Barth RF, Joensuu H: Boron neutron capture therapy for the treatment of glioblastomas and extracranial tumours: as effective, more effective or less effective than photon irradiation?. Radiother Oncol. 2007, 82: 119-122. 10.1016/j.radonc.2007.01.010.
Article
PubMed
Google Scholar
Yang W, Barth RF, Wu G, Huo T, Tjarks W, Ciesielski M, Fenstermaker RA, Ross BD, Wikstrand CJ, Riley KJ, Binns PJ: Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. J Neurooncol. 2009, 95: 355-365. 10.1007/s11060-009-9945-x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barth RF, Coderre JA, Vicente MG, Blue TE: Boron neutron capture therapy of cancer: current status and future prospects. Clin Cancer Res. 2005, 11: 3987-4002. 10.1158/1078-0432.CCR-05-0035.
Article
CAS
PubMed
Google Scholar
Yang W, Barth RF, Wu G, Bandyopadhyaya AK, Thirumamagal BT, Tjarks W, Binns PJ, Riley K, Patel H, Coderre JA, Ciesielski MJ, Fenstermaker RA: Boronated epidermal growth factor as a delivery agent for neutron capture therapy of EGF receptor positive gliomas. Appl Radiat Isot. 2004, 61: 981-985. 10.1016/j.apradiso.2004.05.071.
Article
CAS
PubMed
Google Scholar
Barth RF, Yang W, Coderre JA: Rat brain tumor models to assess the efficacy of boron neutron capture therapy: a critical evaluation. J Neurooncol. 2003, 62: 61-74.
PubMed
Google Scholar
Barth RF: Boron neutron capture therapy at the crossroads: challenges and opportunities. Appl Radiat Isot. 2009, 67: S3-S6. 10.1016/j.apradiso.2009.03.102.
Article
CAS
PubMed
Google Scholar
Yang W, Barth RF, Carpenter DE, Moeschberger ML, Goodman JH: Enhanced delivery of boronophenylalanine for neutron capture therapy by means of intracarotid injection and blood-brain barrier disruption. Neurosurgery. 1996, 38: 985-992. 10.1097/00006123-199605000-00027.
Article
CAS
PubMed
Google Scholar
Barth RF, Yang W, Rotaru JH, Moeschberger ML, Boesel CP, Soloway AH, Joel DD, Nawrocky MM, Ono K, Goodman JH: Boron neutron capture therapy of brain tumors: enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine. Int J Radiat Oncol Biol Phys. 2000, 47: 209-218. 10.1016/S0360-3016(00)00421-1.
Article
CAS
PubMed
Google Scholar
Barth RF, Yang W, Rotaru JH, Moeschberger ML, Joel DD, Nawrocky MM, Goodman JH, Soloway AH: Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption. Cancer Res. 1997, 57: 1129-1136.
CAS
PubMed
Google Scholar
Yang W, Barth RF, Adams DM, Ciesielski MJ, Fenstermaker RA, Shukla S, Tjarks W, Caligiuri MA: Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas. Cancer Res. 2002, 62: 6552-6558.
CAS
PubMed
Google Scholar
Kato I, Fujita Y, Maruhashi A, Kumada H, Ohmae M, Kirihata M, Imahori Y, Suzuki M, Sakrai Y, Sumi T, Iwai S, Nakazawa M, Murata I, Miyamaru H, Ono K: Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies. Appl Radiat Isot. 2009, 67: S37-S42. 10.1016/j.apradiso.2009.03.103.
Article
CAS
PubMed
Google Scholar
Barth RF, Kaur B: Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas. J Neurooncol. 2009, 94: 299-312. 10.1007/s11060-009-9875-7.
Article
PubMed
PubMed Central
Google Scholar
Kawabata S, Miyatake S, Nonoguchi N, Hiramatsu R, Iida K, Miyata S, Yokoyama K, Doi A, Kuroda Y, Kuroiwa T, Michiue H, Kumada H, Kirihata M, Imahori Y, Maruhashi A, Sakurai Y, Suzuki M, Masunaga S, Ono K: Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients. Appl Radiat Isot. 2009, 67: S15-S18. 10.1016/j.apradiso.2009.03.015.
Article
CAS
PubMed
Google Scholar
Miyatake S, Kawabata S, Yokoyama K, Kuroiwa T, Michiue H, Sakurai Y, Kumada H, Suzuki M, Maruhashi A, Kirihata M, Ono K: Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas. J Neurooncol. 2009, 91: 199-206. 10.1007/s11060-008-9699-x.
Article
PubMed
Google Scholar
Gonzalez SJ, Bonomi MR, Santa CG, Blaumann HR, Calzetta LO, Menendez P, Jimenez RR, Longhino J, Feld DB, Dagrosa MA, Argerich C, Castiglia SG, Batistoni DA, Liberman SJ, Roth BM: First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome. Appl Radiat Isot. 2004, 61: 1101-1105. 10.1016/j.apradiso.2004.05.060.
Article
CAS
PubMed
Google Scholar
Yoshida F, Matsumura A, Shibata Y, Yamamoto T, Nakauchi H, Okumura M, Nose T: Cell cycle dependence of boron uptake from two boron compounds used for clinical neutron capture therapy. Cancer Lett. 2002, 187: 135-141. 10.1016/S0304-3835(02)00380-4.
Article
CAS
PubMed
Google Scholar
Masunaga S, Ono K, Takahashi A, Sakurai Y, Ohnishi K, Kobayashi T, Kinashi Y, Takagaki M, Ohnishi T: Impact of the p53 status of the tumor cells on the effect of reactor neutron beam irradiation, with emphasis on the response of intratumor quiescent cells. Jpn J Cancer Res. 2002, 93: 1366-1377.
Article
CAS
PubMed
Google Scholar
Masunaga S, Ono K, Sakurai Y, Takagaki M, Kobayashi T, Kinashi Y, Suzuki M: Evaluation of apoptosis and micronucleation induced by reactor neutron beams with two different cadmium ratios in total and quiescent cell populations within solid tumors. Int J Radiat Oncol Biol Phys. 2001, 51: 828-839. 10.1016/S0360-3016(01)01695-9.
Article
CAS
PubMed
Google Scholar
Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, Shawver LK, Arteaga CL: Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J Biol Chem. 2000, 275: 6987-6995. 10.1074/jbc.275.10.6987.
Article
CAS
PubMed
Google Scholar
Barth RF, Soloway AH, Goodman JH, Gahbauer RA, Gupta N, Blue TE, Yang W, Tjarks W: Boron neutron capture therapy of brain tumors: an emerging therapeutic modality. Neurosurgery. 1999, 44: 433-450. 10.1097/00006123-199903000-00001. 450-451
Article
CAS
PubMed
Google Scholar
Verheij M, Bartelink H: Radiation-induced apoptosis. Cell Tissue Res. 2000, 301: 133-142. 10.1007/s004410000188.
Article
CAS
PubMed
Google Scholar
Pathak R, Dey SK, Sarma A, Khuda-Bukhsh AR: Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to 7Li-beam (LET = 60 keV/microm) and correlation of their survival dynamics to nuclear damages and cell death. Mutat Res. 2007, 628: 56-66.
Article
CAS
PubMed
Google Scholar
Lee HJ, Kim JS, Moon C, Kim JC, Jo SK, Kim SH: Relative biological effectiveness of fast neutrons in a multiorgan assay for apoptosis in mouse. Environ Toxicol. 2008, 23: 233-239. 10.1002/tox.20328.
Article
CAS
PubMed
Google Scholar
Dahlstrom M, Capala J, Lindstrom P, Wasteson A, Lindstrom A: Accumulation of boron in human malignant glioma cells in vitro is cell type dependent. J Neurooncol. 2004, 68: 199-205. 10.1023/B:NEON.0000033489.54011.6b.
Article
PubMed
Google Scholar
Fujita Y, Kato I, Iwai S, Ono K, Suzuki M, Sakurai Y, Ohnishi K, Ohnishi T, Yura Y: Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma. Radiat Oncol. 2009, 4: 63-10.1186/1748-717X-4-63.
Article
PubMed
PubMed Central
Google Scholar
Aromando RF, Heber EM, Trivillin VA, Nigg DW, Schwint AE, Itoiz ME: Insight into the mechanisms underlying tumor response to boron neutron capture therapy in the hamster cheek pouch oral cancer model. J Oral Pathol Med. 2009, 38: 448-454. 10.1111/j.1600-0714.2008.00720.x.
Article
PubMed
Google Scholar
Kamida A, Obayashi S, Kato I, Ono K, Suzuki M, Nagata K, Sakurai Y, Yura Y: Effects of boron neutron capture therapy on human oral squamous cell carcinoma in a nude mouse model. Int J Radiat Biol. 2006, 82: 21-29. 10.1080/09553000600570453.
Article
CAS
PubMed
Google Scholar
Kang MH, Reynolds CP: Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 2009, 15: 1126-1132. 10.1158/1078-0432.CCR-08-0144.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH: An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005, 435: 677-681. 10.1038/nature03579.
Article
CAS
PubMed
Google Scholar
Hotchkiss RS, Strasser A, McDunn JE, Swanson PE: Cell death. N Engl J Med. 2009, 361: 1570-1583. 10.1056/NEJMra0901217.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zerp SF, Stoter R, Kuipers G, Yang D, Lippman ME, van Blitterswijk WJ, Bartelink H, Rooswinkel R, Lafleur V, Verheij M: AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. Radiat Oncol. 2009, 4: 47-10.1186/1748-717X-4-47.
Article
PubMed
PubMed Central
Google Scholar
Ciardiello F, Tortora G: Inhibition of bcl-2 as cancer therapy. Ann Oncol. 2002, 13: 501-502. 10.1093/annonc/mdf191.
Article
CAS
PubMed
Google Scholar
Kim KW, Moretti L, Mitchell LR, Jung DK, Lu B: Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model. Clin Cancer Res. 2009, 15: 6096-6105. 10.1158/1078-0432.CCR-09-0589.
Article
CAS
PubMed
PubMed Central
Google Scholar
Snyder CM, Shroff EH, Liu J, Chandel NS: Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. PLoS One. 2009, 4: e7059-10.1371/journal.pone.0007059.
Article
PubMed
PubMed Central
Google Scholar
Capuani S, Gili T, Bozzali M, Russo S, Porcari P, Cametti C, Muolo M, D'Amore E, Maraviglia B, Lazzarino G, Pastore FS: Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading. Appl Radiat Isot. 2009, 67: S34-S36. 10.1016/j.apradiso.2009.03.017.
Article
CAS
PubMed
Google Scholar
Barth RF, Yang W, Wu G, Swindall M, Byun Y, Narayanasamy S, Tjarks W, Tordoff K, Moeschberger ML, Eriksson S, Binns PJ, Riley KJ: Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors. Proc Natl Acad Sci USA. 2008, 105: 17493-17497. 10.1073/pnas.0809569105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Coderre JA, Gavin PR, Capala J, Ma R, Morris GM, Button TM, Aziz T, Peress NS: Tolerance of the normal canine brain to epithermal neutron irradiation in the presence of p-boronophenylalanine. J Neurooncol. 2000, 48: 27-40. 10.1023/A:1006419210584.
Article
CAS
PubMed
Google Scholar