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  1. Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and ...

    Authors: Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy and Fuyuhiko Tamanoi
    Citation: BMC Cancer 2013 13:198
    Content type: Research article Published on:

  2. Tumor-associated macrophages (TAM) promote malignant progression, yet the repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to analyze which EGFR- and STAT3-activating fac...

    Authors: Philip Vlaicu, Philipp Mertins, Thomas Mayr, Peter Widschwendter, Beyhan Ataseven, Bernhard Högel, Wolfgang Eiermann, Pjotr Knyazev and Axel Ullrich
    Citation: BMC Cancer 2013 13:197
    Content type: Research article Published on:

  3. The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, ...

    Authors: Bilal Alaiyan, Nadia Ilyayev, Alexander Stojadinovic, Mina Izadjoo, Marina Roistacher, Vera Pavlov, Victoria Tzivin, David Halle, Honguang Pan, Barry Trink, Ali O Gure and Aviram Nissan
    Citation: BMC Cancer 2013 13:196
    Content type: Research article Published on:

  4. Prostate cancer (PCa) is the second leading cause of cancer deaths in men in the United States. The prostate-specific antigen (PSA), often found at high levels in the serum of PCa patients, has been used as a ...

    Authors: Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus and Manuel L Penichet
    Citation: BMC Cancer 2013 13:195
    Content type: Research article Published on:

  5. Pancreatic cancer remains one of the deadliest cancers due to lack of early detection and absence of effective treatments. Gemcitabine, the current standard-of-care chemotherapy for pancreatic cancer, has limi...

    Authors: Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks and C Max Schmidt
    Citation: BMC Cancer 2013 13:194
    Content type: Research article Published on:

  7. Overexpression of ubiquitin-conjugating enzyme 2C (UBE2C) has been detected in many types of human cancers, and is correlated with tumor malignancy. However, the role of UBE2C in human nasopharyngeal carcinoma...

    Authors: Zhihua Shen, Xiaofan Jiang, Chao Zeng, Shaojiang Zheng, Botao Luo, Yumei Zeng, Ranran Ding, Hanguo Jiang, Qiyi He, Junli Guo and Wei Jie
    Citation: BMC Cancer 2013 13:192
    Content type: Research article Published on:

  8. The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. However, little...

    Authors: Masao Honda, Taro Yamashita, Tatsuya Yamashita, Kuniaki Arai, Yoshio Sakai, Akito Sakai, Mikiko Nakamura, Eishiro Mizukoshi and Shuichi Kaneko
    Citation: BMC Cancer 2013 13:191
    Content type: Research article Published on:

  9. Surgery is a curative treatment for patients with locally advanced colon cancer, but recurrences are frequent for those with stage III disease. FOLFOX adjuvant chemotherapy has been shown to improve recurrence...

    Authors: Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried, Ahmad Awada, Martine Piccart…
    Citation: BMC Cancer 2013 13:190
    Content type: Study protocol Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:173

  11. Communication about prognosis and treatment choices is essential for informed decision making in advanced cancer. This article describes an investigation designed to facilitate communication and decision makin...

    Authors: Michael Hoerger, Ronald M Epstein, Paul C Winters, Kevin Fiscella, Paul R Duberstein, Robert Gramling, Phyllis N Butow, Supriya G Mohile, Paul R Kaesberg, Wan Tang, Sandy Plumb, Adam Walczak, Anthony L Back, Daniel Tancredi, Alison Venuti, Camille Cipri…
    Citation: BMC Cancer 2013 13:188
    Content type: Study protocol Published on:

  12. Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline ...

    Authors: Juliana Giacomazzi, Simone Selistre, Juliana Duarte, Jorge Pinto Ribeiro, Paulo JC Vieira, Gabriel de Souza Macedo, Cristina Rossi, Mauro Czepielewski, Cristina Brinkmann Oliveira Netto, Pierre Hainaut and Patricia Ashton-Prolla
    Citation: BMC Cancer 2013 13:187
    Content type: Case report Published on:

  13. Several human cancers are known to be associated with inflammation and/or viral infections. However, the influence of tumour-related inflammation on viral uptake is largely unknown. In this study we used oesop...

    Authors: Georgia Schäfer, Siti Kabanda, Beverly van Rooyen, Martina Bergant Marušič, Lawrence Banks and M Iqbal Parker
    Citation: BMC Cancer 2013 13:185
    Content type: Research article Published on:

  14. Ultra-conserved regions (UCRs) are segments of the genome (≥ 200 bp) that exhibit 100% DNA sequence conservation between human, mouse and rat. Transcribed UCRs (T-UCRs) have been shown to be differentially exp...

    Authors: Karen M Watters, Kenneth Bryan, Niamh H Foley, Maria Meehan and Raymond L Stallings
    Citation: BMC Cancer 2013 13:184
    Content type: Research article Published on:

  15. The EGFR 3′ untranslated region (UTR) harbors a polyadenine repeat which is polymorphic (A13/A14) and undergoes somatic deletions in microsatellite instability (MSI) colorectal cancer (CRC). These mutations could...

    Authors: Nasrin Sarafan-Vasseur, David Sefrioui, David Tougeron, Aude Lamy, France Blanchard, Florence Le Pessot, Frédéric Di Fiore, Pierre Michel, Stéphane Bézieau, Jean-Baptiste Latouche, Thierry Frebourg and Richard Sesboüé
    Citation: BMC Cancer 2013 13:183
    Content type: Research article Published on:

  16. Previously some groups demonstrated that CD44 variant 6 (CD44v6) is correlated with progression and metastasis of ovarian cancer. However, a number of other groups failed to find such an association. Moreover,...

    Authors: Jun Shi, Zhou Zhou, Wen Di and Ningli Li
    Citation: BMC Cancer 2013 13:182
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Cancer 2020 20:236

  17. Hyaluronan is an extracellular matrix glycosaminoglycan involved in invasion, proliferation and metastasis of various types of carcinomas. In many cancers, aberrant hyaluronan expression implicates disease pro...

    Authors: Siiskonen Hanna, Poukka Mari, Tyynelä-Korhonen Kristiina, Sironen Reijo and Pasonen-Seppänen Sanna
    Citation: BMC Cancer 2013 13:181
    Content type: Research article Published on:

  18. In addition to possess cross drug resistance characteristic, emerging evidences have shown that multiple-drug resistance (MDR) cancer cells exhibit aberrant metastatic capacity when compared to parental cells....

    Authors: Xia Zhan, Xiaobing Feng, Ying Kong, Yi Chen and Wenfu Tan
    Citation: BMC Cancer 2013 13:180
    Content type: Research article Published on:

  19. Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while not abrogating the efficacy of radiothera...

    Authors: Ralph Pietrofesa, Jason Turowski, Sonia Tyagi, Floyd Dukes, Evguenia Arguiri, Theresa M Busch, Shannon M Gallagher-Colombo, Charalambos C Solomides, Keith A Cengel and Melpo Christofidou-Solomidou
    Citation: BMC Cancer 2013 13:179
    Content type: Research article Published on:

  20. The immune system is a key player in fighting cancer. Thus, we sought to identify a molecular ‘immune response signature’ indicating the presence of epithelial ovarian cancer (EOC) and to combine this with a s...

    Authors: Dietmar Pils, Dan Tong, Gudrun Hager, Eva Obermayr, Stefanie Aust, Georg Heinze, Maria Kohl, Eva Schuster, Andrea Wolf, Jalid Sehouli, Ioana Braicu, Ignace Vergote, Toon Van Gorp, Sven Mahner, Nicole Concin, Paul Speiser…
    Citation: BMC Cancer 2013 13:178
    Content type: Research article Published on:

  21. Leukocytes play an important role in cancer development. However, the impact of chemotherapy-associated neutropenia/lymphopenia on the prognosis of adjuvant chemotherapy is unknown. Here, we aimed to explore t...

    Authors: Hong Chu-Yuan, Peng Jing, Wei Yi-Sheng, Peng He-Ping, Yang Hui, Zhao Chu-Xiong, Liang Guo-Jian and Wang Guo-Qiang
    Citation: BMC Cancer 2013 13:177
    Content type: Research article Published on:

  22. Chemotherapeutic treatment of hepatocellular carcinoma often leads to chemoresistance during therapy or upon relapse of tumors. For the development of better treatments a better understanding of biochemical ch...

    Authors: Christian Marfels, Miriam Hoehn, Ernst Wagner and Michael Günther
    Citation: BMC Cancer 2013 13:176
    Content type: Research article Published on:

  23. Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as ...

    Authors: Patrick C O´Leary, Sarah A Penny, Roisin T Dolan, Catherine M Kelly, Stephen F Madden, Elton Rexhepaj, Donal J Brennan, Amanda H McCann, Fredrik Pontén, Mathias Uhlén, Radoslaw Zagozdzon, Michael J Duffy, Malcolm R Kell, Karin Jirström and William M Gallagher
    Citation: BMC Cancer 2013 13:175
    Content type: Research article Published on:

  24. Acquired resistance to Tamoxifen remains a critical problem in breast cancer patient treatment, yet the underlying causes of resistance have not been fully elucidated. Abberations in the Wnt signalling pathway...

    Authors: Yan Ni Loh, Ellen L Hedditch, Laura A Baker, Eve Jary, Robyn L Ward and Caroline E Ford
    Citation: BMC Cancer 2013 13:174
    Content type: Research article Published on:

  25. We evaluated BCR-ABL1 kinetics in patients treated with nilotinib and analyzed whether a dynamic model of changes in BCR-ABL1 levels over time could be used to predict long-term responses.

    Authors: Andrew M Stein, Giovanni Martinelli, Timothy P Hughes, Martin C Müller, Lan Beppu, Enrico Gottardi, Susan Branford, Simona Soverini, Richard C Woodman, Andreas Hochhaus, Dong-Wook Kim, Giuseppe Saglio and Jerald P Radich
    Citation: BMC Cancer 2013 13:173
    Content type: Research article Published on:

  26. Lipids A, the lipophilic partial structure of lipopolysaccharides, induce regression of several tumor types in animal models. Rather than exerting direct cytotoxic effect, these compounds trigger the immune sy...

    Authors: Nicolas Isambert, Pierre Fumoleau, Catherine Paul, Christophe Ferrand, Sylvie Zanetta, Jacques Bauer, Kevin Ragot, Gérard Lizard, Jean-François Jeannin and Marc Bardou
    Citation: BMC Cancer 2013 13:172
    Content type: Research article Published on:

  27. Tissue invasion and metastasis are acquired abilities of cancer and related to the death in oral squamous cell carcinoma (OSCC). Emerging observations indicate that the epithelial-to-mesenchymal transition (EM...

    Authors: Cong-Chong Yang, Li-Fang Zhu, Xiao-Hui Xu, Tian-Yun Ning, Jin-Hai Ye and Lai-Kui Liu
    Citation: BMC Cancer 2013 13:171
    Content type: Research article Published on:

  28. Advanced or metastatic renal cell carcinoma (RCC) has a poor prognosis, because it is relatively resistant to conventional chemotherapy or radiotherapy. Treatments with human interferon-α2b alone or in combina...

    Authors: Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg and Chien-Hsing Chang
    Citation: BMC Cancer 2013 13:170
    Content type: Research article Published on:

  29. KRAS is an EGFR effector in the RAS/RAF/ERK cascade that is mutated in about 40% of metastatic colorectal cancer (mCRC). Activating mutations in codons 12 and 13 of the KRAS gene are the only established negative...

    Authors: Joana G Guedes, Isabel Veiga, Patrícia Rocha, Pedro Pinto, Carla Pinto, Manuela Pinheiro, Ana Peixoto, Maria Fragoso, Ana Raimundo, Paula Ferreira, Manuela Machado, Nuno Sousa, Paula Lopes, António Araújo, Joana Macedo, Fernando Alves…
    Citation: BMC Cancer 2013 13:169
    Content type: Research article Published on:

  30. Belinostat is a histone deacetylase inhibitor with anti-tumor effect in several pre-clinical tumor models and clinical trials. The aim of the study was to evaluate changes in cell proliferation and glucose upt...

    Authors: Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard and Andreas Kjær
    Citation: BMC Cancer 2013 13:168
    Content type: Research article Published on:

  31. UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, has attracted a great deal of attention as a potent antitumour agent. Several clinical trials of UCN-01 alone or in combination with other agents fo...

    Authors: Guoyi Wu, Linan Xu, Nan Lin and Bo Liu
    Citation: BMC Cancer 2013 13:167
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2014 14:216

  32. Cancer stem cells (CSCs) are notorious for their capacity of tumor progression, metastasis or resistance to chemo-radiotherapy. However, the undisputed role of cancer stem marker, CD133, in colorectal cancers ...

    Authors: Khalilullah Mia-Jan, So Young Jung, Ik-Yong Kim, Sung Soo Oh, EunHee Choi, Sei Jin Chang, Tae Young Kang and Mee-Yon Cho
    Citation: BMC Cancer 2013 13:166
    Content type: Research article Published on:

  33. Clinical interpretation of health related quality of life (HRQOL) scores is challenging. The purpose of this analysis was to interpret score changes and identify minimal clinically important differences (MCID)...

    Authors: Fanxing Hong, Jaclyn L F Bosco, Nigel Bush and Donna L Berry
    Citation: BMC Cancer 2013 13:165
    Content type: Research article Published on:

  34. This open-label study compared docetaxel/gemcitabine vs. paclitaxel/gemcitabine and a weekly (W) vs. 3-weekly (3 W) schedule in metastatic breast cancer (MBC).

    Authors: Lucia Del Mastro, Alessandra Fabi, Mauro Mansutti, Michele De Laurentiis, Antonio Durando, Domenico Franco Merlo, Paolo Bruzzi, Ignazia La Torre, Matteo Ceccarelli, Gbenga Kazeem, Paolo Marchi, Davide Boy, Marco Venturini, Sabino De Placido and Francesco Cognetti
    Citation: BMC Cancer 2013 13:164
    Content type: Research article Published on:

  35. The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has be...

    Authors: George Fountzilas, Urania Dafni, Mattheos Bobos, Vassiliki Kotoula, Anna Batistatou, Ioannis Xanthakis, Christos Papadimitriou, Ioannis Kostopoulos, Triantafillia Koletsa, Eleftheria Tsolaki, Despina Televantou, Eleni Timotheadou, Angelos Koutras, George Klouvas, Epaminontas Samantas, Nikolaos Pisanidis…
    Citation: BMC Cancer 2013 13:163
    Content type: Research article Published on:

  36. Cancer-related fatigue (CRF) is one of the most common and distressing side effects of cancer and its treatment. During and after radiotherapy breast cancer patients often suffer from CRF which frequently impa...

    Authors: Karin Potthoff, Martina E Schmidt, Joachim Wiskemann, Holger Hof, Oliver Klassen, Nina Habermann, Philipp Beckhove, Juergen Debus, Cornelia M Ulrich and Karen Steindorf
    Citation: BMC Cancer 2013 13:162
    Content type: Study protocol Published on:

  37. Differential diagnosis of high-grade dysplastic nodules (HGDN) and well-differentiated hepatocellular carcinoma (WDHCC) represents a challenge to experienced hepatic clinicians, radiologists and hepatopatholog...

    Authors: Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong and Meng-Chao Wu
    Citation: BMC Cancer 2013 13:161
    Content type: Research article Published on:

  38. Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association studie...

    Authors: Maria Peña-Chilet, Maite Blanquer-Maceiras, Maider Ibarrola-Villava, Conrado Martinez-Cadenas, Manuel Martin-Gonzalez, Cristina Gomez-Fernandez, Matias Mayor, Juan Antonio Aviles, Ana Lluch and Gloria Ribas
    Citation: BMC Cancer 2013 13:160
    Content type: Research article Published on:

  40. Systemic inflammation has been linked with cancer development, cancer cachexia and poor outcome. Advanced lung cancer inflammation index (ALI) was developed to assess degree of systemic inflammation at the tim...

    Authors: Syed H Jafri, Runhua Shi and Glenn Mills
    Citation: BMC Cancer 2013 13:158
    Content type: Research article Published on:

  42. L1CAM was originally identified as an adhesion molecule involved in neural development. In many human carcinomas L1CAM is over-expressed and is associated with a bad prognosis. We previously reported that L1CA...

    Authors: Uwe Schirmer, Heidi Fiegl, Marco Pfeifer, Alain G Zeimet, Elisabeth Müller-Holzner, Peter K Bode, Verena Tischler and Peter Altevogt
    Citation: BMC Cancer 2013 13:156
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:1047

  43. 53BP1 binds to the tumor suppressor p53 and has a key role in DNA damage response and repair. Low 53BP1 expression has been associated with decreased survival in breast cancer and has been shown to interact wi...

    Authors: Natalie L Ausborn, Tong Wang, Sabrina C Wentz, Mary Kay Washington, Nipun B Merchant, Zhiguo Zhao, Yu Shyr, Anuradha Bapsi Chakravarthy and Fen Xia
    Citation: BMC Cancer 2013 13:155
    Content type: Research article Published on:

  44. Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resi...

    Authors: Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin and Malin Sund
    Citation: BMC Cancer 2013 13:154
    Content type: Research article Published on:

  45. Besides conventional adjuvant therapies, many breast cancer survivors engage in various activities like exercise, diet and complementary and alternative medicine (CAM) in order to improve their prognosis. Litt...

    Authors: Arnoud J Templeton, Beat Thürlimann, Michael Baumann, Michael Mark, Sarah Stoll, Madeleine Schwizer, Daniel Dietrich and Thomas Ruhstaller
    Citation: BMC Cancer 2013 13:153
    Content type: Research article Published on:

  46. This phase I study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of ganetespib in patients with solid malignancies.

    Authors: Jonathan W Goldman, Robert N Raju, Gregory A Gordon, Iman El-Hariry, Florentina Teofilivici, Vojo M Vukovic, Robert Bradley, Michael D Karol, Yu Chen, Wei Guo, Takayo Inoue and Lee S Rosen
    Citation: BMC Cancer 2013 13:152
    Content type: Research article Published on:

  47. To determine whether ceramide is responsible for the induction of p53-independent early or late apoptosis in response to high- and low-Linear-Energy-Transfer (LET) irradiation.

    Authors: Gersende Alphonse, Mira Maalouf, Priscillia Battiston-Montagne, Dominique Ardail, Michaël Beuve, Robert Rousson, Gisela Taucher-Scholz, Claudia Fournier and Claire Rodriguez-Lafrasse
    Citation: BMC Cancer 2013 13:151
    Content type: Research article Published on:

  48. The insulin-like growth factor-1 (IGF-1) plays an important role in growth of prostate cancer (PCa) cells and facilitating the development and progression of PCa. This study aimed to evaluate the association o...

    Authors: Norihiko Tsuchiya, Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Kazuyuki Numakura, Mingguo Huang, Shingo Hatakeyama, Shigeru Satoh, Seiichi Saito, Chikara Ohyama, Yoichi Arai, Osamu Ogawa and Tomonori Habuchi
    Citation: BMC Cancer 2013 13:150
    Content type: Research article Published on:

  49. Adjuvant chemotherapy for stage III colon cancer is internationally accepted as standard treatment with established efficacy. Several oral fluorouracil (5-FU) derivatives with different properties are availabl...

    Authors: Megumi Ishiguro, Kenjiro Kotake, Genichi Nishimura, Naohiro Tomita, Wataru Ichikawa, Keiichi Takahashi, Toshiaki Watanabe, Tomohisa Furuhata, Ken Kondo, Masaki Mori, Yoshihiro Kakeji, Akiyoshi Kanazawa, Michiya Kobayashi, Masazumi Okajima, Ichinosuke Hyodo, Keiko Miyakoda…
    Citation: BMC Cancer 2013 13:149
    Content type: Study protocol Published on:

  50. Aberrant chromatin structure in cancer cells results from altered proteins involved in its packaging. Heterochromatin protein 1 gamma (HP1γ) is a non-histone heterochromatic protein that functions to maintain ...

    Authors: Jon Slezak, Matthew Truong, Wei Huang and David Jarrard
    Citation: BMC Cancer 2013 13:148
    Content type: Research article Published on:

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