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  1. Prostate cancer is a common disease in men and at present there is no effective therapy available due to its recurrence despite androgen deprivation therapy. The epidermal growth factor receptor family (EGFR/H...

    Authors: Wenqing Qi, Larry S Cooke, Amy Stejskal, Christopher Riley, Kimiko Della Croce, Jose W Saldanha, David Bearss and Daruka Mahadevan
    Citation: BMC Cancer 2009 9:142
  2. Research has shown that ethnicity is a significant predictor of Hodgkin lymphoma (HL). Variations in cancer incidence among ethnic groups in the same country can lead to important information in the search for...

    Authors: Punam Pahwa, Chandima P Karunanayake, John J Spinelli, James A Dosman and Helen H McDuffie
    Citation: BMC Cancer 2009 9:141
  3. Previous studies showed that at the individual level, positron emission tomography (PET) has some benefits for patients and physicians in terms of cancer management and staging. We aimed to describe the benefi...

    Authors: Irawati Lemonnier, Cédric Baumann, Nicolas Jay, Kazem Alzahouri, Patrick Arveux, Damien Jolly, Catherine Lejeune, Michel Velten, Fabien Vitry, Marie-Christine Woronoff-Lemsi and Francis Guillemin
    Citation: BMC Cancer 2009 9:139
  4. Bone marrow transplantation (BMT) is often used in the treatment of various diseases. Before BMT, patients are submitted to a conditioning regimen (CR), which consists of the administration of high doses of ch...

    Authors: Thissiane L Gonçalves, Dalila M Benvegnú, Gabriela Bonfanti, Andressa V Frediani and João Batista T Rocha
    Citation: BMC Cancer 2009 9:138
  5. The purpose of this study is to analyze the combined effects of selected p53 and p73 polymorphisms and their interaction with lifestyle habits on squamous cell carcinoma of the head and neck (SCCHN) risk and prog...

    Authors: Paola Gallì, Gabriella Cadoni, Mariangela Volante, Emma De Feo, Rosarita Amore, Arianna Giorgio, Dario Arzani, Gaetano Paludetti, Gualtiero Ricciardi and Stefania Boccia
    Citation: BMC Cancer 2009 9:137
  6. Invasive growth of epithelial cancers is a complex multi-step process which involves dissolution of the basement membrane. Type IV collagen is a major component in most basement membranes. Type VII collagen is...

    Authors: Hanne Skovbjerg, Dorit Anthonsen, Inger MB Lothe, Kjell M Tveit, Elin H Kure and Lotte K Vogel
    Citation: BMC Cancer 2009 9:136
  7. Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify n...

    Authors: Ming-Szu Hung, Zhidong Xu, Yu-Ching Lin, Jian-Hua Mao, Cheng-Ta Yang, Pey-Jium Chang, David M Jablons and Liang You
    Citation: BMC Cancer 2009 9:135
  8. Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and p...

    Authors: Xiu-Feng Zhang, Ying Zhang, Xiao-Hua Zhang, Su-Mei Zhou, Guan-Gen Yang, Ou-Chen Wang, Gui-Long Guo, Gao-Yi Yang and Xiao-Qu Hu
    Citation: BMC Cancer 2009 9:134
  9. Doxorubicin is an effective breast cancer drug but is hampered by a severe, dose-dependent toxicity. Concomitant administration of doxorubicin and another cancer drug may be able to sensitize tumor cells to th...

    Authors: Xuejun Dong, Anding Liu, Cindy Zer, Jianguo Feng, Zhuan Zhen, Mingfeng Yang and Li Zhong
    Citation: BMC Cancer 2009 9:133
  10. Aberrant activation NF-kappaB has been proposed as a mechanism of drug resistance in pancreatic cancer. Recently, inhibition of glycogen synthase kinase-3 has been shown to exert anti-tumor effects on pancreat...

    Authors: Shadi Mamaghani, Satish Patel and David W Hedley
    Citation: BMC Cancer 2009 9:132
  11. Selection of patients with local failure of nasopharyngeal carcinoma (NPC) for appropriate type of salvage treatment can be difficult due to the lack of data on comparative efficacy of different salvage treatm...

    Authors: Daniel TT Chua, Kwan-Ngai Hung, Victor Lee, Sherry CY Ng and Janice Tsang
    Citation: BMC Cancer 2009 9:131
  12. Evidence that chemotherapy improves survival and quality of life in patients with stage IIIB & IV non small cell lung cancer (NSCLC) is based on large randomized controlled trials. The purpose of this study wa...

    Authors: Janette Vardy, Ryan Dadasovich, Philip Beale, Michael Boyer and Stephen J Clarke
    Citation: BMC Cancer 2009 9:130
  13. In the American region, Puerto Rico (PR) has the highest incidence of oral and pharyngeal cancer (OPC), but racial/ethnic differences have never been assessed and compared with other groups in the United State...

    Authors: Erick Suárez, William A Calo, Eduardo Y Hernández, Elba C Diaz, Nayda R Figueroa and Ana P Ortiz
    Citation: BMC Cancer 2009 9:129
  14. Aberrant regulation of cell migration drives progression of many diseases, including cancer cell invasion and metastasis formation. Analysis of tumour invasion and metastasis in living organisms to date is cum...

    Authors: Ines J Marques, Frank Ulrich Weiss, Danielle H Vlecken, Claudia Nitsche, Jeroen Bakkers, Anne K Lagendijk, Lars Ivo Partecke, Claus-Dieter Heidecke, Markus M Lerch and Christoph P Bagowski
    Citation: BMC Cancer 2009 9:128
  15. Our purpose was to collect preliminary data on newly diagnosed breast cancer patient knowledge of prognosis before and after oncology visits. Many oncologists use a validated prognostic software model, Adjuvan...

    Authors: Jeffrey K Belkora, Hope S Rugo, Dan H Moore, David W Hutton, Daniel F Chen and Laura J Esserman
    Citation: BMC Cancer 2009 9:127
  16. Compared with viral vectors, nonviral vectors are less immunogenic, more stable, safer and easier to replication for application in cancer gene therapy. However, nonviral gene delivery system has not been exte...

    Authors: Yu Kang, Xiaoyan Zhang, Wei Jiang, Chaoqun Wu, Chunmei Chen, Yufang Zheng, Jianren Gu and Congjian Xu
    Citation: BMC Cancer 2009 9:126
  17. Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC). The members of IAP famil...

    Authors: Claudia Augello, Luca Caruso, Marco Maggioni, Matteo Donadon, Marco Montorsi, Roberto Santambrogio, Guido Torzilli, Valentina Vaira, Caterina Pellegrini, Massimo Roncalli, Guido Coggi and Silvano Bosari
    Citation: BMC Cancer 2009 9:125
  18. Methylation of DNA is a common mechanism for silencing genes, and aberrant methylation is increasingly being implicated in many diseases such as cancer. There is a need for robust, inexpensive methods to quant...

    Authors: Eric Smith, Michael E Jones and Paul A Drew
    Citation: BMC Cancer 2009 9:123
  19. Several studies have determined that dietary intake of B vitamins may be associated with breast cancer risk as a result of interactions between 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synt...

    Authors: Enbo Ma, Motoki Iwasaki, Ishihara Junko, Gerson Shigeaki Hamada, Ines Nobuko Nishimoto, Solange Maria Torchia Carvalho, Juvenal Motola Jr, Fábio Martins Laginha and Shoichiro Tsugane
    Citation: BMC Cancer 2009 9:122
  20. A recent model for activation of the zymogen form of matrix metalloproteinase 2 (MMP-2, also known as gelatinase A) has suggested that interactions between the SIBLING protein bone sialoprotein (BSP) and MMP-2...

    Authors: Queena Hwang, Sela Cheifetz, Christopher M Overall, Christopher A McCulloch and Jaro Sodek
    Citation: BMC Cancer 2009 9:121
  21. Phase II studies have shown that the combination of capecitabine and irinotecan (the XELIRI regimen) is active in metastatic colorectal cancer (MCRC). There are, however, no data about the use of the XELIRI re...

    Authors: Erik Skof, Martina Rebersek, Zvezdana Hlebanja and Janja Ocvirk
    Citation: BMC Cancer 2009 9:120
  22. Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-patholo...

    Authors: Oscar Arrieta, David Saavedra-Perez, Roberto Kuri, Alejandro Aviles-Salas, Luis Martinez, Daniel Mendoza-Posada, Patricia Castillo, Alma Astorga, Enrique Guzman and Jaime De la Garza
    Citation: BMC Cancer 2009 9:119
  23. Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbid...

    Authors: Diana Sarfati, Sarah Hill, Tony Blakely, Bridget Robson, Gordon Purdie, Elizabeth Dennett, Donna Cormack and Kevin Dew
    Citation: BMC Cancer 2009 9:116
  24. Estrogens, environmental chemicals with carcinogenic potential, as well as oxidative and carbonyl stresses play a very important role in breast cancer (BC) genesis and progression. Therefore, polymorphisms of ...

    Authors: Cinzia Antognelli, Chiara Del Buono, Vienna Ludovini, Stefania Gori, Vincenzo N Talesa, Lucio Crinò, Francesco Barberini and Antonio Rulli
    Citation: BMC Cancer 2009 9:115
  25. The study tested the hypothesis that apoptosis can prevent and control growth of neoplastic cells. Previous studies in-vitro have shown that the pro-apoptotic P2X7 receptor regulates growth of epithelial cells. T...

    Authors: Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim and George I Gorodeski
    Citation: BMC Cancer 2009 9:114
  26. The study of somatic DNA instabilities constitutes a debatable topic because different causes can lead to seeming DNA alteration patterns between different cells or tissues from the same individual. Carcinogen...

    Authors: Hans-Jürgen Bandelt and Antonio Salas
    Citation: BMC Cancer 2009 9:113
  27. This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusion...

    Authors: Jean-Luc Raoul, Jean-Luc Van Laethem, Marc Peeters, Catherine Brezault, Fares Husseini, Laurent Cals, Johannes Nippgen, Anja-Helena Loos and Philippe Rougier
    Citation: BMC Cancer 2009 9:112
  28. Mutations in the KRAS gene are one of the most frequent genetic abnormalities in ovarian carcinoma. They are of renewed interest as new epidermal growth factor receptor (EGFR)-targeted therapies are being investi...

    Authors: Veronika Auner, Gernot Kriegshäuser, Dan Tong, Reinhard Horvat, Alexander Reinthaller, Alexander Mustea and Robert Zeillinger
    Citation: BMC Cancer 2009 9:111
  29. Because treatment of advanced gastric cancer (AGC) patients after failure with first-line chemotherapy remains controversial, we performed this retrospective analysis based on the data obtained from 1455 patie...

    Authors: Sang Hoon Ji, Do Hyoung Lim, Seong Yoon Yi, Hyo Song Kim, Hyun Jung Jun, Kyoung Ha Kim, Myung Hee Chang, Min Jae Park, Ji Eun Uhm, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim and Won Ki Kang
    Citation: BMC Cancer 2009 9:110
  30. Sentinel lymph node (SLN) biopsy is a widely used diagnostic procedure in the management of early breast cancer. When SLN is free of metastasis, complete axillary dissection may be skipped for staging in clini...

    Authors: Anna V Britto, André A Schenka, Natália G Moraes-Schenka, Marcelo Alvarenga, Júlia Y Shinzato, José Vassallo and Laura S Ward
    Citation: BMC Cancer 2009 9:109
  31. One of the basic prerequisites for generating evidence-based data is the availability of classification systems. Attempts to date to classify breast cancer operations have focussed on specific problems, e.g. t...

    Authors: Jürgen Hoffmann and Diethelm Wallwiener
    Citation: BMC Cancer 2009 9:108
  32. Antineoplastic drug cisplatin remains the drug of choice for various solid tumours including breast cancer. But dose dependent nephrotoxicity is the major drawback in majority of platinum based chemotherapy re...

    Authors: Kulbhushan Tikoo, Parveen Kumar and Jeena Gupta
    Citation: BMC Cancer 2009 9:107
  33. Pancreatic cancer is a devastating disease characterized by dismal 5-year survival rates and limited treatment options. In an effort to provide useful models for preclinical evaluation of new experimental ther...

    Authors: Cynthia S Snyder, Sharmeela Kaushal, Yuko Kono, Hop S Tran Cao, Robert M Hoffman and Michael Bouvet
    Citation: BMC Cancer 2009 9:106
  34. Prognostic scores might be useful tools both in clinical practice and clinical trials, where they can be used as stratification parameter. The available scores for patients with brain metastases have never bee...

    Authors: Carsten Nieder, Kirsten Marienhagen, Sabrina T Astner and Michael Molls
    Citation: BMC Cancer 2009 9:105
  35. Breast cancer belongs to the most frequent and severe cancer types in human. Since excretion of modified nucleosides from increased RNA metabolism has been proposed as a potential target in pathogenesis of bre...

    Authors: Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell and Bernd Kammerer
    Citation: BMC Cancer 2009 9:104
  36. Insulin-like growth factor binding protein 5 (IGFBP5) has been shown to be associated with breast cancer metastasis in clinical marker studies. However, a major difficulty in understanding how IGFBP5 functions...

    Authors: Mustafa Akkiprik, Limei Hu, Aysegul Sahin, Xishan Hao and Wei Zhang
    Citation: BMC Cancer 2009 9:103
  37. Bone metastases are frequent complications of breast cancer. Recent literature implicates multiple chemokines in the formation of bone metastases in breast cancer. However, the molecular mechanism of metastati...

    Authors: Dongqing Cai, Jie Cao, Zhen Li, Xin Zheng, Yao Yao, Wanglin Li and Ziqiang Yuan
    Citation: BMC Cancer 2009 9:102
  38. In recurrent malignant gliomas (MGs), a high rate of haematological toxicity is observed with the use of fotemustine at the conventional schedule (100 mg/m2 weekly for 3 consecutive weeks followed by triweekly ad...

    Authors: Alessandra Fabi, Giulio Metro, Michelangelo Russillo, Antonello Vidiri, Carmine Maria Carapella, Marta Maschio, Francesco Cognetti, Bruno Jandolo, Maria Alessandra Mirri, Isabella Sperduti, Stefano Telera, Mariantonia Carosi and Andrea Pace
    Citation: BMC Cancer 2009 9:101
  39. During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis. Heat shock protein 27(HSP27) is confirmed as...

    Authors: Kun Guo, Nan Xiao Kang, Yan Li, Lu Sun, Lin Gan, Feng Jie Cui, Mei Dong Gao and Kun Yin Liu
    Citation: BMC Cancer 2009 9:100
  40. Colorectal carcinoma is one of the major causes of morbidity and mortality in the Western World. Novel therapeutic approaches are needed for colorectal carcinoma. Curcumin, the active component and yellow pigm...

    Authors: Ling Cen, Brian Hutzen, Sarah Ball, Stephanie DeAngelis, Chun-Liang Chen, James R Fuchs, Chenglong Li, Pui-Kai Li and Jiayuh Lin
    Citation: BMC Cancer 2009 9:99
  41. During the last part of the 1990s the chance of surviving breast cancer increased. Changes in survival functions reflect a mixture of effects. Both, the introduction of adjuvant treatments and early screening ...

    Authors: Ester Vilaprinyo, Montserrat Rué, Rafael Marcos-Gragera and Montserrat Martínez-Alonso
    Citation: BMC Cancer 2009 9:98
  42. Resistance of high-risk metastatic neuroblastoma (HR-NB) to high dose chemotherapy (HD-CT) raises a major therapeutic challenge in pediatric oncology. Patients are treated by maintenance CT. For some patients,...

    Authors: Gilda Raguénez, Annick Mühlethaler-Mottet, Roland Meier, Caroline Duros, Jean Bénard and Nicole Gross
    Citation: BMC Cancer 2009 9:97
  43. The extent of angiogenesis is an important prognostic factor for colorectal carcinoma, however, there are few studies concerning changes in angiogenesis with radiotherapy (RTX). Our aim was to investigate chan...

    Authors: Saulius Svagzdys, Vaiva Lesauskaite, Dainius Pavalkis, Irena NedzelskienÄ—, Darius Pranys and Algimantas Tamelis
    Citation: BMC Cancer 2009 9:95
  44. Interactions between cancer cells and stroma are critical for growth and invasiveness of epithelial tumors. The biochemical mechanisms behind tumor-stromal interactions leading to increased invasiveness and me...

    Authors: Remedios Castelló-Cros, David R Khan, Jeffrey Simons, Matthildi Valianou and Edna Cukierman
    Citation: BMC Cancer 2009 9:94
  45. The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons. One major aspect is the lack of typical cytological crite...

    Authors: Nora Hinsch, Matthias Frank, Claudia Döring, Christian Vorländer and Martin-Leo Hansmann
    Citation: BMC Cancer 2009 9:93

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