki Okano and Yoshiya Ueyama
    Citation: BMC Cancer 2016 16:548
    Content type: Research article Published on:

  41. Circulating tumour cells (CTCs) have been found to be a prognostic marker for reduced disease free survival, breast cancer–specific survival, and overall survival before the start of systemic treatment.

    Authors: Theresa Vilsmaier, Brigitte Rack, Wolfgang Janni, Udo Jeschke and Tobias Weissenbacher
    Citation: BMC Cancer 2016 16:547
    Content type: Research article Published on:

  42. Long-term prognostic significance of loss of heterozygosity on chromosome 9p21 for localized renal cell carcinoma following surgery remains unreported. The study assessed the frequency of deletions of differen...

    Authors: Ismail El-Mokadem, Alison Lim, Thomas Kidd, Katherine Garret, Norman Pratt, David Batty, Stewart Fleming and Ghulam Nabi
    Citation: BMC Cancer 2016 16:546
    Content type: Research article Published on:

  43. Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. Treatment of a solid tumor by an effective vector for a suicide gene remains a challenge. Given the l...

    Authors: Changdong Wang, Yongping Ma, Qiongwen Hu, Tingting Xie, Jiayan Wu, Fan Zeng and Fangzhou Song
    Citation: BMC Cancer 2016 16:545
    Content type: Research article Published on:

  44. Work is a central resource for cancer survivors as it not only provides income but also impacts health and quality of life. Additionally, work helps survivors to cope with the perceived critical life event. Th...

    Authors: Julian Wienert, Betje Schwarz and Matthias Bethge
    Citation: BMC Cancer 2016 16:544
    Content type: Study protocol Published on:

  45. Sorafenib is the standard first-line therapy for hepatocellular carcinoma (HCC) and probably ectopic hepatocellular carcinoma (EHCC) as well. No report involves a side effect of delayed high fever of sorafenib...

    Authors: Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang and Jianguo Sun
    Citation: BMC Cancer 2016 16:543
    Content type: Case report Published on:

  46. Ganglioneuroma (GN) and ganglioneuroblastoma intermixed (GNBI) are mature variants of neuroblastic tumors (NT). It is still discussed whether incomplete resection of GN/GNBI impairs the outcome of patients.

    Authors: Boris Decarolis, Thorsten Simon, Barbara Krug, Ivo Leuschner, Christian Vokuhl, Peter Kaatsch, Dietrich von Schweinitz, Thomas Klingebiel, Ingo Mueller, Lothar Schweigerer, Frank Berthold and Barbara Hero
    Citation: BMC Cancer 2016 16:542
    Content type: Research article Published on:

  48. Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, nove...

    Authors: Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf and Abdelilah Aboussekhra
    Citation: BMC Cancer 2016 16:540
    Content type: Research article Published on:

  49. The efficacy and safety of rituximab-based chemotherapy (R-chemo), the standard regimen for patients with diffuse large B-cell lymphoma (DLBCL), which is more common in Asia than in Western countries, are well...

    Authors: Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li…
    Citation: BMC Cancer 2016 16:537
    Content type: Research article Published on:

  50. Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with...

    Authors: Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng and Zhi Wang
    Citation: BMC Cancer 2016 16:530
    Content type: Research article Published on:

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