Skip to main content


Page 288 of 304

  1. Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones.

    Authors: Lara Bethke, Emily Webb, Gabrielle Sellick, Matthew Rudd, Stephen Penegar, Laura Withey, Mobshra Qureshi and Richard Houlston
    Citation: BMC Cancer 2007 7:123
  2. Endoglin (CD105) has been considered a prognostic marker for hepatocellular carcinoma (HCC), and widely used as an appropriate targeting for antiangenesis therapy in some cancers. Our aim was to evaluate the d...

    Authors: Decai Yu, Linyuan Zhuang, Xitai Sun, Jun Chen, Yongzhong Yao, Kui Meng and Yitao Ding
    Citation: BMC Cancer 2007 7:122
  3. Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survi...

    Authors: Vijaya L Damaraju, David Y Bouffard, Clarence KW Wong, Marilyn L Clarke, John R Mackey, Lorraine Leblond, Carol E Cass, Mike Grey and Henriette Gourdeau
    Citation: BMC Cancer 2007 7:121
  4. Although methylation-mediated inactivation of expression of RASSF1A, a candidate tumor suppressor gene, has been observed in several human cancers, the data concerning alteration of RASSF1A expression and meth...

    Authors: Mei Ye, Bing Xia, Qiusha Guo, Feng Zhou and Xiaolian Zhang
    Citation: BMC Cancer 2007 7:120
  5. Dendritic cells (DCs) are professional antigen-presenting cells with the ability to induce primary T-cell responses and are commonly produced by culturing monocytes in the presence of IL-4 and GM-CSF for 5–7 d...

    Authors: Silvija Jarnjak-Jankovic, Hege Hammerstad, Stein Sæbøe-Larssen, Gunnar Kvalheim and Gustav Gaudernack
    Citation: BMC Cancer 2007 7:119
  6. Drug-metabolizing enzymes play a role in chemical carcinogenesis through enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene polymorphisms of several cytochrome P450 e...

    Authors: Guillermo Gervasini, Elena García-Martín, José M Ladero, Rosa Pizarro, Javier Sastre, Carmen Martínez, Monserrat García, Manuel Diaz-Rubio and José AG Agúndez
    Citation: BMC Cancer 2007 7:118
  7. Whereas ultra-short stay (day care or 24 hour hospitalisation) following breast cancer surgery was introduced in the US and Canada in the 1990s, it is not yet common practice in Europe. This paper describes th...

    Authors: Mascha de Kok, Caroline NA Frotscher, Trudy van der Weijden, Alfons GH Kessels, Carmen D Dirksen, Cornelis JH van de Velde, Jan A Roukema, Antoine VRJ Bell, Fred W van der Ent and Maarten F von Meyenfeldt
    Citation: BMC Cancer 2007 7:117
  8. Pseudomyxoma peritonei (PMP) is a rare malignant disease, most commonly originating from appendiceal lesions and characterized by accumulation of mucinous tumor tissue in the peritoneal cavity. Since the disea...

    Authors: Kjersti Flatmark, Wenche Reed, Thomas Halvorsen, Olaf Sørensen, Johan N Wiig, Stein G Larsen, Øystein Fodstad and Karl-Erik Giercksky
    Citation: BMC Cancer 2007 7:116
  9. Gene-gene and gene-environment interactions involved in the metabolism of carcinogens may increase the risk of cancer. Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2...

    Authors: Chunhong Fan, Mingjuan Jin, Kun Chen, Yongjing Zhang, Shuangshuang Zhang and Bing Liu
    Citation: BMC Cancer 2007 7:115
  10. The present study was conducted to analyze the value of ([18F] fluoromisonidazole (FMISO) and [18F]-2-fluoro-2'-deoxyglucose (FDG) PET as well as color pixel density (CPD) and tumor perfusion (TP) assessed by col...

    Authors: Bernd Gagel, Marc Piroth, Michael Pinkawa, Patrick Reinartz, Michael Zimny, Hans J Kaiser, Sven Stanzel, Branka Asadpour, Cengiz Demirel, Kurt Hamacher, Heinz H Coenen, Thomas Scholbach, Payam Maneschi, Ercole DiMartino and Michael J Eble
    Citation: BMC Cancer 2007 7:113
  11. The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radioc...

    Authors: Bernd Gagel, Marc Piroth, Michael Pinkawa, Patrick Reinartz, Thomas Krohn, Hans J Kaiser, Sven Stanzel, Christian Breuer, Branka Asadpour, Axel Schmachtenberg and Michael J Eble
    Citation: BMC Cancer 2007 7:112
  12. Stat3 has been classified as a proto-oncogene and constitutive Stat3 signaling appears to be involved in oncogenesis of human cancers. However, whether constitutive Stat3 signaling plays a role in the survival a...

    Authors: Chun-Liang Chen, Abbey Loy, Ling Cen, Christina Chan, Fu-Chuan Hsieh, Gong Cheng, Bryant Wu, Stephen J Qualman, Keita Kunisada, Keiko Yamauchi-Takihara and Jiayuh Lin
    Citation: BMC Cancer 2007 7:111
  13. Setting priorities for the funding of new anti-cancer agents is becoming increasingly complex. The funding of adjuvant trastuzumab for breast cancer has brought this dilemma to the fore. In this paper we revie...

    Authors: Christopher M Booth, George Dranitsaris, M Corona Gainford, Scott Berry, Michael Fralick, John Fralick, Joanna Sue and Mark Clemons
    Citation: BMC Cancer 2007 7:110
  14. Melanoma is the major cause of skin cancer deaths and melanoma incidence doubles every 10 to 20 years. However, little is known about melanoma pathway aberrations. Here we applied the robust Gene Identificatio...

    Authors: Kuo Ping Chiu, Pramila Ariyaratne, Han Xu, Adrian Tan, Patrick Ng, Edison Tak-Bun Liu, Yijun Ruan, Chia-Lin Wei and Wing-Kin Ken Sung
    Citation: BMC Cancer 2007 7:109
  15. TRAIL plays an important role in host immunosurveillance against tumor progression, as it induces apoptosis of tumor cells but not normal cells, and thus has great therapeutic potential for cancer treatment. T...

    Authors: Nadarajah Vigneswaran, Darryl C Baucum, Jean Wu, Yahuan Lou, Jerry Bouquot, Susan Muller and Wolfgang Zacharias
    Citation: BMC Cancer 2007 7:108
  16. Endostatin is a potent endogenous anti-angiogenic agent which inhibits tumour growth. A non-synonymous coding polymorphism in the Endostatin gene is thought to affect Endostatin activity. We aimed to determine...

    Authors: Sabapathy P Balasubramanian, Simon S Cross, Jenny Globe, Angela Cox, Nicola J Brown and Malcolm W Reed
    Citation: BMC Cancer 2007 7:107
  17. To assess progression-free survival (PFS) as the appropriate end-point for phase II trials for anaplastic gliomas (AGs) and to determine the impact of PFS on survival-based phase III trials.

    Authors: Victor A Levin, Sandra Ictech and Kenneth R Hess
    Citation: BMC Cancer 2007 7:106
  18. Lymphangiomas are neoplasias of childhood. Their etiology is unknown and a causal therapy does not exist. The recent discovery of highly specific markers for lymphatic endothelial cells (LECs) has permitted th...

    Authors: Susanne Norgall, Maria Papoutsi, Jochen Rössler, Lothar Schweigerer, Jörg Wilting and Herbert A Weich
    Citation: BMC Cancer 2007 7:105
  19. Intraperitoneal tumor cell attachment after resection of gastrointestinal cancer may lead to a developing of peritoneal carcinosis. Intraabdominal application of phospholipids shows a significant decrease of a...

    Authors: Jens Otto, Petra Lynen Jansen, Stefan Lucas, Volker Schumpelick and Marc Jansen
    Citation: BMC Cancer 2007 7:104
  20. Quality of life (QOL) issues are of interest in cancer because effective methods of treatment and detection have led to an increase in the number of long-term survivors. The objectives of the study were: to as...

    Authors: Abdel W Awadalla, Jude U Ohaeri, Abdullah Gholoum, Ahmed OA Khalid, Hussein MA Hamad and Anila Jacob
    Citation: BMC Cancer 2007 7:102
  21. In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral ...

    Authors: Ping-Ho Chen, Tien-Yu Shieh, Pei-Shan Ho, Chi-Cheng Tsai, Yi-Hsin Yang, Ying-Chu Lin, Min-Shan Ko, Pei-Chien Tsai, Shang-Lun Chiang, Hung-Pin Tu and Ying-Chin Ko
    Citation: BMC Cancer 2007 7:101
  22. The planned nationwide implementation of mammography screening 2007 in Germany will increase the occurrence of mammographically detected breast abnormalities. These abnormalities are normally evaluated by mini...

    Authors: Alexander Kluttig, Pietro Trocchi, Anke Heinig, Hans-Juergen Holzhausen, Christiane Taege, Steffen Hauptmann, Werner Boecker, Thomas Decker, Thomas Loening, Andrea Schmidt-Pokrzywniak, Christoph Thomssen, Tilmann Lantzsch, Joerg Buchmann and Andreas Stang
    Citation: BMC Cancer 2007 7:100
  23. cMyc and p27 are key genes implicated in carcinogenesis. Whether polymorphisms in these genes affect breast cancer risk or prognosis is still unclear. In this study, we focus on a rare non-synonymous polymorph...

    Authors: Jane C Figueiredo, Julia A Knight, Stewart Cho, Sevtap Savas, U Venus Onay, Laurent Briollais, Pamela J Goodwin, John R McLaughlin, Irene L Andrulis and Hilmi Ozcelik
    Citation: BMC Cancer 2007 7:99
  24. Recent studies have demonstrated the effectiveness of cisplatin-based combinations in patients with advanced transitional cell carcinoma(TCC) of the urothelium. Concern over cisplatin toxicity instigated a sea...

    Authors: Nong Xu, Xiao Chen Zhang, Jian Ping Xiong, Wei Jia Fang, Lan Fang Yu, Jiong Qian and Ling Zhang
    Citation: BMC Cancer 2007 7:98
  25. The incidence of oesophageal adenocarcinoma is increasing rapidly in the developed world. The serine-threonine protein kinase and proto-oncogene Akt has been reported to regulate proliferation and apoptosis in...

    Authors: Ian LP Beales, Olorunseun Ogunwobi, Ewen Cameron, Khalid El-Amin, Gabriel Mutungi and Mark Wilkinson
    Citation: BMC Cancer 2007 7:97
  26. We studied the RNA expression of the genes in response to glucose from 5 mM (condition of normoglycemia) to 20 mM (condition of hyperglycemia/diabetes) by microarray analysis in breast cancer derived cell line...

    Authors: Francesco Turturro, Ellen Friday and Tomas Welbourne
    Citation: BMC Cancer 2007 7:96
  27. Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played a...

    Authors: Jiali Zhang and Bin Peng
    Citation: BMC Cancer 2007 7:95
  28. The RECIST guidelines are commonly used in phase II and III clinical trials. The correct definition of response can be controversial in some situations, as in the case we describe.

    Authors: Vito Amoroso, Frida Pittiani, Salvatore Grisanti, Francesca Valcamonico, Edda Simoncini, Vittorio D Ferrari and Giovanni Marini
    Citation: BMC Cancer 2007 7:94
  29. Pregnancy is infrequently complicated by the diagnosis of a concurrent breast cancer. This presents a particularly complicated clinical problem. The treatment of breast cancer in young women involves a number ...

    Authors: Michael J Naughton and Matthew Ellis
    Citation: BMC Cancer 2007 7:93
  30. To evaluate the efficacy and the toxicity of front line FOLFOX4 combined with bevacizumab in patients with metastatsic CRC (mCRC).

    Authors: Christos Emmanouilides, Georgia Sfakiotaki, Nikolaos Androulakis, Kostas Kalbakis, Charalambos Christophylakis, Antonia Kalykaki, Lambros Vamvakas, Athanasios Kotsakis, Sofia Agelaki, Eleni Diamandidou, Nikolaos Touroutoglou, Adam Chatzidakis, Vassilis Georgoulias, Dimitris Mavroudis and John Souglakos
    Citation: BMC Cancer 2007 7:91
  31. The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by suitable laboratory animal models, such as animals treated with the tobacco-speci...

    Authors: Bo Ye, Yu-Xia Zhang, Fei Yang, Hong-Lei Chen, Dong Xia, Ming-Qiu Liu and Bai-Tang Lai
    Citation: BMC Cancer 2007 7:90
  32. Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma tumours were associated with ...

    Authors: Patrick Warnat, André Oberthuer, Matthias Fischer, Frank Westermann, Roland Eils and Benedikt Brors
    Citation: BMC Cancer 2007 7:89
  33. B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HL...

    Authors: Cheng-Shyong Chang, Julia H Chang, Nicholas C Hsu, Hsuan-Yu Lin and Chih-Yuan Chung
    Citation: BMC Cancer 2007 7:88
  34. The novel cytokine, interleukin (IL)-18, is a strong interferon-γ inducer and costimulatory factor in Th1 cell activation. IL-18 triggers IFN-γ production and enhances cytolytic activity in both T and NK cells...

    Authors: Chi-Young Chang, Jienny Lee, Eun-Young Kim, Hae-Jung Park, Choon-Hyuck Kwon, Jae-Won Joh and Sung-Joo Kim
    Citation: BMC Cancer 2007 7:87
  35. Colorectal cancer (CRC) is the second most frequent tumor in developed countries. Since survival from CRC depends mostly on disease stage at the time of diagnosis, individuals with symptoms or signs suspicious...

    Authors: Magdalena Esteva, Maria Ramos, Elena Cabeza, Joan Llobera, Amador Ruiz, Salvador Pita, Josep M Segura, Jose M Cortés and Luis González-Lujan
    Citation: BMC Cancer 2007 7:86
  36. The breast cancer susceptibility gene, BRCA1, is implicated in multiple cellular processes including DNA repair, the transactivation of genes, and the ubiquitination of proteins; however its precise functions rem...

    Authors: Sherry L Winter, Lucine Bosnoyan-Collins, Dushanthi Pinnaduwage and Irene L Andrulis
    Citation: BMC Cancer 2007 7:85
  37. Chronic inflammation is well known to be a risk factor for colon cancer. Previously we established a novel mouse model of inflammation-related colon carcinogenesis, which is useful to examine the involvement o...

    Authors: Rikako Suzuki, Shingo Miyamoto, Yumiko Yasui, Shigeyuki Sugie and Takuji Tanaka
    Citation: BMC Cancer 2007 7:84
  38. Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispos...

    Authors: Bernd Frank, Kari Hemminki, Alfons Meindl, Barbara Wappenschmidt, Christian Sutter, Marion Kiechle, Peter Bugert, Rita K Schmutzler, Claus R Bartram and Barbara Burwinkel
    Citation: BMC Cancer 2007 7:83
  39. The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk...

    Authors: Yun Bai, Liang Xu, Xiaobo Yang, Zhibin Hu, Jing Yuan, Feng Wang, Minhua Shao, Wentao Yuan, Ji Qian, Hongxia Ma, Ying Wang, Hongliang Liu, Weihong Chen, Lin Yang, Guangfu Jing, Xiang Huo…
    Citation: BMC Cancer 2007 7:81
  40. A low incidence of breast cancer in the Mediterranean basin suggests that a high consumption of Extra Virgin Olive Oil (EVOO) might confer this benefit. While the anti-HER2 oncogene effects of the main ω-9 fat...

    Authors: Javier A Menendez, Alejandro Vazquez-Martin, Ramon Colomer, Joan Brunet, Alegria Carrasco-Pancorbo, Rocio Garcia-Villalba, Alberto Fernandez-Gutierrez and Antonio Segura-Carretero
    Citation: BMC Cancer 2007 7:80
  41. Spain has one of the lowest rates of breast cancer in Europe, though estimated incidence has risen substantially in recent decades. Some years ago, the Spanish Cancer Mortality Atlas showed Spain as having a h...

    Authors: Marina Pollán, Rebeca Ramis, Nuria Aragonés, Beatriz Pérez-Gómez, Diana Gómez, Virginia Lope, Javier García-Pérez, Jose Miguel Carrasco, Maria José García-Mendizábal and Gonzalo López-Abente
    Citation: BMC Cancer 2007 7:78
  42. Adjuvant chemotherapy has been proven to be beneficial for patients with early stage non-small cell lung cancer. However, toxicity and insufficient dose delivery have been critical issues with the chemotherapy...

    Authors: Michael Kreuter, Johan Vansteenkiste, Frank Griesinger, Hans Hoffmann, Hendrik Dienemann, Paul De Leyn and Michael Thomas
    Citation: BMC Cancer 2007 7:77
  43. Most studies have found no increased risk of colon cancer associated with hormone replacement therapy (HRT), or even a decreased risk. But information about the effects of different HRT preparations is lacking.

    Authors: Jürgen C Dinger, Lothar AJ Heinemann, Sabine Möhner, Do Minh Thai and Anita Assmann
    Citation: BMC Cancer 2007 7:76
  44. Current research evidence indicates that women should return to normal use of their arm after breast cancer surgery. However, it appears some women continue to hold the view that they are supposed to protect t...

    Authors: Teresa S Lee, Sharon L Kilbreath, Gerard Sullivan, Kathryn M Refshauge and Jane M Beith
    Citation: BMC Cancer 2007 7:75
  45. Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter methylation and mutations in some oncogenes and tumor...

    Authors: Yang Liu, Weimin Gao, Jill M Siegfried, Joel L Weissfeld, James D Luketich and Phouthone Keohavong
    Citation: BMC Cancer 2007 7:74

Featured videos

View featured videos from across the BMC-series journals