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  1. Carcinogenesis affects not only humans but almost all metazoan species. Understanding the rules driving the occurrence of cancers in the wild is currently expected to provide crucial insights into identifying ...

    Authors: Hugo Ducasse, Beata Ujvari, Eric Solary, Marion Vittecoq, Audrey Arnal, Florence Bernex, Nelly Pirot, Dorothée Misse, François Bonhomme, François Renaud, Frédéric Thomas and Benjamin Roche
    Citation: BMC Cancer 2015 15:792
    Content type: Debate Published on:

  2. Tumor-associated macrophages (TAMs) promote tumor progression and have an effect on survival in human cancer. However, little is known regarding their influence on tumor progression and prognosis in human hila...

    Authors: Georgi Atanasov, Hans-Michael Hau, Corinna Dietel, Christian Benzing, Felix Krenzien, Andreas Brandl, Georg Wiltberger, Ivan Matia, Isabel Prager, Katrin Schierle, Simon C. Robson, Anja Reutzel-Selke, Johann Pratschke, Moritz Schmelzle and Sven Jonas
    Citation: BMC Cancer 2015 15:790
    Content type: Research article Published on:

  3. Cancer survivorship has emerged as an important aspect of oncology due to the possibility of physical and psychosocial complications. The purpose of this study was to assess the feasibility of the Ambulatory M...

    Authors: Gisèle Compaci, Manuela Rueter, Sébastien Lamy, Lucie Oberic, Christian Recher, Maryse Lapeyre-Mestre, Guy Laurent and Fabien Despas
    Citation: BMC Cancer 2015 15:781
    Content type: Research article Published on:

  4. Infection by the liver fluke, Opisthorchis viverrini, remains an important public health problem in Thailand and has resulted in the highest prevalence of infection and incidence of subsequent cholangiocarcinoma ...

    Authors: Supot Kamsa-ard, Vor Luvira, Ake Pugkhem, Varisara Luvira, Bandit Thinkhamrop, Krittika Suwanrungruang and Vajarabhongsa Bhudhisawasdi
    Citation: BMC Cancer 2015 15:776
    Content type: Research article Published on:

  5. Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, howeve...

    Authors: Priscilla S. Simon, Sarah K. Sharman, Chunwan Lu, Dafeng Yang, Amy V. Paschall, Sidhartha S. Tulachan and Kebin Liu
    Citation: BMC Cancer 2015 15:770
    Content type: Research article Published on:

  6. Alterations in methylation patterns, miRNA expression, and stem cell protein expression occur in germ cell tumors (GCTs). Our goal is to integrate molecular data across platforms to identify molecular signatur...

    Authors: Jenny N. Poynter, Jessica R. B. M. Bestrashniy, Kevin A. T. Silverstein, Anthony J. Hooten, Christopher Lees, Julie A. Ross and Jakub Tolar
    Citation: BMC Cancer 2015 15:769
    Content type: Research article Published on:

  7. Triple-negative breast cancers represent an important clinical challenge, as these cancers do not respond to conventional endocrine therapies or other available targeted agents. Phycocyanin (PC), a natural, wa...

    Authors: Mathangi Ravi, Shilpa Tentu, Ganga Baskar, Surabhi Rohan Prasad, Swetha Raghavan, Prajisha Jayaprakash, Jeyaraman Jeyakanthan, Suresh K Rayala and Ganesh Venkatraman
    Citation: BMC Cancer 2015 15:768
    Content type: Research article Published on:

  8. Treatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodalit...

    Authors: J. Joshua Smith, Oliver S. Chow, Marc J. Gollub, Garrett M. Nash, Larissa K. Temple, Martin R. Weiser, José G. Guillem, Philip B. Paty, Karin Avila and Julio Garcia-Aguilar
    Citation: BMC Cancer 2015 15:767
    Content type: Study protocol Published on:

  9. CXC chemokine receptor 2 (CXCR2) has been reported to play an important role in the proliferation and invasion of gastric cancer cells. The present study aims to investigate the impact of CXCR2 expression on t...

    Authors: Zhenglin Wang, Hao Liu, Zhenbin Shen, Xuefei Wang, Heng Zhang, Jing Qin, Jiejie Xu, Yihong Sun and Xinyu Qin
    Citation: BMC Cancer 2015 15:766
    Content type: Research article Published on:

  10. About one third of breast cancer survivors suffer from persistent severe fatigue after completion of curative cancer treatment. Face-to-face cognitive behavioral therapy (F2F CBT), especially designed for fati...

    Authors: H. J. G. Abrahams, M. F. M. Gielissen, M. M. Goedendorp, T. Berends, M. E. W. J. Peters, H. Poort, C. A. H. H. V. M. Verhagen and H. Knoop
    Citation: BMC Cancer 2015 15:765
    Content type: Study protocol Published on:

  11. In locally advanced rectal cancer (LARC) preoperative chemoradiation (CRT) is the standard of care, but the risk of local recurrence is low with good quality total mesorectal excision (TME), although many stil...

    Authors: R. Glynne-Jones, N. Hava, V. Goh, S. Bosompem, J. Bridgewater, I. Chau, A. Gaya, H. Wasan, B. Moran, L. Melcher, A. MacDonald, M. Osborne, S. Beare, M. Jitlal, A. Lopes, M. Hall…
    Citation: BMC Cancer 2015 15:764
    Content type: Study protocol Published on:

  12. Considering cell cycle dependent cytotoxicity, intercalation of chemotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) may be a treatment option in non-small cell lung cancer ...

    Authors: Yoon Ji Choi, Dae Ho Lee, Chang Min Choi, Jung Shin Lee, Seung Jin Lee, Jin-Hee Ahn and Sang-We Kim
    Citation: BMC Cancer 2015 15:763
    Content type: Research article Published on:

  13. Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no predictive biomarkers in clinical practice for cytotoxic drugs. We used...

    Authors: Kasia Matula, Elaina Collie-Duguid, Graeme Murray, Khyati Parikh, Heike Grabsch, Patrick Tan, Salina Lalwani, Roberta Garau, Yuhan Ong, Gillian Bain, Asa-Dahle Smith, Gordon Urquhart, Jacek Bielawski, Michael Finnegan and Russell Petty
    Citation: BMC Cancer 2015 15:762
    Content type: Research article Published on:

  14. Microcalcifications can be the early and only presenting sign of breast cancer. One shared characteristic of breast cancer is the appearance of mammographic mammary microcalcifications that can routinely be us...

    Authors: Andrés M. Castellaro, Alfredo Tonda, Hugo H. Cejas, Héctor Ferreyra, Beatriz L. Caputto, Oscar A. Pucci and German A. Gil
    Citation: BMC Cancer 2015 15:761
    Content type: Research article Published on:

  15. TP53 gene mutation is widely known as one of the determinants of impaired chemosensitivity. p53 is a tumor-suppressor protein in humans encoded by the TP53 gene. Some studies have shown that TP53 gene mutation an...

    Authors: Hiroki Osumi, Eiji Shinozaki, Mitsukuni Suenaga, Yosuke Kumekawa, Mariko Ogura, Masato Ozaka, Satoshi Matsusaka, Keisho Chin, Noriko Yamamoto and Nobuyuki Mizunuma
    Citation: BMC Cancer 2015 15:760
    Content type: Research article Published on:

  16. Neovascularization and peritumoral edema are hallmarks of glioblastoma (GBM). Programmed cell death 10 (PDCD10) plays a pivotal role in regulating apoptosis, neoangiogenesis and vessel permeability and is impl...

    Authors: Nicole Lambertz, Nicolai El Hindy, Ilonka Kreitschmann-Andermahr, Klaus Peter Stein, Philipp Dammann, Neriman Oezkan, Oliver Mueller, Ulrich Sure and Yuan Zhu
    Citation: BMC Cancer 2015 15:759
    Content type: Research article Published on:

  17. Head and neck mucosal melanoma (HNMM) is a rare type of malignant tumor that frequently exhibits postoperative recurrence and distant metastasis. Many clinicians administer postoperative adjuvant radiotherapy ...

    Authors: Wei Li, Yalian Yu, Hailong Wang, Aihui Yan and Xuejun Jiang
    Citation: BMC Cancer 2015 15:758
    Content type: Research article Published on:

  19. Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature of AML. GATA4 has been suggested to be a tumor suppressor gen...

    Authors: Yan-Fang Tao, Fang Fang, Shao-Yan Hu, Jun Lu, Lan Cao, Wen-Li Zhao, Pei-Fang Xiao, Zhi-Heng Li, Na-Na Wang, Li-Xiao Xu, Xiao-Juan Du, Li-Chao Sun, Yan-Hong Li, Yi-Ping Li, Yun-Yun Xu, Jian Ni…
    Citation: BMC Cancer 2015 15:756
    Content type: Research article Published on:

  20. The BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulat...

    Authors: Meriem Boukerroucha, Claire Josse, Sonia ElGuendi, Bouchra Boujemla, Pierre Frères, Raphaël Marée, Stephane Wenric, Karin Segers, Joelle Collignon, Guy Jerusalem and Vincent Bours
    Citation: BMC Cancer 2015 15:755
    Content type: Research article Published on:

  21. This study was designed to investigate the impact of liver cirrhosis due to chronic hepatitis C virus (HCV) infection on the disease-free and overall survival of ovarian cancer patients undergoing a standard p...

    Authors: Basel Refky, Sherif Kotb, Tamer Fady, Ahmad Marwan, Doaa Abd El-Khalek, Waleed Elnahas, Mohamed T. Hafez, Eduard Malik and Amr A. Soliman
    Citation: BMC Cancer 2015 15:754
    Content type: Research article Published on:

  22. The aetiology of urological cancers is poorly understood and variations in incidence by ethnic group may provide insights into the relative importance of genetic and environmental risk factors. Our objective w...

    Authors: Mahiben Maruthappu, Isobel Barnes, Shameq Sayeed and Raghib Ali
    Citation: BMC Cancer 2015 15:753
    Content type: Research article Published on:

  23. Osteosarcoma is a typical bone cancer that primarily affects adolescents. The therapeutic activity of drugs is limited by their severe drug-related toxicities, therefore, a therapeutic approach which is less t...

    Authors: Bin Chen, Jie-Zuan Yang, Li-Feng Wang, Yi-Jun Zhang and Xiang-Jin Lin
    Citation: BMC Cancer 2015 15:752
    Content type: Research article Published on:

  24. No screening programs are available for ovarian or endometrial cancer. One reason for this is the low incidence of the conditions, resulting in low positive predictive values for tests, which are not very spec...

    Authors: Stefanie Burghaus, Lothar Häberle, Michael G. Schrauder, Katharina Heusinger, Falk C. Thiel, Alexander Hein, David Wachter, Johanna Strehl, Arndt Hartmann, Arif B. Ekici, Stefan P. Renner, Matthias W. Beckmann and Peter A. Fasching
    Citation: BMC Cancer 2015 15:751
    Content type: Research article Published on:

  25. Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). In a single-center retrospe...

    Authors: Leif Hendrik Dröge, Hanne Elisabeth Weber, Manuel Guhlich, Martin Leu, Lena-Christin Conradi, Jochen Gaedcke, Steffen Hennies, Markus Karl Herrmann, Margret Rave-Fränk and Hendrik Andreas Wolff
    Citation: BMC Cancer 2015 15:750
    Content type: Research article Published on:

  26. To evaluate whether apparent diffusion coefficient (ADC) value of gastric cancer obtained from diffusion weighted imaging (DWI) correlates with the HER2 status.

    Authors: Jian He, Hua Shi, Zhuping Zhou, Jun Chen, Wenxian Guan, Hao Wang, Haiping Yu, Song Liu, Zhengyang Zhou, Xiaofeng Yang and Tian Liu
    Citation: BMC Cancer 2015 15:749
    Content type: Research article Published on:

  27. MicroRNAs (miRNAs) are small noncoding RNAs that potentially play a critical role in tumorigenesis. Mounting evidence indicates that one specific miRNA: miR-320b is down regulated in numerous human cancers, in...

    Authors: Hantao Wang, Fuao Cao, Xu Li, Hua Miao, Jifu E, Junjie Xing and Chuan-gang Fu
    Citation: BMC Cancer 2015 15:748
    Content type: Research article Published on:

  28. More than half of the patients selected based on KRAS mutation status fail to respond to the treatment with cetuximab in metastatic colorectal cancer (mCRC). We designed a study to identify additional biomarkers ...

    Authors: Seung Tae Kim, Tae Jin Ahn, Eunjin Lee, In-Gu Do, Su Jin Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Suk Hyeong Kim, Jeeyun Lee and Hee Cheol Kim
    Citation: BMC Cancer 2015 15:747
    Content type: Research article Published on:

  29. Stomatin-like protein 2 (SLP-2, also known as STOML2) is a stomatin homologue of uncertain function. SLP-2 overexpression has been suggested to be associated with cancer progression, resulting in adverse clini...

    Authors: Fei Sun, Wen Ding, Jie-Hua He, Xiao-Jing Wang, Ze-Biao Ma and Yan-Fang Li
    Citation: BMC Cancer 2015 15:746
    Content type: Research article Published on:

  30. Clinical care of unstable spinal bone metastases in many centers often includes patient immobilization by means of an orthopedic corset in order to prevent pathological fractures. The aim of this retrospective...

    Authors: Harald Rief, Robert Förster, Stefan Rieken, Thomas Bruckner, Ingmar Schlampp, Tilman Bostel and Jürgen Debus
    Citation: BMC Cancer 2015 15:745
    Content type: Research article Published on:

  31. In 5–20 % of patients with cervical high-grade squamous intraepithelial lesion (HSIL), a positive margin after the loop electrosurgical excision procedure (LEEP) is associated with persistence/recurrence, but ...

    Authors: Menghan Zhu, Yuan He, Jan PA Baak, Xianrong Zhou, Yuqing Qu, Long Sui, Weiwei Feng and Qing Wang
    Citation: BMC Cancer 2015 15:744
    Content type: Research article Published on:

  32. Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various solid tumors. This study aimed to evaluate the prognostic role of NLR in patients with laryngeal squamous cell carcin...

    Authors: Xiu-Ping Tu, Qian-Hui Qiu, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang and Shao-Hua Chen
    Citation: BMC Cancer 2015 15:743
    Content type: Research article Published on:

  33. Heparan sulfate proteoglycans (HSPGs) are complex molecules involved in the growth, invasion and metastatic properties of cancerous cells. This study analyses the alterations in the expression patterns of thes...

    Authors: Iván Fernández-Vega, Olivia García-Suárez, Beatriz García, Ainara Crespo, Aurora Astudillo and Luis M. Quirós
    Citation: BMC Cancer 2015 15:742
    Content type: Research article Published on:

  35. Docetaxel monotherapy is one of the standard treatments for non-small-cell lung cancer in elderly patients. The addition of bevacizumab to docetaxel seems promising; however, the feasibility of this combinatio...

    Authors: Yusuke Takagi, Yukio Hosomi, Fumihiro Oshita, Hiroaki Okamoto, Nobuhiko Seki, Koichi Minato, Hiromi Aono, Kouzo Yamada, Yusuke Okuma, Naoya Hida, Takahiko Sakamoto, Yosuke Miura, Makiko Yomota, Akira Satoh, Hideo Kunitoh, Kentaro Sakamaki…
    Citation: BMC Cancer 2015 15:740
    Content type: Research article Published on:

  36. Neoadjuvant chemotherapy (NAC) using platinum and irinotecan (CPT-11) followed by radical excision has been shown to be a valid treatment for locally advanced squamous cervical cancer (SCC) patients. However, ...

    Authors: Naoki Horikawa, Tsukasa Baba, Noriomi Matsumura, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Masafumi Koshiyama, Yumiko Yoshioka and Ikuo Konishi
    Citation: BMC Cancer 2015 15:739
    Content type: Research article Published on:

  37. Novel synthesized analogs of Aplidin, PM01215 and PM02781, were tested for antiangiogenic effects on primary human endothelial cells in vitro and for inhibition of angiogenesis and tumor growth in vivo.

    Authors: Bojana Borjan, Normann Steiner, Silvia Karbon, Johann Kern, Andrés Francesch, Martin Hermann, Wolfgang Willenbacher, Eberhard Gunsilius and Gerold Untergasser
    Citation: BMC Cancer 2015 15:738
    Content type: Research article Published on:

  38. The human Sushi Domain-Containing Protein 4 (SUSD4) was recently shown to function as a novel inhibitor of the complement system, but its role in tumor progression is unknown.

    Authors: Emelie Englund, Bart Reitsma, Ben C. King, Astrid Escudero-Esparza, Sioned Owen, Akira Orimo, Marcin Okroj, Lola Anagnostaki, Wen G. Jiang, Karin Jirström and Anna M. Blom
    Citation: BMC Cancer 2015 15:737
    Content type: Research article Published on:

  39. Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigene...

    Authors: Alexandra Kalmár, Bálint Péterfia, Péter Hollósi, Orsolya Galamb, Sándor Spisák, Barnabás Wichmann, András Bodor, Kinga Tóth, Árpád V. Patai, Gábor Valcz, Zsófia Brigitta Nagy, Vivien Kubák, Zsolt Tulassay, Ilona Kovalszky and Béla Molnár
    Citation: BMC Cancer 2015 15:736
    Content type: Research article Published on:

  40. The early age at retinoblastoma occurrence, the most common eye malignancy in childhood, suggests that perinatal factors may contribute to its etiology.

    Authors: Julia E. Heck, Negar Omidakhsh, Saeedeh Azary, Beate Ritz, Ondine S. von Ehrenstein, Greta R. Bunin and Arupa Ganguly
    Citation: BMC Cancer 2015 15:735
    Content type: Research article Published on:

  41. In German breast cancer care, the S1-guidelines of the 1990s were substituted by national S3-guidelines in 2003. The application of guidelines became mandatory for certified breast cancer centers. The aim of t...

    Authors: Christian O. Jacke, Ute S. Albert and Matthias Kalder
    Citation: BMC Cancer 2015 15:734
    Content type: Research article Published on:

  42. Several observational studies suggest that coffee consumption may be associated with an increased risk of gastric cancer, but the results are inconsistent. We conducted a meta-analysis to evaluate the relation...

    Authors: Liqing Li, Yong Gan, Chunmei Wu, Xianguo Qu, Gang Sun and Zuxun Lu
    Citation: BMC Cancer 2015 15:733
    Content type: Research article Published on:

  43. BRAF and MEK are component of the MAPK/ERK pathway and inhibitors of these proteins have significantly improved the outcome of metastatic melanoma. We report for the first time two sequential episodes of pneum...

    Authors: Violaine Giraud, Christine Longvert, Solène Houlle-Crepin, Claire Danel, Sylvie Labrune, Philippe Camus, Philippe Saiag and Thierry Chinet
    Citation: BMC Cancer 2015 15:732
    Content type: Case report Published on:

  44. Chemotherapy is an important therapeutic approach for non-small cell lung cancer (NSCLC). However, a successful long-term treatment can be prevented by the occurring of chemotherapy resistance frequently, and ...

    Authors: Jian Zhao, Wenfan Fu, Hongying Liao, Lu Dai, Zeyong Jiang, Youguang Pan, Haoda Huang, Yijun Mo, Siwen Li, Guangping Yang and Jun Yin
    Citation: BMC Cancer 2015 15:731
    Content type: Research article Published on:

  45. The side population (SP) of cancer cells is reportedly enriched with cancer stem cells (CSCs), however, the functional role and clinical relevance of CSC marker molecules upregulated in the SP of head and neck...

    Authors: Noboru Habu, Yorihisa Imanishi, Kaori Kameyama, Masayuki Shimoda, Yutaka Tokumaru, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Hiroyuki Ozawa, Toshiki Tomita, Masato Fujii and Kaoru Ogawa
    Citation: BMC Cancer 2015 15:730
    Content type: Research article Published on:

  46. The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was...

    Authors: Eric Hervouet, Aurore Claude-Taupin, Thierry Gauthier, Valérie Perez, Annick Fraichard, Pascale Adami, Gilles Despouy, Franck Monnien, Marie-Paule Algros, Michèle Jouvenot, Régis Delage-Mourroux and Michaël Boyer-Guittaut
    Citation: BMC Cancer 2015 15:729
    Content type: Research article Published on:

  48. The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in patients with breast cancer remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopatho...

    Authors: Daqing Jiang, Zhaohua Gao, Zhengang Cai, Meixian Wang and Jianjun He
    Citation: BMC Cancer 2015 15:727
    Content type: Research article Published on:

  49. Induction chemotherapy incorporating docetaxel, cisplatin and 5- fluorouracil before radiotherapy may improve the outcome of patients with advanced head and neck cancer. Nevertheless, the addition of docetaxel...

    Authors: Thomas Melchardt, Clemens Hufnagl, Teresa Magnes, Lukas Weiss, Georg Hutarew, Daniel Neureiter, Alexander Schlattau, Gerhard Moser, Alexander Gaggl, Wolfgang Tränkenschuh, Richard Greil and Alexander Egle
    Citation: BMC Cancer 2015 15:725
    Content type: Research article Published on:

  50. Although the occurrence of acute myeloid leukemia (AML) after chemotherapy for multiple myeloma (MM) is common in clinical settings, the simultaneous occurrence of these malignancies in patients without previo...

    Authors: Wang Lu-qun, Li Hao, Li Xiang-xin, Li Fang-lin, Wang Ling-ling, Chen Xue-liang and Hou Ming
    Citation: BMC Cancer 2015 15:724
    Content type: Case report Published on:

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