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  1. Stereotactic body radiation therapy (SBRT) has emerged as an alternative treatment for patients with early stage non-small cell lung cancer (NSCLC) or metastatic pulmonary tumors. However, for isolated lung me...

    Authors: Weijie Xiong, Qingfeng Xu, Yong Xu, Changjin Sun, Na Li, Lin Zhou, Yongmei Liu, Xiaojuan Zhou, Yongsheng Wang, Jin Wang, Sen Bai, You Lu and Youling Gong
    Citation: BMC Cancer 2014 14:719
    Content type: Research article Published on:

  2. Glioblastoma is a highly malignant brain tumor for which no cure is available. To identify new therapeutic targets, we performed a mutation analysis of kinase genes in glioblastoma.

    Authors: Fonnet E Bleeker, Simona Lamba, Carlo Zanon, Remco J Molenaar, Theo JM Hulsebos, Dirk Troost, Angela A van Tilborg, W Peter Vandertop, Sieger Leenstra, Cornelis JF van Noorden and Alberto Bardelli
    Citation: BMC Cancer 2014 14:718
    Content type: Research article Published on:

  3. Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase causes a mixed or hybrid form of concurrent a...

    Authors: Dongdong Chen, Mingke Song, Osama Mohamad and Shan Ping Yu
    Citation: BMC Cancer 2014 14:716
    Content type: Research article Published on:

  4. Variation in tumor biology in African-American (AA) and Caucasian (CAU) women with breast cancer is poorly defined. Activated leukocyte cell adhesion molecule (ALCAM) is a bad prognostic factor of breast cance...

    Authors: Fang Tan, Marina Mosunjac, Amy L Adams, Beverly Adade, Oleyad Taye, Yijuan Hu, Monica Rizzo and Solomon F Ofori-Acquah
    Citation: BMC Cancer 2014 14:715
    Content type: Research article Published on:

  5. MicroRNAs (miRNAs) offer great potential as cancer biomarkers. The importance of miRNAs profiling in tissue and body fluids in colorectal cancer (CRC) have been addressed respectively in many studies. The purp...

    Authors: Lingling Xu, Minzhe Li, Min Wang, Dong Yan, Guosheng Feng and Guangyu An
    Citation: BMC Cancer 2014 14:714
    Content type: Research article Published on:

  6. Transduction of human mesenchymal stem cells (MSCs) with type 5 adenoviruses (Ad5) is limited in the efficacy because of the poor expression level of the coxsackie adenovirus receptor (CAR) molecules. We exami...

    Authors: Takeo Suzuki, Kiyoko Kawamura, Quanhai Li, Shinya Okamoto, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi and Masatoshi Tagawa
    Citation: BMC Cancer 2014 14:713
    Content type: Research article Published on:

  7. It is estimated that 20% of all cancer cases are caused by obesity. Vitamin D is thought to be one of the mechanisms underlying this association. This review aims to summarise the evidence for the mediating ef...

    Authors: Thurkaa Shanmugalingam, Danielle Crawley, Cecilia Bosco, Jennifer Melvin, Sabine Rohrmann, Simon Chowdhury, Lars Holmberg and Mieke Van Hemelrijck
    Citation: BMC Cancer 2014 14:712
    Content type: Research article Published on:

  8. After breast-conserving radiation therapy most patients experience acute skin toxicity to some degree. This may impair patients’ quality of life, cause pain and discomfort. In this study, we investigated treat...

    Authors: Sofie De Langhe, Thomas Mulliez, Liv Veldeman, Vincent Remouchamps, Annick van Greveling, Monique Gilsoul, Eline De Schepper, Kim De Ruyck, Wilfried De Neve and Hubert Thierens
    Citation: BMC Cancer 2014 14:711
    Content type: Research article Published on:

  10. Patients with malignant mesothelioma have a poor prognosis and only 40% respond to first line treatment; a combination of pemetrexed and cisplatin or carboplatin. We used primary malignant mesothelioma cells a...

    Authors: Adam Szulkin, Rita Ötvös, Carl-Olof Hillerdal, Aytekin Celep, Eviane Yousef-Fadhel, Henriette Skribek, Anders Hjerpe, László Székely and Katalin Dobra
    Citation: BMC Cancer 2014 14:709
    Content type: Research article Published on:

  11. Dysregulation of transcriptional programs leads to cell malfunctioning and can have an impact in cancer development. Our study aims to characterize global differences between transcriptional regulatory program...

    Authors: David Cordero, Xavier Solé, Marta Crous-Bou, Rebeca Sanz-Pamplona, Laia Paré-Brunet, Elisabet Guinó, David Olivares, Antonio Berenguer, Cristina Santos, Ramón Salazar, Sebastiano Biondo and Víctor Moreno
    Citation: BMC Cancer 2014 14:708
    Content type: Research article Published on:

  12. Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. No previous study has investigated t...

    Authors: Qian Xiao, Linda Liao, Charles E Matthews, Wong-Ho Chow, Faith Davis, Kendra Schwartz, Mark Purdue, Jonathan N Hofmann and Joanne Colt
    Citation: BMC Cancer 2014 14:707
    Content type: Research article Published on:

  13. Chemoradiotherapy (CRT) is an effective modality for stage I esophageal squamous cell carcinoma (ESCC). However, salvage treatments are often required even if complete response (CR) has been achieved. To this ...

    Authors: Yoshito Hayashi, Tsutomu Nishida, Masahiko Tsujii, Shusaku Tsutsui, Katsumi Yamamoto, Fumiaki Isohashi, Makoto Yamasaki, Hiroshi Miyata, Motohiko Kato, Takuya Yamada, Shinichiro Shinzaki, Hideki Iijima, Kazuhiko Ogawa, Yuichiro Doki and Tetsuo Takehara
    Citation: BMC Cancer 2014 14:706
    Content type: Research article Published on:

  15. Disorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7 was found to inhibit E-cadherin expression in MDCK cells and play imp...

    Authors: Chuifeng Fan, Yuan Miao, Xiupeng Zhang, Di Liu, Guiyang Jiang, Xuyong Lin, Qiang Han, Lan Luan, Zhonghai Xu and Enhua Wang
    Citation: BMC Cancer 2014 14:704
    Content type: Research article Published on:

  17. Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of content...

    Authors: Romano Demicheli and Federico Ambrogi
    Citation: BMC Cancer 2014 14:702
    Content type: Research article Published on:

  18. Ductal carcinomas of the parotid gland are rare, highly aggressive, have a poor prognosis and are histologically similar to Ductal Breast Cancer. We report what we believe to be the first case in literature of...

    Authors: Saúl Campos-Gómez, Jose H Flores-Arredondo, Rita Dorantes-Heredia, Mónica Chapa-Ibargüengoitia and Roberto de la Peña-Lopez
    Citation: BMC Cancer 2014 14:701
    Content type: Case report Published on:

  19. The population of elderly people is increasing and so is the population of breast cancer patients aged ≥80 years. The aim of our retrospective study was to identify independent prognostic factors for the durat...

    Authors: Nikola Besic, Hana Besic, Barbara Peric, Gasper Pilko, Rok Petric, Jan Zmuc, Radan Dzodic and Andraz Perhavec
    Citation: BMC Cancer 2014 14:700
    Content type: Research article Published on:

  20. Aptamers have emerged as excellent molecular probes for cancer diagnosis and therapy. The aim of the current study was to determine the feasibility of using DNA aptamer cy-apt 20 developed by live cell-SELEX f...

    Authors: Hong-Yong Cao, Ai-Hua Yuan, Wei Chen, Xue-Song Shi and Yi Miao
    Citation: BMC Cancer 2014 14:699
    Content type: Research article Published on:

  21. Little aetiological epidemiological research has been undertaken for major cancers occurring in teenagers and young adults (TYA). Population mixing, as a possible proxy for infectious exposure, has been well r...

    Authors: Marlous van Laar, Daniel P Stark, Patricia McKinney, Roger C Parslow, Sally E Kinsey, Susan V Picton and Richard G Feltbower
    Citation: BMC Cancer 2014 14:698
    Content type: Research article Published on:

  22. Lung cancer remains one of the most prevalent forms of cancer. Radiotherapy, with or without other therapeutic modalities, is an effective treatment. Our objective was to report on the use of radiotherapy for ...

    Authors: Isabel Tovar, Jose Expósito, Javier Jaén, Enrique Alonso, Miguel Martínez, Rosa Guerrero, Juan P Arrebola and Rosario Del Moral
    Citation: BMC Cancer 2014 14:697
    Content type: Research article Published on:

  23. The aim of the study was to explore the serum levels of eight angiogenesis biomarkers in patients with benign, borderline or malignant epithelial ovarian neoplasms and to compare them to those of healthy contr...

    Authors: Hanna Sallinen, Tommi Heikura, Jonna Koponen, Veli-Matti Kosma, Seppo Heinonen, Seppo Ylä-Herttuala and Maarit Anttila
    Citation: BMC Cancer 2014 14:696
    Content type: Research article Published on:

  24. In Morocco, knowledge of cancer risk factors, a crucial element in the process of behavioral change, has never been evaluated. This study aims to provide information on the level of awareness of cancer risk fa...

    Authors: Karima El Rhazi, Bahia Bennani, Samira El Fakir, Ahmadou Boly, Rachid Bekkali, Ahmed Zidouh and Chakib Nejjari
    Citation: BMC Cancer 2014 14:695
    Content type: Research article Published on:

  25. Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The high mobility group A2 (HMGA2) protein was found to be highly expressed in human OSCC an...

    Authors: Katharina Anna Sterenczak, Andre Eckardt, Andreas Kampmann, Saskia Willenbrock, Nina Eberle, Florian Länger, Sven Kleinschmidt, Marion Hewicker-Trautwein, Hans Kreipe, Ingo Nolte, Hugo Murua Escobar and Nils Claudius Gellrich
    Citation: BMC Cancer 2014 14:694
    Content type: Research article Published on:

  26. Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARα). Although PML-RARα is crucially important for pathogenesis...

    Authors: Chengwu Zeng, Yan Xu, Ling Xu, Xibao Yu, Jingjing Cheng, Lijian Yang, Shaohua Chen and Yangqiu Li
    Citation: BMC Cancer 2014 14:693
    Content type: Research article Published on:

  27. Radiotherapy is an important treatment strategy for head and neck cancers. Tumor hypoxia and repopulation adversely affect the radiotherapy outcome. Accordingly, fractionated radiotherapy with dose escalation ...

    Authors: Chowdhury Nusrat Fatema, Songji Zhao, Yan Zhao, Wenwen Yu, Ken-ichi Nishijima, Koichi Yasuda, Yoshimasa Kitagawa, Nagara Tamaki and Yuji Kuge
    Citation: BMC Cancer 2014 14:692
    Content type: Research article Published on:

  28. Paraneoplastic neurological syndromes (PNS) have frequently been described in patients with lung or breast cancer. However, some reports also described a correlation to carcinoid tumors, probably triggered via...

    Authors: Michael Boch, Anja Rinke, Peter Rexin, Maria Seipelt, Dörte Brödje, Marvin Schober, Thomas M Gress, Patrick Michl and Sebastian Krug
    Citation: BMC Cancer 2014 14:691
    Content type: Case report Published on:

  29. Metastatic breast cancer has consistently been viewed as a non-curable disease. Specific palliative treatments such as chemotherapy and hormone therapy have resulted in a mean overall survival of approximately...

    Authors: Erika Viel, Flavie Arbion, Catherine Barbe and Philippe Bougnoux
    Citation: BMC Cancer 2014 14:690
    Content type: Case report Published on:

  30. Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research s...

    Authors: Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan and Weidong Zhang
    Citation: BMC Cancer 2014 14:689
    Content type: Research article Published on:

  31. Ovarian cancer (OVCA) is the leading cause of death from gynecological cancer, with poorer survival for African American (AA) women compared to whites. However, little is known about risk factors for OVCA in A...

    Authors: Joellen M Schildkraut, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michelle L Cote, Ellen Funkhouser, Edward Peters, Ann G Schwartz, Paul Terry, Kristin Wallace, Lucy Akushevich, Frances Wang, Sydnee Crankshaw and Patricia G Moorman
    Citation: BMC Cancer 2014 14:688
    Content type: Research article Published on:

  32. Cancer stem cells (CSCs) have been reported to play an important role in chemoradiation resistance. Although the association of CSC markers with clinicopathological outcomes after neoadjuvant chemoradiotherapy...

    Authors: Tatsuzo Mizukami, Hirofumi Kamachi, Tomoko Mitsuhashi, Yosuke Tsuruga, Yutaka Hatanaka, Toshiya Kamiyama, Yoshihiro Matsuno and Akinobu Taketomi
    Citation: BMC Cancer 2014 14:687
    Content type: Research article Published on:

  33. Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, an...

    Authors: Jiangbo Liu, Jiguang Ma, Zheng Wu, Wei Li, Dong Zhang, Liang Han, Fengfei Wang, Katie M Reindl, Erxi Wu and Qingyong Ma
    Citation: BMC Cancer 2014 14:686
    Content type: Research article Published on:

  34. About 10-15% of adult gastrointestinal stromal tumors (GIST) and the vast majority of pediatric GIST do not harbour KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations (J Clin Oncol 22:3813–38...

    Authors: Margherita Nannini, Annalisa Astolfi, Milena Urbini, Valentina Indio, Donatella Santini, Michael C Heinrich, Christopher L Corless, Claudio Ceccarelli, Maristella Saponara, Anna Mandrioli, Cristian Lolli, Giorgio Ercolani, Giovanni Brandi, Guido Biasco and Maria A Pantaleo
    Citation: BMC Cancer 2014 14:685
    Content type: Research article Published on:

  35. Recent advances have shown that histology and genetic biomarkers are important in patient selection, which have led to significantly better outcomes for lung cancer patients. However, most new treatments only ...

    Authors: Jin-Ji Yang, Cheng Huang, Gong-Yan Chen, Yong Song, Ying Cheng, Hong-Hong Yan, Qing Zhou and Yi-Long Wu
    Citation: BMC Cancer 2014 14:684
    Content type: Study protocol Published on:

  36. Crizotinib was granted accelerated approval by the Food and Drug Administration in 2011 for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). To evaluate the effica...

    Authors: Haili Qian, Feng Gao, Haijuan Wang and Fei Ma
    Citation: BMC Cancer 2014 14:683
    Content type: Research article Published on:

  37. Cancer-specific survival estimates rely on precise and correct data on the cause of death; however, these data can be difficult to acquire, particularly in elderly patients where comorbidity is common. Further...

    Authors: Katja Maretty-Nielsen, Ninna Aggerholm-Pedersen, Johnny Keller, Akmal Safwat, Steen Baerentzen and Alma B Pedersen
    Citation: BMC Cancer 2014 14:682
    Content type: Research article Published on:

  38. Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR b...

    Authors: Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray and Francis J Hornicek
    Citation: BMC Cancer 2014 14:681
    Content type: Research article Published on:

  39. Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral b...

    Authors: Jie Zhang, Deyang Li, Falin Qu, Yibing Chen, Gang Li, Hequn Jiang, Xiaojun Huang, Hushan Yang and Jinliang Xing
    Citation: BMC Cancer 2014 14:680
    Content type: Research article Published on:

  40. Oral tongue squamous cell carcinomas (TSCC) are a unique subset of head and neck cancers with a distinct demographic profile, where up to half of the cases are never smokers. A small proportion of patients wit...

    Authors: Daniel SW Tan, Weining Wang, Hui Sun Leong, Pui Hoon Sew, Dawn P Lau, Fui Teen Chong, Sai Sakktee Krisna, Tony KH Lim and N Gopalakrishna Iyer
    Citation: BMC Cancer 2014 14:679
    Content type: Research article Published on:

  41. miRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether and how it plays a role in the laryngeal carcinoma is unknown.

    Authors: Yuan Tian, Shuang Fu, Guang-Bin Qiu, Zhen-Ming Xu, Ning Liu, Xiao-Wen Zhang, Sheng Chen, Ye Wang, Kai-Lai Sun and Wei-Neng Fu
    Citation: BMC Cancer 2014 14:678
    Content type: Research article Published on:

  42. Bladder cancer is one of the most common cancers worldwide. Fibulin-1, a multi-functional extracellular matrix protein, has been demonstrated to be involved in many kinds of cancers, while its function in blad...

    Authors: Wei Xiao, Ji Wang, Heng Li, Ding Xia, Gan Yu, Weimin Yao, Yang Yang, Haibing Xiao, Bin Lang, Xin Ma, Xiaolin Guo, Wei Guan, Hua Xu, Jihong Liu, Xu Zhang and Zhangqun Ye
    Citation: BMC Cancer 2014 14:677
    Content type: Research article Published on:

  43. Lymphovascular invasion (LBVI) including lymphatic (LVI) and blood (BVI) vessel invasion is a critical step in cancer metastasis. In breast cancer, the optimal detection method of LBVI remains unclear. This re...

    Authors: Fadia J A Gujam, James J Going, Zahra M A Mohammed, Clare Orange, Joanne Edwards and Donald C McMillan
    Citation: BMC Cancer 2014 14:676
    Content type: Research article Published on:

  44. Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodr...

    Authors: Christopher A McGoldrick, Yu-Lin Jiang, Marianne Brannon, Koyamangalath Krishnan and William L Stone
    Citation: BMC Cancer 2014 14:675
    Content type: Research article Published on:

  45. Malignant mesothelioma (MM) carries a poor prognosis and response rates to palliative chemotherapy remain low. Identifying patients with MM that are unlikely to respond to chemotherapy could prevent futile tre...

    Authors: Mark Linch, Spyridon Gennatas, Stanislav Kazikin, Jhangir Iqbal, Ranga Gunapala, Kathryn Priest, Joanne Severn, Alison Norton, Bee Ayite, Jaishree Bhosle, Mary O’Brien and Sanjay Popat
    Citation: BMC Cancer 2014 14:674
    Content type: Research article Published on:

  46. Most biomarkers in prostate cancer have only been evaluated in surgical cohorts. The value of these biomarkers in a different therapy context remains unclear. Our objective was to test a panel of surgical biom...

    Authors: Naveen Kachroo, Anne Y Warren and Vincent J Gnanapragasam
    Citation: BMC Cancer 2014 14:673
    Content type: Research article Published on:

  47. Metastases-directed therapy (MDT) with surgery or stereotactic body radiotherapy (SBRT) is emerging as a new treatment option for prostate cancer (PCa) patients with a limited number of metastases (≤3) at recu...

    Authors: Karel Decaestecker, Gert De Meerleer, Filip Ameye, Valerie Fonteyne, Bieke Lambert, Steven Joniau, Louke Delrue, Ignace Billiet, Wim Duthoy, Sarah Junius, Wouter Huysse, Nicolaas Lumen and Piet Ost
    Citation: BMC Cancer 2014 14:671
    Content type: Study protocol Published on:

  49. Previously we have suggested that cancer cells develop a mechanism(s) which allows for either: silencing of the wild-type TP53 transcription, degradation of the wild-type TP53 mRNA, or selective overproduction of...

    Authors: Marta Winiecka-Klimek, Malgorzata Szybka, Piotr Rieske, Sylwester Piaskowski, Michal Bienkowski, Maciej Walczak, Marcin Pacholczyk, Michal Rostkowski, Jolanta Zieba, Mateusz Banaszczyk, Krystyna Hulas-Bigoszewska, Joanna Peciak, Rafal Pawliczak and Ewelina Stoczynska-Fidelus
    Citation: BMC Cancer 2014 14:669
    Content type: Research article Published on:

  50. Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Here, we reported the effect of AChE on gastric cancer therapy.

    Authors: Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu and Liang Chu
    Citation: BMC Cancer 2014 14:668
    Content type: Research article Published on:

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