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  1. Treatment options for patients with metastatic colorectal cancer (mCRC) include anti-epithelial growth factor therapies, which, in Europe, are indicated in patients with RAS wild-type tumours only and require pri...

    Authors: Annemarie Boleij, Véronique Tack, Aliki Taylor, George Kafatos, Sophie Jenkins-Anderson, Lien Tembuyser, Els Dequeker and J. Han van Krieken
    Citation: BMC Cancer 2016 16:825
    Content type: Research article Published on:

  3. CancerMath is a set of web-based prognostic tools which predict nodal status and survival up to 15 years after diagnosis of breast cancer. This study validated its performance in a Southeast Asian setting.

    Authors: Hui Miao, Mikael Hartman, Helena M. Verkooijen, Nur Aishah Taib, Hoong-Seam Wong, Shridevi Subramaniam, Cheng-Har Yip, Ern-Yu Tan, Patrick Chan, Soo-Chin Lee and Nirmala Bhoo-Pathy
    Citation: BMC Cancer 2016 16:820
    Content type: Research article Published on:

  4. Breast and cancer screening uptake has been found to be lower among women with serious mental illness (SMI). This study aims to corroborate these findings in the UK and to identify variation in screening uptak...

    Authors: Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart and Max J. Henderson
    Citation: BMC Cancer 2016 16:819
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:152

  5. Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as eff...

    Authors: Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan, Da-liu Min and Hai-yan Hu
    Citation: BMC Cancer 2016 16:818
    Content type: Research article Published on:

  6. The phase 3 MPACT trial in patients with metastatic pancreatic cancer demonstrated superior efficacy of nab-paclitaxel (nab-P) + gemcitabine (Gem) vs Gem monotherapy for all endpoints examined including overall s...

    Authors: Arndt Vogel, Josefine Römmler-Zehrer, Jack Shiansong Li, Desmond McGovern, Alfredo Romano and Michael Stahl
    Citation: BMC Cancer 2016 16:817
    Content type: Research article Published on:

  7. Whilst multi-parametric magnetic resonance imaging (mp-MRI) has been a significant advance in the diagnosis of prostate cancer, scanning all patients with elevated prostate specific antigen (PSA) levels is con...

    Authors: Edward Johnston, Hayley Pye, Elisenda Bonet-Carne, Eleftheria Panagiotaki, Dominic Patel, Myria Galazi, Susan Heavey, Lina Carmona, Alexander Freeman, Giorgia Trevisan, Clare Allen, Alexander Kirkham, Keith Burling, Nicola Stevens, David Hawkes, Mark Emberton…
    Citation: BMC Cancer 2016 16:816
    Content type: Study protocol Published on:

  9. Mammalian target of rapamycin (mTOR) represents a key downstream intermediate for a myriad of oncogenic receptor tyrosine kinases. In the case of the insulin-like growth factor (IGF) pathway, the mTOR complex ...

    Authors: Marc A. Becker, Xiaonan Hou, Piyawan Tienchaianada, Brian B. Haines, Sean C. Harrington, S. John Weroha, Sriram Sathyanarayanan and Paul Haluska
    Citation: BMC Cancer 2016 16:814
    Content type: Research article Published on:

  10. Previous studies have reported that eEF-2 kinase is associated with tumour cell sensitivity to certain therapies. In the present study, we investigated the relationship between eEF-2 kinase and lapatinib, a du...

    Authors: Lin Liu, PeiYu Huang, ZhiHui Wang, Nan Chen, Con Tang, Zhong Lin and PeiJian Peng
    Citation: BMC Cancer 2016 16:813
    Content type: Research article Published on:

  11. Solid tumors, such as hepato-pancreato-biliary cancer, develop tumor hypoxia with tumor growth. Despite advances in surgery, a majority of these patients are in an unresectable condition. At this stage standar...

    Authors: Perparim Limani, Michael Linecker, Philipp Kron, Panagiotis Samaras, Bernhard Pestalozzi, Roger Stupp, Alexander Jetter, Philipp Dutkowski, Beat Müllhaupt, Andrea Schlegel, Claude Nicolau, Jean-Marie Lehn, Henrik Petrowsky, Bostjan Humar, Rolf Graf and Pierre-Alain Clavien
    Citation: BMC Cancer 2016 16:812
    Content type: Study protocol Published on:

  12. Triple-negative breast cancer (TNBC) with a BRCA1-like molecular signature has been demonstrated to remarkably respond to platinum-based chemotherapy and might be suited for a future treatment with poly(ADP-ri...

    Authors: Eva Gross, Harm van Tinteren, Zhou Li, Sandra Raab, Christina Meul, Stefanie Avril, Nadja Laddach, Michaela Aubele, Corinna Propping, Apostolos Gkazepis, Manfred Schmitt, Alfons Meindl, Petra M. Nederlof, Marion Kiechle and Esther H. Lips
    Citation: BMC Cancer 2016 16:811
    Content type: Research article Published on:

  13. Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide and is associated with substantial mortality. Because HCCs have strong resistance to conventional chemotherapeutic agents, n...

    Authors: Jae-Woo Jang, Yeonhwa Song, Kang Mo Kim, Jin-Sun Kim, Eun Kyung Choi, Joon Kim and Haengran Seo
    Citation: BMC Cancer 2016 16:810
    Content type: Research article Published on:

  14. Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs...

    Authors: Claire de Oliveira, Reka Pataky, Karen E. Bremner, Jagadish Rangrej, Kelvin K. W. Chan, Winson Y. Cheung, Jeffrey S. Hoch, Stuart Peacock and Murray D. Krahn
    Citation: BMC Cancer 2016 16:809
    Content type: Research article Published on:

  15. To evaluate the accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) in breast cancer patients with axillary lymph node (ALN) metastasis.

    Authors: Yue Yu, Ning Cui, Heng-Yu Li, Yan-Mei Wu, Lu Xu, Min Fang and Yuan Sheng
    Citation: BMC Cancer 2016 16:808
    Content type: Research article Published on:

  16. Genes in inflammatory pathways play a pivotal role in the development of colorectal cancer. We conducted a two-stage case-control study and aimed at screening the colorectal cancer-associated genetic variation...

    Authors: Chunxiao Xu, Dan Zhou, Feixia Pan, Yi Liu, Dandan zhang, Aifen Lin, Xiaoping Miao, Yaqin Ni, Duo Lv, Shuai Zhang, Xiaobo Li, Yimin Zhu and Maode Lai
    Citation: BMC Cancer 2016 16:807
    Content type: Research article Published on:

  17. Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), a class of non-coding small RNAs, can post-tran...

    Authors: Qiao Zhu, Li Gong, Jun Wang, Qian Tu, Li Yao, Jia-Rui Zhang, Xiu-Juan Han, Shao-Jun Zhu, Shu-Mei Wang, Yan-Hong Li and Wei Zhang
    Citation: BMC Cancer 2016 16:806
    Content type: Research article Published on:

  18. Pathological stage and grade have limited ability to predict the outcomes of superficial urothelial bladder carcinoma at initial transurethral resection (TUR). AT-motif binding factor 1 (ATBF1) is a tumor supp...

    Authors: Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, Osamu Yamamoto, Hiromi Ito, Yoshihiko Tomita, Yuchi Naruse, Akira Sakamaki, Yoko Ishii…
    Citation: BMC Cancer 2016 16:805
    Content type: Research article Published on:

  19. When individuals stop working due to cancer this represents a loss to society – the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from a...

    Authors: Alison Pearce, Cathy Bradley, Paul Hanly, Ciaran O’Neill, Audrey Alforque Thomas, Michal Molcho and Linda Sharp
    Citation: BMC Cancer 2016 16:804
    Content type: Research article Published on:

  21. Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurab...

    Authors: Matthieu Hanf, David Chiron, Sophie de Visme, Cyrille Touzeau, Hervé Maisonneuve, Henry Jardel, Catherine Pellat-Deceunynck, Martine Amiot and Steven le Gouill
    Citation: BMC Cancer 2016 16:802
    Content type: Study protocol Published on:

  22. Most cases of disseminated carcinomatosis of the bone marrow (DCBM) arise from gastric cancer. DCBM from pancreatic cancer is very rare. We herein present a case of DCBM from pancreatic cancer.

    Authors: Hiroki Namikawa, Yasuhiko Takemoto, Ayako Makuuchi, Masanori Kobayashi, Shigeki Kinuhata, Mina Morimura, Takashi Ikebe, Hiromu Tanaka and Taichi Shuto
    Citation: BMC Cancer 2016 16:801
    Content type: Case report Published on:

  23. N-cadherin is a trans-membrane adhesion molecule associated with advanced carcinoma progression and poor prognosis. The effect of N-cadherin on matrix metalloproteinase 9 (MMP-9) regulation is implicated in hu...

    Authors: Chih-Chin Hsu, Shiang-Fu Huang, Jong-Shyan Wang, Wing-Keung Chu, Ju-En Nien, Wei-Shan Chen and Shu-Er Chow
    Citation: BMC Cancer 2016 16:800
    Content type: Research article Published on:

  24. Urothelial carcinoma of the urinary bladder (UCB) is the 4th most common cancer type in men in developed countries, and tumor recurrence or progression occurs in more than half of the patients. Previous studies r...

    Authors: B. K. Andreassen, B. Aagnes, R. Gislefoss, M. Andreassen and R. Wahlqvist
    Citation: BMC Cancer 2016 16:799
    Content type: Research article Published on:

  25. Historically, local control of recurrent sarcomas has been limited to radiotherapy when surgical re-resection is not feasible. For metastatic carcinomas to the bone or soft tissue, radiotherapy and some interv...

    Authors: Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba and Hideo Morioka
    Citation: BMC Cancer 2016 16:798
    Content type: Research article Published on:

  26. Mutations in the tumor suppressor gene von Hippel-Lindau (VHL) underlie a hereditary cancer syndrome—VHL disease—and are also frequently observed in sporadic renal cell carcinoma of the clear cell type (ccRCC). V...

    Authors: Hannah L. Bader and Tien Hsu
    Citation: BMC Cancer 2016 16:797
    Content type: Research article Published on:

  27. Southern China is an endemic area for primary liver cancer (PLC), but it is unclear if rates have changed in recent decades. We evaluated PLC incidence and estimated the effects of age, period of diagnosis, an...

    Authors: Wenyi Liu, Qing Liu, Qihong Huang, Yuqiang Lu, Shanghang Xie, Aihua Lin and Sumei Cao
    Citation: BMC Cancer 2016 16:796
    Content type: Research article Published on:

  28. This study addresses involvement of major 5-fluorouracil (5-FU) pathway genes in the prognosis of colorectal carcinoma patients.

    Authors: T. Kunicka, P. Prochazka, I. Krus, P. Bendova, M. Protivova, S. Susova, V. Hlavac, V. Liska, P. Novak, M. Schneiderova, P. Pitule, J. Bruha, O. Vycital, P. Vodicka and P. Soucek
    Citation: BMC Cancer 2016 16:795
    Content type: Research article Published on:

  30. Gemcitabine is currently the standard chemotherapy for the adjuvant treatment of pancreatic cancer. This chemotherapeutic agent is generally well-tolerated, myelosuppression and gastrointestinal toxicity being...

    Authors: Elisabetta Fenocchio, Ilaria Depetris, Delia Campanella, Lucia Garetto, Fabrizio Carnevale Schianca, Danilo Galizia, Giovanni Grignani, Massimo Aglietta and Francesco Leone
    Citation: BMC Cancer 2016 16:793
    Content type: Case report Published on:

  31. Serum C-reactive protein (CRP), an acute inflammatory response biomarker, has been recognized as an indicator of malignant disease progression. However, the prognostic significance of CRP levels collected befo...

    Authors: Zi-Ying Lin, Zhen-Xing Liang, Pei-Lin Zhuang, Jie-Wei Chen, Yun Cao, Li-Xu Yan, Jing-Ping Yun, Dan Xie and Mu-Yan Cai
    Citation: BMC Cancer 2016 16:792
    Content type: Research article Published on:

  32. Angiogenesis is generally involved during the cancer development and hematogenous metastasis. Vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) are considered to have an imp...

    Authors: Chenbo Ding, Longmei Li, Taoyu Yang, Xiaobo Fan and Guoqiu Wu
    Citation: BMC Cancer 2016 16:791
    Content type: Research article Published on:

  33. Renal cell carcinoma (RCC) is one of the tumors most refractory to chemotherapy to date. Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin (CPS), a natural active ingredient o...

    Authors: Tao Liu, Gang Wang, Huangheng Tao, Zhonghua Yang, Yongzhi Wang, Zhe Meng, Rui Cao, Yu Xiao, Xinghuan Wang and Jiajie Zhou
    Citation: BMC Cancer 2016 16:790
    Content type: Research article Published on:

  34. The extracellular matrix (ECM), one of the key components of tumor microenvironment, has a tremendous impact on cancer development and highly influences tumor cell features. ECM affects vital cellular function...

    Authors: Vaidotas Stankevicius, Gintautas Vasauskas, Danute Bulotiene, Stase Butkyte, Sonata Jarmalaite, Ricardas Rotomskis and Kestutis Suziedelis
    Citation: BMC Cancer 2016 16:789
    Content type: Research article Published on:

  35. Claudin-4 is a transmembrane protein expressed at high levels in the majority of epithelial ovarian tumors, irrespective of subtype, and has been associated with tumor cells that are both chemoresistant and hi...

    Authors: Douglas A. Hicks, Carly E. Galimanis, Patricia G. Webb, Monique A. Spillman, Kian Behbakht, Margaret C. Neville and Heidi K. Baumgartner
    Citation: BMC Cancer 2016 16:788
    Content type: Research article Published on:

  36. Although this effect is well known, tailored treatment methods have not yet been broadly adopted. The aim of this study was to identify those patient characteristics that most influence the impairment of quali...

    Authors: Elisabeth Peters, Laura Mendoza Schulz and Monika Reuss-Borst
    Citation: BMC Cancer 2016 16:787
    Content type: Research article Published on:

  37. Pancreatic cancer is among the top 5 most common cancers worldwide, but is particularly devastating due to its insidious nature. Complete surgical resection remains the only potential curative treatment, altho...

    Authors: Mišo Gostimir, Sean Bennett, Terence Moyana, Harman Sekhon and Guillaume Martel
    Citation: BMC Cancer 2016 16:786
    Content type: Case report Published on:

  38. The risk of several types of cancer is increased in type 2 diabetes mellitus. The earliest possible diagnosis of cancer – difficult within regular outpatient diabetes care - is of utmost importance for patient...

    Authors: Mariusz Dąbrowski, Elektra Szymańska-Garbacz, Zofia Miszczyszyn, Tadeusz Dereziński and Leszek Czupryniak
    Citation: BMC Cancer 2016 16:785
    Content type: Research article Published on:

  39. MicroRNAs (miRNAs) regulate the expression of networks of genes and their dysregulation is well documented in human malignancies; however, limited information exists regarding the impact of miRNAs on the devel...

    Authors: Joelle M. Fenger, Ryan D. Roberts, O. Hans Iwenofu, Misty D. Bear, Xiaoli Zhang, Jason I. Couto, Jaime F. Modiano, William C. Kisseberth and Cheryl A. London
    Citation: BMC Cancer 2016 16:784
    Content type: Research article Published on:

  41. p63, a member of the p53 protein family, plays key roles in epithelial development and carcinogenesis. In breast cancer, p63 expression has been found predominantly in basal-A (epithelial-type) triple-negative...

    Authors: Marta Nekulova, Jitka Holcakova, Xiaolian Gu, Vaclav Hrabal, Sotiris Galtsidis, Paulina Orzol, Yajing Liu, Stella Logotheti, Vassilis Zoumpourlis, Karin Nylander, Philip J Coates and Borivoj Vojtesek
    Citation: BMC Cancer 2016 16:782
    Content type: Research article Published on:

  42. The successful targeting of neuroblastoma (NB) by associating tumor-initiating cells (TICs) is a major challenge in the development of new therapeutic strategies. The subfamily of aldehyde dehydrogenases 1 (AL...

    Authors: Marjorie Flahaut, Nicolas Jauquier, Nadja Chevalier, Katya Nardou, Katia Balmas Bourloud, Jean-Marc Joseph, David Barras, Christian Widmann, Nicole Gross, Raffaele Renella and Annick Mühlethaler-Mottet
    Citation: BMC Cancer 2016 16:781
    Content type: Research article Published on:

  43. Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevaciz...

    Authors: Christoph Rochlitz, Martin Bigler, Roger von Moos, Jürg Bernhard, Klazien Matter-Walstra, Andreas Wicki, Khalil Zaman, Sandro Anchisi, Marc Küng, Kyung-Jae Na, Daniela Bärtschi, Markus Borner, Tamara Rordorf, Daniel Rauch, Andreas Müller, Thomas Ruhstaller…
    Citation: BMC Cancer 2016 16:780
    Content type: Research article Published on:

  44. TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesopha...

    Authors: David Propper, Keith Jones, D. Alan Anthoney, Wasat Mansoor, Daniel Ford, Martin Eatock, Roshan Agarwal, Michiyasu Inatani, Tomohisa Saito, Masaichi Abe and T. R. Jeffry Evans
    Citation: BMC Cancer 2016 16:779
    Content type: Research article Published on:

  45. Inhaled corticosteroids (ICS) have been associated with decreased lung cancer risk. However, they have been associated with pulmonary infections (tuberculosis [TB] and pneumonia) in patients with chronic obstr...

    Authors: Ming-Fang Wu, Zhi-Hong Jian, Jing-Yang Huang, Cheng-Feng Jan, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Chien-Chang Ho, Chia-Chi Lung, Hui-Hsien Pan, Min-Chen Wu and Yung-Po Liaw
    Citation: BMC Cancer 2016 16:778
    Content type: Research article Published on:

  46. Extramedullary plasmacytoma (EMP) is a rare malignant disease that lacks a unique clinical staging system to predict the survival of EMP patients and to design individualized treatment. Instead, clinicians hav...

    Authors: Qian Zhu, Xiong Zou, Rui You, Rou Jiang, Meng-Xia Zhang, You-Ping Liu, Chao-Nan Qian, Hai-Qiang Mai, Ming-Huang Hong, Ling Guo and Ming-Yuan Chen
    Citation: BMC Cancer 2016 16:777
    Content type: Research article Published on:

  47. Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an estab...

    Authors: F. N. Fjeldheim, H. Frydenberg, V. G. Flote, A. McTiernan, A-S Furberg, P. T. Ellison, E. S. Barrett, T. Wilsgaard, G. Jasienska, G. Ursin, E. A. Wist and I. Thune
    Citation: BMC Cancer 2016 16:776
    Content type: Research article Published on:

  48. Concurrent chemotherapy and radiation is the standard treatment for unresectable stage III Lung adenocarcinoma. However, no optimal concurrent chemotherapeutic regimen has been described. This study aimed to a...

    Authors: Yiyu Lu, Weiguang Gu, Jin Deng, Hua Yang and Wen Yang
    Citation: BMC Cancer 2016 16:775
    Content type: Research article Published on:

  49. The study aimed to evaluate the long-term outcome in patients with advanced local recurrent nasopharyngeal carcinoma (NPC) treated with or without reirradiation.

    Authors: Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Lu Zhang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ming-Yuan Chen, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma…
    Citation: BMC Cancer 2016 16:774
    Content type: Research article Published on:

  50. Given the prevalence of untreated pain among cancer patients, there have been calls for more and better research in the domain. Increasingly, calls for less waste and more optimal use of trial data collected a...

    Authors: Odile Sauzet, Maren Kleine and John E. Williams
    Citation: BMC Cancer 2016 16:771
    Content type: Research article Published on:

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